Development of the next-generation diagnosis method for depression by using byomakers based on pathophysiological mechanism

• Project/Area Number: 17H04252
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Fujita Health University
• Principal Investigator: 鍋島 俊隆 藤田医科大学, 保健学研究科, 客員教授 (70076751)
• Co-Investigator(Kenkyū-buntansha): 山本 康子 藤田医科大学, 保健学研究科, 准教授 (00331869) ; 毛利 彰宏 藤田医科大学, 保健学研究科, 准教授 (20597851) ; 國澤 和生 藤田医科大学, 保健学研究科, 助教 (60780773) ; 齋藤 邦明 藤田医科大学, 保健学研究科, 教授 (80262765)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 精神薬理学 / 診断バイオマーカー / うつ病 / セロトニントランスポーター / ユビキチン化 / MAGE-D1 / バイオマーカー

Outline of Annual Research Achievements

妊娠・出産などは大きなストレスとなり、周産期に約10～15％がうつ病を発症している。産後うつ病は育児放棄や虐待などにつながることがある。周産期における抑うつの早期発見・治療は重要であるが、妊娠期・産後の定期検診での産婦人科医師による診断・治療は難しい。周産期における抑うつの診断ができるバイオマーカーの探索が求められている。そこで、周産期の閾値下の抑うつ状態の患者の血液中のセロトニントランスポーターのユビキチン化レベルと、心理検査の結果との相関を検討した。精神科診断面接マニュアル(SCID)により、被験者を年齢などの背景が類似するが、妊娠初期や産後において過去1ヶ月にうつ病エピソードを有する患者と有しない患者に分類し、血小板中セロトニントランスポーターのユビキチン化タンパク量を比較した。妊娠初期や産後のどちらの時期においても、うつ病エピソードを有する患者ではユビキチン化セロトニントランスポーター量の減少もしくはそのユビキチン化率の低下が認められた。さらに、SCIDではエジンバラ産後うつ病質問票（EPDS）に基づき、妊娠初期や産後において抑うつが認められた患者（EPDSスコア9以上）と認められない患者（EPDSスコア9未満）に分け、血小板中セロトニントランスポーターのユビキチン化タンパク量を測定した。妊娠初期において抑うつが認められた患者ではユビキチン化セロトニントランスポーター量の減少およびそのユビキチン化率の低下が認められた。産後において、抑うつが認められた患者と認められない患者ではユビキチン化セロトニントランスポーター量およびそのユビキチン化率に変化は認められなかった。これら結果より、血小板中ユビキチン化セロトニントランスポーターはうつ病エピソードに対するバイオマーカーになりうること共に、妊娠期の閾値下の抑うつ状態に対するバイオマーカーとしての有用性も示唆された。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究は計画通りに概ね進捗しており、これまで実験動物とヒトの両方で、ユビキチン化セロトニントランスポーターはうつ様行動や気質のバイオマーカーとなる可能性を明らかとした。マウスではストレス負荷により血液中ユビキチン化セロトニントランスポーターの発現量が減少し、ヒトではうつ様気質・性格と血液中ユビキチン化セロトニントランスポーターの発現量の低下が関連することを明らかにすることができた。さらに、今年度はバイオマーカーとしてのユビキチン化セロトニントランスポーターの臨床応用を目指して、うつ患者でも血液中ユビキチン化セロトニントランスポーターの発現量が低下するか検討した。興味深いことに周産期の抑うつ患者で血液中セロトニントランスポーターのユビキチン化レベルの低下と抑うつに相関が認められた、今後、さらに多くのうつ合併症の患者の診断に、血中セロトニントランスポーターをバイオマーカーとして応用できるか検討するために、うつ様症状の発現頻度が高い疼痛性障害患者において、血中セロトニントランスポーターのユビキチン化レベルと抑うつとの関連を評価する予定である。すでに臨床医と共同してうつを合併した疼痛性障害患者血液サンプルを収集中である。

Strategy for Future Research Activity

身体疾患はうつ病のリスク因子であり、関連する自殺が問題になっている。しかし、一般病院では精神科医は不足し、身体疾患に伴う様々な精神医学問題に対して、専門家が連携して対処するリエゾンが出来る施設は限られており、抑うつ状態を診断するバイオマーカーが待望されている。そこで、うつ様症状の発現頻度が高い疼痛性障害患者において、血中セロトニントランスポーターのユビキチン化レベルと①初診時における抑うつ状態の有無、および②抗うつ薬による治療効果との関連について、検討を行う。

Research Products

• [Int'l Joint Research] Kangwon National University(韓国)
• [Int'l Joint Research] Shengyan Pharmaceutical University(中国)
• [Int'l Joint Research] Hassanuddin University(インドネシア)
• [Int'l Joint Research] National Taiwan University(その他の国・地域)
• [Int'l Joint Research] Kangwon National University(韓国)
• [Int'l Joint Research] Shengyan Pharmaceutical University(中国)
• [Int'l Joint Research] National Taiwan University(中華民国(台湾）)
• [Int'l Joint Research] Kangwon National University(South Korea)
• [Int'l Joint Research] Nathional Taiwan University(Republic of China)
• [Journal Article] Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder (2020)
  • Author(s): Masashi Sakurai, Yasuko Yamamoto, Noriyo Kanayama, Masaya Hasegawa, Akihiro Mouri, Masao Takemura, Hidetoshi Matsunami, Tomoya Miyauchi, Tatsuya Tokura, Hiroyuki Kimura, Mikiko Ito, Eri Umemura, Aiji Sato (Boku) , Wataru Nagashima, Takashi Tonoike, Kenichi Kurita, Norio Ozaki, Toshitaka Nabeshima and Kuniaki Saito
  • Journal Title: Scientific Reports Volume: 10 Pages: 1961-1961
  • DOI: 10.1038/s41598-020-58806-w
  • Peer Reviewed / Open Access
• [Journal Article] Lithium attenuates d‐amphetamine‐induced hyperlocomotor activity in mice via inhibition of interaction between cyclooxygenase‐2 and indoleamine‐2,3‐dioxygenase (2020)
  • Author(s): Phan Dieu‐Hien、Shin Eun‐Joo、Jeong Ji Hoon、Tran Hai‐Quyen、Sharma Naveen、Nguyen Bao Trong、Jung Tae Woo、Nah Seung‐Yeol、Saito Kuniaki、Nabeshima Toshitaka、Kim Hyoung‐Chun
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: 47 Pages: 790-797
  • DOI: 10.1111/1440-1681.13243
  • Peer Reviewed / Open Access
• [Journal Article] Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia (2020)
  • Author(s): Masahito Sawahata, Daisuke Mori, Yuko Arioka, Hisako Kubo, Itaru Kushima, Kanako Kitagawa, Akira Sobue, Emiko Shishido, Mariko Sekiguchi, Akiko Kodama, Ryosuke Ikeda, Branko Aleksic, Hiroki Kimura, Kanako Ishizuka, Taku Nagai, Kozo Kaibuchi, Toshitaka Nabeshima, Kiyofumi Yamada, Norio Ozaki
  • Journal Title: Psychiatry Clin Neurosci. Volume: 1 Pages: 1-10
  • DOI: 10.1111/pcn.12993
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine (2020)
  • Author(s): Tran Hai-Quyen、Shin Eun-Joo、Saito Kuniaki、Tran The-Vinh、Phan Dieu-Hien、Sharma Naveen、Kim Dae-Won、Choi Soo Young、Jeong Ji Hoon、Jang Choon-Gon、Cheong Jae Hoon、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Food and Chemical Toxicology Volume: 136 Pages: 110986-110986
  • DOI: 10.1016/j.fct.2019.110986
  • Peer Reviewed / Open Access
• [Journal Article] Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues (2019)
  • Author(s): Yoshida Yukihiro、Fujigaki Hidetsugu、Kato Koichi、Yamazaki Kyoka、Fujigaki Suwako、Kunisawa Kazuo、Yamamoto Yasuko、Mouri Akihiro、Oda Akifumi、Nabeshima Toshitaka、Saito Kuniaki
  • Journal Title: Scientific Reports Volume: 9 Pages: 10243-10243
  • DOI: 10.1038/s41598-019-46666-y
  • Peer Reviewed / Open Access
• [Journal Article] Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression (2019)
  • Author(s): Lu Qiaohui、Mouri Akihiro、Yang Yang、Kunisawa Kazuo、Teshigawara Tomoaki、Hirakawa Mami、Mori Yuko、Yamamoto Yasuko、Libo Zou、Nabeshima Toshitaka、Saito Kuniaki
  • Journal Title: Behavioural Brain Research Volume: 372 Pages: 112053-112053
  • DOI: 10.1016/j.bbr.2019.112053
  • Peer Reviewed
• [Journal Article] Indoleamine 2,3‐dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma (2019)
  • Author(s): Yamasuge Wakana、Yamamoto Yasuko、Fujigaki Hidetsugu、Hoshi Masato、Nakamoto Kentaro、Kunisawa Kazuo、Mouri Akihiro、Nabeshima Toshitaka、Saito Kuniaki
  • Journal Title: Cancer Sci. Volume: 110 Pages: 3061-3067
  • DOI: 10.1111/cas.14179
  • Peer Reviewed / Open Access
• [Journal Article] Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms (2019)
  • Author(s): Teshigawara Tomoaki、Mouri Akihiro、Kubo Hisako、Nakamura Yukako、Shiino Tomoko、Okada Takashi、Morikawa Mako、Nabeshima Toshitaka、Ozaki Norio、Yamamoto Yasuko、Saito Kuniaki
  • Journal Title: Journal of Affective Disorders Volume: 255 Pages: 168-176
  • DOI: 10.1016/j.jad.2019.05.028
  • Peer Reviewed
• [Journal Article] Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia (2019)
  • Author(s): Fujigaki Hidetsugu、Mouri Akihiro、Yamamoto Yasuko、Nabeshima Toshitaka、Saito Kuniaki
  • Journal Title: Neurochem Int Volume: 125 Pages: 1-6
  • DOI: 10.1016/j.neuint.2019.02.001
  • Peer Reviewed
• [Journal Article] Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (2019)
  • Author(s): Hasegawa Sho、Yoshimi Akira、Mouri Akihiro、Uchida Yoji、Hida Hirotake、Mishina Masayoshi、Yamada Kiyofumi、Ozaki Norio、Nabeshima Toshitaka、Noda Yukihiro
  • Journal Title: Neuropharmacology Volume: 148 Pages: 107-116
  • DOI: 10.1016/j.neuropharm.2018.12.020
  • Peer Reviewed
• [Journal Article] Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty. (2019)
  • Author(s): Fujikawa A, Noda Y, Yamamoto H, Tanga N, Sakaguchi G, Hattori S, Song W-J, Sora I, Nabeshima T, Katsuura G, Noda M.
  • Journal Title: PLoS ONE Volume: 14
  • DOI: 10.1371/journal.pone.0221205
  • Peer Reviewed / Open Access
• [Journal Article] 5-HT1A receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKCδ and p47phox (2019)
  • Author(s): Tran Hai-Quyen、Shin Eun-Joo、Hoai Nguyen Bao-Chau、Phan Dieu-Hien、Kang Min-Ji、Jang Choon-Gon、Jeong Ji Hoon、Nah Seung-Yeol、Mouri Akihiro、Saito Kuniaki、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Food and Chemical Toxicology Volume: 123 Pages: 125-141
  • DOI: 10.1016/j.fct.2018.10.049
  • Peer Reviewed / Open Access
• [Journal Article] Molecular mechanisms for nicotine intoxication (2019)
  • Author(s): Alkam Tursun、Nabeshima Toshitaka
  • Journal Title: Neurochemistry International Volume: 125 Pages: 117-126
  • DOI: 10.1016/j.neuint.2019.02.006
• [Journal Article] Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1) (2019)
  • Author(s): Shimizu Chikako、Wakita Yoshihisa、Inoue Takashi、Hiramitsu Masanori、Okada Miki、Mitani Yutaka、Segawa Shuichi、Tsuchiya Youichi、Nabeshima Toshitaka
  • Journal Title: Scientific Reports Volume: 9 Pages: 3671-3671
  • DOI: 10.1038/s41598-019-40253-x
  • Peer Reviewed / Open Access
• [Journal Article] Significance of protein kinase C in the neuropsychotoxicity induced by methamphetamine-like psychostimulants (2019)
  • Author(s): Shin Eun-Joo、Dang Duy-Khanh、Hwang Young Gwang、Tran Hai-Quyen、Sharma Naveen、Jeong Ji Hoon、Jang Choon-Gon、Nah Seung-Yeol、Nabeshima Toshitaka、Yoneda Yukio、Cadet Jean Lud、Kim Hyoung-Chun
  • Journal Title: Neurochemistry International Volume: 124 Pages: 162-170
  • DOI: 10.1016/j.neuint.2019.01.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Japanese Encephalitis- and Dengue-Associated Acute Encephalitis Syndrome Cases in Myanmar (2019)
  • Author(s): Kyaw Aung Kyaw、Ngwe Tun Mya Myat、Nabeshima Takeshi、Buerano Corazon C.、Ando Tsuyoshi、Inoue Shingo、Hayasaka Daisuke、Lim Chang-Kweng、Saijo Masayuki、Thu Hlaing Myat、Thant Kyaw Zin、Morita Kouichi
  • Journal Title: The American Journal of Tropical Medicine and Hygiene Volume: 100 Pages: 643-646
  • DOI: 10.4269/ajtmh.18-0530
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling (2019)
  • Author(s): Mai Huynh Nhu、Nguyen Lan Thuy Ty、Shin Eun-Joo、Kim Dae-Joong、Jeong Ji Hoon、Chung Yoon Hee、Lei Xin Gen、Sharma Naveen、Jang Choon-Gon、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Free Radical Biology and Medicine Volume: 131 Pages: 408-431
  • DOI: 10.1016/j.freeradbiomed.2018.12.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Theanine attenuates memory impairments induced by klotho gene depletion in mice (2019)
  • Author(s): Nguyen Bao Trong、Sharma Naveen、Shin Eun-Joo、Jeong Ji Hoon、Lee Sung Hoon、Jang Choon-Gon、Nah Seung-Yeol、Nabeshima Toshitaka、Yoneda Yukio、Kim Hyoung-Chun
  • Journal Title: Food & Function Volume: 10 Pages: 325-332
  • DOI: 10.1039/c8fo01577e
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protective potentials of far-infrared ray against neuropsychotoxic conditions (2019)
  • Author(s): Sharma Naveen、Shin Eun-Joo、Kim Nam Hun、Cho Eun-Hee、Jeong Ji Hoon、Jang Choon-Gon、Nah Seung-Yeol、Nabeshima Toshitaka、Yoneda Yukio、Cadet Jean Lud、Kim Hyoung-Chun
  • Journal Title: Neurochemistry International Volume: 122 Pages: 144-148
  • DOI: 10.1016/j.neuint.2018.11.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling (2018)
  • Author(s): Yamamoto Yasuko、Yamasuge Wakana、Imai Shinjiro、Kunisawa Kazuo、Hoshi Masato、Fujigaki Hidetsugu、Mouri Akihiro、Nabeshima Toshitaka、Saito Kuniaki
  • Journal Title: Sci Rep Volume: 8 Pages: 15917-15917
  • DOI: 10.1038/s41598-018-34166-4
  • Peer Reviewed / Open Access
• [Journal Article] Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. (2018)
  • Author(s): Yamada, S., Itoh, N., Nagai, T., Nakai, T., Ibi, D., Nakajima, A., Nabeshima, T., Yamada, K.
  • Journal Title: Journal of Neuroinflammation Volume: 15 Pages: 295-295
  • DOI: 10.1186/s12974-018-1332-0
  • Peer Reviewed / Open Access
• [Journal Article] Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice (2018)
  • Author(s): Bin Saifullah Md. Ali、Nagai Taku、Kuroda Keisuke、Wulaer Bolati、Nabeshima Toshitaka、Kaibuchi Kozo、Yamada Kiyofumi
  • Journal Title: Sci. Rep. Volume: 8 Pages: 14413-14413
  • DOI: 10.1038/s41598-018-32840-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clozapine attenuates mitochondrial burdens and abnormal behaviors elicited by phencyclidine in mice via inhibition of p47phox; Possible involvements of phosphoinositide 3-kinase/Akt signaling (2018)
  • Author(s): Tran Hai-Quyen、Park Se J、Shin Eun-Joo、Tran The-Vinh、Sharma Naveen、Lee Yu J、Jeong Ji H、Jang Choon-Gon、Kim Dae-Joong、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Journal of Psychopharmacology Volume: 32 Pages: 1233-1251
  • DOI: 10.1177/0269881118795244
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of protein kinase Cδ in dopaminergic neurotoxic events (2018)
  • Author(s): Shin Eun-Joo、Hwang Young Gwang、Sharma Naveen、Tran Hai-Quyen、Dang Duy-Khanh、Jang Choon-Gon、Jeong Ji Hoon、Nah Seung-Yeol、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Food and Chemical Toxicology Volume: 121 Pages: 254-261
  • DOI: 10.1016/j.fct.2018.09.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. (2018)
  • Author(s): Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N.
  • Journal Title: Sci. Rep. Volume: 8 Pages: 13046-13046
  • DOI: 10.1038/s41598-018-31390-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice (2018)
  • Author(s): Shimizu Chikako、Mitani Yutaka、Tsuchiya Youichi、Nabeshima Toshitaka
  • Journal Title: Biol. Pharm. Bull. Volume: 41 Issue: 7 Pages: 1049-1061
  • DOI: 10.1248/bpb.b18-00093
  • NAID: 130006736170
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to Far Infrared Ray Protects Methamphetamine-Induced Behavioral Sensitization in Glutathione Peroxidase-1 Knockout Mice via Attenuating Mitochondrial Burdens and Dopamine D1 Receptor Activation (2018)
  • Author(s): Mai Huynh Nhu、Sharma Naveen、Shin Eun-Joo、Nguyen Bao Trong、Jeong Ji Hoon、Jang Choon-Gon、Cho Eun-Hee、Nah Seung Yeol、Kim Nam Hun、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Neurochemical Research Volume: 43 Pages: 1118-1135
  • DOI: 10.1007/s11064-018-2528-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings (2018)
  • Author(s): Mai Huynh Nhu、Chung Yoon Hee、Shin Eun-Joo、Sharma Naveen、Jeong Ji Hoon、Jang Choon-Gon、Saito Kuniaki、Nabeshima Toshitaka、Reglodi Dora、Kim Hyoung-Chun
  • Journal Title: Food and Chemical Toxicology Volume: 116 Pages: 249-263
  • DOI: 10.1016/j.fct.2018.04.031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice (2018)
  • Author(s): Wulaer B, Nagai T, Sobue A, Itoh N, Kuroda K, Kaibuchi K, Nabeshima T, Yamada K
  • Journal Title: Gene Brain Behav. Volume: 印刷中
  • DOI: 10.1111/gbb.12478
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysfunction of serotoninergic and dopaminergic neuronal systems in the antidepressant-resistant impairment of social behaviors induced by social defeat stress exposure as juveniles. (2018)
  • Author(s): Hasegawa S, Miyake Y, Yoshimi A, Mouri A, Hida H, Yamada K, Ozaki N, Nabeshima T, Noda Y.
  • Journal Title: Int J Neuropsychopharmacol Volume: 印刷中 Pages: 837-846
  • DOI: 10.1093/ijnp/pyy038
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to far-infrared rays attenuates methamphetamine-induced recognition memory impairment via modulation of the muscarinic M1 receptor, Nrf2, and PKC (2018)
  • Author(s): Mai Huynh Nhu、Sharma Naveen、Shin Eun-Joo、Nguyen Bao Trong、Nguyen Phuong Tram、Jeong Ji Hoon、Jang Choon-Gon、Cho Eun-Hee、Nah Seung-Yeol、Kim Nam Hun、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Neurochemistry International Volume: 116 Pages: 63-76
  • DOI: 10.1016/j.neuint.2018.03.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders. Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mou (2018)
  • Author(s): Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.
  • Journal Title: Br J Pharmacol Volume: 印刷中 Pages: 2414-2427
  • DOI: 10.1111/bph.14198
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exposure to far-infrared ray attenuates methamphetamine-induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine (2018)
  • Author(s): Mai Huynh Nhu、Sharma Naveen、Shin Eun-Joo、Nguyen Bao Trong、Nguyen Phuong Tram、Jeong Ji Hoon、Cho Eun-Hee、Lee Yu Jeung、Kim Nam Hun、Jang Choon-Gon、Nabeshima Toshitaka、Kim Hyoung-Chun
  • Journal Title: Journal of Neuroscience Research Volume: 96 Pages: 1294-1310
  • DOI: 10.1002/jnr.24228
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT1A Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. (2018)
  • Author(s): Tran HQ, Lee Y, Shin EJ, Jang CG, Jeong JH, Mouri A, Saito K, Nabeshima T, Kim HC.
  • Journal Title: Molecular Neurobiology Volume: 印刷中 Pages: 7802-7821
  • DOI: 10.1007/s12035-018-0938-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter. (2018)
  • Author(s): Yamazaki M, Yamada H, Munetsuna E, Ishikawa H, Mizuno G, Mukuda T, Mouri A, Nabeshima T, Saito K, Suzuki K, Hashimoto S, Ohashi K.
  • Journal Title: FASEB J Volume: 32 Pages: 2549-2562
  • DOI: 10.1096/fj.201700783rr
  • Peer Reviewed / Open Access
• [Journal Article] Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. (2018)
  • Author(s): A Sobue, N Ito, T Nagai, W Shan, K Hada, Nakajima A, Y Murakami, A Mouri, Y Yamamoto, T Nabeshima, K Saito, K Yamada
  • Journal Title: Glia. Volume: 66 Pages: 1034-1052
  • DOI: 10.1002/glia.23299
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis. (2018)
  • Author(s): Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T, Noda Y.
  • Journal Title: Neuropharmacology. Volume: 133 Pages: 23-37
  • DOI: 10.1016/j.neuropharm.2018.01.016
  • Peer Reviewed / Open Access
• [Journal Article] MK-801, but not naloxone, attenuates high-dose dextromethorphan-induced convulsive behavior: Possible involvement of the GluN2B receptor. (2017)
  • Author(s): Tran HQ, Chung YH, Shin EJ, Tran TV, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Kim HC.
  • Journal Title: Toxicol Appl Pharmacol. Volume: 334 Pages: 158-166
  • DOI: 10.1016/j.taap.2017.09.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization (2017)
  • Author(s): Akihiro Mouri, Yukihiro Noda, Minae Niwa, Yurie Matsumoto, Takayoshi Mamiya, Atsumi Nitta, Kiyofumi Yamada, Shoei Furukawa, Tatsunori Iwamura, Toshitaka Nabeshima
  • Journal Title: Behav Brain Res. Volume: 329 Pages: 157-165
  • DOI: 10.1016/j.bbr.2017.04.052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice (2017)
  • Author(s): Yurie Matsumoto, Minae Niwa, Akihiro Mouri, Yukihiro Noda, Takeshi Fukushima, Norio Ozaki, Toshitaka Nabeshima
  • Journal Title: Psychopharmacology (Berl). Volume: 234 Pages: 3055-3074
  • DOI: 10.1007/s00213-017-4704-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions (2017)
  • Author(s): Tashiro T , Murakami Y , Mouri A , Imamura Y, Nabeshima T, Yamamoto, Y , Saito, K
  • Journal Title: Behavioral Brain Research Volume: 317 Pages: 279-285
  • DOI: 10.1016/j.bbr.2016.09.050
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 口腔内慢性疼痛患者における血中ユビキチン化セロトニントランスポーターの発現変化． (2020)
  • Author(s): 中村 真理子、吉見 陽、毛利 彰宏、鍋島 俊隆、林 千裕、徳倉 達也、木村 宏之、岩本 邦弘、伊藤 幹子、栗田 賢一、尾崎 紀夫、野田 幸裕
  • Organizer: 日本薬学会１４０回年会（2020.3.15-17 京都）
• [Presentation] QPRTの欠損はキノリン酸によるドパミン作動性神経系における酸化ストレスを介した運動・認知機能障害を惹起する． (2020)
  • Author(s): 毛利 彰宏、新島 萌、勅使河原 知明、國澤 和生、窪田 悠力、山本 康子、齋藤 邦明、鍋島 俊隆
  • Organizer: 第９３回日本薬理学会年会（2020.3.16-18横浜）
• [Presentation] リーリン遺伝子のエキソン欠失を有するマウスはタッチスクリーン型視覚弁別試験において認知障害を呈する． (2020)
  • Author(s): Dong Geyao、永井 拓、Liao Jingzhu、森 大輔、Wulaer Bolati、鍋島 俊隆、尾崎 紀夫、山田 清文
  • Organizer: 第９３回日本薬理学会年会（2020.3.16-18横浜）
• [Presentation] 精神疾患の環境的要因におけるプロスタグランジンE2の役割 (2020)
  • Author(s): 肥田 裕丈、毛利 彰宏、高須 光平、武藤 利奈、内田 美月、古屋敷 智之、成宮 周、鍋島 俊隆、山田 清文、吉見 陽、尾崎 紀夫、野田 幸裕
  • Organizer: 第９３回日本薬理学会年会（2020.3.16-18横浜）
• [Presentation] ARHGAP10変異マウス側坐核および線条体神経細胞の変化による行動障害． (2020)
  • Author(s): 羽田 和弘、Wulaer Bolati、永井 拓、祖父江 顕、澤幡 雅仁、伊藤 教道、森 大輔、久島 周、鍋島 俊隆、尾崎 紀夫、山田 清文：
  • Organizer: 第９３回日本薬理学会年会（2020.3.16-18横浜）
• [Presentation] ファスジルの投与は皮質線条体回路を介してメタンフェタミン単回投与により誘発されるC57BL/6Jマウスの認知障害を改善する. (2019)
  • Author(s): Liao Ji、永井 拓、Wulaer Bolati、鍋島 俊隆、山田 清文
  • Organizer: 第135回薬理学会近畿部会 (2019.6.21岐阜)
• [Presentation] 難治性統合失調症患者由来ARHGAP10遺伝子変異マウスにおけるメタンフェタミン誘発性認知機能障害に対するファスジルの効果. (2019)
  • Author(s): 廖 セイ竹 永井 拓 森 大輔 Wulaer B 羽田 和弘 鍋島 俊隆 尾崎 紀夫 山田 清文
  • Organizer: 第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28 新潟）
• [Presentation] どのように研究を進めるのか (2019)
  • Author(s): 鍋島俊隆
  • Organizer: . 第65 回日本薬学会東海支部大会 (2019.7.6, 名古屋)
  • Invited
• [Presentation] アストログリア由来MHCIは病理的変化により社会性および認知機能障害を誘発した. (2019)
  • Author(s): 羽田 和弘 祖父江 顕 Bolati Wulaer 伊藤 教道 中島 晶 鍋島 俊隆 永井 拓 山田 清文
  • Organizer: 第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28 新潟）
• [Presentation] Reelinの前頭前皮質内投与がMK801誘発性行動障害およびc-Fos発現に与える影響. (2019)
  • Author(s): 澤幡 雅仁 浅野 裕樹 常浦 祐未 永井 拓 河野 孝夫 鍋島 俊隆 服部 光治 山田 清文
  • Organizer: 第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28 新潟）
• [Presentation] Involvement of Noradrenergic Function in the Behavioral Changes in MAGE-D1 KO Mice. (2019)
  • Author(s): 毛利彰宏、平川茉実、渡辺研、國澤和生、森優子、窪田悠力、新島萌、山本康子、野田幸裕、鍋島俊隆、齋藤邦明
  • Organizer: 第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28 新潟）
• [Presentation] IDO1は社会的敗北ストレス下におけるストレス脆弱性を制御する/ IDO1 regulates vulnerability to social defeat stress. (2019)
  • Author(s): 國澤和生、毛利彰宏、小菅愛加、飯田翼、Wulaer Bolati、山本康子、齋藤邦明、鍋島俊隆：
  • Organizer: 第42回日本神経科学大会第62回日本神経化学会大会合同大会（2019.7.25-28 新潟）
• [Presentation] トリプトファン代謝経路が抑うつに与える影響-基礎研究と臨床研究のクロストーク-、 (2019)
  • Author(s): 毛利彰宏、國澤和生、窪田悠力、新島萌 、森優子、勅使河原知明、藤垣英嗣、山本康子、尾崎紀夫、齋藤邦明、鍋島俊隆
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2019（2019.8.31東京）
• [Presentation] Involvement of glutamate receptors in the impairment of social behaviors induced by social defeat stress exposure as juveniles. (2019)
  • Author(s): Mikio Yoshida, Sho Hasegawa, Mizuki Uchida, Yoji Uchida, Akihiro Mouri, Akira Yoshimi, Masayoshi Mishina, Norio Ozaki, Toshitaka Nabeshima, Yukihiro Noda
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Development of biomarker for depression focused on serotonergic systems from animal models. (2019)
  • Author(s): Akihiro Mouri, Kazuo Kunisawa, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Kynurenine 3-monooxygenase regulates expression of depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptor by kynurenic acid. AsCNP2019 (2019.10.11-13, 福岡) (2019)
  • Author(s): Akihiro Mouri, Yuko Mori, Kazuo Kunisawa, Mami Hirakawa, Tomoaki Teshigawara, Hisayoshi Kubota, Moe Niijima, Hidetsugu Fujigaki, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] The role of tryptophan metabolism in major depressive disorder (2019)
  • Author(s): Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Bolati Wulaer, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Repeated social defeat stress induces microglial activation and myelin abnormality in the corpus callosum: a potential link to depression-like behavior. (2019)
  • Author(s): Tsubasa Iida, Kazuo Kunisawa, Sei Saitoh, Aika Kosuge, Bolati Wulaer, Willy Jaya Suento, Yasuko Yamamoto, Akihiro Mouri, Kuniaki Saito and Toshitaka Nabeshima
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Impaired neurogenesis in the dentate gyrus of adult ShatiKO mice (2019)
  • Author(s): Bolati Wulaer, Kazuo Kunisawa, Willy Jaya Suento, Tsubasa Iida, Aika Kosuge, Atsumi Nitta, Akihiro Mouri, Kuniaki Saito Toshitaka Nabeshima
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Lipopolysaccharide injection triggers Indoleamine-2,3-dioxygenase1 and miR-874-3p interaction which leads to depression-like behavior in mouse． (2019)
  • Author(s): Willy Jaya Suento, Kazuo Kunisawa, Bolati Wulaer, Tsubasa Iida, Aika Kosuge, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Repeated social defeat stress induces depression-like behavior through the decrease of GLT-1 ubiquitination in the prefrontal cortex of mice． (2019)
  • Author(s): Aika Kosuge, Kazuo Kunisawa, Tsubasa Iida, Bolati Wulaer, Willy Jaya Suento, Yasuko Yamamoto, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] The deficit of quinolinic acid phosphoribosyltransferase induces hypolocomotion and cognitive impairment through impairment of dopaminergic neuronal function (2019)
  • Author(s): Moe Niijima, Akihiro Mouri, Tomoaki Teshigawara, Kazuo Kunisawa, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] Deficiency of kynurenine 3-monooxygenase increases vulnerability to the PCP-induced behavioral abnormalities (2019)
  • Author(s): Hisayoshi Kubota, Akihiro Mouri, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
  • Organizer: AsCNP2019 (2019.10.11-13, 福岡)
  • Int'l Joint Research
• [Presentation] The α6 subunit-containing GABAA receptor is a novel therapeutic target for schizophrenia and migraine. ) (2019)
  • Author(s): Lih-Chu Chiou, Hsin-Jung Lee, Ming Tatt Lee, Hung-Ruei Tzeng, Pi-Chuan Fan, Hisayoshi Kubota, Akihiro Mouri, Daniel E Knutson, James Cook6 Margot Ernst, Werner Sieghart, Toshitaka Nabeshima
  • Organizer: The 49th Annual Meeting of the Society for Neuroscience . (2019.10.19-23, Chicago
  • Int'l Joint Research
• [Presentation] 人工知能を用いたストレス負荷マウスの表情評価. (2019)
  • Author(s): 多田遼矢，毛利彰宏，寺本篤司，國澤和生，山田あゆみ，長谷川眞也，倉橋仁美，浅野僚子，窪田悠力，新島萌，山本康子，齋藤邦明，鍋島俊隆
  • Organizer: 日本生体医工学会東海支部大会（2019.10.26名古屋）
• [Presentation] 成熟マウスにおけるReelinの前頭前皮質内微量投与がMK801誘発性行動障害及びcFos 発現に与える影響． (2019)
  • Author(s): 澤幡雅仁、浅野裕樹、永井 拓、河野孝夫、鍋島俊隆、服部光治、山田清文
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会 （2019.11.10名古屋）
• [Presentation] 成熟マウスの前頭前皮質における Reelin シグナルの活性化がMK801誘発性行動障害に与える影響． (2019)
  • Author(s): 澤幡 雅仁、浅野 裕樹、永井 拓、河野 孝夫、鍋島 俊隆、服部 光治、山田 清文
  • Organizer: 第136回日本薬理学会近畿部会（2019.11.23枚方市）
• [Presentation] How we use biomakers to diagnose despression? (2019)
  • Author(s): Toshitaka Nabeshima
  • Organizer: AsCNP-ASIAN Iinternationa Congress of Neuropsychopharmacology2018
  • Int'l Joint Research / Invited
• [Presentation] 幼若期ストレスがCCKR2tgマウスの学習記憶に及ぼす影響 (2019)
  • Author(s): 永田翔吾、間宮隆吉、鍋島俊隆、平松正行
  • Organizer: 日本薬学会第139回年会
• [Presentation] Antidepressant effects of XJ-Et-8 in mice chronically exposed to corticosterone (2019)
  • Author(s): Jiajing Shan, Akihiro Mouri, Yang Yang, Qiaohui Lu, Kazuo Kunisawa , Tomoaki Teshigawara , Mami Hirakawa , Yuko Mori , Yasuko Yamamoto , Zou Libo , Toshitaka Nabeshima, Kuniaki Saito,
  • Organizer: 第92回日本薬理学会年会
• [Presentation] 慢性予測不能軽度ストレス負荷は側坐核のドパミン機能亢進と前頭皮質・海馬のセロトニン機能低下を伴ううつ様行動を惹起する (2019)
  • Author(s): 毛利 彰宏、キョヘイ ル、ヤン ヤン、國澤 和生、勅使河原 知明、平川 茉実、森 優子、山本 康子、シュウ リボ、鍋島 俊隆、齋藤 邦明
  • Organizer: 第92回日本薬理学会年会
• [Presentation] 抗精神病薬の長期投与による脳機能への影響 (2018)
  • Author(s): 鍋島俊隆
  • Organizer: 第28回日本臨床精神神経薬理学会 第48回日本神経精神薬理学会合同年会
  • Invited
• [Presentation] 新規統合失調症関連遺伝子ARHGAP10変異マウスの行動薬理的・神経化学的解析 (2018)
  • Author(s): 羽田和弘、永井拓、伊藤教通、祖父江顕、Wulaer Bolati, 朱文俊、森大輔、久島周、鍋島俊隆、尾崎紀夫、山田清文
  • Organizer: 第133薬理学会近畿部会
• [Presentation] うつ病発症におけるトリプトファン代謝の関与 (2018)
  • Author(s): 國澤和生、毛利彰宏、山本康子、齋藤邦明、鍋島俊隆
  • Organizer: 第３４回日本ストレス学会学術総会
• [Presentation] Repeated social defeat induces social interaction deficits associated with the alteration of kynurenine pathway activity in the prefrontal cortex (2018)
  • Author(s): Kazuo Kunisawa, Akihiro Mouri, Aika Kosuge, Tsubasa Iida, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: WCP2018 Kyoto
  • Int'l Joint Research
• [Presentation] The perinatal mice administered prostaglandin E2 develop psychobehavioral and neuronal impairments in adults (2018)
  • Author(s): Hirotake Hida, Akihiro Mouri, Kentaro Mori, Saori Takeuchi, Toshitaka Nabeshima, Kiyofumi Yamada, Norio Ozaki, Tomoyuki Furuyashiki, Shu Narumiya, Yukihiro Noda
  • Organizer: WCP2018 Kyoto
  • Int'l Joint Research
• [Presentation] Prostaglandin E receptor subtype EP1 deficiency elicits AD/HD-like behavior correlated with a dysfunction of dopamine D1 receptor-ERK signaling in the prefrontal cortex (2018)
  • Author(s): Akihiro Mouri,Tomoyuki Furuyashiki, Kazuo Kunisawa, Yasuko Yamamoto, Kiyofumi Yamada, Yukihiro Noda, Kuniaki Saito, Shu Narumiya, Toshitaka Nabeshima
  • Organizer: WCP2018 Kyoto
  • Int'l Joint Research
• [Presentation] Npas4-Homer1a pathway regulates neuronal homeostasis in animal model of epilepsy (2018)
  • Author(s): Taku Nagai, Wei Shan, Motoki Tanaka, Norimichi Itoh, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Masahiro Sokabe, Kiyofumi Yamada
  • Organizer: WCP2018 Kyoto
  • Int'l Joint Research
• [Presentation] The cerebellar α6 subunit-containing GABAA receptor: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders (2018)
  • Author(s): Lih-Chu Chiou, Hsin-Jung Lee, M argot Ernst, Wei-Jan Huang, Akihiro Mouri, Marco Treven, Takayoshi Mamiya, James Cook, Werner Sieghart, Toshitaka Nabeshima
  • Organizer: WCP2018 Kyoto
  • Int'l Joint Research
• [Presentation] Involvement of kynurenine pathway in behavioral impairments in the offspring induced by the prenatal poly I: C injection (2018)
  • Author(s): Moe Niijima, Akihiro Mouri, Tomoaki Teshigawara, Kazuo Kunisawa, Hisayoshi Kubota, Mami Hirakawa, Yuko Mori, Masato Hoshi, Toshitaka Nabeshima, Kuniaki Saito
  • Organizer: WCP2018 Kyoto
  • Int'l Joint Research
• [Presentation] DEVELOPMENT OF ANIMAL MODELS AND BIOMARKER FOR DEPRESSION FOCUSED ON SEROTONERGIC SYSTEMS (2018)
  • Author(s): Akihiro Mouri1, Kazuo Kunisawa2, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: 15th International Society for Tryptophan Research (ISTRY) Conference
  • Int'l Joint Research
• [Presentation] MAGE-D1 REGULATES EXPRESSION OF DEPRESSION-LIKE BEHAVIOR THROUGH SEROTONIN TRANSPORTER UBIQUITYLATION (2018)
  • Author(s): Akihiro Mouri, Kazuo Kunisawa, Mami Hirakawa, Yuko Mori, Ken Watanabe, Hidetsugu Fujigaki, Yasuko Yamamoto, Yukihiro Noda, Kuniaki Saito, Toshitaka Nabeshima
  • Organizer: 15th International Society for Tryptophan Research (ISTRY) Conference
  • Int'l Joint Research
• [Presentation] 成熟マウスにおけるReelinの前頭前皮質内投与がMK801誘発性行動障害に与える影響 (2018)
  • Author(s): 浅野裕樹、澤幡雅仁、北川佳奈子、常浦祐未、永井拓、河野孝夫、鍋島俊隆、服部光治、山田清文
  • Organizer: 第134回薬理学会近畿部会
• [Presentation] 幼若期社会的敗北ストレス負荷による治療抵抗性の社会性行動障害におけるモノアミン作動性神経系の機能異常 (2018)
  • Author(s): 長谷川章、三宅裕里子、吉見 陽、毛利彰宏、肥田裕丈、山田清文、尾崎紀夫、鍋島俊隆、野田幸裕
  • Organizer: 第2回日本精神薬学会総会・学術集会
• [Presentation] Depressive symptoms and L-Tryptophan -Kynurenine pathway metabolism focus on neuro-inflammation. (2017)
  • Author(s): Kuniaki Saito
  • Organizer: The 5th Congress of Asian College pof Neuropsychopharmacology( 2017.4.27-29, Indonesia)
  • Int'l Joint Research
• [Presentation] The Ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients. (2017)
  • Author(s): Akihiro Mouri
  • Organizer: The 5th Congress of Asian College pof Neuropsychopharmacology( 2017.4.27-29, Indonesia)
  • Int'l Joint Research
• [Book] visual core pharma 薬物治療学 (2019)
  • Author(s): 吉尾 隆, 鍋島俊隆 他
  • Total Pages: 912
  • Publisher: 南山堂; 改訂9版 (2020/3/13)
  • ISBN: 9784525720599
• [Book] Neuroscience of Nicotine (2019)
  • Author(s): Tursun Alkam and Toshitaka Nabeshima(Chaper 6 and 24)
  • Total Pages: 566
  • Publisher: Elsevier Inc
  • ISBN: 9780128130353
• [Remarks]
  • URL: http://www.adsrl-fhu.com/staff/
• [Remarks]
  • URL: http://www.adsrl-fhu.com/staff/
• [Remarks] 藤田保健衛生大学医療科学部寄附研究部門 先進診断システム探索部門
  • URL: http://www.adsrl-fhu.com/staff/
• [Patent(Industrial Property Rights)] うつ病マーカー、アッセイ方法、測定方法、うつ病薬のスクリーニング方法及びキット (2017)
  • Inventor(s): 鍋島俊隆、毛利彰宏
  • Industrial Property Rights Holder: 学校法人 名城大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Acquisition Date: 2018