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Biology of lifespan and size of vertebrate using fish as a model

Research Project

Project/Area Number 17H03869
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Aquatic life science
Research InstitutionThe University of Tokyo

Principal Investigator

Kinoshita Shigeharu  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40401179)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords寿命 / 老化 / 魚 / 筋肉 / 成長ホルモン / 体サイズ / 成長 / オートファジー / 魚類 / ゼブラフィッシュ / 幹細胞 / オンデンザメ / mTOR / 水産学 / 比較トランスクリプトーム / 比較ゲノム
Outline of Final Research Achievements

Fish exhibit a variety of anti-aging characteristics, and are an interesting target for exploring the diversity of lifespan and aging, with some species living much longer than the maximum human lifespan and some species dying in less than a year. In this study, we proposed that the mTOR signaling, which regulates the balance between growth and aging, may be suppressed in fish during the aged stage in relation to the maintenance of lifelong muscle growth and regeneration, which is one of the anti-aging properties shown by fish. We also showed that excessive promotion of mTOR signaling promotes growth, but at the expense of various important anti-aging processes such as autophagy and DNA repair pathways, which in turn promote aging. We also revealed the possibility of post-spawning senescent cell accumulation in short-lived fish and the common genetic evolution of long-lived species in long-lived fish.

Academic Significance and Societal Importance of the Research Achievements

脊椎動物は種によって成長や寿命が多様である。魚類は様々な抗老化特性を示すが、mTORなど脊椎動物に共通する寿命や老化の制御機構において、加齢段階で哺乳類とは異なるを活性を持つことが示された。また、これらカスケードを人為的に操作することで、成長のバランスが崩れると、どのようなメカニズムで老化が促進されるかを明らかにした。こうした知見は脊椎動物一般の老化や寿命を考える上で重要である。また、魚類の短命種や超長命種について、幾つか寿命特性と関連する可能性のある遺伝子やカスケードを見出した。これらについては今後さらに検討が必要であるが、脊椎動物の新しい寿命や老化の制御機構の発見につながる可能性がある。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (19 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results) Presentation (15 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results)

  • [Journal Article] Sodium alginate supplementation modulates gut microbiota, health parameters, growth performance and growth‐related gene expression in Malaysian Mahseer Tor tambroides2019

    • Author(s)
      Asaduzzaman Md、Iehata Shumpei、Moudud Islam Md、Kader Md Abdul、Ambok Bolong Abol‐Munafi、Ikeda Daisuke、Kinoshita Shigeharu
    • Journal Title

      Aquaculture Nutrition

      Volume: 25 Issue: 6 Pages: 1300-1317

    • DOI

      10.1111/anu.12950

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Zebrafish Acromegaly Model Elevates DNA Damage and Impairs DNA Repair Pathways2018

    • Author(s)
      Elbialy Abdalla、Asakawa Shuichi、Watabe Shugo、Kinoshita Shigeharu
    • Journal Title

      Biology

      Volume: 7 Issue: 4 Pages: 47-47

    • DOI

      10.3390/biology7040047

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoter analysis of the fish gene of slow/cardiac-type myosin heavy chain implicated in specification of muscle fiber types2018

    • Author(s)
      Kinoshita S, Ceyhun SB, Md A, Siddique BS, Akolkar DB, Asakawa S, Watabe S.
    • Journal Title

      Fish Physiology and Biochemistry

      Volume: 44 Issue: 2 Pages: 679-691

    • DOI

      10.1007/s10695-018-0463-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host gut-derived probiotic bacteria promote hypertrophic muscle progression and upregulate growth-related gene expression of slow-growing Malaysian Mahseer Tor tambroides2018

    • Author(s)
      Asaduzzaman Md、Sofia Ezzah、Shakil Abrar、Haque Nayeema Ferdausy、Khan M. Nurul Absar、Ikeda Daisuke、Kinoshita Shigeharu、Abol-Munafi Ambok Bolong
    • Journal Title

      Aquaculture Reports

      Volume: 9 Pages: 37-45

    • DOI

      10.1016/j.aqrep.2017.12.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] TGF-βsuperfamily in aging of zebrafish skeletal muscle2019

    • Author(s)
      S. Toma, W.T. Wang, Y. Kijima, A.K. Elbialy, Y. Igarashi, S. Asakawa, S. Watabe, S. Kinoshita
    • Organizer
      International Symposium on Aquatic Metagenomics 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成長ホルモン過剰魚におけるDNA損傷の蓄積に関する検討2019

    • Author(s)
      Elbialy Abdallah Khairy・浅川修一・ 渡部終五・木下滋晴
    • Organizer
      令和元年度日本水産学会秋季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成長ホルモン過剰発現ゼブラフィッシュにおけるオートファジーの抑制と小胞体ストレスの亢進.2018

    • Author(s)
      ELBIALY Abdallah Khairy, 木下滋晴, 吉武和敏, 浅川修一, 渡部終五.
    • Organizer
      第20回マリンバイオテクノロジー学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 不老不死は可能なのか?魚をモデルにヒトの寿命と老化を探る.2018

    • Author(s)
      木下滋晴
    • Organizer
      第82回SCCJ研究討論会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] コイ科魚類の比較ゲノム解析を用いた寿命・老化特性の探索2018

    • Author(s)
      木島佑輔・吉武和敏・木下滋晴・浅川修一・渡部終五
    • Organizer
      平成31年度公益社団法人日本水産学会春季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Reduction of autophagy in acromegaly mimic zebrafish induce endoplasmic reticulum stress2018

    • Author(s)
      Abdallah Khairy Elbialy・Kasutoshi Yoshitake・Shigeharu Kinoshita・ Shuichi Asakawa・Shugo Watabe
    • Organizer
      2018年度水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュとラットの比較トランスクリプトーム解析2018

    • Author(s)
      木島佑輔・汪婉桐・五十嵐洋治・木下滋晴・吉武和敏・浅川修一・ 鈴木 穣・渡部終五
    • Organizer
      2018年度水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 魚類におけるmyomiRNAの進化および分布2017

    • Author(s)
      木下滋晴, Bhuiyan Sharmin Siddique, Chaninya Wongkarangkana, 浅川修一, 渡部終五
    • Organizer
      第19回マリンバイオテクノロジー学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Molecular Basis for the Indeterminate Growth of Fish Skeletal Muscle2017

    • Author(s)
      S. Kinoshita・W.T. Wang・Y. Kijima・S. Toma・A.K. Elbialy・S. Zhang・M. Mizukoshi, Y. Igarashi・S. Asakawa・S. Watabe
    • Organizer
      10th European ZebraFish Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aging,Autophagy and Apoptosis in Growth Hormone-Transgenic Zebrafish Larvae2017

    • Author(s)
      A. K. Elbialy・W. Wang・S. Kinoshita・S. Asakawa・S. Watabe
    • Organizer
      10th European ZebraFish Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitatively Analyzing TOR-dependent Autophagy in GH Transgenic Zebrafish Embryos By 3D Image Analysis2017

    • Author(s)
      A. K. Elbialy・S. Kinoshita・S. Asakawa・S. Watabe
    • Organizer
      JSFS85 International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular basis for the negligible senescence of fish skeletal muscle2017

    • Author(s)
      Shigeharu Kinoshita・WanTong Wang・Yusuke Kijima・Shogo Toma・Abdalla Khiry Elbialy・Yoji Igarashi・Shuichi Asakawa・Shugo Watabe
    • Organizer
      JSFS85 International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] xpression changes of myostatin and GDF11 with aging of zebrafish skeletal muscle2017

    • Author(s)
      W.T. Wang・S. Toma・Y. Kijima・A.K. Elbialy・Y. Igarashi・S. Kinoshita・S. Asakawa・S. Watabe
    • Organizer
      JSFS85 International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Age-related expression changes in telomere maintenance genes of zebrafish revealed by RNA-seq2017

    • Author(s)
      Yusuke Kijima, Wangtong Wang, Yoji Igarashi, Shigeharu Kinoshita, Shuichi Asakawa, Shugo Watabe
    • Organizer
      JSFS85 International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular basis on the indeterminate growth observed in fish skeletal muscle2017

    • Author(s)
      Shigeharu Kinoshita
    • Organizer
      Fisheries & Aquaculture 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2022-12-28  

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