| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
The aim of the study is to investigate the mechanisms how enhanced epithelial cell death of the skin and small intestine induces pathological conditions in embryos or newborn mice. An increase in cell death in keratinocytes in new born mice induced interleukin 6 production, which subsequently blocked the expression of keratinocyte differentiation markers. This blockade further exacerbated skin barrier function, resulting in premature death of newborn mice.
Necroptosis of intestinal epithelial cells (IECs) in embryos induced activation of type 3 innate lymphoid cells (ILC3s), resulting in embryonic lethality along with upregulation of Reg3b, Reg3g, and Il22 expressions. Activation of innate immunity did not appear to be suppressed in the intestine of embryos due to immaturity of acquired immunity. Thus, aberrantly activated ILC3s induced IL-22 production, which subsequently induced massive apoptosis of IECs and embryonic lethality.
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