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An integrated approach for cell cycle control of pluripotent stem cell-derived cardiomyocytes

Research Project

Project/Area Number 17H04176
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

Yoshida Yoshinori  京都大学, iPS細胞研究所, 准教授 (20447965)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords細胞周期 / 心筋細胞 / iPS細胞 / 細胞移植 / 転写因子 / 循環器 / 再生医療 / 多能性幹細胞 / 再生医学
Outline of Final Research Achievements

In this study, we investigated the cell cycle control of iPS cell-derived cardiomyocytes. We identified that CCA-1 activated the cell cycle of iPS cell-derived cardiomyocytes and increased their proliferative capacity. In addition, we confirmed that the graft efficiency after cell transplantation was improved by transplanting cardiomyocytes treated with CCA-1 into infarcted hearts of immunodeficient mice. Further, comprehensive gene expression analysis identified genes that serve as markers for cell-cycle active cardiomyocytes.

Academic Significance and Societal Importance of the Research Achievements

多能性幹細胞(ES/iPS細胞)から心筋細胞に分化するにつれて細胞周期は不活性化し増殖しない細胞となっていく。またヒト成人の心臓はほとんど分裂しないため一度心筋梗塞などで傷害を受けた心筋は回復しないことが知られている。本研究においてiPS細胞から分化した心筋細胞の細胞周期を制御することを目的として研究を行った。心筋細胞の細胞周期を活性化する化合物を同定し、同化合物を用いて処理した心筋細胞を移植すると移植生着効率が改善することを明らかにした。心筋細胞移植治療においては細胞周期が治療効率に関与すると考えられ、効率の高い細胞移植治療を確立するための重要な知見となることが期待される。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Products Report
  • Research Products

    (71 results)

All 2024 2023 2021 2020 2019 2018 2017

All Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 13 results,  Open Access: 10 results) Presentation (53 results) (of which Int'l Joint Research: 31 results,  Invited: 25 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation2024

    • Author(s)
      Fujiwara Yuya、Miki Kenji、Deguchi Kohei、Naka Yuki、Sasaki Masako、Sakoda Ayaka、Narita Megumi、Imaichi Sachiko、Sugo Tsukasa、Funakoshi Shunsuke、Nishimoto Tomoyuki、Imahashi Kenichi、Yoshida Yoshinori
    • Journal Title

      Stem Cell Reports

      Volume: 7 Issue: 1 Pages: 231-231

    • DOI

      10.1038/s42003-024-05809-2

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of 3D-Multicellular Human iPSC-Heart Organoids for the Noninvasive Assessment of Cardiac Fibrosis2024

    • Author(s)
      Lucena-Cacace A, Tian Y, Yoshida Y
    • Journal Title

      Methods in Molecular Biology

      Volume: 2803 Pages: 35-48

    • DOI

      10.1007/978-1-0716-3846-0_3

    • ISBN
      9781071638453, 9781071638460
    • Related Report
      Products Report
    • Open Access
  • [Journal Article] Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart2023

    • Author(s)
      Kasamoto Manabu、Funakoshi Shunsuke、Hatani Takeshi、Okubo Chikako、Nishi Yohei、Tsujisaka Yuta、Nishikawa Misato、Narita Megumi、Ohta Akira、Kimura Takeshi、Yoshida Yoshinori
    • Journal Title

      Stem Cell Reports

      Volume: 18 Issue: 8 Pages: 1672-1685

    • DOI

      10.1016/j.stemcr.2023.06.006

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells.2020

    • Author(s)
      Fukushima H, Yoshioka M, Kawatou M, Lopez-Davila V, Takeda M, Kanda Y, Sekino Y, Yoshida Y,Yamashita JK
    • Journal Title

      PLoS One

      Volume: 15 Issue: 11 Pages: 0241287-0241287

    • DOI

      10.1371/journal.pone.0241287

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish2020

    • Author(s)
      Okamoto Ryuji、Goto Itaru、Nishimura Yuhei、Kobayashi Issei、Hashizume Ryotaro、Yoshida Yoshinori、Ito Rie、Kobayashi Yuhko、Nishikawa Misato、Ali Yusuf、Saito Shunsuke、Tanaka Toshio、Sawa Yoshiki、Ito Masaaki、Dohi Kaoru
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 10 Pages: 0240129-0240129

    • DOI

      10.1371/journal.pone.0240129

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model2020

    • Author(s)
      Hirose Sayako、Makiyama Takeru、Melgari Dario、Yamamoto Yuta、Wuriyanghai Yimin、Yokoi Fumika、Nishiuchi Suguru、Harita Takeshi、Hayano Mamoru、Kohjitani Hirohiko、Gao Jingshan、Kashiwa Asami、Nishikawa Misato、Wu Jie、Yoshimoto Jun、Chonabayashi Kazuhisa、Ohno Seiko、Yoshida Yoshinori、Horie Minoru、Kimura Takeshi
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 8 Pages: 761-761

    • DOI

      10.3389/fcell.2020.00761

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LincRNA alleviates cardiac systolic dysfunction under pressure overload.2020

    • Author(s)
      Kuwabara Y, Tsuji S, Nishiga M, Izuhara M, Ito S, Nagao K, Horie T, Watanabe S, Koyama S, Kiryu H, Nakashima Y, Baba O, Nakao T, Nishino T, Sowa N, Miyasaka Y, Hatani T, Ide Y, Nakazeki F, Kimura M, Yoshida Y, Inada T, Kimura T, Ono K.
    • Journal Title

      Commun Biol.

      Volume: 3 Issue: 1 Pages: 434-434

    • DOI

      10.1038/s42003-020-01164-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility2019

    • Author(s)
      Xu Huaigeng、Wang Bo、Ono Miyuki、Kagita Akihiro、Fujii Kaho、Sasakawa Noriko、Ueda Tatsuki、Gee Peter、Nishikawa Misato、Nomura Masaki、Kitaoka Fumiyo、Takahashi Tomoko、Okita Keisuke、Yoshida Yoshinori、Kaneko Shin、Hotta Akitsu
    • Journal Title

      Cell Stem Cell

      Volume: 24 Issue: 4 Pages: 566-578.e7

    • DOI

      10.1016/j.stem.2019.02.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.2019

    • Author(s)
      Wu JC, Garg P, Yoshida Y, Yamanaka S, Gepstein L, Hulot JS, Knollmann BC, Schwartz PJ.
    • Journal Title

      Circ Res.

      Volume: 125(6) Issue: 6 Pages: 653-658

    • DOI

      10.1161/circresaha.119.315209

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.2019

    • Author(s)
      Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K, Watanabe A, Inoue H, Yamashita JK, Todani M, Nakagawa M, Osawa M, Yashiro Y, Yamanaka S, Osafune K.
    • Journal Title

      Physiol Rev

      Volume: 99 Issue: 1 Pages: 78-114

    • DOI

      10.1152/physrev.00039.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients2019

    • Author(s)
      Takaki Tadashi、Inagaki Azusa、Chonabayashi Kazuhisa、Inoue Keiji、Miki Kenji、Ohno Seiko、Makiyama Takeru、Horie Minoru、Yoshida Yoshinori
    • Journal Title

      Stem Cells International

      Volume: 2019 Pages: 1-12

    • DOI

      10.1155/2019/7532657

    • NAID

      120006634620

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of Human Induced Pluripotent Stem Cells to Cardiomyocytes Using Embryoid Bodies2018

    • Author(s)
      Hatani T, Miki K, Yoshida Y
    • Journal Title

      Methods in Molecular Biology

      Volume: 1816 Pages: 79-92

    • DOI

      10.1007/978-1-4939-8597-5_6

    • ISBN
      9781493985968, 9781493985975
    • Related Report
      2018 Annual Research Report
  • [Journal Article] Complex aberrant splicing in the induced pluripotent stem cell?derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation2018

    • Author(s)
      Wuriyanghai Yimin、Makiyama Takeru、Sasaki Kenichi、Kamakura Tsukasa、Yamamoto Yuta、Hayano Mamoru、Harita Takeshi、Nishiuchi Suguru、Chen Jiarong、Kohjitani Hirohiko、Hirose Sayako、Yokoi Fumika、Gao Jingshan、Chonabayashi Kazuhisa、Watanabe Ken、Ohno Seiko、Yoshida Yoshinori、Kimura Takeshi、Horie Minoru
    • Journal Title

      Heart Rhythm

      Volume: 15 Issue: 10 Pages: 1566-1574

    • DOI

      10.1016/j.hrthm.2018.05.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nano-structural analysis of engrafted human induced pluripotent stem cell-derived cardiomyocytes in mouse hearts using a genetic-probe APEX2.2018

    • Author(s)
      Hatani T, Funakoshi S, Deerinck TJ, Bushong EA, Kimura T, Takeshima H, Ellisman MH, Hoshijima M, Yoshida Y.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 505(4) Issue: 4 Pages: 1251-1256

    • DOI

      10.1016/j.bbrc.2018.10.020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induced Pluripotent Stem Cells Ten Years Later: For Cardiac Applications2017

    • Author(s)
      Yoshida Y, Yamanaka S
    • Journal Title

      Circulation Research

      Volume: 120(12) Issue: 12 Pages: 1958-1968

    • DOI

      10.1161/circresaha.117.311080

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] SMAD3 Mediates the Specification of Human-Induced Pluripotent Stem Cell-Derived Epicardium into Progenitors for the Cardiac Pericyte Lineage2024

    • Author(s)
      Yutaro Miyoshi, Yoshinori Yoshida
    • Organizer
      第88回日本循環器学会学術集会
    • Related Report
      Products Report
  • [Presentation] Machine Learning-Based Drug Screening System Using Human iPS Cell-Derived Cardiomyocytes and Cardiac Tissues to Discover Novel Therapies for Drug-Induced Cardiotoxicity2024

    • Author(s)
      Shunsuke Funakoshi, Masako Sasaki, Shigeru Kondo, Yuki Naka, Kenichi Imahashi, Yoshinori Yoshida
    • Organizer
      第88回日本循環器学会学術集会
    • Related Report
      Products Report
  • [Presentation] Developing Efficient Myocardial Reconstruction Therapy Using iPS Cells2024

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      Dubai Stem Cell Congress 2024
    • Related Report
      Products Report
    • Int'l Joint Research / Invited
  • [Presentation] The Application of Multimodal Analysis to Cardiac Biopsy Samples Facilitates a Quantitative and Mechanistic Framework for Investigating Cardiac Fibrosis2024

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      第88回日本循環器学会学術集会
    • Related Report
      Products Report
  • [Presentation] グラフト形成効率の高い心筋細胞移植法の開発2024

    • Author(s)
      吉田善紀
    • Organizer
      第23回日本再生医療学会
    • Related Report
      Products Report
  • [Presentation] Generation of mature epicardium derived from human-induced pluripotent stem cells via inhibition of mTOR signaling2023

    • Author(s)
      Tian Yu, Antonio Lucena-Cacace, Yoshinori Yoshida
    • Organizer
      ISSCR 20th Annual Meeting
    • Related Report
      Products Report
    • Int'l Joint Research
  • [Presentation] Generation of cardiac cells and tissues from iPS cells for biomedical applications2023

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      CARDIOVASCULAR BIOENGINEERING (CVBE) SYMPOSIUM 2023
    • Related Report
      Products Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞周期制御による高効率心筋再建治療法の開発2023

    • Author(s)
      吉田善紀
    • Organizer
      第27回日本心不全学会学術集会
    • Related Report
      Products Report
  • [Presentation] Efficient Reconstruction of the Failing Heart Using iPS Cells2023

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      ADSOC 2023 Bone Marrow Transplant & Cellular Therapy Congress
    • Related Report
      Products Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiac pharmacology study using human iPS cell-derived mature cardiac tissues.2023

    • Author(s)
      吉田善紀
    • Organizer
      第97回日本薬理学会年会
    • Related Report
      Products Report
    • Invited
  • [Presentation] Cell Cycle Activated iPS Cell Derived Cardiomyocytes Achieve Efficient Transplantation2021

    • Author(s)
      Manabu Kasamoto
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Generation of mature cardiomyocytes from pluripotent stem cells and their biomedical applications2021

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Profiling HAND1 and HAND2 expressions during cardiogenesis using hiPSCs2020

    • Author(s)
      Chikako Okubo and Yoshinori Yoshida
    • Organizer
      ISSCR 18th virtual
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Profiling expressions of HAND1 and HAND2 during cardiogenesis using hiPSCs2020

    • Author(s)
      Chikako Okubo and Yoshinori Yoshida
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Establishment of pathological models using iPS cell-derived cardiomyocytes and their application to drug discovery and toxicity tests2020

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      第47回日本毒性学会学術年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Application of genome editing technology for iPS cell research2020

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Development of Cardiac Regeneration Using Highly Engraftable Cardiomyocytes2020

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Elucidation of Myocardial Differentiation from Single Cell Analysis2020

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Efficient Large-scale Purification of Human iPSC derived Cardiomyocytes by Synthetic MicroRNA Switch and Magnetic-activated Cell Sorting activated Cell Sorting2020

    • Author(s)
      Takeshi Hatani, Chikako Okubo, Yoshihiko Fujita, Kazuhisa Chonabayashi, Hirohide Saito, Yoshinori Yoshida
    • Organizer
      ISSCR 18th virtual
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypoxia in Cell Reprogramming and Differentiationツ?2020

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      Keystone symposia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Single cell analysis elucidates the mechanism of Cardiac and Hematopoietic differentiation from human pluripotent stem cells2019

    • Author(s)
      Masayuki Umeda, Chihiro Okada, Akira Watanabe, Akifumi Kondo-Takaori, and Yoshinori Yoshida
    • Organizer
      ISSCR 17th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of Mature Cardiomyocytes from Pluriponte Stem Cells2019

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      40th Heart Rhythm Scientific Sessions
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Maturation of pluripotent stem cell-derived cardiomyocytes for biomedical applications2019

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      ISACB+ISVTE 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Efficient large-scale purification of human iPSC-derived cardiomyocytes by synthetic microrna switch and magnetic activated cell sorting2019

    • Author(s)
      Takeshi Hatani, Chikako Okubo, Yoshihiko Fujita, Kazuhisa Chonabayashi, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of a cell surface marker which is differentially expressed between ventricular and atrial cardiomyocytes derived from human induced-pluripotent stem cell2019

    • Author(s)
      Misato Koakutsu, Kenji Miki, Masako Sasaki, Stephanie Napier, Tomoyuki Nishimoto, Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Brand-New Compound Activates Cell Cycle of Induced Pluripotent Stem Cell Derived Cardiomocytes, and Promotes Efficient Cardiac Engraftment2019

    • Author(s)
      Manabu Kasamoto, Shunsuke Funakoshi, Takeshi Hatani, Yoshinori Yoshida, Takeshi Kimura
    • Organizer
      American Heart Association Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maturation of pluripotent stem cell-derived cardiomyocytes2019

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      12th Asian-Pacific Heart Rhythm Society Scientific Session
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of hiPSCs-derived 3D heart tissue maturation method using ERRホウ agonist and mechanical stress2019

    • Author(s)
      Yuya Fujiwara, Kohei Deguchi, Masako Sasaki, Yuki Naka, Kenji Miki, Tomoyuki Nishimoto, Yoshinori Yoshida
    • Organizer
      CiRA国際シンポジウム2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generation of mature iPSC cardiomyocytes for cardiac regeneration2019

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      Joint Workshop in Medicine, University of Zurich and Kyoto University
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトiPS細胞を用いた肥大型心筋症の病態モデル構築と新規治療法の探索2019

    • Author(s)
      吉田善紀
    • Organizer
      第18回再生医療学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Efficient Purification of Human iPSC-derived Cardiomyocytes in a Large ScaleUsing a Synthetic MicroRNA Switch and Magnetic-activated Cell Sorting2019

    • Author(s)
      Takeshi Hatani
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Generation of human pluripotent stem cell-derived mature cardiomyocytes for biomedical applications2019

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      15th Winter Brain & Heart Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞を用いた心疾患の新しい治療の開発2019

    • Author(s)
      吉田善紀
    • Organizer
      シンポジウム「iPS細胞がつくる未来の健康」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The Discovery of Brand-new Compound which Accelerate the Cell Cycle to Achieve the Efficient iPS cell-derived Cardiomyocyte Engraftment to the Infarction Modeled Mouse2018

    • Author(s)
      Manabu Kasamoto, Takeshi Hatani, Shunsuke Funakoshi, Yoshinori Yoshida, Takeshi Kimura
    • Organizer
      第3回J-ISCP学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Discovery of Brand-new Compound which Accelerate the Cell Cycle to Achieve the Efficient iPS cell-derived Cardiomyocyte Engraftment to the Infarction Modeled Mouse.2018

    • Author(s)
      Manabu Kasamoto, Takeshi Hatani, Shunsuke Funakoshi, Chikako Okubo, Tadashi Takak, Kenji Mik, Takeshi Kimura, Yoshinori Yoshida
    • Organizer
      ISSCR 16th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Toward in vitro construction of iPSC-derived human heart-like tissue2018

    • Author(s)
      Julia Junghof, Koichi Nakayama, Yoshinori Yoshida
    • Organizer
      ISSCR 16th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modeling of cardiac diseases using iPS cells2018

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      TERMIS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] EFFICIENT CARDIAC REGENERATION THERAPY BY CELL CYCLE ACTIVATION OF IPSC-DERIVED CARDIOMYOCYTES2018

    • Author(s)
      Manabu Kasamoto, Shunsuke Funakoshi, Takeshi Hatani, Takeshi Kimura, Yoshinori Yoshida
    • Organizer
      第2回日本循環器学会基礎研究フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes2018

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      11th Asian-Pacific Heart Rhythm Society Scientific Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Disease Modeling of Cardiac Diseases Using Induced Pluripotent Stem Cells2018

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      11th Asian-Pacific Heart Rhythm Society Scientific Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Efficient Purification of Human iPSC-derived Cardiomyocytes in a Large ScaleUsing a Synthetic MicroRNA Switch and Magnetic-activated Cell Sorting2018

    • Author(s)
      Takeshi Hatani, Kazuhisa Chonabayashi, Yoshihiko Fujita, Takeshi Kimura, Hirohide Saito, Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nano-structural Analysis of Engrafted Human iPSC-derived Cardiomyocytes in a Mouse Model of Myocardial Infarction Using APEX22018

    • Author(s)
      Takeshi Hatani, Shunsuke Funakoshi, Thomas J. Deerinck, Eric A. Bushong, Takeshi Kimura, Mark H. Ellisman, Masahiko Hoshijima, Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] EFFICIENT CARDIAC REGENERATION THERAPY BY CELL CYCLE ACTIVATION OF IPSC-DERIVED CARDIOMYOCYTES2018

    • Author(s)
      Manabu Kasamoto, Shunsuke Funakoshi, Takeshi Hatani, Takeshi Kimura, Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒトiPS細胞を用いた肥大型心筋症の病態モデル構築と新規治療法の探索2018

    • Author(s)
      吉田善紀
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] iPS細胞の循環器領域での臨床応用に向けた研究2018

    • Author(s)
      吉田善紀
    • Organizer
      小倉ライブデモンストレーション
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Induction of cardiomyocyte maturation for biomedical applications2018

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      Technion-Kyoto Joint meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Generation of mature cardiomyocytes from human pluripotent stem cells2018

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      12th Catholic International Stem Cell Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiac regeneration using human iPSC derived cardiomyocytes2018

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      Forum of Regenerative Medicine in Taipei
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell Cycle Modification of iPSC-derived ardiomyocyte for Cardiac Cell Therapy.2018

    • Author(s)
      Manabu Kasamoto
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Stably Expressed APEX2 Identifies T-tubules and Dyad Formation in Engrafted iPSC-derived Cardiomyocytes in a Mouse Model of Myocardial Infarction.2017

    • Author(s)
      Takeshi Hatani , Shunsuke Funakoshi, Thomas J. Deerinck, Eric A. Bushong, Takeshi Kimura, Shinya Yamanaka, Mark H. Ellisman, Masahiko Hoshijima, Yoshinori Yoshida
    • Organizer
      ISSCR 15th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Imaging iPSC-derived Cardiomyocytes Engrafted in a Mouse Model of Myocardial Infarction Using Stably Expressed APEX2.2017

    • Author(s)
      Takeshi Hatani, Shunsuke Funakoshi, Thomas J. Deerinck, Eric A. Bushong, Takeshi Kimura, Shinya Yamanaka, Mark H. Ellisman, Masahiko Hoshijima, Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IPS-Cell-Derived Cardiomyocyte Disease Modeling.2017

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      American Heart Association Scientific Sessions 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Elucidation of the mechanism of cardiomyocyte maturation using single cell transcriptome analysis.2017

    • Author(s)
      Yoshinori Yoshida
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] 心筋細胞増殖促進剤及びその利用2024

    • Inventor(s)
      吉田善紀、羽溪健、笠本学、舟越俊介
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2024
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 心筋細胞増殖促進剤及びその利用2023

    • Inventor(s)
      吉田善紀, 羽渓健, 鈴木涼介, 川端慎吾
    • Industrial Property Rights Holder
      国立大学法人京都大学, 三洋化成工業株式会社
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2023
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 心筋細胞増殖促進剤及びその利用2018

    • Inventor(s)
      吉田善紀/羽溪健/笠本学/舟越俊介
    • Industrial Property Rights Holder
      吉田善紀/羽溪健/笠本学/舟越俊介
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-021729
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2025-03-27  

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