| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
We previously showed that PLZF plays a critical role in MLL-ENL-mediated leukemogenesis, and Eya2, an essential gene for eye development in Drosophila, was found to be important as a downstream molecule of PLZF in the leukemogenesis. Here we report that Eya2 has a critical role in leukemogenesis by E2A-HLF, a responsible gene for one of the most aggressive pediatric lymphoid leukemias, suggesting Eya2 as a possible target for a molecular therapy against therapy-resistant leukemias. Meanwhile, Tet1, one of the upregulated genes downstream of MLL-ENL, has been found to give no effects on the phenotype of MLL-ENL-mediated leukemia, by analyses using Tet1 conditional knockout mice we have developed.
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