|Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|Outline of Final Research Achievements
Selenoprotein P (SeP), a plasma protein containing essential trace element selenium, functions as a transporter of selenium, delivering selenium to the cells. We found the increase of SeP levels in type 2 diabetes patients and have reported that increased SeP (excess SeP) worsen glucose metabolism via the increase of insulin resistance in the skeletal muscle and liver. In the present study, we found that excess SeP is incorporated into the pancreatic beta cells via SeP receptors and decreases insulin secretion via ER stress. Furthermore, we found the physiological role of SeP expression in the pancreatic beta cells and stated the novel metabolism regulation between the pancreas and liver via insulin and SeP.