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Predicting the emergence of drug-resistant malaria: Development of a comprehensive laboratory evolution system with accelerated evolution system

Research Project

Project/Area Number 17H04074
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including sanitary zoology)
Research InstitutionJuntendo University

Principal Investigator

Mita Toshihiro  順天堂大学, 医学(系)研究科(研究院), 教授 (80318013)

Co-Investigator(Kenkyū-buntansha) 平井 誠  順天堂大学, 医学部, 准教授 (50326849)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsマラリア / 薬剤耐性 / 進化 / 高度変異原虫 / ミューテータ / 実験室進化 / 実験進化
Outline of Final Research Achievements

We successfully produced protozoa in a few weeks that could survive and proliferate at the piperaquine concentration 6 times higher than that of susceptible strains. There were eight common mutations in these, including the N351I mutation in the chloroquine-resistant gene, crt. When this mutation was introduced into a susceptible strain, a slight decrease in susceptibility to piperaquine and a marked decrease in growth rate were observed. These indicate that the remaining mutation(s) may be involved in the decreased susceptibility and/or compensation of fitness. Further analysis is underway on the significance of these mutations to piperaquine resistance. In a validation study on real malaria samples, we has evidenced the emergence of artemisinin-resistant falciparum malaria in Uganda, which was the first report of the artemisinin resistance in Africa. We have also revealed that there was nearly half the resistance to mefloquine in Uganda.

Academic Significance and Societal Importance of the Research Achievements

本研究によってマラリア原虫が薬剤耐性を獲得するまでのプロセスをラボで迅速に解明する道が開けた。自然界に薬剤耐性マラリアが出現する前に起こる遺伝的な変化を解明することによって、流行地域における耐性が出現する前にアラートを出すことを可能とする。この段階で迅速に治療政策を変更することによって耐性が実際に出現することを防止できる。これによって新薬開発→耐性出現→新薬開発、という終わりないレースに終止符を打つ。2050年には抗生物質耐性病原体の蔓延による世界の死亡数はがん死亡数を上回るとされており、本研究構想が対策の実際面や開発に与える社会的波及面でのインパクトは高い。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (80 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (10 results) Journal Article (24 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 21 results,  Open Access: 21 results) Presentation (44 results) (of which Int'l Joint Research: 14 results,  Invited: 5 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] グル大学(ウガンダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] WHO(スイス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] デバイン大学(パプアニューギニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ウォルター・アンド・イライザ・ホール医学研究所(オーストラリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] グル大学(ウガンダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] デバイン大学(パプアニューギニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] マヒドン大学(タイ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Evidence of Artemisinin-Resistant Malaria in Africa.2021

    • Author(s)
      Balikagala B, Fukuda N, Ikeda M, Katuro OT, Tachibana SI, Yamauchi M, Opio W, Emoto S, Anywar DA, Kimura E, Palacpac NMQ, Odongo-Aginya EI, Ogwang M, Horii T, Mita T.
    • Journal Title

      N Engl J Med.

      Volume: 385 Issue: 13 Pages: 1163-71

    • DOI

      10.1056/nejmoa2101746

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo.2021

    • Author(s)
      Mita T, Hirai M, Maki Y, Nahar S, Yoshida N, Oshima Y, Kikuchi H, Kubohara Y.
    • Journal Title

      Biochem Pharmacol

      Volume: - Pages: 114834-114834

    • DOI

      10.1016/j.bcp.2021.114834

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pb103 Regulates Zygote/Ookinete Development in Plasmodium berghei via Double Zinc Finger Domains.2021

    • Author(s)
      Hirai M, Maeta A, Mori T and Mita T.
    • Journal Title

      Pathogens

      Volume: 10(12) Issue: 12 Pages: 1536-1536

    • DOI

      10.3390/pathogens10121536

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.2021

    • Author(s)
      Yoshida N, Yamauchi M, Morikawa R, Hombhanje F, Mita T.
    • Journal Title

      Malar J.

      Volume: 20 Issue: 1 Pages: 410-410

    • DOI

      10.1186/s12936-021-03933-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation of Mutants With Reduced Susceptibility to Piperaquine From a Mutator of the Rodent Malaria Parasite Plasmodium berghei.2021

    • Author(s)
      Ikeda M, Hirai M, Tachibana SI, Mori T, Mita T.
    • Journal Title

      Front Cell Infect Microbiol.

      Volume: - Pages: 672691-672691

    • DOI

      10.3389/fcimb.2021.672691

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fitness of sulfadoxine-resistant Plasmodium berghei harboring a single mutation in dihydropteroate synthase (dhps).2021

    • Author(s)
      Yamauchi M, Hirai M, Tachibana SI, Mori T, Mita T.
    • Journal Title

      Acta Trop.

      Volume: - Pages: 106049-106049

    • DOI

      10.1016/j.actatropica.2021.106049

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in Northern Uganda2021

    • Author(s)
      Fukuda N, Tachibana S-I、Ikeda M、Sakurai-Yatsushiro M、Balikagala B、Katuro O、Yamauchi M、Emoto S、Hashimoto M、Yatsushiro S、Sekihara Makoto、et al
    • Journal Title

      Parasitology International

      Volume: 81 Pages: 102277-102277

    • DOI

      10.1016/j.parint.2020.102277

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Malaria parasite species composition of Plasmodium infections among asymptomatic and symptomatic school-age children in rural and urban areas of Kinshasa, Democratic Republic of Congo.2021

    • Author(s)
      Nundu SS, Culleton R, Simpson SV, Arima H, Muyembe JJ, Mita T,Ahuka S, Yamamoto T.
    • Journal Title

      Malar J.

      Volume: 20 Issue: 1 Pages: 389-389

    • DOI

      10.1186/s12936-021-03919-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Postulated Process of Axoneme Organization in the Male Gametogenesis of Malaria Parasite Plasmodium berghei2020

    • Author(s)
      Kubo-Irie Miyoko、Hirai Makoto、Irie Masaru、Mohri Hideo
    • Journal Title

      Zoological Science

      Volume: 38 Issue: 2 Pages: 187-192

    • DOI

      10.2108/zs200064

    • NAID

      210000163224

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative Detection of Plasmodium falciparum Using, LUNA-FL, A Fluorescent Cell Counter2020

    • Author(s)
      Hashimoto Muneaki、Yokota Kazumichi、Kajimoto Kazuaki、Matsumoto Musashi、Tatsumi Atsuro、Yamamoto Kenichi、Hyodo Tomonori、Matsushita Kiichiro、Minakawa Noboru、Mita Toshihiro、Oka Hiroaki、Kataoka Masatoshi
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 9 Pages: 1356-1356

    • DOI

      10.3390/microorganisms8091356

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO2 nanofiber filter2020

    • Author(s)
      Yamamoto Takeki、Hashimoto Muneaki、Nagatomi Kenji、Nogami Takahiro、Sofue Yasuyuki、Hayashi Takuya、Ido Yusuke、Yatsushiro Shouki、Abe Kaori、Kajimoto Kazuaki、Tamari Noriko、Awuor Beatrice、Sonye George、Kongere James、Munga Stephen、Ohashi Jun、Oka Hiroaki、Minakawa Noboru、Kataoka Masatoshi、Mita Toshihiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 6585-6585

    • DOI

      10.1038/s41598-020-63615-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda2020

    • Author(s)
      Balikagala Betty、Sakurai-Yatsushiro Miki、Hirai Makoto  et al
    • Journal Title

      Malaria Journal

      Volume: 19 Issue: 1 Pages: 1-12

    • DOI

      10.1186/s12936-020-03157-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Highly Sensitive and Rapid Quantitative Detection of Plasmodium falciparum Using an Image Cytometer2020

    • Author(s)
      Hashimoto Muneaki、Yokota Kazumichi、Kajimoto Kazuaki、Matsumoto Musashi、Tatsumi Atsuro、Nakajima Yoshihiro、Mita Toshihiro、Minakawa Noboru、Oka Hiroaki、Kataoka Masatoshi
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 11 Pages: 1769-1769

    • DOI

      10.3390/microorganisms8111769

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea2020

    • Author(s)
      Miotto Olivo、Sekihara Makoto、Tachibana Shin-Ichiro、Yamauchi Masato et al
    • Journal Title

      PLOS Pathogens

      Volume: 16 Issue: 12 Pages: e1009133-e1009133

    • DOI

      10.1371/journal.ppat.1009133

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nucleic acid purification from dried blood spot on FTA Elute Card provides template for polymerase chain reaction for highly sensitive Plasmodium detection2019

    • Author(s)
      Hashimoto Muneaki、Bando Mika、Kido Jun-ichi、Yokota Kazumichi、Mita Toshihiro、Kajimoto Kazuaki、Kataoka Masatoshi
    • Journal Title

      Parasitology International

      Volume: 73 Pages: 101941-101941

    • DOI

      10.1016/j.parint.2019.101941

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a highly sensitive, quantitative, and rapid detection system for Plasmodium falciparum-infected red blood cells using a fluorescent blue-ray optical system2019

    • Author(s)
      Yamamoto Takeki、Yatsushiro Shouki、Hashimoto Muneaki、Kajimoto Kazuaki、Ido Yusuke、Abe Kaori、Sofue Yasuyuki、Nogami Takahiro、Hayashi Takuya、Nagatomi Kenji、Minakawa Noboru、Oka Hiroaki、Mita Toshihiro、Kataoka Masatoshi
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 132 Pages: 375-381

    • DOI

      10.1016/j.bios.2019.02.064

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] See-through observation of malaria parasite behaviors in the mosquito vector2019

    • Author(s)
      Mori Toshiyuki、Hirai Makoto、Mita Toshihiro
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1768-1768

    • DOI

      10.1038/s41598-019-38529-3

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda.2019

    • Author(s)
      Subissi L, Kanoi BN, Balikagala B, Egwang TG, Oguike M, Verra F, Proietti C, Bousema T, Drakeley CJ, Sepulveda N.
    • Journal Title

      Trans R Soc Trop Med Hyg.

      Volume: 113 Issue: 7 Pages: 370-8

    • DOI

      10.1093/trstmh/trz015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid selection of sulphadoxine-resistant Plasmodium falciparum and its effect on within-population genetic diversity in Papua New Guinea.2018

    • Author(s)
      Mita T, Hombhanje F, Takahashi N, Sekihara M, Yamauchi M, Tsukahara T, Kaneko A, Endo H, Ohashi J. (Corresponding author)
    • Journal Title

      Scientific reports.

      Volume: 8 Issue: 1 Pages: 5565-5565

    • DOI

      10.1038/s41598-018-23811-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea2018

    • Author(s)
      Sekihara M, Tachibana S-I, Yamauchi M, Yatsushiro S, Tiwara S, Fukuda N, Ikeda M, Mori T, Hirai M, Hombhanje F, Mita T
    • Journal Title

      Malaria Journal

      Volume: 17 Issue: 1 Pages: 434-434

    • DOI

      10.1186/s12936-018-2585-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 薬剤耐性マラリア原虫の進化2018

    • Author(s)
      美田敏宏
    • Journal Title

      生物の科学 遺伝

      Volume: 72 Pages: 382-388

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 薬剤耐性マラリアの最新疫学知見2018

    • Author(s)
      美田敏宏
    • Journal Title

      病原微生物検出情報 国立感染症研究所

      Volume: 39 Pages: 173-174

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 蚊媒介感染症に関する最近の話題2017

    • Author(s)
      美田敏宏
    • Journal Title

      臨床と微生物

      Volume: 44 Pages: 263-268

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Absence of in vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda.2017

    • Author(s)
      Balikagala B, Mita T, Ikeda M, Sakurai M, Yatsushiro S, Takahashi N, Tachibana SI, Auma M, Ntege EH, Ito D, Takashima E, Palacpac NM, Egwang TG, Onen JO, Kataoka M, Kimura E, Horii T, Tsuboi T.
    • Journal Title

      Malar J.

      Volume: 16(1) Issue: 1 Pages: 1-23

    • DOI

      10.1186/s12936-016-1663-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ネズミマラリア原虫Kelch13のインターラクトーム解析2021

    • Author(s)
      平井 誠、森 稔幸、美田 敏宏
    • Organizer
      第90回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 熱帯熱マラリア原虫-血管内皮間の接着と脂質代謝異常の関連2021

    • Author(s)
      福田 直到,Balikagala B,江本 桜子,上野 剛,Katuro O,Palacpac N,木村 英作,三井田 孝,堀井 俊宏,美田 敏宏
    • Organizer
      第90回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] パプアニューギニアにおけるKelch 13 C580Y変異熱帯熱マラリア原虫の出現と現状2021

    • Author(s)
      吉田 菜穂子、山内 祐人、森川 瞭介、宋 書馨、平井 誠、美田 敏宏
    • Organizer
      第90回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Emergence of artemisinin resistance in Africa2021

    • Author(s)
      Betty Balikagala
    • Organizer
      第90回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Papua New Guinea におけるマラリア迅速検査の感度と特異度の解析2021

    • Author(s)
      シジルエルデネ ムンフソブド、吉田 菜穂子、千葉 結奈、Francis Hombhanje、美田 敏宏
    • Organizer
      第 80 回日本寄生虫学会東日本支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 20年にわたるパプアニューギニアでのサルファドキシン・ピリメサミンの使用は薬剤耐性をもたらしたか?2021

    • Author(s)
      原田 治亮、吉田 菜穂子、山内 祐人、Francis Hombhanje、美田 敏宏
    • Organizer
      第 80 回日本寄生虫学会東日本支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血清リポタンパクは熱帯熱マラリア原虫の増殖を促進するのか?2021

    • Author(s)
      宋 書馨、吉田 菜穂子、稲葉 悠、堀 敦詞、福田 直到、三井田 孝、美田 敏宏
    • Organizer
      第 80 回日本寄生虫学会東日本支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ビオチン化によって同定された、マラリア原虫メス側受精因子2020

    • Author(s)
      森 稔幸、平井 誠、美田 敏宏
    • Organizer
      第89回日本寄生虫学会誌上大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アルテミシニン耐性マーカーKelch13 ネズミマラリア原虫オルソログの機能解析2020

    • Author(s)
      平井 誠、森 稔幸、美田 敏宏
    • Organizer
      第89回日本寄生虫学会誌上大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血管内皮との接着は熱帯熱マラリア原虫のアルテミシニン抵抗性を増強する2020

    • Author(s)
      福田 直到,Balikagala B,山内祐人,牧 喜子,江本 桜子,落合 紗雪,Katuro O,橘 真一郎,Anywar D,Palacpac N,木村 英作,Odingo-Aginya E,三井田 孝,堀井 俊宏,美田 敏宏
    • Organizer
      第89回 日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アフリカに出現したアルテミシニン耐性2020

    • Author(s)
      美田敏宏
    • Organizer
      日本熱帯医学会受賞記念講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] In vivo artemisinin resistance has emerged in Uganda (Africa).2020

    • Author(s)
      Balikagala Betty,
    • Organizer
      The United States-Japan Cooperative Medical Science Program. The 50th Joint Conference on Parasitic Diseases
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ビオチン化を利用した、マラリア原虫新規受精因子の探索2019

    • Author(s)
      森稔幸、平井誠、美田敏宏
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ビオチン化を用いた、新規マラリア原虫赤血球侵入関連因子の探索2019

    • Author(s)
      落合紗雪、前田樹里、平井誠、美田敏宏、森稔幸
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウガンダにおけるマラリア予防政策とその実態2019

    • Author(s)
      片山瑞希、山内祐人、美田敏宏
    • Organizer
      第79回日本寄生虫学会東日本支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウガンダ北部マラリア原虫集団におけるアルテミシニン耐性レベルの推移2019

    • Author(s)
      池田 美恵 , 金子 恵 , 橘 真一郎 , 山内 祐人 , バリカガラ ベティ, 江本 桜子 , 福田 直到 , 牧 喜子, 森 稔幸 , 平井 誠 , 橋本 宗明 , カツロ オスベルト , アウマ マリー, アニワー デニス , バラクパック ニリアン, 片岡 正俊, アギニア エマニュエル, 木村 英作, 堀井 俊宏 , 美田 敏宏
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] In-vivo artemisinin resistance may have emerged in Uganda,2019

    • Author(s)
      バリカガラ ベテイ , 池田 美恵 , 橘 真一郎 , 山内 祐人 , 福田 直到 , 関原 誠 , 江本 桜子 , Katuro Osbert T., Opio Walter, Auma Mary , Anywar Denis A. , 森 稔幸 ,平井 誠 , 片岡 正俊 , Palacpac Nirianne M.Q. , Odongo-Aginya Emmanuel I., 木村 英作 , 堀井 俊宏 , 美田 敏宏
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 蚊-マウスモデルにおけるサルファドキシン耐性マラリア原虫の適応度に関する研究2019

    • Author(s)
      山内 祐人, 平井 誠, 橘 慎一郎, 森 稔幸, 美田 敏宏
    • Organizer
      第88回日本寄生虫学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マラリアの現状と薬剤耐性の最前線2019

    • Author(s)
      美田敏宏
    • Organizer
      日本細胞性粘菌学会第9回例会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Synthetic biotin ligase enables to label surface invasion factors of cultured human malaria parasite, Plasmodium falciparum.2019

    • Author(s)
      Ochiai S, Maeda J, Hirai M, Mita T, Mori T.
    • Organizer
      68th Annual Meeting, Maryland USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Emergence of artemisinin-resistant P. falciparum with kelch13 C580Y mutations on the island of New Guinea.2019

    • Author(s)
      Miotto O, Sekihara M, Tachibana S, Yamauchi M, Pearson R, Amato R, Goncalves S, Somya M, Noviyanti R, Marfurt J, Auburn S, Price R, Mueller I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel M, Laman M, Barry A, Ringwald P, Ohashi J, Hombhanje F, Kwiatkowski D, Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidemiology and evolution of artemisinin-resistant Plasmodium faliparum parasites.2019

    • Author(s)
      Mita T
    • Organizer
      Asia - Pacific Scientific Workshop.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Altered gut microbiota composition in Plasmodium falciparum patients in Uganda2018

    • Author(s)
      Taniguchi T. Miyauchi E. Olia A. Nagayasu E. Osbert K. Suzue K. Imai T. Shimokawa C. Onishi R. Odongo-Aginya EI. Palacpac N. Maruyama H. Kimura E. Mita T. Ohno H. Horii T.andHisaeda H.
    • Organizer
      14th International congress of parastiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Global issue of drug resistant malaria and population structure of malaria parasites for global malaria control2018

    • Author(s)
      Mita T. Tachibana S. Sekihara M. Yamauchi M. Hombhanje F.andOhashi J
    • Organizer
      14th International congress of parastiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of Artemisinin-resistant Plasmodium falciparum with High Survival Rates in Uganda2018

    • Author(s)
      Mita T. Ikeda M. Kaneko M. Tachibana S. Balikagala B. Sakurai-Yatsushiro M. Yatsushiro S. Takahashi N. Yamauchi M. Sekihara M. Hashimoto M. Obwoya PS. Auma MA. Anywar DA. Odongo-Aginya EI. Hirai M. Ohashi J. Palacpac NMQ. Kataoka M. Tsuboi T. Kimura E.andHorii T
    • Organizer
      14th International congress of parastiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 原虫学・寄生虫学が現代のトップサイエンスにもたらす貢献 マラリアミューテーター マラリア原虫薬剤耐性進化解明の新たな研究ツール.2017

    • Author(s)
      平井誠, 池田美恵, 橘真一郎, 美田敏宏.
    • Organizer
      生命科学系学会合同年次大会.
    • Related Report
      2017 Annual Research Report
  • [Presentation] End malaria-マラリアのeliminationをめざして アルテミシニン耐性の評価・検出ツールは出そろったか? 流行地でのフィールド調査から見えてきた問題点.2017

    • Author(s)
      美田敏宏
    • Organizer
      生命科学系学会合同年次大会.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 人類を助ける進化学研究:進化し続ける薬剤耐性マラリアの克服.2017

    • Author(s)
      美田敏宏
    • Organizer
      公益信託 進化学振興木村資生基金 “微生物と人類の共存”をゲノムの視点から考える.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ウガンダにおけるin vivo薬剤耐性試験およびRSAを用いたアルテミシニン耐性疫学調査.2017

    • Author(s)
      池田美恵, 橘真一郎, 山内祐人, Auma M, 関原誠, 森稔幸, 平井誠, Palacpac N, 木村英作, Aginya E, 堀井俊宏, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウガンダ国の熱帯熱マラリア患者において腸内細菌叢の変化が起こる.2017

    • Author(s)
      谷口委代, 宮内栄治, OliaAlex, 長安英治, OsbertKaturo, 鈴江一友, 今井孝, 下川周子, 大西里咲, I. O-A, PalacpacNirianne, 丸山治彦, 木村英作, 美田敏宏, 大野博司, 堀井俊宏, 久枝一.
    • Organizer
      グローバルヘルス合同大会プログラム・抄録集.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ネズミマラリア原虫の有性生殖関連分子の機能解析.2017

    • Author(s)
      前多晟壮, 森稔幸, 平井誠, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マラリア原虫有性生殖の透視観察法の開発2017

    • Author(s)
      森稔幸, 平井誠, 美田敏宏
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウガンダにおける熱帯熱マラリア原虫キニーネ感受性の実態.2017

    • Author(s)
      山内祐人, 橘真一郎, 池田美恵, 関原誠, Balikagala B, 八代-櫻井美樹, 平井誠, Palacpac N, 木村英作, 堀井俊宏, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫ミトコンドリアのプロテオーム解析 二次元電気泳動法とショットガン質量分析.2017

    • Author(s)
      高宮信三郎, 數野彩子, 峯木礼子, 三浦芳樹, 美田敏宏.
    • Organizer
      生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ascaris suum 成虫およびCaenorhabditis elegans ミトコンドリアのプロテオーム解析: 二次元ゲル電気泳動法とショットガン質量分析法.2017

    • Author(s)
      高宮信三郎, 数野彩子, 峯木礼子, 三浦芳樹, 美田敏宏
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 宿主内競争による熱帯熱マラリア原虫のクロロキン感受性の回復.2017

    • Author(s)
      橘真一郎, 池田美恵, Balikagala B, 櫻井美樹, 八代聖基, 関原誠, 山内祐人, Auma MA, 平井誠, 森稔幸, Palacpac N, 片岡正俊, 木村英作, 堀井俊宏, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Epidemiology of antimalarial drug resistance in Papua New Guinea.2017

    • Author(s)
      関原誠, 橘真一郎, 美田敏宏.
    • Organizer
      第86回日本寄生虫学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prerequisite Emergence of Background Mutations For Kelch13-Related Artemisinin-Resistant Plasmodium Falciparum Isolates.2017

    • Author(s)
      Tachibana S-I, Mori T, Hirai M, Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of See-Through Imaging Methods for Sexual Reproduction of Malaria Parasites.2017

    • Author(s)
      Mori T, Hirai M, Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of artemisinin-resistant Plasmodium falciparum isolates with ex-vivo ring-stage survival assay in Uganda.2017

    • Author(s)
      Mita T, Ikeda M, Kaneko M, Balikagala B, Tachibana S-I, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Hashimoto M, Katuro O, Olia A, Obwoya P, Auma M, Anywar D, Odongo-Aginya E, Hirai M, Palacpac N, Kataoka M, Tsuboi T, Kimura E, Horii T.
    • Organizer
      Keystone Symposia Conference: Malaria:
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A mutator Plasmodium berghei model to investigate antimalarial drug resistance.2017

    • Author(s)
      Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pb102, A Novel Gene Essential for Female Fertility or Ookinete Maturation of Murine Malaria Parasite, Plasmodium Berghei.2017

    • Author(s)
      Maeta A, Hirai M, Mori T, Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria.2017

    • Author(s)
      Kataoka M, Yatsushiro S, Yamamoto T, Oka H, Okello-Onen J, Odongo-Aginya E, Palacpac N, Mita T, Baba Y, Horii T.
    • Organizer
      Keystone Symposia Conference: Malaria
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation of Piperaquine Resistant Rodent Malaria Parasite from Mutator Malaria.2017

    • Author(s)
      Hirai M, Ikeda M, Tachibana S-I, Mita T
    • Organizer
      American Society of Tropical Medicine and Hygiene 66th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] マラリア原虫の増殖抑制剤2019

    • Inventor(s)
      美田敏宏
    • Industrial Property Rights Holder
      美田敏宏
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] マラリア原虫の増殖抑制剤2019

    • Inventor(s)
      美田敏宏、久保原禅
    • Industrial Property Rights Holder
      美田敏宏、久保原禅
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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