| Project/Area Number |
17H04135
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 景子 愛媛大学, 医学系研究科, 准教授 (40341432)
古川 慎哉 愛媛大学, 医学系研究科, 准教授 (60444733)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 出生前コーホート研究 / 横断研究 / 行動的問題 / 周産期曝露 / 遺伝子多型 / 妊娠中栄養摂取 / 遺伝環境要因交互作用 / 環境要因 / 遺伝要因 / 衛生 / ゲノム / 疫学 / 公衆衛生学 / 母子保健 |
|---|
| Outline of Final Research Achievements |
In the Kyushu Okinawa Maternal and Child Health Study (KOMCHS), maternal intake levels of monounsaturated fatty acids, α-linolenic acid, n-6 polyunsaturated fatty acids, linoleic acid, caffeine, folate, vitamin B6, vitamin B2, vegetables, fruit, apples, citrus fruit, vitamin C, and calcium during pregnancy were significantly associated with any of the behavioral problems in Japanese children aged 5 years. BAIAP2 SNP rs8079781 was significantly related to the risk of emotional problems and a significant interaction was observed between BAIAP2 SNP rs8079781 and smoking in the household during the first year of life affecting childhood emotional problems.
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| Academic Significance and Societal Importance of the Research Achievements |
妊娠中から生まれた子を追跡する出生前コーホート研究である九州・沖縄母子保健研究のデータを活用した。妊娠中の栄養摂取、周産期喫煙曝露、子の遺伝情報等の曝露情報及び5歳時におけるStrengths and Difficulties Questionnaire（SDQ: 子どもの強さと困難さアンケート）の親評定フォームに基づいた行動的問題を結果因子とし、更には広範囲で詳細な交絡因子の情報を用いて解析を行い、日本人における多数のエビデンスを創出した。世界的にも先駆的な研究テーマを設定できたため、世界初のエビデンスを複数公表することができた。
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