Elucidation of the molecular basis of spermatogenesis for the development of tests and treatment
| Project/Area Number |
17H04331
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SATO Youichi 徳島大学, 大学院医歯薬学研究部(薬学域), 准教授 (10363160)
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| Co-Investigator(Kenkyū-buntansha) |
岩本 晃明 国際医療福祉大学, 臨床医学研究センター, 教授 (60046117)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 男性不妊症 / アンドロロジー / ゲノム / 遺伝子改変動物 / 男性不妊 / 次世代シーケンス / 遺伝子改変マウス |
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| Outline of Final Research Achievements |
From the next-generation sequence analysis of non-obstructive azoospermia patients, we found that the causes of male infertility differ from individual to individual, and it is necessary to develop a treatment method according to each cause. Moreover, it was suggested that genomic information could be used to construct the model formula for sperm recovery prediction by microdissection testicular sperm extraction. Furthermore, ERBB4 was identified as a locus associated with sperm motility, and LRRIQ1 was identified as a locus associated with Inhibin B levels.
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| Academic Significance and Societal Importance of the Research Achievements |
不妊症と診断されても根本的な治療法は確立されておらず、患者は身体的、精神的、経済的に大きな負担を抱えている。本研究成果により、顕微鏡下精巣内精子採取術による精子回収を予測することができれば、精子回収の見込みの無い手術の回避につながり、患者の身体的、経済的な負担が軽減され、挙児希望の不妊カップルの期待に応えられる可能性が出てくる。また、同定した遺伝子をターゲットとした治療薬の開発へとつながることが期待される。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels2020
Author(s)
Youichi Sato, Atsushi Tajima, Misaki Kiguchi, Suzu Kogusuri, Aki Fujii, Takehiro Sato, Shiari Nozawa, Miki Yoshiik, Makiko Naka-Mieno, Kosuke Kojo, Masahiro Uchida, Haruki Tsuchiya, Kazumitu Yamasaki, Issei Imoto, Teruaki Iwamoto
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Association of TUSC1 and DPF3 gene polymorphisms with male infertility2018
Author(s)
Sato Youichi、Hasegawa Chise、Tajima Atsushi、Nozawa Shiari、Yoshiike Miki、Koh Eitetsue、Kanaya Jiro、Namiki Mikio、Matsumiya Kiyomi、Tsujimura Akira、Komatsu Kiyoshi、Itoh Naoki、Eguchi Jiro、Yamauchi Aiko、Iwamoto Teruaki
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Journal Title
Journal of Assisted Reproduction and Genetics
Volume: 35
Issue: 2
Pages: 257-263
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies.2017
Author(s)
Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.
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Journal Title
Hum Reprod Open
Volume: 2017
Issue: 1
Pages: 1-8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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