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Structural diversity and biosynthetic mechanisms of O-mannosyl glycans in mammals

Research Project

Project/Area Number 17H03987
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Manya Hiroshi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (20321870)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords糖鎖 / 神経疾患 / 筋疾患 / O-マンノース型糖鎖
Outline of Final Research Achievements

We found the CDP-glycerol (CDP-Gro), which is a novel sugar alcohol nucleotide donor in mammals, and identified that the PCYT2 is CDP-Gro synthase. The biosynthesis of functional O-mannosyl glycans require the formation of tandem ribitol phosphate structure by transfer from CDP-ribitol (CDP-Rbo), but glycerol phosphate (GroP) transferred from CDP-Gro inhibited the formation of tandem ribitol phosphate structure. We also determined the crystal structures of POMGNT2, POMK, and FKRP, which are biosynthetic enzymes of O-mannosyl glycans in mammals, revealing the detailed mechanism of the glycosylation by each enzyme.

Academic Significance and Societal Importance of the Research Achievements

哺乳類におけるCDP-Groの発見とその合成酵素PCYT2の同定により、これまで哺乳類で知られていなかった新しい代謝経路が明らかとなった。さらに、CDP-GroとCDP-Rboという2つの糖供与体の競合により糖鎖合成を制御するという新しいメカニズムも明らかとなった。また、結晶構造を解明した酵素は先天性筋ジストロフィー症の原因遺伝子であることから、触媒機構の解明は疾患変異による病態機序を理解する上で重要である。本研究により、生物学的にも医学的にも重要な成果が得られた。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(74 results)

All 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (20 results) Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 11 results,  Acknowledgement Compliant: 1 results) Presentation (34 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Radboud University Medical Center(オランダ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Peking University First Hospital/Peking Union Medical College(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] McGill University Health Centre(カナダ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Radboud University Medical Center(オランダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Peking University First Hospital/Peking Union Medical College(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] McGill University Health Centre(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Radboud University Medical Center(オランダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Peking University First Hospital/Peking Union Medical College(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] McGill University Health Centre(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Radboud University Medical Center(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Peking University First Hospital/Peking Union Medical College(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] McGill University Health Centre(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Radboud University Medical Center(オランダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Peking University First Hospital/Peking Union Medical College(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] McGill University Health Centre(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model2022

    • Author(s)
      Tokuoka Hideki、Imae Rieko、Nakashima Hitomi、Manya Hiroshi、Masuda Chiaki、Hoshino Shunsuke、Kobayashi Kazuhiro、Lefeber Dirk J.、Matsumoto Riki、Okada Takashi、Endo Tamao、Kanagawa Motoi、Toda Tatsushi
    • Journal Title

      Nature Communications

      Volume: 13 Pages: 1847-1847

    • DOI

      10.1038/s41467-022-29473-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The structure of POMGNT2 provides new insights into the mechanism to determine the functional <i>O</i> ‐mannosylation site on α‐dystroglycan2021

    • Author(s)
      Imae Rieko、Kuwabara Naoyuki、Manya Hiroshi、Tanaka Tomohiro、Tsuyuguchi Masato、Mizuno Mamoru、Endo Tamao、Kato Ryuichi
    • Journal Title

      Genes to Cells

      Volume: 26 Pages: 485-494

    • DOI

      10.1111/gtc.12853

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PCYT2 synthesizes CDP-glycerol in mammals and reduced PCYT2 enhances the expression of functionally glycosylated α-dystroglycan2021

    • Author(s)
      Imae Rieko、Manya Hiroshi、Tsumoto Hiroki、Miura Yuri、Endo Tamao
    • Journal Title

      Journal of Biochemistry

      Volume: 170 Pages: 183-194

    • DOI

      10.1093/jb/mvab069

    • NAID

      40022723391

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT12020

    • Author(s)
      Manya Hiroshi、Kuwabara Naoyuki、Kato Ryuichi、Endo Tamao
    • Journal Title

      Methods in Molecular Biology

      Volume: 2132 Pages: 609-619

    • DOI

      10.1007/978-1-0716-0430-4_52

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic Mechanisms of a Unique Ribitol Phosphate-containing Glycan by FKRP, a Ribitol Phosphate Transferase2020

    • Author(s)
      Imae R, Kuwabara N, Manya H, Kato R, Endo T
    • Journal Title

      TIGG

      Volume: 32 Issue: 190 Pages: E195-E200

    • DOI

      10.4052/tigg.2008.1e

      10.4052/tigg.2008.1E

    • NAID

      130007942390

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.2020

    • Author(s)
      Kuwabara N, Imae R, Manya H, Tanaka T, Mizuno M, Tsumoto H, Kanagawa M, Kobayashi K, Toda T, Senda T, Endo T, Kato R.
    • Journal Title

      Nat Commun

      Volume: 11 Pages: 303-303

    • DOI

      10.1038/s41467-019-14220-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of <i>O</i>-Mannosyl Glycan Biosynthesis in Mammals2019

    • Author(s)
      Manya Hiroshi
    • Journal Title

      TIGG

      Volume: 31 Issue: 181 Pages: SE63-SE64

    • DOI

      10.4052/tigg.1930.2se

      10.4052/tigg.1930.2SE

    • NAID

      130007683661

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] CDP-glycerol inhibits the synthesis of the functionalO-mannosyl glycan of α-dystroglycan2018

    • Author(s)
      Imae Rieko、Manya Hiroshi、Tsumoto Hiroki、Osumi Kenji、Tanaka Tomohiro、Mizuno Mamoru、Kanagawa Motoi、Kobayashi Kazuhiro、Toda Tatsushi、Endo Tamao
    • Journal Title

      J. Biol. Chem.

      Volume: 293 Pages: 12186-12198

    • DOI

      10.1074/jbc.ra118.003197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.2018

    • Author(s)
      Nishihara, R., Kobayashi, K., Imae, R., Tsumoto, H., Manya, H., Mizuno, M., Kanagawa, M., Endo, T., and Toda, T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 497 Pages: 1025-1030

    • DOI

      10.1016/j.bbrc.2018.02.162

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy2017

    • Author(s)
      M.Nagae, S.K.Mishra, M.Neyazaki, R.Oi, A.Ikeda, N.Matsugaki, S.Akashi, H.Manya, M.Mizuno, H.Yagi, K.Kato, T.Senda, T.Endo, T.Nogi, and Y.Yamaguchi
    • Journal Title

      Genes Cells.

      Volume: - Pages: 348-359

    • DOI

      10.1111/gtc.12480

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tatsushi Toda and Tamao Endo win 107th Japan Academy Prize2017

    • Author(s)
      Kanagawa Motoi、Manya Hiroshi
    • Journal Title

      Glycobiology

      Volume: 27 Pages: 599-600

    • DOI

      10.1093/glycob/cwx040

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] Experimental phase determination with selenomethionine or mercury-derivatization in serial femtosecond crystallography.2017

    • Author(s)
      Yamashita, K., et al.
    • Journal Title

      IUCr J.

      Volume: 4 Pages: 639-647

    • DOI

      10.1107/s2052252517008557

    • NAID

      120006335658

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycosylation with ribitol-phosphate in mammals: New insights into the O -mannosyl glycan.2017

    • Author(s)
      Manya, H., and Endo, T.
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1861 Pages: 2462-2472

    • DOI

      10.1016/j.bbagen.2017.06.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism for the Deficiency in Post-Phosphoryl Modification of α-Dystroglycan Observed in POMGnT1-Caused Muscular Dystrophy2017

    • Author(s)
      桑原 直之, 加藤 龍一, 萬谷 博, 遠藤 玉夫
    • Journal Title

      Journal of the Crystallographic Society of Japan

      Volume: 59 Issue: 2-3 Pages: 114-120

    • DOI

      10.5940/jcrsj.59.114

    • NAID

      130006767785

    • ISSN
      0369-4585, 1884-5576
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of ribitol-phosphate in mammalian O-mannosyl glycan and its biosynthetic mechanisms2017

    • Author(s)
      萬谷 博、遠藤 玉夫
    • Journal Title

      生化学

      Volume: 89 Issue: 5 Pages: 605-612

    • DOI

      10.14952/SEIKAGAKU.2017.890605

    • ISSN
      0037-1017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 構造解析に基づくO-マンノース型糖鎖の生合成機構2021

    • Author(s)
      萬谷博, 今江理恵子, 桑原直之, 田中智博, 露口正人, 水野真盛, 加藤龍一, 遠藤玉夫
    • Organizer
      第40回日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] タンデムリビトールリン酸含有O-マンノシルグリカンの系統的合成とその糖鎖機能2021

    • Author(s)
      田村純一, 田村敬裕, 真鍋法義, 大野詩歩, 山口芳樹, 萬谷博, 遠藤玉夫
    • Organizer
      第40回日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 間質-細胞相互作用を制御するO-マンノース型糖鎖の生合成機構2021

    • Author(s)
      萬谷博
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] CDP-エタノールアミン合成酵素PCYT2によるCDP-グリセロールの合成およびα-ジストログリカンの制御2021

    • Author(s)
      今江理恵子, 萬谷博, 津元裕樹, 三浦ゆり, 遠藤玉夫
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 哺乳動物細胞におけるリビトールリン酸生合成経路の解析2021

    • Author(s)
      星野駿介, 今江理恵子, 萬谷博, 遠藤玉夫
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 筋ジストロフィー症に関わる糖転移酵素POMGNT2の基質認識の分子機構2021

    • Author(s)
      露口正人, 桑原直之, 萬谷博, 今江理恵子, 田中智博, 水野真盛, 遠藤玉夫, 加藤龍一
    • Organizer
      第44回日本分子生物学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 構造・生化学から分かってきたO-マンノース型糖鎖の生合成機構2021

    • Author(s)
      萬谷博
    • Organizer
      第7回日本筋学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] RboP5-3GalNAcbの系統的合成と糖転移受容体機能2021

    • Author(s)
      田村純一、田村敬裕、永瀬真央、真鍋法義、大野詩歩、星野駿介、山口芳樹、萬谷博、遠藤玉夫
    • Organizer
      日本農芸化学会2022大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CDP-エタノールアミン合成酵素PCYT2によるCDP-グリセロール生合成機構の発見およびα-ジストログリカンの機能制御2021

    • Author(s)
      今江理恵子、萬谷博、津元裕樹、三浦ゆり、遠藤玉夫
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 哺乳類におけるリビトールリン酸産生酵素の解析2021

    • Author(s)
      星野駿介、今江理恵子、萬谷博、遠藤玉夫
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 筋ジストロフィー症原因遺伝子産物FKRPによるO-マンノース型糖鎖へのリビトールリン酸転移機構2021

    • Author(s)
      今江 理恵子、桑原 直之、萬谷 博、加藤 龍一、遠藤 玉夫
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リビトールリン酸転移酵素FKRPによるO-マンノース型糖鎖伸長機構2020

    • Author(s)
      今江理恵子、桑原直之、萬谷博、加藤龍一、遠藤玉夫
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] O-マンノース型糖鎖の伸長過程におけるFKRPによるリビトールリン酸転移機構2020

    • Author(s)
      今江理恵子、桑原直之、萬谷博、加藤龍一、遠藤玉夫
    • Organizer
      第39回日本糖質学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] グリセロールリン酸供与体CDP-グリセロールの哺乳動物における定量分析2019

    • Author(s)
      今江理恵子、萬谷博、津元裕樹、石渡俊行、遠藤玉夫
    • Organizer
      第38回日本糖質学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 哺乳動物培養細胞および組織におけるCDP-グリセロールの定量分析2019

    • Author(s)
      今江理恵子、萬谷博、津元裕樹、石渡俊行、遠藤玉夫
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] α-ジストログリカン糖鎖合成阻害因子CDP-グリセロールの定量分析2019

    • Author(s)
      今江理恵子, 萬谷博, 津元裕樹, 遠藤玉夫
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 糖鎖を利用した先天性筋ジストロフィー症の治療法開発2018

    • Author(s)
      萬谷博、赤阪啓子、今江理恵子、遠藤玉夫
    • Organizer
      TOBIRA 第7回研究交流フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Substrates recognition and oligomerization mechanism of Fukutin-related protein (FKRP).2018

    • Author(s)
      Naoyuki Kuwabara, Hiroshi Manya, Rieko Imae, Tomohiro Tanaka, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Mamoru Mizuno, Toshiya Senda, Tamao Endo, Ryuichi Kato
    • Organizer
      11th International Symposium on Glycosyltransferases (GlycoT 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 福山型筋ジストロフィー原因遺伝子産物fukutinのグリセロールリン酸転移活性.2018

    • Author(s)
      萬谷博、今江理恵子、津元裕樹、田中智博、水野真盛、金川基、小林千浩、戸田達史、遠藤玉夫
    • Organizer
      第4回日本筋学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規糖鎖修飾体グリセロールリン酸によるα-ジストログリカンの機能糖鎖合成阻害.2018

    • Author(s)
      今江理恵子、萬谷博、津元裕樹、田中智博、水野真盛、金川基、小林千浩、戸田達史、遠藤玉夫
    • Organizer
      第37回日本糖質学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] CDP-glycerolはα-ジストログリカンの糖鎖伸長を阻害する.2018

    • Author(s)
      今江理恵子、萬谷博、津元裕樹、田中智博、水野真盛、金川基、小林千浩、戸田達史、遠藤玉夫
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖鎖異常による先天性筋ジストロフィー症の病態解明と薬学的展.2018

    • Author(s)
      萬谷博
    • Organizer
      第62回日本薬学会関東支部大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Inhibitory effect of CDP-glycerol on the synthesis of the O-mannosyl glycan of α-dystroglycan2018

    • Author(s)
      Rieko Imae, Hiroshi Manya, Hiroki Tsumoto, Tamao Endo
    • Organizer
      首都大学東京バイオコンファレンス2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Biosynthesis of O-mannosyl glycan in mammals.2018

    • Author(s)
      Hiroshi Manya
    • Organizer
      糖鎖創薬研究拠点キックオフシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] CDP-グリセロール添加によるα-ジストログリカンの機能糖鎖伸長およびラミニン結合能への影響.2018

    • Author(s)
      今江理恵子、萬谷博、津元裕樹、遠藤玉夫
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新規糖鎖修飾機構の理解に基づく筋ジストロフィー症の病態解明と創薬への応用2018

    • Author(s)
      萬谷博
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 筋ジストロフィー症原因遺伝子産物TMEM5によるジストログリカンの機能糖鎖修飾2017

    • Author(s)
      萬谷博, 山口芳樹, 金川基, 小林千浩, 田尻道子, 赤阪-萬谷啓子, 川上宏子, 水野真盛, 和田芳直, 戸田達史
    • Organizer
      第36回日本糖質学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ジストログリカノパチー原因遺伝子産物Protein O-Mannosyl Kinase (POMK)の構造生物学的研究,ポスター2017

    • Author(s)
      長江雅倫, Sushil K. Mishra, 根谷崎牧子, 大井里香, 池田明美, 松垣直宏, 明石知子, 萬谷博, 水野真盛, 矢木宏和, 加藤晃一, 千田俊哉, 遠藤玉夫, 禾晃和, 山口芳樹
    • Organizer
      第36回日本糖質学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Fukutin-related protein (FKRP)の結晶構造と基質認識機構解析2017

    • Author(s)
      桑原直之, 萬谷博, 金川基, 今江理恵子, 田中智博, 小林千浩, 戸田達史, 水野真盛, 遠藤玉夫, 加藤龍一
    • Organizer
      第36回日本糖質学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan2017

    • Author(s)
      Naoyuki Kuwabara, Hiroshi Manya, Takeyuki Yamada, Hiroaki Tateno, Motoi Kanagawa, Kazuhiro Kobayashi, Keiko Akasaka-Manya, Yuriko Hirose, Mamoru Mizuno, Mitsunori Ikeguchi, Tatsushi Toda, Jun Hirabayashi, Toshiya Senda, Tamao Endo, Ryuichi Kato
    • Organizer
      4th International Symposium on Glyconjugates (GlycoXXIV)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新規O-マンノース型糖鎖の発見とその異常による先天性筋ジストロフィー症2017

    • Author(s)
      萬谷博
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] POMGnT1の構造解析による筋ジストロフィー疾患発症機序解明2017

    • Author(s)
      桑原直之, 萬谷博, 山田健之, 舘野浩章, 金川基, 小林千浩, 赤阪-萬谷啓子, 弘瀬友理子, 水野真盛, 池口満徳, 戸田達史, 平林淳, 千田俊哉, 遠藤玉夫, 加藤龍一
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 哺乳類細胞発現系によるFukutin-related protein (FKRP)の大量精製と結晶構造決定2017

    • Author(s)
      桑原直之, 萬谷博, 今江理恵子, 遠藤玉夫, 千田俊哉, 加藤龍一
    • Organizer
      2017年度量子ビームサイエンスフェスタ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 筋ジストロフィー症原因遺伝子産物フクチンはジストログリカン糖鎖にグリセロールリン酸を導入する活性を有する2017

    • Author(s)
      今江理恵子, 萬谷博, 津元裕樹, 田中智博, 水野真盛, 金川基, 小林千浩, 戸田達史, 遠藤玉夫
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京都健康長寿医療センター

    • URL

      https://www.tmghig.jp/research/index.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 東京都健康長寿医療センター研究所

    • URL

      http://www.tmghig.jp/research/index.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] O-マンノシルグリカン関連化合物および糖鎖伸長プライマーとしてのその使用2021

    • Inventor(s)
      田村純一、田村敬裕、遠藤玉夫、萬谷博、星野駿介
    • Industrial Property Rights Holder
      鳥取大学、東京都健康長寿医療センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-174154
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] ジストログリカン糖鎖修飾異常に伴う疾患の治療剤及び関連酵素測定法2017

    • Inventor(s)
      戸田達史、小林千浩、金川基、遠藤玉夫、萬谷博、和田芳直、田尻道子
    • Industrial Property Rights Holder
      神戸大学、東京都健康長寿医療センター、大阪母子センター
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2022
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] Therapeutic agent for diseases associated with abnormalities in dystroglycan sugar chain modification and method for assaying associated enzyme2017

    • Inventor(s)
      Toda T, Manya H, et al.
    • Industrial Property Rights Holder
      Kobe Univ., et al.
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas

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Published: 2017-04-28   Modified: 2023-01-30  

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