Development of innovative cancer treatment technology by enhancing intratumoral penetration and cellular uptake of nanoparticles by weak electric current
| Project/Area Number |
17H03976
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KOGURE Kentaro 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 (70262540)
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| Co-Investigator(Kenkyū-buntansha) |
南川 典昭 徳島大学, 大学院医歯薬学研究部(薬学域), 教授 (40209820)
田中 保 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 教授 (90258301)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | ドラッグデリバリー / 微弱電流 / ナノ粒子 / がん治療 / 微弱電流処理 |
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| Outline of Final Research Achievements |
The purpose of this study was to establish an efficient cancer treatment method by enhancing the EPR effect and inducing intracellular uptake of nanoparticles by iontophoresis (IP). We succeeded in increasing the tumor accumulation of nanoparticles administered intravenously to tumor-bearing mice by about 2 times by IP. We also found that IP increased FITC-labeled dextran leakage in embryonic chicken eggs by about 2-fold. We also found that tumor tissue IP reduced the expression level of connexin Cx43 and promoted phosphorylation, activated GTPase through Hsp90 protein activation, and induced unique endocytosis. In addition, the combination of IP and anti-cancer nanoparticles tended to suppress tumor growth more than administration of nanoparticles alone.
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| Academic Significance and Societal Importance of the Research Achievements |
微弱電流を用いる薬物送達技術イオントフォレシスによって、腫瘍組織の生理機能を変化させることで、ナノ粒子等の薬物送達効率を向上させることに成功したことは、世界で初めての成果であり、がん治療薬物領域の発展に大きく貢献するものである。また、近年ヒトのがんでは、EPR効果が見られないとも言われているが、イオントフォレシスを組合わせることでEPR効果を誘起することが可能になり、がん治療効果の増強に繋がることから、国民の健康福祉に貢献することが期待される。
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Report
(4 results)
Research Products
(15 results)
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[Presentation] Effective cellular delivery of intelligent shRNA expression device by faint electricity2017
Author(s)
Kogure K, Tarashima N, Fujikawa K, Oshima Y, Torao T, Mimura M, Hasan M, Hama S, Tanaka T, Saito H, Minakawa N
Organizer
6th FIP Pharmaceutical Sciences World Congress (PSWC)
Related Report
Int'l Joint Research
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