Emerging process of Enterohemorrhagic Escherichia coli revealed by a large-scale genome analysis
Project/Area Number |
17H04077
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including mycology)
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
梶谷 嶺 東京工業大学, 生命理工学院, 助教 (40756706)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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Keywords | 志賀毒素産生性大腸菌 / 腸管病原性大腸菌 / 志賀毒素 / 3型分泌装置 / 進化 / ゲノム / 腸管出血性大腸菌 / 病原性 / ファージ |
Outline of Final Research Achievements |
To develop infection control strategies, better understanding of the evolutionary processes of pathogens is essential. Shiga toxin (Stx)-producing Escherichia coli (STEC) and enteropathogenic E. coli (EPEC) are important human pathogens sharing cattle as the primary reservoir. Here, a large-scale genomic comparison of bovine and human commensal E. coli and clinical STEC and EPEC strains reveals that bovine commensal strains are phylogenetically distinct from human commensal strains and that the bovine-adapted lineage is serving as evolutionary sources of the emergence of STEC and EPEC. Identification of virulence gene communities each accumulated in STEC and EPEC suggests the presence of a selection pressure(s) to promote their accumulation in bovine intestine, which could be targets for developing efficient strategies to control these pathogens.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、ウシ腸内には、ウシ常在大腸菌へ多数の病原因子を蓄積させる選択圧が存在する可能性が示された。その選択圧の候補の1つとして、ウシ腸内で大腸菌を捕食している原生生物が挙げられる。今後は、その選択圧を明らかにし、病原性大腸菌出現の仕組みを完全に解明することで、病原性大腸菌を制御する手法の開発が可能となり、病原性大腸菌感染症の予防や安全な食肉生産に繋がると期待される。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains.2019
Author(s)
Arimizu Y, Kirino Y, Sato MP, Uno K, Sato T, Gotoh Y, Auvray F, Brugere H, Oswald E, Mainil JG, Anklam KS, Dopfer D, Yoshino S, Ooka T, Tanizawa Y, Nakamura Y, Iguchi A, Morita-Ishihara T, Ohnishi M, Akashi K, Hayashi T, Ogura Y
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Journal Title
Genome Research
Volume: 29
Issue: 9
Pages: 1495-1505
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The population structure of enterohemorrhagic Escherichia coli O26:H11 with recent and repeated stx2 acquisition in multiple lineages2018
Author(s)
Yoshitoshi Ogura, Kazuko Seto, Shuji Yoshino, Junko Isobe, Yoshiki Etoh, Keiko Kimata, Eriko Maeda, Denis Pierard, Masahiro Kusumoto, Masato Akiba, Tadasuke Ooka, Nozomi Ishijima, Ken-ichi Lee, Sunao Iyoda, Jacques G. Mainil, and Tetsuya Hayashi
Organizer
10th international symposium on Shiga toxin producing Escherichia coli infections
Related Report
Int'l Joint Research
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