Understanding the intestinal homeostasis from the perspective of ubiquitin modification

• Project/Area Number: 17H04024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Fukushima Medical University (2019-2020); Tokyo Medical and Dental University (2017-2018)
• Principal Investigator: Onizawa Michio 福島県立医科大学, 医学部, 助教 (30783352)
• Co-Investigator(Kenkyū-buntansha): 渡辺 守 東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 炎症性腸疾患 / 腸内環境 / 微生物 / 下部消化管 / 食品 / 修飾後翻訳

Outline of Final Research Achievements

It is thought that environmental factors such as intestinal microflora and diet play critical roles in the development of inflammatory bowel disease. However, it is little known as to what kind of environmental factors are involved in this disease and how these factors affect the intestinal homeostasis. We observed that more proteins are ubiquitinated in the large intestine of germ free mice than in that of specific pathogen free mice. We showed that mass spectrometric analysis enables comprehensive identification of ubiquitinated proteins in the colon. We also found that oral administration of D-serine, not L-serine, has a preventive and therapeutic effect in a naive T cell transfer model of chronic colitis.

Academic Significance and Societal Importance of the Research Achievements

生体環境による組織のモニタリング手法としてトランスクリプトーム解析が一般的であるが、本研究により、組織の網羅的ユビキチン化修飾解析技術も有用であること示した。また、IBDとDアミノ酸の関連は不明であったが、DセリンがIBDモデルを抑制することを示した本研究結果は、IBDにおけるDアミノ酸研究発展の必要性を示している。合わせて本研究成果は、DセリンによるIBDの画期的な予防法・新規治療法の開発の基盤になり得ると思われる。

Research Products

• [Journal Article] CEACAM1 specifically suppresses B cell receptor signaling-mediated activation.. (2021)
  • Author(s): Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 535 Pages: 99-105
  • DOI: 10.1016/j.bbrc.2020.11.126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis (2021)
  • Author(s): Watanabe Sho、Nishimura Ryu、Shirasaki Tomoaki、Katsukura Nobuhiro、Hibiya Shuji、Kirimura Susumu、Negi Mariko、Okamoto Ryuichi、Matsumoto Yuka、Nakamura Tetsuya、Watanabe Mamoru、Tsuchiya Kiichiro
  • Journal Title: J Crohns Colitis. Volume: inpress Pages: 1558-1572
  • DOI: 10.1093/ecco-jcc/jjab032
  • Peer Reviewed
• [Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. (2021)
  • Author(s): Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 11 Pages: 1483-1503
  • DOI: 10.1016/j.jcmgh.2021.01.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm (2021)
  • Author(s): Katsukura Nobuhiro、Watanabe Sho、Shirasaki Tomoaki、Hibiya Shuji、Kano Yoshihito、Akahoshi Keiichi、Tanabe Minoru、Kirimura Susumu、Akashi Takumi、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
  • Journal Title: Cancer Sci. Volume: 112 Pages: 932-944
  • DOI: 10.1111/cas.14755
  • Peer Reviewed / Open Access
• [Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients (2021)
  • Author(s): Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
  • Journal Title: Biochem Biophys Rep Volume: 25 Pages: 100906-100906
  • DOI: 10.1016/j.bbrep.2020.100906
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Upregulation of complement C1q reflects mucosal regeneration in a mouse model of colitis (2020)
  • Author(s): Gunji Naohiko、Katakura Kyoko、Abe Kazumichi、Kawashima Kazumasa、Fujiwara Tatsuo、Onizawa Michio、Takahashi Atsushi、Ohira Hiromasa
  • Journal Title: Medical Molecular Morphology Volume: －
  • DOI: 10.1007/s00795-020-00266-2
  • Peer Reviewed
• [Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. (2020)
  • Author(s): Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
  • Journal Title: FEBS Lett. Volume: 594 Pages: 1586-1595
  • DOI: 10.1002/1873-3468.13748
  • Peer Reviewed / Open Access
• [Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo (2020)
  • Author(s): Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 523 Pages: 328-335
  • DOI: 10.1016/j.bbrc.2019.12.021
  • Peer Reviewed / Open Access
• [Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage (2020)
  • Author(s): Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 522 Pages: 971-977
  • DOI: 10.1016/j.bbrc.2019.11.158
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer. (2019)
  • Author(s): Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
  • Journal Title: Molecular Cancer Research Volume: in press Pages: 1459-1467
  • DOI: 10.1158/1541-7786.mcr-18-1195
  • Peer Reviewed / Open Access
• [Journal Article] Genetic and environmental factors drive personalized medicine for Crohn’s disease (2019)
  • Author(s): Oshima Shigeru、Watanabe Mamoru
  • Journal Title: J Clin Invest. Volume: 128 Pages: 4758-4760
  • DOI: 10.1172/jci124303
  • Peer Reviewed
• [Journal Article] Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-α in the Inflamed Intestinal Epithelia of IBD Patients (2019)
  • Author(s): Kawamoto Ami、Nagata Sayaka、Anzai Sho、Takahashi Junichi、Kawai Mao、Hama Minami、Nogawa Daichi、Yamamoto Kouhei、Kuno Reiko、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru
  • Journal Title: J Crohns Colitis Volume: 13 Pages: 495-509
  • DOI: 10.1093/ecco-jcc/jjy180
  • Peer Reviewed
• [Journal Article] Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1. (2018)
  • Author(s): Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe
  • Journal Title: Autophagy Volume: 22 Pages: 347-358
  • DOI: 10.1080/15548627.2017.1407889
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of ATOH1 + Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium (2018)
  • Author(s): Ishibashi Fumiaki、Shimizu Hiromichi、Nakata Toru、Fujii Satoru、Suzuki Kohei、Kawamoto Ami、Anzai Sho、Kuno Reiko、Nagata Sayaka、Ito Go、Murano Tatsuro、Mizutani Tomohiro、Oshima Shigeru、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru、Okamoto Ryuichi
  • Journal Title: Stem Cell Rep. Volume: 10 Pages: 27-42
  • DOI: 10.1016/j.stemcr.2017.11.006
  • Peer Reviewed / Open Access
• [Journal Article] YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration (2018)
  • Author(s): Yui S、Azzolin L、Maimets M、Pedersen MT、Fordham RP、Hansen SL、Larsen HL、Guiu Jordi、Alves MRP、Rundsten CF、Johansen JV、Li Y、Madsen CD、Nakamura T、Watanabe M、Nielsen OH、Schweiger PJ、Piccolo S、Jensen KB
  • Journal Title: Cell Stem Cell Volume: 22 Pages: 35-49
  • DOI: 10.1016/j.stem.2017.11.001
  • Peer Reviewed / Open Access
• [Journal Article] Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties (2018)
  • Author(s): Suzuki Kohei、Murano Tatsuro、Shimizu Hiromichi、Ito Go、Nakata Toru、Fujii Satoru、Ishibashi Fumiaki、Kawamoto Ami、Anzai Sho、Kuno Reiko、Kuwabara Konomi、Takahashi Junichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Ohtsuka Kazuo、Watanabe Mamoru、Okamoto Ryuichi
  • Journal Title: J Gastroenterol. Volume: 印刷中 Pages: 1035-1047
  • DOI: 10.1007/s00535-018-1437-3
  • Peer Reviewed / Open Access
• [Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model. (2018)
  • Author(s): Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
  • Journal Title: Biochem Biophys res Commun. Volume: 496 Pages: 367-373
  • DOI: 10.1016/j.bbrc.2018.01.053
  • Peer Reviewed / Open Access
• [Presentation] BCR signaling in lymphoid tissues regulated by the long isoform of Ceacam1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Yudai Kojima, Michio Onizawa, Taro Watabe, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: Federation of Clinical Immunology Societies 2020
  • Int'l Joint Research
• [Presentation] BCR signaling in lymphoid tissues is regulated by the long isoform of Ceacam1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Yudai Kojima, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: MICS 2020
  • Int'l Joint Research
• [Presentation] B cell receptor signaling in lymphoid tissues may be regulated by CEACAM1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Mamoru Watanabe.
  • Organizer: European Crohn’s and Colitis Organization 2020
  • Int'l Joint Research
• [Presentation] BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1. (2019)
  • Author(s): Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Yudai Kojima, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: 第48回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Analysis of APL expression in an animal model of chronic colitis (2019)
  • Author(s): Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Daiki Yamada, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
  • Organizer: Federation of Clinical Immunology Societies.
  • Int'l Joint Research
• [Presentation] APL downregulation in an animal model of chronic colitis. (2019)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
  • Organizer: Asian Organization of Crohn’s and Colitis
  • Int'l Joint Research
• [Presentation] UC-related and segment-specific properties of patientderived colonic organoids. (2019)
  • Author(s): Suzuki K, Shimizu H, Kawai M, Takahashi J, Anzai S, Kawamoto A, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
  • Organizer: ECCO 2019
  • Int'l Joint Research
• [Presentation] Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. (2019)
  • Author(s): Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M
  • Organizer: ECCO 2019
  • Int'l Joint Research
• [Presentation] TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation. (2019)
  • Author(s): Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
  • Organizer: ECCO 2019
  • Int'l Joint Research
• [Presentation] Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. (2018)
  • Author(s): Yui S, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M
  • Organizer: GI Research Academy
  • Int'l Joint Research
• [Presentation] Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells. (2018)
  • Author(s): Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M
  • Organizer: DDW 2018
  • Int'l Joint Research
• [Presentation] Analysis of ileocecal immune response in an animal model of colitis using intra-vital imaging. (2018)
  • Author(s): Watabe T, Nagaishi T, Tsugawa N, Kojima Y, Jose N, Hosoya A, Adachi T, Watanabe M
  • Organizer: DDW 2018
  • Int'l Joint Research
• [Presentation] Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients. (2018)
  • Author(s): Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
  • Organizer: DDW 2018
  • Int'l Joint Research
• [Presentation] Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis. (2018)
  • Author(s): Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M
  • Organizer: DDW 2018
  • Int'l Joint Research
• [Presentation] Mice overexpressing MKL1 in macrophages are susceptible to the development of colitis. (2018)
  • Author(s): An J, Nagaishi T, Watabe T, Naruse TK., Watanabe M, Kimura A
  • Organizer: DDW 2018
  • Int'l Joint Research
• [Presentation] Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signaling. (2018)
  • Author(s): Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R
  • Organizer: ISSCR 2018
  • Int'l Joint Research
• [Presentation] Analysis of cecal immune response in a murine model of colitis using intravital imaging. (2018)
  • Author(s): Nagaishi T, Watabe T, Tsugawa N, Kojima Y, Jose N, Yamada D, Adachi T, Watanabe M
  • Organizer: FOCIS 2018
  • Int'l Joint Research
• [Presentation] Mice overexpressing MKL1 in macrophages are susceptible to DSS-induced colitis. (2018)
  • Author(s): An J, Nagaishi T, Watabe T, Naruse TK., Watanabe M, Kimura
  • Organizer: FOCIS 2018
  • Int'l Joint Research
• [Presentation] Overexpression of MKL1 in Macrophages leads to the development of murine colitis. (2018)
  • Author(s): An J, Nagaishi T, Watabe T, Naruse TK., Watanabe M, Kimura A
  • Organizer: MICS 2018
  • Int'l Joint Research
• [Presentation] Development of a new mouse model of short bowel syndrome that may allow for the assessment of therapeutic efficacy of heterotopic transplantation of small intestinal organoids. (2018)
  • Author(s): Matsumoto Y, Watanabe M, Nakamura T
  • Organizer: 5th TERMIS World Congress 2018
  • Int'l Joint Research
• [Presentation] Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties. (2018)
  • Author(s): Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R
  • Organizer: 5th TERMIS World Congress 2018
  • Int'l Joint Research
• [Presentation] Regenerative medicine for the treatment of inflammatory bowel disease. (2018)
  • Author(s): Okamoto R, Watanabe M
  • Organizer: 5th TERMIS World Congress 2018
  • Int'l Joint Research
• [Presentation] Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. (2018)
  • Author(s): Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R
  • Organizer: UEGW 2018
  • Int'l Joint Research
• [Presentation] Long-lived secretory cells residing in the mouse proximal colon serve as reserve stem cells under DNA damage-induced mucosal injury. (2018)
  • Author(s): Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R
  • Organizer: UEGW 2018
  • Int'l Joint Research
• [Presentation] Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation. (2018)
  • Author(s): Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M
  • Organizer: UEGW 2018
  • Int'l Joint Research
• [Presentation] Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient. (2018)
  • Author(s): Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M
  • Organizer: UEGW 2018
  • Int'l Joint Research
• [Presentation] B cell-mediated ileocecal immune response is activated in the early phase of colitis development. (2018)
  • Author(s): Kojima Y, Nagaishi T, Watabe T, Tsugawa N, Jose N, Yamada D, Hosoya A, Adachi T, Watanabe M
  • Organizer: UEGW 2018
  • Int'l Joint Research
• [Presentation] Mice overexpressing MKL1 in macrophages experience fulminant colitis. (2018)
  • Author(s): An J, Nagaishi T, Watabe T, Naruse TK., Watanabe M, Kimura A
  • Organizer: UEGW 2018
  • Int'l Joint Research
• [Presentation] Downregulated APL expression in T cells in the setting of chronic colitis. (2018)
  • Author(s): Kojima Y, Nagaishi T, Watabe T, Yamada D, Tsugawa N, Jose N, Hosoya A, Shimizu M, Onizawa M, Watanabe M
  • Organizer: 第47回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] Introduction to IBD Centre at Tokyo Medical and Dental University. (2018)
  • Author(s): Watanabe M
  • Organizer: IBD Center of Excellence
  • Int'l Joint Research / Invited
• [Presentation] Intestinal Epithelial Stem Cell Organoid and IBD. (2018)
  • Author(s): Watanabe M
  • Organizer: 第55回日本消化器免疫学会
  • Int'l Joint Research / Invited
• [Presentation] Regeneration of intestinal epithelial cell and IBD (2018)
  • Author(s): Watanabe M
  • Organizer: Falk symposium 2018
  • Int'l Joint Research / Invited
• [Patent(Industrial Property Rights)] 炎症性腸疾患の予防又は改善剤 (2020)
  • Inventor(s): 鬼澤 道夫、渡辺 守、浅川 剛人、 大 平 弘正
  • Industrial Property Rights Holder: 鬼澤 道夫、渡辺 守、浅川 剛人、 大 平 弘正
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2020-171646
  • Filing Date: 2020