| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
The aim of this study was to elucidate the interaction of DNA damage responses with replication of intranuclear replicating RNA viruses, such as Borna disease virus (BoDV). In this study, we found that IFI16, a DNA damage sensor molecule, recognizes nuclear replication of BoDV and triggers host immune responses. We also found that DNA-PK, which is involved in the DNA damage response, is localized at BoDV viral factories and of which activation affect BoDV replication. Furthermore, we showed that ADAR2, a nuclear RNA-editing enzyme that is also shown to be associated with DNA damage responses, contributes to avoidance of the innate immune response and the establishment of persistent infection by introducing A-to-G editing into the genomic RNA of BoDV.
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