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Study on preventive method of development and/or rupture of abdominal aortic aneurysm

Research Project

Project/Area Number 17H03822
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionKindai University

Principal Investigator

zaima nobuhiro  近畿大学, 農学部, 准教授 (40455572)

Co-Investigator(Kenkyū-buntansha) 佐々木 健  浜松医科大学, 医学部, 技術専門員 (20397433)
田中 宏樹  浜松医科大学, 医学部, 特任研究員 (50456563)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords腹部大動脈瘤 / 血管 / 大動脈瘤 / 脂肪細胞 / 栄養学 / 脂質
Outline of Final Research Achievements

Abdominal aortic aneurysm is a vascular disease with silent graduation of abdominal aorta. Several previous studies suggested that dietary habits affect the development of abdominal aortic aneurysm. However, the relationship between dietary habits and abdominal aortic aneurysm are clearly unknown. In this study, we found several food factors which have pro-aneurysm and anti-aneurysm effect. In addition, we reported mechanisms of action of the food factors. These findings provide important basic evidence to develop method of preventing abdominal aortic aneurysm.

Academic Significance and Societal Importance of the Research Achievements

これまで不明な点が多かった腹部大動脈瘤の進展と食生活の関係を明らかにするために必要な基礎研究基盤を構築した。構築した基礎研究基盤から、腹部大動脈瘤の進展を抑制する可能性のある成分や促進する可能性のある成分などが明らかになった。これらの研究は、腹部大動脈瘤の破裂を食品成分で予防するための方法の確立に貢献できると期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (49 results)

All 2021 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 5 results) Presentation (36 results) (of which Int'l Joint Research: 2 results,  Invited: 9 results)

  • [Journal Article] Similar distribution of orally administered eicosapentaenoic acid and M2 macrophage marker in the hypoperfusion-induced abdominal aortic aneurysm wall2021

    • Author(s)
      Fujishima Rena、Kugo Hirona、Yanagimoto Kenichi、Enomoto Hirofumi、Moriyama Tatsuya、Zaima Nobuhiro
    • Journal Title

      Food & Function

      Volume: in press Issue: 8 Pages: 3469-3475

    • DOI

      10.1039/d0fo03317k

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-Dependent Pathological Changes in Hypoperfusion-Induced Abdominal Aortic Aneurysm2021

    • Author(s)
      Kugo Hirona、Sukketsiri Wanida、Tanaka Hiroki、Fujishima Rena、Moriyama Tatsuya、Zaima Nobuhiro
    • Journal Title

      Biology

      Volume: 10 Issue: 2 Pages: 149-149

    • DOI

      10.3390/biology10020149

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Seed Coat Extract of Black Soybean Decreases Nicotine-Induced Vascular Fiber Degradation by Suppressing Matrix Metalloproteinase 2 Expression2020

    • Author(s)
      Hoshino K, Kugo H, Miyamoto C, Hashimoto K, Murase H, Mizuno M, Moriyama T, Zaima N.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 66 Issue: 1 Pages: 75-81

    • DOI

      10.3177/jnsv.66.75

    • NAID

      130007803611

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2020-02-29
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model2020

    • Author(s)
      Tanaka Hiroki、Zaima Nobuhiro、Kugo Hirona、Yata Tatsuro、Iida Yasunori、Hashimoto Keisuke、Miyamoto Chie、Sasaki Takeshi、Sano Hideto、Suzuki Yuko、Moriyama Tatsuya、Shimizu Hideyuki、Inuzuka Kazunori、Urano Tetsumei、Unno Naoki
    • Journal Title

      Annals of Vascular Surgery

      Volume: 63 Pages: 382-390

    • DOI

      10.1016/j.avsg.2019.08.082

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ovariectomy increases the incidence and diameter of abdominal aortic aneurysm in a hypoperfusion-induced abdominal aortic aneurysm animal model.2019

    • Author(s)
      Miyamoto C, Kugo H, Hashimoto K, Moriyama T, Zaima N.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 18330-18330

    • DOI

      10.1038/s41598-019-54829-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of perivascular adipose tissue in the appearance of ectopic adipocytes in the abdominal aortic aneurysmal wall.2019

    • Author(s)
      Kugo H, Moriyama T, Zaima N.
    • Journal Title

      Adipocyte

      Volume: 8 Issue: 1 Pages: 229-239

    • DOI

      10.1080/21623945.2019.1636625

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sesame Extract Attenuates the Degradation of Collagen and Elastin Fibers in the Vascular Walls of Nicotine-administered Mice2019

    • Author(s)
      Kugo Hirona、Miyamoto Chie、Sawaragi Ayaka、Hoshino Kiyoto、Hamatani Yuka、Matsumura Shinichi、Yoshioka Yuri、Moriyama Tatsuya、Zaima Nobuhiro
    • Journal Title

      Journal of Oleo Science

      Volume: 68 Issue: 1 Pages: 79-85

    • DOI

      10.5650/jos.ess18200

    • NAID

      130007541844

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological Implication of Adipocytes in AAA Development and the Rupture2018

    • Author(s)
      Kugo Hirona、Tanaka Hiroki、Moriyama Tatsuya、Zaima Nobuhiro
    • Journal Title

      Annals of Vascular Diseases

      Volume: 11 Issue: 2 Pages: 159-168

    • DOI

      10.3400/avd.ra.17-00130

    • NAID

      130007410749

    • ISSN
      1881-641X, 1881-6428
    • Year and Date
      2018-06-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary DNA Attenuates the Degradation of Elastin Fibers in the Aortic Wall in Nicotine-Administrated Mice2018

    • Author(s)
      HASHIMOTO Keisuke、ZAIMA Nobuhiro、SEKIGUCHI Hirotaka、KUGO Hirona、MIYAMOTO Chie、HOSHINO Kiyoto、KAWASAKI Natsumi、SUTOH Keita、USUMI Koji、MORIYAMA Tatsuya
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 64 Issue: 4 Pages: 271-276

    • DOI

      10.3177/jnsv.64.271

    • NAID

      130007472692

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appearance of Adipocytes in Thoracic Aortic Aneurysm2018

    • Author(s)
      Kugo Hirona、Ikeda Yoshihiko、Moriyama Tatsuya、Zaima Nobuhiro
    • Journal Title

      Journal of Oleo Science

      Volume: 67 Issue: 12 Pages: 1543-1549

    • DOI

      10.5650/jos.ess18122

    • NAID

      130007539095

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Effect of a High-Fat Diet on the Development of Abdominal Aortic Aneurysm in a Vascular Hypoperfusion-Induced Animal Model2018

    • Author(s)
      Hashimoto Keisuke、Kugo Hirona、Tanaka Hiroki、Iwamoto Kazuko、Miyamoto Chie、Urano Tetsumei、Unno Naoki、Hayamizu Kohsuke、Zaima Nobuhiro、Moriyama Tatsuya
    • Journal Title

      Journal of Vascular Research

      Volume: 55 Issue: 2 Pages: 63-74

    • DOI

      10.1159/000481780

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipocytes and abdominal aortic aneurysm: Putative potential role of adipocytes in the process of AAA development2018

    • Author(s)
      Kugo Hirona、Moriyama Tatsuya、Zaima Nobuhiro
    • Journal Title

      Current Drug Targets

      Volume: 印刷中 Issue: 11 Pages: 1228-1232

    • DOI

      10.2174/1389450119666180115164103

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of high sucrose diet on development of abdominal aortic aneurysm in hypoperfusion-induced animal model2018

    • Author(s)
      Miyamoto Chie, Kugo Hirona, Sawaragi Ayaka, Zaima Nobuhiro, Moriyama Tatsuya
    • Journal Title

      Journal of Oleo Science

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腹部大動脈瘤の進展と破裂に対する魚油投与の影響評価2020

    • Author(s)
      藤嶋玲奈、星野健斗、久後裕菜、毛利陽平、柳本賢一、財満信宏、森山達哉
    • Organizer
      第3回日本食品科学工学会関西支部大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 「質量分析イメージングで代謝物・機能性成分を見る」2019

    • Author(s)
      財満 信宏
    • Organizer
      日本栄養・食糧学会関東支部大会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 「EPA・DHA・魚油の生理機能」2019

    • Author(s)
      財満 信宏
    • Organizer
      中性脂肪学会第3回学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 大動脈壁の循環不全によって誘導される脂肪細胞異常出現機構とその病理学的意義2019

    • Author(s)
      財満 信宏、久後 裕菜、森山 達哉
    • Organizer
      第60回日本脈管学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] New pathology of abdominal aortic aneurysm and potential method for its prevention2019

    • Author(s)
      Nobuhiro ZAIMA
    • Organizer
      Kyoto Biomolecular Mass Spectrometry Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腹部大動脈瘤ー血管の破裂と中性脂肪の関係ー2018

    • Author(s)
      財満信宏
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 質量分析イメージングによって発見した、動脈硬化・腹部大動脈瘤における新規病態とそれらを標的とした予防・治療の可能性2018

    • Author(s)
      財満信宏
    • Organizer
      第43回日本医用マススペクトル学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 中性脂肪代謝を中心に見た動脈硬化と腹部大動脈瘤2018

    • Author(s)
      財満信宏
    • Organizer
      第50回日本動脈硬化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 腹部大動脈瘤に対する高脂肪食・高シュークロース食の影響の違い2018

    • Author(s)
      宮本智絵、久後裕菜、橋本佳祐、財満信宏、森山達哉
    • Organizer
      日本栄養・食糧学会 第57回近畿支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食餌性DNAがニコチン投与マウスの血管壁に及ぼす影響の評価2018

    • Author(s)
      星野健斗、久後裕菜、宮本智絵、関口博太、須藤慶太、宇住晃治、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] EPA高含有魚油摂取がニコチン投与マウスの血管壁に及ぼす影響の評価2018

    • Author(s)
      星野健斗、久後裕菜、宮本智絵、小野里恵、柳本賢一、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹部大動脈瘤発症に対する魚油の予防効果の検討2018

    • Author(s)
      藤嶋玲奈、宮本智絵、星野健斗、久後裕菜、毛利陽平、柳本賢一、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹部大動脈瘤の破裂に対するEPA高含有魚油摂取の影響評価2018

    • Author(s)
      宮本智絵、久後裕菜、星野健斗、柳本賢一、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹部大動脈瘤の進展・破裂に及ぼす食事の影響評価2018

    • Author(s)
      宮本智絵、久後裕菜、星野健斗、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹部大動脈瘤における異所性脂肪細胞出現に対する血管周囲脂肪の影響2018

    • Author(s)
      久後裕菜、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血管壁異所性脂肪細胞が腹部大動脈瘤破裂に及ぼす影響の評価2018

    • Author(s)
      久後裕菜、宮本智絵、星野健斗、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 低栄養状態が脂肪細胞分化に及ぼす影響2018

    • Author(s)
      岩本和子、吸原慧紀、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第2回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血管壁に異常出現する脂肪細胞が腹部大動脈瘤破裂に及ぼす影響の評価2018

    • Author(s)
      財満信宏、久後裕菜、田中宏樹、柳本賢一、佐々木健、浦野哲盟、海野直樹、森山達哉
    • Organizer
      第59回日本脈管学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] EPA高含有魚油投与が腹部大動脈瘤の進展と破裂に及ぼす影響の評価2018

    • Author(s)
      久後裕菜、財満信宏、田中宏樹、柳本賢一、佐々木健、浦野哲盟、海野直樹、森山達哉
    • Organizer
      第59回日本脈管学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] セサミン・セサモリンの投与がニコチン投与マウスの血管壁に及ぼす影響の評価2018

    • Author(s)
      久後裕菜、宮本智絵、松村晋一、吉岡百合、財満信宏、森山達哉
    • Organizer
      日本油化学会第57回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹部大動脈瘤の進展・破裂に対するEPA高含有魚油の予防効果の検討2018

    • Author(s)
      久後裕菜、橋本佳祐、宮本智絵、柳本賢一、財満信宏、森山達哉
    • Organizer
      第72回日本栄養食糧学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 黒大豆種皮抽出物の摂取がニコチン投与マウスの血管壁に及ぼす影響の評価2018

    • Author(s)
      星野健斗、久後裕菜、橋本佳祐、宮本智絵、川崎奈津美、村瀬浩、水野雅敏、財満信宏、森山達哉
    • Organizer
      第72回日本栄養食糧学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腹部大動脈瘤進展・破裂に及ぼすEPA高含有魚油の影響の評価2018

    • Author(s)
      久後裕菜、橋本佳祐、宮本智絵、柳本賢一、財満信宏、森山達哉
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 魚油摂取がニコチン投与マウスの血管壁に及ぼす影響の評価」2017

    • Author(s)
      星野健斗、久後裕菜、小野里 恵、宮本智絵、橋本佳祐、柳本賢一、財満信宏、森山達哉
    • Organizer
      日本栄養・食糧学会 第56回近畿支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高シュークロース食の摂取が腹部大動脈瘤の進展・破裂に及ぼす影響の病理学的評価2017

    • Author(s)
      宮本智絵、橋本佳祐、久後裕菜、財満信宏、森山達哉
    • Organizer
      日本栄養・食糧学会 第56回近畿支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪分の過剰摂取は血管壁への脂質の蓄積を通じてAAA の破裂リスクを増加させる2017

    • Author(s)
      橋本佳祐、久後裕菜、宮本智絵、財満信宏、森山達哉
    • Organizer
      日本栄養・食糧学会 第56回近畿支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Studies on rupture mechanisms of abdominal aortic aneurysm formed in hypoperfusion-induced animal2017

    • Author(s)
      Nobuhiro Zaima, Hirona Kugo, Keisuke Hashimoto, Chie Miyamoto, Kenichi Yanagimoto, Tatsuya Moriyama
    • Organizer
      The Asian Conference on Oleo Science 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腹部大動脈瘤血管壁における脂肪細胞出現機構の解明2017

    • Author(s)
      久後裕菜、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第1回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高シュークロース食の摂取が腹部大動脈瘤の進展・破裂と血管壁に出現する脂肪細胞へ及ぼす影響の病理的評価2017

    • Author(s)
      宮本智絵、橋本佳祐、久後裕菜、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第1回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪分の過剰摂取がAAAに与える影響2017

    • Author(s)
      橋本佳祐、久後裕菜、宮本智絵、財満信宏、森山達哉
    • Organizer
      中性脂肪学会第1回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腹部大動脈瘤の破裂機構の解明と破裂予防法の検討2017

    • Author(s)
      財満信宏、久後裕菜、田中宏樹、柳本賢一、佐々木健、浦野哲盟、海野直樹、森山達哉
    • Organizer
      第59回日本脂質生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高シュークロース食摂取による腹部大動脈瘤の進展・破裂への影響評価2017

    • Author(s)
      宮本智絵、橋本佳祐、久後裕菜、財満信宏、森山達哉
    • Organizer
      第71回日本栄養・食糧学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血管壁に異常出現した脂肪細胞が腹部大動脈瘤破裂を誘導する2017

    • Author(s)
      久後裕菜、財満信宏、田中宏樹、毛利陽平、柳本賢一、佐々木健、浦野哲盟、海野直樹、森山達哉
    • Organizer
      第71回日本栄養・食糧学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MALDI-MSIによる代謝物イメージングによって発見した動脈硬化・腹部大動脈瘤における新規病態と予防法の検討2017

    • Author(s)
      財満信宏
    • Organizer
      第8回機能性油脂懇話会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 動脈硬化・腹部大動脈瘤における新規病態の発見と機能性成分による予防の可能性2017

    • Author(s)
      財満信宏
    • Organizer
      2017年度健康食品管理士近畿支部 第1回講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腹部大動脈瘤破裂と TG の関係2017

    • Author(s)
      財満信宏
    • Organizer
      中性脂肪学会第1回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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