Development of novel anti-cancer strategy targeting protein phosphatases
| Project/Area Number |
17H03915
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Ohama Takashi 山口大学, 共同獣医学部, 准教授 (50579018)
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| Co-Investigator(Kenkyū-buntansha) |
大松 勉 東京農工大学, 農学部, 准教授 (60455392)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | がん幹細胞 / PP2A / 骨肉腫 / 比較腫瘍学 / SET / E2F1 / がん / 薬理学 |
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| Outline of Final Research Achievements |
This project aimed to propose the efficacy of anti-cancer drug development targeting protein phosphatase activation, by clearing the role of SET/I2PP2A, an endogenous inhibitory protein for protein phosphatase 2A (PP2A), on cancer promotion. We revealed the molecular mechanisms of SET-mediating cancer promotion in canine mammary tumors, canine osteosarcomas, and human various tumors including stomach cancers. We also found that SET-targeting drugs exert anti-cancer effects on these canine and human cancers. We published five original papers for these research findings, and are preparing for the submission for two sub-projects.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、リン酸化酵素キナーゼに対する阻害剤に偏重している分子標的抗がん剤開発の分野に「ホスファターゼを活性化する」創薬という新たな視座を提供するための基盤的研究である。この視座に立った創薬は、従来の「キナーゼを阻害する」薬剤と相加・相乗効果が期待できるだけでなく、ホスファターゼ活性の低下はキナーゼ阻害剤に対する耐性の獲得にも重要であることから、キナーゼ阻害剤に抵抗性または耐性を獲得した症例に対しても効果が期待でき、ファースト・イン・クラスの画期的な創薬に繋がる可能性を秘めている。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis2018
Author(s)
Enjoji Shuhei、Yabe Ryotaro、Tsuji Shunya、Yoshimura Kazuhiro、Kawasaki Hideyoshi、Sakurai Masashi、Sakai Yusuke、Takenouchi Hiroko、Yoshino Shigefumi、Hazama Shoichi、Nagano Hiroaki、Oshima Hiroko、Oshima Masanobu、Vitek Michael P.、Matsuura Tetsuya、Hippo Yoshitaka、Usui Tatsuya、Ohama Takashi、Sato Koichi
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Journal Title
Molecular Cancer Research
Volume: 16
Issue: 3
Pages: 554-563
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The role of SET/I2PP2A in canine mammary tumors2017
Author(s)
Kake Satoru、Tsuji Shunya、Enjoji Shuhei、Hanasaki Sayaka、Hayase Hiroshi、Yabe Ryotaro、Tanaka Yuiko、Nakagawa Takayuki、Liu Hao-Ping、Chang Shih-Chieh、Usui Tatsuya、Ohama Takashi、Sato Koichi
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 4279-4279
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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