Development of multicontrast three-dimensional ocular imaging system using novel bioimaging techniques
| Project/Area Number |
17H04350
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安野 嘉晃 筑波大学, 医学医療系, 教授 (10344871)
岡本 史樹 筑波大学, 医学医療系, 講師 (30334064)
平岡 孝浩 筑波大学, 医学医療系, 准教授 (30359575)
加治 優一 筑波大学, 医学医療系, 准教授 (50361332)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 光干渉断層計 / OCT / 偏光感受型 / 複屈折 / phase retardation / 円錐角膜 / 濾過胞 / 線維化 / 偏光 / 緑内障 / 緑内障手術 / Jones matrix / イメージング |
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| Outline of Final Research Achievements |
We developed a novel multicontrast three-dimensional ocular imaging system using original bioimaging techniques. By analyzing the phase retardation of incident light signals into the eye, the device can conduct in vivo evaluation of collagen fiber degeneration and changes in tissue strength of the eye. The test model was engineered and registered as a designated management medical equipment (class II). New findings were obtained in human eyes with early keratoconus and after glaucoma filtering surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
眼の形状を検査する方法はこれまでに様々なものが開発されてきたが，眼の組織の質的変化や強度といった情報を，in vivoにおいて非侵襲で評価する方法はこれまでに無かった．多くの眼疾患は，組織のコラーゲンが変性して生じたり，強度が変化することが発症の引き金になる．眼に対する手術後の評価でもこういった情報は重要である．我々は新しい光干渉断層計を開発し，世界に先駆けてヒト眼の前眼部疾患に応用することにより，種々の知見を得ている．
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids.2020
Author(s)
El-Sadek I, Miyazawa A, Tzu-Wei Shen L, Makita S, Fukuda S, Yamashita T, Oka Y, Mukherjee P, Matsusaka A, Oshika T, Kano H, Yoshiaki Y.
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Journal Title
Biomedical optics
Volume: 11
Pages: 6231-6231
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] SHG-specificity of cellular Rootletin filaments enables naive imaging with universal conservation2017
Author(s)
Toshihiro Akiyama, Akihito Inoko, Yuichi Kaji, Shigenobu Yonemura, Kisa Kakiguchi, Hiroki Segawa, Kei Ishitsuka, Masaki Yoshida, Osamu Numata, Philippe Leproux, Vincent Couderc, Tetsuro Oshika, Hideaki Kano
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Journal Title
Sci Rep
Volume: 7
Pages: 39967-39967
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Birefringence dynamics imaging for ex-vivo tissue activity quantification using polarization-sensitive optical coherence tomography2019
Author(s)
Mukherjee P, Abd El-Sadek IG, Miyazawa A, Shen LTW, Fukuda S, Yamashita T, Oka Y, Matsusaka S, Oshika T, Kano H, Yasuno Y
Organizer
Optics & Photonics Japan 2019
Related Report
Invited
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[Presentation] Short and long time-course ex vivo tissues activity quantification by multifunctional OCT2019
Author(s)
Abd El-Sadek IG, Miyazawa A, Shen LTW, Fukuda S, Yamashita T, Oka Y, Mukherjee P, Makita S, Matsusaka S, Oshika T, Kano H, Yasuno Y
Organizer
Optics & Photonics Japan 2019
Related Report
Invited
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