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Fundamental genetic analysis research for Precision Neurosurgery

Research Project

Project/Area Number 17H04301
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurosurgery
Research InstitutionThe University of Tokyo

Principal Investigator

Saito Nobuhito  東京大学, 医学部附属病院, 教授 (60262002)

Co-Investigator(Kenkyū-buntansha) 中冨 浩文  東京大学, 医学部附属病院, 准教授 (10420209)
宮脇 哲  東京大学, 医学部附属病院, 講師 (70407914)
高柳 俊作  東京大学, 医学部附属病院, 助教 (90406489)
今井 英明  東京大学, 医学部附属病院, 特任講師 (70359587)
武笠 晃丈  東京大学, 医学部附属病院, 講師 (90463869)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsゲノムコホート / 神経線維腫症2型 / 体細胞モザイク / 頭蓋内血管狭窄 / RNF213 / rare variant / 髄膜腫 / NF2 / Precision Medecine / 遺伝子型 / 遺伝性脳血管疾患 / 遺伝性良性脳腫瘍 / MF2 / CCM / 遺伝性両性脳腫瘍 / Precision Medicine
Outline of Final Research Achievements

In hereditary brain diseases (benign brain tumors and vascular diseases), benign brain tumors and vascular lesions occur in the central nervous system temporally and spatially, worsening the functional prognosis over time and leading to death. It is one of the refractory diseases among the field of neurosurgery. In this study, we constructed a genomic cohort with detailed clinical information for hereditary brain diseases. Regarding neurofibromatosis type 2 (NF2), it was clarified that the somatic mosaic of the NF2 gene is involved in many cases. As for intracranial artery stenosis (moyamoya disease), rare variants of RNF213 related to the disease were identified. In meningiomas, which are often found in NF2 patients, the associations between genetic variants and the anatomical site of occurrence and pathological diagnosis was clarified.

Academic Significance and Societal Importance of the Research Achievements

遺伝性脳疾患(良性脳腫瘍・血管疾患)の詳細な臨床情報を有するゲノムコホートを構築し、今後の発展的研究の基盤を樹立した。神経線維腫症2型にはおいてはこれまで遺伝的要因が不明であった患者の大部分に体細胞モザイクが関わっていることを明らかにし、遺伝子診断が向上に寄与すると考えられる。頭蓋内血管狭窄(もやもや病)に関しても新たな疾患関連遺伝子変異を同定して、診断の向上および発症メカニズムの解明につながる成果と考えられる。また髄膜腫においては、発生部位による特徴的な遺伝子変異の違いは硬膜の部位により発生起源に影響を受けている可能性を示唆する結果であり、発症のメカニズムの解明につながると考えられる。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (50 results)

All 2020 2018 2017

All Journal Article (17 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 15 results,  Open Access: 6 results) Presentation (27 results) (of which Int'l Joint Research: 5 results) Book (6 results)

  • [Journal Article] Association between the onset pattern of adult moyamoya disease and risk factors for stroke2020

    • Author(s)
      Hirano Y, Miyawaki S, Imai H, Hongo H, Ohara K, Dofuku S, Teranishi Y, Nakatomi H, Saito N
    • Journal Title

      Stroke

      Volume: 51(10) Issue: 10 Pages: 3124-3128

    • DOI

      10.1161/strokeaha.120.030653

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Small Cell Variant of Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma of the Dura Mimicking Tentorial Meningioma.2020

    • Author(s)
      Hirano Y.、Miyawaki S.、Satou M.、Taoka K.、Toyama K.、Ikemura M.、Tanaka R.、Takayanagi S.、Tanaka S.、Nakatomi H.、Kurokawa M.、Saito N.
    • Journal Title

      World Neurosurg

      Volume: 138 Pages: 169-173

    • DOI

      10.1016/j.wneu.2020.02.171

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Vascular anomaly of the posterior circulation associated with intracranial lipoma-like lesion in the cerebral peduncle manifesting as oculomotor nerve palsy2020

    • Author(s)
      Hirano Yudai、Miyawaki Satoru、Yamada Keisuke、Shinya Yuki、Kin Taichi、Amemiya Shiori、Asakawa Yasumasa、Nakatomi Hirofumi、Saito Nobuhito
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 72 Pages: 463-466

    • DOI

      10.1016/j.jocn.2019.12.020

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive Investigation of RNF213 Nonsynonymous Variants Associated with Intracranial Artery Stenosis2020

    • Author(s)
      Hongo H, Miyawaki S, Imai H, Shimizu M, Yagi S, Mitsui J, Ishiura H, Yoshimura J, Doi K, Qu W, Teranishi Y, Okano A, Ono H, Nakatomi H, Shimizu T, Morishita S, Tsuji S, and Saito N
    • Journal Title

      Scientific reports

      Volume: 10(1) Issue: 1 Pages: 11942-11942

    • DOI

      10.1038/s41598-020-68888-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retro-odontoid Pseudotumor: Two Cases of Intradural Ganglion Cysts Arising From the Odontoid Process with Syringobulbia.2020

    • Author(s)
      Miyazawa R.、Miyawaki S.、Yamada K.、Amemiya S.、Ikemura M.、Hinata M.、Uchikawa H.、Shiode T.、Kin T.、Takai K.、Nakatomi H.、Saito N.
    • Journal Title

      World Neurosurg

      Volume: 144 Pages: 148-153

    • DOI

      10.1016/j.wneu.2020.08.120

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Giant Fusiform and Dolichoectatic Aneurysms of the Basilar Trunk and Vertebrobasilar Junction-Clinicopathological and Surgical Outcome.2020

    • Author(s)
      Nakatomi H.、Kiyofuji S.、Ono H.、Tanaka M.、Kamiyama H.、Takizawa K.、Imai H.、Saito N.、Shiokawa Y.、Morita A.、Flemming K. D.、Link M. J.
    • Journal Title

      Neurosurgery

      Volume: 88(1) Issue: 1 Pages: 82-95

    • DOI

      10.1093/neuros/nyaa317

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemorrhagic Onset Intracranial Artery Dissection of Middle Cerebral Artery Followed by Progressive Arterial Stenosis with Genetic Variant RNF213 p.Arg4810Lys (rs112735431)2020

    • Author(s)
      Shinya Y, Miyawaki S, Nakatomi H, Shin M, Teraoka A, Saito N
    • Journal Title

      World Neurosurgery

      Volume: 141 Pages: 192

    • DOI

      10.1016/j.wneu.2020.04.241

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted deep sequencing of DNA from multiple tissue types improves the diagnostic rate and reveals a highly diverse phenotype of mosaic neurofibromatosis type 2.2020

    • Author(s)
      Teranishi Y.、Miyawaki S.、Hongo H.、Dofuku S.、Okano A.、Takayanagi S.、Ota T.、Yoshimura J.、Qu W.、Mitsui J.、Nakatomi H.、Morishita S.、Tsuji S.、Saito N.
    • Journal Title

      J Med Genet

      Volume: なし Issue: 10 Pages: 701-711

    • DOI

      10.1136/jmedgenet-2020-106973

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De Novo Development of Moyamoya Disease after Stereotactic Radiosurgery for Brain Arteriovenous Malformation in a Patient With RNF213 p.Arg4810Lys (rs112735431)2020

    • Author(s)
      Torazawa S, Miyawaki S, Shinya Y, Kawashima M, Hasegawa H, Dofuku S, Uchikawa H, Kin T, Shin M, Nakatomi H, Saito N.
    • Journal Title

      World Neurosurgery

      Volume: 140 Pages: 276

    • DOI

      10.1016/j.wneu.2020.05.068

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Trends in Neurosurgical Research : From the 1950s and Onward2020

    • Author(s)
      花大洵、齊藤延人.
    • Journal Title

      Japanese Journal of Neurosurgery

      Volume: 29 Issue: 11 Pages: 784-792

    • DOI

      10.7887/jcns.29.784

    • NAID

      130007942354

    • ISSN
      0917-950X, 2187-3100
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Genetic Factor for Intracranial Artery Stenosis2020

    • Author(s)
      宮脇 哲, 齊藤 延人
    • Journal Title

      Japanese Journal of Neurosurgery

      Volume: 29 Issue: 10 Pages: 680-689

    • DOI

      10.7887/jcns.29.680

    • NAID

      130007930275

    • ISSN
      0917-950X, 2187-3100
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response to Letter to the Editor Regarding “Genetic Analysis of Ring Finger Protein 213 (RNF213) c.14576G>A in Intracranial Atherosclerosis of the Anterior and Posterior Circulations”2018

    • Author(s)
      Miyawaki Satoru、Shinya Yuki、Imai Hideaki、Hongo Hiroki、Ono Hideaki、Takenobu Atsumi、Nakatomi Hirofumi、Teraoka Akira、Saito Nobuhito
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 27 Issue: 10 Pages: 2894-2895

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.07.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Analysis of RNF213 c.14576G>A in Intracranial Atherosclerosis of the Anterior and Posterior Circulation.2017

    • Author(s)
      Shinya Y, Miyawaki S, Imai H, Hongo H, Ono H, Takenobu A, Nakatomi H, Teraoka A and Saito N.
    • Journal Title

      Stroke Cerebrovasc Dis

      Volume: 26(11) Issue: 11 Pages: 2638-2644

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.06.043

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Smaller Outer Diameter of Atherosclerotic Middle Cerebral Artery Associated with RNF213 c.14576G>A Variant (rs112735431).2017

    • Author(s)
      Hongo H, Miyawaki S, Imai H, Shinya Y, Hideaki O, Mori H, Nakatomi H, Kunimatsu A, Saito N.
    • Journal Title

      Surg Neurol Int

      Volume: 5;8 Issue: 1 Pages: 104-104

    • DOI

      10.4103/sni.sni_59_17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic analysis of intracranial major artery stenosis: Analysis of moyamoya disease associated gene <i>RNF213</i>2017

    • Author(s)
      宮脇哲、今井英明、斉藤延人
    • Journal Title

      Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)

      Volume: 28 Issue: 2 Pages: 341-345

    • DOI

      10.16977/cbfm.28.2_341

    • NAID

      130006008205

    • ISSN
      0915-9401, 2188-7519
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] くも膜下出血 病因と病態2017

    • Author(s)
      宮脇哲、斉藤延人。
    • Journal Title

      日本臨牀

      Volume: 75巻増刊5 動脈・静脈の疾患(下) Pages: 647-651

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 海綿状血管種の自然歴2017

    • Author(s)
      宮脇哲。
    • Journal Title

      クリニカルニューロサイエンス

      Volume: 35/10 Pages: 1191-1193

    • Related Report
      2017 Annual Research Report
  • [Presentation] もやもや病関連RNF213バリアントの網羅的解析2020

    • Author(s)
      本郷博貴、宮脇哲、今井英明、清水暢裕、寺西裕、堂福翔吾、小原健太、小野秀明、中冨浩文、斉藤延人
    • Organizer
      第45回日本脳卒中学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頭蓋内動脈狭窄におけるRNF213変異の解析2020

    • Author(s)
      本郷博貴、宮脇哲、今井英明、清水暢裕、寺西裕、堂福翔吾、小原健太、石神大一郎、小野秀明、中冨浩文、斉藤延人
    • Organizer
      第65回日本人類遺伝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characteristics of Mosaic Neurofibromatosis type 2 Revealed by Deep Sequence for Multiple Tissue DNA2020

    • Author(s)
      Yu Teranishi, Satoru Miyawaki, Hiroki Hongo, Shogo Dofuku, Atsushi Okano, Shunsaku Takayanagi, Takahiro Ota, Jun Yoshimura, Wei Qu, Jun Mitsui, Hirofumi Nakatomi, Shinichi Morishita, Shoji Tsuji, Nobuhito Saito
    • Organizer
      2020 Europiean NF Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 網羅的遺伝子解析によって明らかになった神経線維腫症2型(NF2)の多様な臨床的・遺伝的背景2020

    • Author(s)
      寺西裕、宮脇哲、小原健太、本郷博貴、堂福翔吾、高柳俊作、中冨浩文、齊藤延人
    • Organizer
      第26回日本遺伝性腫瘍学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経線維腫症2型(NF2)の遺伝子解析によって明らかになった多様な臨床的・遺伝的背景2020

    • Author(s)
      寺西裕、宮脇哲、石神大一郎、小原健太、本郷博貴、堂福翔吾、高柳俊作、中冨浩文、齊藤延人
    • Organizer
      第79回日本脳神経外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 複数組織DNAに対するtarget deep sequenceによって明らかになった神経線維腫症2型(NF2)の多様な臨床的・遺伝的背景2020

    • Author(s)
      寺西裕、宮脇哲、石神大一郎、小原健太、本郷博貴、堂福翔吾、高柳俊作、中冨浩文、齊藤延人
    • Organizer
      第29回日本聴神経腫瘍研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経線維腫症2型(NF2)の遺伝子解析によって明らかになった多様な臨床的・遺伝的背景2020

    • Author(s)
      寺西裕、宮脇哲、石神大一郎、小原健太、本郷博貴、堂福翔吾、高柳俊作、中冨浩文、齊藤延人
    • Organizer
      第25回日本脳腫瘍の外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頭蓋内動脈硬化におけるRNF213変異の網羅的検討2018

    • Author(s)
      本郷 博貴, 宮脇 哲, 今井 英明, 清水 暢裕, 八木 伸一, 新谷 祐貴, 小野 秀明, 中冨 浩文, 清水 庸夫, 斉藤 延人.
    • Organizer
      第19回日本分子脳神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] もやもや病・頭蓋内動脈狭窄に関連するRNF213変異の網羅的検索2018

    • Author(s)
      本郷 博貴, 宮脇 哲, 今井 英明, 清水 暢裕, 八木 伸一, 新谷 祐貴, 小野 秀明, 中冨 浩文, 清水 庸夫, 斉藤 延人.
    • Organizer
      日本脳神経外科学会第77回学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] もやもや病・頭蓋内動脈狭窄におけるRNF213変異の関連解析―RNF213全エクソンの解析を用いた網羅的検証―2018

    • Author(s)
      本郷 博貴, 宮脇 哲, 今井 英明, 清水 暢裕, 八木 伸一, 新谷 祐貴, 小野 秀明, 中冨 浩文, 清水 庸夫, 斉藤 延人.
    • Organizer
      第61回日本脳循環代謝学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Genetic investigation of five Japanese CCM cases by whole-exome sequencing.2018

    • Author(s)
      Hiroki Hongo, Satoru Miyawaki, Yu Teranishi, Atsushi Okano, Shogo Dofuku, Hirofumi Nakatomi, Nobuhito Saito.
    • Organizer
      14th CCM Scientific Meeting.
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳海綿状血管奇形の遺伝的要因 -多発例5例の全エクソン解析による検討2018

    • Author(s)
      本郷 博貴, 宮脇 哲, 寺西 裕, 岡野 淳, 堂福 翔吾, 中冨 浩文, 斉藤 延人.
    • Organizer
      第44回日本脳卒中学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 症候性頭蓋内主幹動脈狭窄における遺伝子変異の解析2018

    • Author(s)
      堂福翔吾、宮脇哲、今井英明、清水暢裕、本郷博貴、岡野淳、寺西裕、小野秀明、中冨浩文、清水庸夫、斉藤延人
    • Organizer
      第19回日本分子脳神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 頭蓋内主幹動脈狭窄における症候化に関わる遺伝子変異の解析2018

    • Author(s)
      堂福翔吾、宮脇哲、今井英明、清水暢裕、本郷博貴、岡野淳、寺西裕、小野秀明、中冨浩文、清水庸夫、斉藤延人
    • Organizer
      第76回日本脳神経外科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clinical-genotype correlation analysis enables prediction of functional prognosis in Japanese NF2 patients2018

    • Author(s)
      寺西裕,宮脇哲,本郷博貴,堂福翔吾,岡野淳,高柳俊作,中冨浩文,斉藤延人
    • Organizer
      日本人類遺伝学会 第63回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prediction of functional prognosis in Japanese NF2 patients by phenotype-genotype correlation2018

    • Author(s)
      寺西裕,宮脇哲,本郷博貴,堂福翔吾,岡野淳,高柳俊作,中冨浩文,斉藤延人
    • Organizer
      NF Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経線維腫症2型の遺伝的背景解明に向けた取り組み (変異遺伝子解析および臨床関連解析)2018

    • Author(s)
      寺西裕,宮脇哲,本郷博貴,堂福翔吾,岡野淳,高柳俊作,中冨浩文,斉藤延人
    • Organizer
      第24回家族性腫瘍学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経線維腫症2型(NF2)関連聴神経腫瘍に伴う2018

    • Author(s)
      寺西裕,宮脇哲,本郷博貴,堂福翔吾,岡野淳,高柳俊作,中冨浩文,斉藤延人
    • Organizer
      日本脳神経外科学会第77回学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Phenotype-genotype correlationをベースにした神経線維腫症2型患者の機能予後予測2018

    • Author(s)
      寺西裕,宮脇哲,本郷博貴,堂福翔吾,岡野淳,高柳俊作,中冨浩文,斉藤延人
    • Organizer
      第19回日本分子脳神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 遺伝子解析結果をベースにした神経線維腫症2型患者(NF2)の機能予後予測2018

    • Author(s)
      寺西裕,宮脇哲,本郷博貴,堂福翔吾,岡野淳,高柳俊作,中冨浩文,斉藤延人
    • Organizer
      第23回日本脳腫瘍の外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Onset symptoms and germline mutation variation in neurofibromatosis type22017

    • Author(s)
      寺西裕,宮脇哲,岡野淳,高柳俊作,武笠晃丈,中冨浩文,斉藤延人
    • Organizer
      NF Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経線維腫症2型の遺伝的背景解明に向けた変異遺伝子解析および臨床解析2017

    • Author(s)
      寺西裕,宮脇哲,岡野淳,高柳俊作,武笠晃丈,中冨浩文,斉藤延人
    • Organizer
      日本人類遺伝学会 第62回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経線維腫症2型の遺伝的背景解明に向けた取り組み (変異遺伝子解析および臨床関連解析)2017

    • Author(s)
      寺西裕,宮脇哲,岡野淳,高柳俊作,武笠晃丈,中冨浩文,斉藤延人
    • Organizer
      日本脳神経外科学会 第76回学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭蓋底髄膜腫の発生部位、病理診断、driver genetic mutationに基づいたプロファイリング2017

    • Author(s)
      岡野淳、宮脇哲、寺西裕、武笠晃丈、辛正廣、中冨浩文、斉藤延人
    • Organizer
      第35回日本脳腫瘍学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭蓋内主幹動脈硬化の遺伝的要因―RNF213遺伝子の網羅的解析―2017

    • Author(s)
      本郷博貴、宮脇哲、今井英明、清水暢裕、八木伸一、新谷祐貴、小野秀明、中冨浩文、清水庸夫、斉藤延人
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Association between outer diameter of intracranial atherosclerosis and RNF213 c.14576G>A variant2017

    • Author(s)
      Hiroki Hongo, Satoru Miyawaki, Hideaki Imai, Yuki Shinya, Hideaki Ono, Harushi Mori, Hirofumi Nakatomi, Akira Kunimatsu, Nobuhito Saito
    • Organizer
      第32回日本脳神経外科国際学会フォーラム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between outer diameter of atherosclerotic middle cerebral artery and RNF213 c.14576G>A variant (rs112735431)2017

    • Author(s)
      Hiroki Hongo, Satoru Miyawaki, Hideaki Imai, Yuki Shinya, Hideaki Ono, Harushi Mori, Hirofumi Nakatomi, Akira Kunimatsu, Nobuhito Saito
    • Organizer
      The 8th Korea-Japan Joint Stroke Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 新臨床内科学第10版2020

    • Author(s)
      斉藤延人
    • Total Pages
      2002
    • Publisher
      医学書院
    • ISBN
      9784260038065
    • Related Report
      2019 Annual Research Report
  • [Book] 今日の治療指針20202020

    • Author(s)
      齊藤延人
    • Total Pages
      2192
    • Publisher
      医学書院
    • ISBN
      9784260039390
    • Related Report
      2019 Annual Research Report
  • [Book] 専門家による私の治療 脳動脈瘤2020

    • Author(s)
      齊藤延人
    • Total Pages
      1568
    • Publisher
      日本医事新報
    • ISBN
      9784784946518
    • Related Report
      2019 Annual Research Report
  • [Book] 完全版 脳血管内治療学2018

    • Author(s)
      宮脇哲、斉藤延人
    • Total Pages
      512
    • Publisher
      メディカ出版
    • ISBN
      9784840464895
    • Related Report
      2018 Annual Research Report
  • [Book] 最新精神・神経遺伝学研究と遺伝カウンセリング2017

    • Author(s)
      宮脇哲、斉藤延人。(戸田達史編集)
    • Total Pages
      308
    • Publisher
      メディカルドゥ
    • ISBN
      9784944157655
    • Related Report
      2017 Annual Research Report
  • [Book] 日本医師会雑誌 146巻・特別号(1) 脳血管障害のエッセンス2017

    • Author(s)
      宮脇哲、斉藤延人。(鈴木則宏、峰松一夫、寳金清博、水間正澄編集)
    • Total Pages
      347
    • Publisher
      日本医師会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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