|Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|Outline of Final Research Achievements
The identification and physiological significance of the cell subtypes of the novel CRH release pathway were clarified using AgRP cell-selective (arcuate nucleus) and CRH cell-selective (paraventricular nucleus) genetically modified mice. Blood corticosterone levels were measured in undernutrition stress model and the difference from pharmacogenetic stimulation of AgRP cells was evaluated. As a result, pharmacogenetic stimulation of the entire AgRP cells activated CRH cells in the paraventricular nucleus. Undernutrition also activated a part of AgRP cells but not CRH cells. Serum corticosterone increased in both cases. From the above, we elucidated the mechanism by which a part of AgRP cell population in the arcuate nucleus respond to malnutrition, which increases the activity of the novel HPA axis at median eminence and causes CRH secretion.