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Association of acute care with DALY or QALY in patients with stroke

Research Project

Project/Area Number 17H04143
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical and hospital managemen
Research InstitutionKyushu University

Principal Investigator

Kamouchi Masahiro  九州大学, 医学研究院, 教授 (80346783)

Co-Investigator(Kenkyū-buntansha) 福田 治久  九州大学, 医学研究院, 准教授 (30572119)
松尾 龍  九州大学, 医学研究院, 准教授 (60744589)
北園 孝成  九州大学, 医学研究院, 教授 (70284487)
馬場園 明  九州大学, 医学研究院, 教授 (90228685)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords脳卒中 / 急性期医療 / 生活の質 / 予後 / 機能予後 / 医療 / QOL / 生命予後 / 社会医学 / ADL / DALY / QALY
Outline of Final Research Achievements

We prospectively enrolled patients with stroke who were hospitalized in seven participating stroke centers in Fukuoka, Japan within seven days of onset after obtaining written informed consent to the prospective study. We investigated baseline characteristics of the patients on admission, clinical courses during hospitalization, and functional outcome as well as prognosis after discharge.
We found that a variety of factors, including patients’ characteristics, environmental factors, and stroke care and therapy, were associated with short-term and long-term risks of unfavorable functional outcomes and death after onset. Additionally, we investigated quality of life using EQ-5D-5L questionnaire at discharge in patients with stroke and evaluated the association between patients’ characteristics and quality of life. Based on these data, we established database systems to estimate quality-adjusted life year and disability-adjusted life year in patients with stroke.

Academic Significance and Societal Importance of the Research Achievements

本研究は大規模数の脳卒中患者を対象に網羅的な調査を行い、脳卒中発症後の機能予後、生命予後の実態を明らかにした。個々の患者要因を勘案した上で、脳卒中患者における機能予後、生命予後に関連する患者要因、生物学的因子、環境要因、医療要因を同定することができた。また、長期にわたる再発、生存に関連する因子、薬剤の効果を明らかにした。時代とともに医療技術は日々進歩を続け、患者状態は変化する中で、本研究の成果をもとに脳卒中医療の効果を推定することが可能となる。脳卒中急性期医療と脳卒中後の機能予後、生命予後の関係性を知る上で重要な情報基盤となりうる。

Report

(5 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (43 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 18 results,  Open Access: 7 results) Presentation (25 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results)

  • [Journal Article] Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence2022

    • Author(s)
      Fukuda Kenji et al.
    • Journal Title

      Stroke

      Volume: 53 Issue: 1 Pages: 70-78

    • DOI

      10.1161/strokeaha.120.033751

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke2021

    • Author(s)
      Kiyohara Takuya et al.
    • Journal Title

      Stroke

      Volume: 52 Issue: 8 Pages: 2621-2628

    • DOI

      10.1161/strokeaha.120.031392

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry2021

    • Author(s)
      Wakisaka Yoshinobu、Matsuo Ryu、Nakamura Kuniyuki、Ago Tetsuro、Kamouchi Masahiro、Kitazono Takanari、on behalf of the Fukuoka Stroke Registry Investigators
    • Journal Title

      Cerebrovascular Diseases

      Volume: online Issue: 4 Pages: 1-7

    • DOI

      10.1159/000514368

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex Differences in the Risk of 30-Day Death After Acute Ischemic Stroke2021

    • Author(s)
      Irie Fumi et al.
    • Journal Title

      Neurology: Clinical Practice

      Volume: 11 Issue: 6

    • DOI

      10.1212/cpj.0000000000001087

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional Disparity of Reperfusion Therapy for Acute Ischemic Stroke in Japan: A Retrospective Analysis of Nationwide Claims Data from 2010 to 20152021

    • Author(s)
      Maeda Megumi、Fukuda Haruhisa、Matsuo Ryu、Ago Tetsuro、Kitazono Takanari、Kamouchi Masahiro
    • Journal Title

      Journal of the American Heart Association

      Volume: 10 Issue: 20

    • DOI

      10.1161/jaha.121.021853

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide temporal trend analysis of reperfusion therapy utilization and mortality in acute ischemic stroke patients in Japan2021

    • Author(s)
      Maeda Megumi、Fukuda Haruhisa、Matsuo Ryu、Kiyuna Fumi、Ago Tetsuro、Kitazono Takanari、Kamouchi Masahiro
    • Journal Title

      Medicine

      Volume: 100 Issue: 1 Pages: e24145-e24145

    • DOI

      10.1097/md.0000000000024145

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism2020

    • Author(s)
      Sato Noriko、Matsuo Ryu、Kiyuna Fumi、Nakamura Kuniyuki、Hata Jun、Wakisaka Yoshinobu、Ago Tetsuro、Kamouchi Masahiro、Kitazono Takanari、collab. on behalf of the Fukuoka Stroke Registry Investigators
    • Journal Title

      Cerebrovascular Diseases

      Volume: 49 Issue: 6 Pages: 601-608

    • DOI

      10.1159/000510773

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of a learning health system on acute care and medical complications after intracerebral hemorrhage2020

    • Author(s)
      Matsumoto Koutarou、Nohara Yasunobu、Wakata Yoshifumi、Yamashita Takanori、Kozuma Yukio、Sugeta Rui、Yamakawa Miki、Yamauchi Fumiko、Miyashita Eri、Takezaki Tatsuya、Yamashiro Shigeo、Nishi Toru、Machida Jiro、Soejima Hidehisa、Kamouchi Masahiro、Nakashima Naoki
    • Journal Title

      Learning Health Systems

      Volume: 5 Issue: 2

    • DOI

      10.1002/lrh2.10223

    • NAID

      120007141558

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stroke Prognostic Scores and Data-Driven Prediction of Clinical Outcomes After Acute Ischemic Stroke2020

    • Author(s)
      Matsumoto Koutarou、Nohara Yasunobu、Soejima Hidehisa、Yonehara Toshiro、Nakashima Naoki、Kamouchi Masahiro
    • Journal Title

      Stroke

      Volume: 51 Issue: 5 Pages: 1477-1483

    • DOI

      10.1161/strokeaha.119.027300

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poor glycemic control and posterior circulation ischemic stroke.2019

    • Author(s)
      Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T.
    • Journal Title

      Neurol Clin Pract

      Volume: 9 Issue: 2 Pages: 129-139

    • DOI

      10.1212/cpj.0000000000000608

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global Outcome Assessment Life-long after stroke in young adults initiative-the GOAL initiative: study protocol and rationale of a multicentre retrospective individual patient data meta-analysis2019

    • Author(s)
      Ekker Merel、Jacob Mina、van Dongen Myrna, et al.
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 11 Pages: e031144-e031144

    • DOI

      10.1136/bmjopen-2019-031144

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serum magnesium and calcium levels in relation to ischemic stroke2019

    • Author(s)
      Larsson Susanna C.、Traylor Matthew、Burgess Stephen、Boncoraglio Giorgio B.、Jern Christina、Micha?lsson Karl、Markus Hugh S.、for the MEGASTROKE project of the International Stroke Genetics Consortium
    • Journal Title

      Neurology

      Volume: 92 Issue: 9

    • DOI

      10.1212/wnl.0000000000007001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm.2018

    • Author(s)
      Shono Y, Sugimori H, Matsuo R, Fukushima Y, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators..
    • Journal Title

      Int J Stroke.

      Volume: 1 Issue: 7 Pages: 734-742

    • DOI

      10.1177/1747493018765263

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin resistance and clinical outcomes after acute ischemic stroke2018

    • Author(s)
      Ago Tetsuro、Matsuo Ryu、Hata Jun、Wakisaka Yoshinobu、Kuroda Junya、Kitazono Takanari、Kamouchi Masahiro、On behalf of the Fukuoka Stroke Registry Investigators
    • Journal Title

      Neurology

      Volume: 90 Issue: 17 Pages: e1470-e1477

    • DOI

      10.1212/wnl.0000000000005358

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Embolic Sources with Cause-Specific Functional Outcomes Among Adults with Cryptogenic Stroke.2018

    • Author(s)
      Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.
    • Journal Title

      JAMA Netw Open

      Volume: 1 Issue: 5 Pages: e182953-e182953

    • DOI

      10.1001/jamanetworkopen.2018.2953

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes2018

    • Author(s)
      Malik R, Chauhan G, Traylor M, Minegishi N, AFGen Consortium,BioBank Japan Cooperative Hospital Group; MEGASTROKE Consortium
    • Journal Title

      Nat Genet

      Volume: 50 Issue: 4 Pages: 524-537

    • DOI

      10.1038/s41588-018-0058-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke2017

    • Author(s)
      Matsuo Ryu、Yamaguchi Yuko、Matsushita Tomonaga、Hata Jun、Kiyuna Fumi、Fukuda Kenji、Wakisaka Yoshinobu、Kuroda Junya、Ago Tetsuro、Kitazono Takanari、Kamouchi Masahiro、on behalf of the Fukuoka Stroke Registry Investigators†
    • Journal Title

      Stroke

      Volume: 48 Issue: 11 Pages: 3049-3056

    • DOI

      10.1161/strokeaha.117.018132

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Left Atrial Size and Long‐Term Risk of Recurrent Stroke After Acute Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation2017

    • Author(s)
      Ogata Toshiyasu、Matsuo Ryu、Kiyuna Fumi、Hata Jun、Ago Tetsuro、Tsuboi Yoshio、Kitazono Takanari、Kamouchi Masahiro、the FSR Investigators
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 8

    • DOI

      10.1161/jaha.117.006402

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳梗塞のプロテオーム解析2021

    • Author(s)
      鴨打正浩,松尾龍、脇坂義信、吾郷哲朗、北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Fukuoka Stroke Registry2021

    • Author(s)
      鴨打正浩,松尾龍、脇坂義信、吾郷哲朗、北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳梗塞発症前に認知症を有する症例の脳梗塞の病態と脳梗塞後機能転帰2021

    • Author(s)
      脇坂義信、松尾龍、吾郷哲朗、鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性腎臓病合併脳梗塞患者の臨床転帰2021

    • Author(s)
      松尾龍、鴨打正浩,脇坂義信、吾郷哲朗、北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 本邦における若年性脳梗塞の特徴: Fukuoka Stroke Registry2021

    • Author(s)
      大屋祐一郎,松尾龍,中村晋之,佐藤倫子,脇坂佳世,植木香奈,脇坂義信,吾郷哲朗,鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 急性期脳梗塞患者において腹囲が機能転帰に与える影響 -Fukuoka Stroke Registry-2021

    • Author(s)
      脇坂佳世,松尾龍,大屋祐一郎,植木香奈,佐藤倫子,中村晋之,脇坂義信,吾郷哲朗,鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 蛋白尿またはeGFR低下と急性期虚血性脳卒中発症後の長期臨床転帰の関連:Fukuoka Stroke Registry2021

    • Author(s)
      植木香奈,松尾龍,桑城貴弘,中村晋之,脇坂義信,吾郷哲朗,鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 認知症患者での脳梗塞発症前コリンエステラーゼ阻害薬使用と脳梗塞後転帰の関連:Fukuoka Stroke Registry2021

    • Author(s)
      脇坂義信,松尾龍,中村晋之,吾郷哲朗,鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 頭蓋内動脈硬化症に対する急性期血管内治療の現状:Fukuoka Stroke Registry2021

    • Author(s)
      木附信二,佐藤倫子,脇坂祐毅,古賀統之,金沢信,田中淳,松木孝之,松下知永,福嶌由尚,脇坂義信,吾郷哲朗,福田賢治,鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 血清尿酸値低値は脳梗塞後の短期機能転帰不良に関連する:Fukuoka Stroke Registry2021

    • Author(s)
      中村晋之,松尾龍,脇坂義信,吾郷哲朗,鴨打正浩,北園孝成
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳梗塞後のインスリン抵抗性と長期臨床転帰の関連: Fukuoka Stroke Registry2020

    • Author(s)
      清原卓也, 松尾龍, 松岡幹晃, 由比智裕, 中村晋之, 後藤聖司, 熊井康敬, 脇坂義信, 吾郷哲朗, 北園孝成, 鴨打正浩
    • Organizer
      第45回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳梗塞急性期の体温と神経学的転帰との関連: Fukuoka Stroke Registry2020

    • Author(s)
      賣豆紀智美, 松尾龍, 大崎正登, 生野雄二, 杉森宏, 荒川修治, 脇坂義信, 吾郷哲朗, 鴨打正浩, 北園孝成
    • Organizer
      第45回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高齢者脳卒中の予防と治療 高齢者脳卒中の特徴2020

    • Author(s)
      北園孝成, 松尾龍, 鴨打正浩
    • Organizer
      第45回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳微小出血の個数および分布と脳梗塞再発の関連2020

    • Author(s)
      森田隆雄,桑城貴弘,和田晋一,森興太,徳永啓介,船水章央,陣内重郎,矢坂正弘,鴨打正浩,北園孝成,岡田靖
    • Organizer
      第45回日本脳卒中学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Impact of current smoking on clinical outcomes in patients with acute reperfusion therapy after ischemic stroke2020

    • Author(s)
      Matsuo R, Nakamura K, Wakisaka Y, Kitazono T, Ago T
    • Organizer
      The Joint European Organization and World Stroke Organization Conference 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヘルスデータと医療2020

    • Author(s)
      鴨打正浩
    • Organizer
      第58回日本医療・病院管理学会学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 認知症予防のための脳ドック 認知症の危険因子と防御因子2020

    • Author(s)
      鴨打正浩
    • Organizer
      第29回日本脳ドック学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Short-term exposure to fine particulate matter (PM2.5) and risk of ischemic stroke in Japan2018

    • Author(s)
      Ryu Matsuo et al.
    • Organizer
      11th World Stroke Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insulin resistance and clinical outcomes after acute ischemic stroke2018

    • Author(s)
      Tetsuro Ago, Ryu Matsuo, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Takanari Kitazono, Masahiro Kamouchi, on behalf of the Fukuoka Stroke Registry Investigators
    • Organizer
      European Stroke Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Secondary prevention and prognosis in ischemic stroke patients with atrial fibrillation and atherothrombotic disease:Fukuoka Stroke Registry2018

    • Author(s)
      Shunsuke Kimura, Masato Osaki, Shota Sakai, Masaoki Hidaka, Shuji Arakawa, Ryu Matsuo, Masahiro Kamouchi, Tetsuro Ago, Takanari Kitazono
    • Organizer
      European Stroke Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognosis in Mild or Rapidly Improving Ischemic Stroke Not Treated with Recombinant Tissue Plasminogen Activator: Fukuoka Stroke Registry.2018

    • Author(s)
      Sakai S, Osaki M, Kimura S, Hidaka M, Arakawa S, Ago T, Matsuo R, Kamouchi M, Kitazono T
    • Organizer
      International Stroke Conference 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thrombolytic Therapy for Acute Ischemic Stroke Caused by Intracranial Artery Dissection: Fukuoka Stroke Registry2017

    • Author(s)
      Arakawa S, Osaki M, Sakai S, Kimura S, Hidaka M, Fukuta Y, Ago T, Kitazono T
    • Organizer
      Asian Pacific Stroke Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of pre-stroke cholinesterase inhibitor treatment on short-term functional outcome in acute ischemic stroke patients with pre-stroke dementia: the Fukuoka Stroke Registry2017

    • Author(s)
      Wakisaka Y, Matsuo R, Kuroda J, Ago T, Kamouchi M, Kitazono T
    • Organizer
      8th Korea-Japan Joint Stroke Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short-term exposure to fine particulate matter increased hospital admissions for ischaemic stroke in Japan2017

    • Author(s)
      Michikawa T, Matuso R, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M, on behalf of the Fukuoka Stroke Registry Investigators
    • Organizer
      29th Annual Scientific Conference of the International Society of Environmental Epidemiology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of onset-to-door time on clinical outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry2017

    • Author(s)
      Matsuo R, Yamaguchi Y, Matsushita T, Fukuda K, Kiyuna F, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T, on behalf of the FSR investigators.
    • Organizer
      3rd European Stroke Organisation Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2023-01-30  

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