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Clarification of the homeostatic mechanism and activation of dental pulp progenitor/quiescent stem cells using proteomic approach

Research Project

Project/Area Number 17H04366
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

Ohshima Hayato  新潟大学, 医歯学系, 教授 (70251824)

Co-Investigator(Kenkyū-buntansha) 下村 淳子  日本歯科大学, 新潟生命歯学部, 准教授 (00386286)
山本 格  新潟大学, 医歯学総合研究科, 特任教授 (30092737)
依田 浩子  新潟大学, 医歯学系, 准教授 (60293213)
大津 圭史  岩手医科大学, 歯学部, 准教授 (60509066)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords歯学 / プロテオーム / 発生・分化 / 細胞・組織 / 歯髄幹細胞 / 歯髄 / 長期ラベル細胞 / 静的幹細胞 / TetOP-H2B-GFPマウス / 前駆細胞 / 幹細胞ニッチ
Outline of Final Research Achievements

Analysis using TetOP-H2B-GFP mice demonstrated that quiescent stem/progenitor cells resided in the subodontoblastic layer in addition to the perivascular niche in the center of pulp tissue and that the domain of insulin-like growth factor binding protein 5 (IGFBP5) expression was overlapped with this niche. During 3-7 days after autograft, IGFBP5-positve cells were maintained in the dental pulp and lacked a TUNEL-positive reaction, suggesting that IGFBP5 plays a pivotal role in regulating the survival and apoptosis of dental pulp stem cells during both tooth development and pulpal healing following tooth injury. Proteome analysis showed that 156 odontoblast, 183 subodontoblastic, and 76 central pulp tissue layers -specific proteins were identified in molars and that these layers shared 76-988 proteins. The apical bud epithelium and subjacent mesenchyme possessed 258 and 318 tissue-specific proteins, respectively, and shared 1350 proteins in continuously growing incisors.

Academic Significance and Societal Importance of the Research Achievements

通常の状態では、歯髄ではめったに自己複製が起こらないので、歯髄には静的幹細胞が存在し、外的侵襲後に幹細胞が活性化状態になると考えられる。本研究により、歯髄幹細胞ニッチの維持におけるIGFBP5の役割、象牙芽細胞下層細胞におけるNestinタンパクの役割、幹細胞の増殖制御における微小環境の酸素の役割などを解明した。歯の発生過程および外的侵襲後の歯髄治癒過程における幹細胞を含む細胞群・シグナル分子・細胞外マトリックス相互作用の解明が歯の再生研究の進展の鍵を握っており、生体における細胞間相互作用を考える上で、遺伝子発現だけでなく、時空間的なタンパク質の変化を捉えることが、生物現象解明には必要である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (52 results)

All 2020 2019 2018 2017 Other

All Journal Article (32 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 32 results,  Open Access: 18 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Int'l Joint Research: 4 results,  Invited: 7 results) Remarks (2 results)

  • [Journal Article] Functional Expression of Sodium-Dependent Glucose Transporter in Amelogenesis.2020

    • Author(s)
      Ida-Yonemochi H, Otsu K, Harada H, Ohshima H.
    • Journal Title

      Journal of Dental Research

      Volume: - Issue: 8 Pages: 1-10

    • DOI

      10.1177/0022034520916130

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adjunct use of mouth rinses with a sonic toothbrush accelerates the detachment of a Streptococcus mutans biofilm: an in vitro study2020

    • Author(s)
      Ohsumi Tatsuya、Takenaka Shoji、Sakaue Yuuki、Suzuki Yuki、Nagata Ryoko、Hasegawa Taisuke、Ohshima Hayato、Terao Yutaka、Noiri Yuichiro
    • Journal Title

      BMC Oral Health

      Volume: 20 Issue: 1 Pages: 161-161

    • DOI

      10.1186/s12903-020-01144-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Msx1 deficiency interacts with hypoxia and induces a morphogenetic regulation during lip development2020

    • Author(s)
      Nakatomi Mitsushiro、Ludwig Kerstin U.、Knapp Michael、Kist Ralf、Lisgo Steven、Ohshima Hayato、Mangold Elisabeth、Peters Heiko
    • Journal Title

      Development

      Volume: in press

    • DOI

      10.1242/dev.189175

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Oral biosciences: The annual review 20192020

    • Author(s)
      Ohshima Hayato、Amizuka Norio
    • Journal Title

      Journal of Oral Biosciences

      Volume: 62 Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.job.2020.02.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucose Transporter 2 and 4 Are Involved in Glucose Supply during Pulpal Wound Healing after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars2020

    • Author(s)
      Tohma Aiko、Ohkura Naoto、Yoshiba Kunihiko、Takeuchi Ryosuke、Yoshiba Nagako、Edanami Naoki、Shirakashi Mari、Ibn Belal Razi Saifullah、Ohshima Hayato、Noiri Yuichiro
    • Journal Title

      Journal of Endodontics

      Volume: 46 Issue: 1 Pages: 81-88

    • DOI

      10.1016/j.joen.2019.10.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dentin Matrix Protein 1 Compensates for Lack of Osteopontin in Regulating Odontoblastlike Cell Differentiation after Tooth Injury in Mice2020

    • Author(s)
      Saito Kotaro、Nakatomi Mitsushiro、Ohshima Hayato
    • Journal Title

      Journal of Endodontics

      Volume: 46 Issue: 1 Pages: 89-96

    • DOI

      10.1016/j.joen.2019.10.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemistry and gene expression of GLUT1, RUNX2 and MTOR in reparative dentinogenesis2020

    • Author(s)
      Takeuchi Ryosuke、Ohkura Naoto、Yoshiba Kunihiko、Tohma Aiko、Yoshiba Nagako、Edanami Naoki、Shirakashi Mari、Belal Razi Saifullah Ibn、Ohshima Hayato、Noiri Yuichiro
    • Journal Title

      Oral Diseases

      Volume: 26 Issue: 2 Pages: 341-349

    • DOI

      10.1111/odi.13230

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs2019

    • Author(s)
      KHADIZA Naznin、HASEGAWA Tomoka、NAGAI Tomoya、YAMAMOTO Tomomaya、MIYAMOTO- TAKASAKI Yukina、HONGO Hiromi、ABE Miki、HARAGUCHI Mai、YAMAMOTO Tsuneyuki、YIMIN、QIU Zixuan、SASAKI Muneteru、KUROSHIMA Shinichiro、OHSHIMA Hayato、FREITAS Paulo Henrique Luiz de、LI Minqi、YAWAKA Yasutaka、AMIZUKA Norio
    • Journal Title

      Biomedical Research

      Volume: 40 Issue: 4 Pages: 133-143

    • DOI

      10.2220/biomedres.40.133

    • NAID

      130007689882

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2019-08-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reduced enamel epithelium-derived cell niche in the junctional epithelium are maintained for a long time in mice2019

    • Author(s)
      Soda M, Saito K, Ida-Yonemochi H, Nakakura-Ohshima K, Kenmotsu S, Ohshima H
    • Journal Title

      J Periodontol

      Volume: Sep 9 Issue: 6 Pages: 819-827

    • DOI

      10.1002/jper.19-0269

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental arthritis and Porphyromonas gingivalis administration synergistically decrease bone regeneration in femoral cortical defects2019

    • Author(s)
      Okumura Go、Kondo Naoki、Sato Keisuke、Yamazaki Kazuhisa、Ohshima Hayato、Kawashima Hiroyuki、Ogose Akira、Endo Naoto
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 20031-20031

    • DOI

      10.1038/s41598-019-56265-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The putative role of insulin-like growth factor (IGF)-binding protein 5 independent of IGF in the maintenance of pulpal homeostasis in mice.2019

    • Author(s)
      Saito K, Ohshima H
    • Journal Title

      Regen Ther

      Volume: 11 Pages: 217-224

    • DOI

      10.1016/j.reth.2019.08.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice2019

    • Author(s)
      Aizawa Chisato、Saito Kotaro、Ohshima Hayato
    • Journal Title

      Journal of Oral Biosciences

      Volume: 61 Issue: 3 Pages: 157-162

    • DOI

      10.1016/j.job.2019.07.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Horizontal Sequential Cutting Method to Estimate the Effectiveness of Dentin Disinfection by Using Confocal Laser Scanning Microscopy2019

    • Author(s)
      Hasegawa Taisuke、Takenaka Shoji、Wakamatsu Rika、Ohsumi Tatsuya、Domon Hisanori、Ohshima Hayato、Terao Yutaka、Noiri Yuichiro
    • Journal Title

      Journal of Endodontics

      Volume: 45 Issue: 9 Pages: 1142-1147

    • DOI

      10.1016/j.joen.2019.06.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a novel glass ionomer cement containing fluoro-zinc-silicate fillers on biofilm formation and dentin ion incorporation2019

    • Author(s)
      Hasegawa Taisuke、Takenaka Shoji、Ohsumi Tatsuya、Ida Takako、Ohshima Hayato、Terao Yutaka、Naksagoon Traithawit、Maeda Takeyasu、Noiri Yuichiro
    • Journal Title

      Clinical Oral Investigations

      Volume: 24 Issue: 2 Pages: 963-970

    • DOI

      10.1007/s00784-019-02991-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral biosciences: The annual review 20182019

    • Author(s)
      Amizuka N, Ohshima H
    • Journal Title

      J Oral Biosci

      Volume: 61 Issue: 1 Pages: 1-4

    • DOI

      10.1016/j.job.2019.01.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular enzymatically synthesized glycogen promotes osteogenesis by activating osteoblast differentiation via Akt/GSK-3beta signaling pathway2019

    • Author(s)
      Ida-Yonemochi H, Nakagawa E, Takata H, Furuyashiki T, Kakutani R, Tanaka M, Ohshima H
    • Journal Title

      J Cell Physiol

      Volume: 234 Issue: 8 Pages: 13602-13616

    • DOI

      10.1002/jcp.28039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability2019

    • Author(s)
      Soda Miki、Saitoh Issei、Murakami Tomoya、Inada Emi、Iwase Yoko、Noguchi Hirofumi、Shibasaki Shinji、Kurosawa Mie、Sawami Tadashi、Terunuma Miho、Kubota Naoko、Terao Yutaka、Ohshima Hayato、Hayasaki Haruaki、Sato Masahiro
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1490-1490

    • DOI

      10.1038/s41598-018-37291-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth2019

    • Author(s)
      Seino Y, Nakatomi M, Ida-Yonemochi H, Koga D, Ushiki T, Ohshima H
    • Journal Title

      J. Oral Biosci.

      Volume: 61 Issue: 1 Pages: 55-63

    • DOI

      10.1016/j.job.2019.01.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Orthodontic forc application upregulated pain-associated prostaglanidn=2/PGI2-receptor/TRPV1 pathway-related gene expression in rat molars2018

    • Author(s)
      Mariko Ohkura, Naoto Ohkura, Nagako Yoshiba, Kunihiko Yoshiba, Hiroko Ida-Yonemochi, Hayato Ohshima, Isao Saito, Takashi Okiji
    • Journal Title

      Odontology

      Volume: 160(1) Issue: 1 Pages: 2-10

    • DOI

      10.1007/s10266-017-0309-2

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Donor-host tissue interaction in the allogenic transplanted tooth germ with special reference to periodontal tissue2018

    • Author(s)
      Nakaki T, Nakakura-Ohshima K, Nakagawa E, Ishikawa Y, Saito K, Ida-Yonemochi H, Ohshima H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 60 Issue: 1 Pages: 21-30

    • DOI

      10.1016/j.job.2018.02.002

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nestin expression is differently regulated between odontoblasts and the subodontoblastic layer in mice2018

    • Author(s)
      Nakatomi M, Quispe-Salcedo A, Sakaguchi M, Ida-Yonemochi H, Okano H, Ohshima H
    • Journal Title

      Histochem Cell Biol

      Volume: 149 Issue: 4 Pages: 383-391

    • DOI

      10.1007/s00418-018-1651-3

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Msx2 prevents stratified squamous epithelium formation in the enamel organ2018

    • Author(s)
      Nakatomi M, Ida-Yonemochi H, Nakatomi C, Saito K, Kenmotsu S, Maas RL, Ohshima H
    • Journal Title

      J Dent Res

      Volume: 97 Issue: 12 Pages: 1355-1364

    • DOI

      10.1177/0022034518777746

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-12018

    • Author(s)
      Ida-Yonemochi Hiroko、Morita Wataru、Sugiura Nobuo、Kawakami Ryosuke、Morioka Yuki、Takeuchi Yuka、Sato Toshiya、Shibata Shunichi、Watanabe Hideto、Imamura Takeshi、Igarashi Michihiro、Ohshima Hayato、Takeuchi Kosei
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17134-17134

    • DOI

      10.1038/s41598-018-35412-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral biosciences: The annual review 20172018

    • Author(s)
      Ohshima Hayato
    • Journal Title

      Journal of Oral Biosciences

      Volume: 60 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.job.2017.12.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation capacity and maintenance of dental pulp stem/progenitor cells in the process of pulpal healing following tooth injuries.2017

    • Author(s)
      Saito K, Ohshima H
    • Journal Title

      J Oral Biosci

      Volume: 59(2) Issue: 2 Pages: 63-70

    • DOI

      10.1016/j.job.2017.03.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a new mouse model for studying dental pulpal responses to GaAlAs laser irradiation2017

    • Author(s)
      Sugawara S, Shigetani Y, Kenmotsu S, kiji T, Ohshima H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 59 Issue: 1 Pages: 38-43

    • DOI

      10.1016/j.job.2016.10.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Osteopontin-deficiency disturbs direct osteogenesis in the process of achieving osseointegration following immediate placement of endosseous implants2017

    • Author(s)
      S Makishi, K Saito, H Ohshima
    • Journal Title

      Clinical Implant Dentistry and Related Research

      Volume: 印刷中 Issue: 3 Pages: 496-504

    • DOI

      10.1111/cid.12467

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers.2017

    • Author(s)
      Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H
    • Journal Title

      Archives of Oral Biology

      Volume: 81 Pages: 110-120

    • DOI

      10.1016/j.archoralbio.2017.04.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities2017

    • Author(s)
      Iwamoto Tsutomu、Nakamura Takashi、Ishikawa Masaki、Yoshizaki Keigo、Sugimoto Asuna、Ida-Yonemochi Hiroko、Ohshima Hayato、Saito Masahiro、Yamada Yoshihiko、Fukumoto Satoshi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: 0177557-0177557

    • DOI

      10.1371/journal.pone.0177557

    • NAID

      120006534958

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quiescent adult stem cells in murine teeth are regulated by Shh signaling2017

    • Author(s)
      Ishikawa Y, Nakatomi M, Ida-Yonemochi H, Ohshima H
    • Journal Title

      Cell Tissue Res.

      Volume: 369 Issue: 3 Pages: 497-512

    • DOI

      10.1007/s00441-017-2632-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The positional and ultrastructural changes in peripheral pulp capillaries correlate with the active phase of dentin deposit and mineralization in rat molars2017

    • Author(s)
      Yuta Seino, Yoshiro Takano, Hayato Ohshima
    • Journal Title

      Journal of Oral Biosciences

      Volume: 59(3) Issue: 3 Pages: 163-171

    • DOI

      10.1016/j.job.2017.05.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars2017

    • Author(s)
      Ohkura Naoto、Edanami Naoki、Takeuchi Ryosuke、Tohma Aiko、Ohkura Mariko、Yoshiba Nagako、Yoshiba Kunihiko、Ida-Yonemochi Hiroko、Ohshima Hayato、Okiji Takashi、Noiri Yuichiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-017-07167-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 歯,歯周組織の発生から学ぶ2020

    • Author(s)
      大島勇人,川瀬知之
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mutual interaction between dentin matrix protein 1 and osteopontin in the mechanism of odontoblast-like cell differentiation following tooth injury2019

    • Author(s)
      Ohshima H, Saito K
    • Organizer
      The 7th Tripartite Conference on Tooth and Bone in Development & Regeneration (TCTBDR 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オーバービュー:象牙芽細胞と骨芽細胞の分化の違いを考える2019

    • Author(s)
      大島勇人
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The function of IGFBP3 and IGFBP5 during tooth development and pulpal healing after tooth injury2019

    • Author(s)
      Ohshima H, Aizawa C, Saito K
    • Organizer
      13th Tooth Morphogenesis & Differentiation (TMD) Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯胚上皮及び歯髄幹細胞・象牙芽細胞維持に関わる Shh-Ptch-Gli シグナル経路2019

    • Author(s)
      石川裕子,依田浩子,斎藤浩太郎,中富満城,大島勇人
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 歯髄恒常性維持に関わるinsulin-like growth factor (IGF) binding protein 5のIGF非依存的役割2019

    • Author(s)
      大島勇人,斎藤浩太郎
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of subodontoblastic layer for pulpal healing after tooth injuries2018

    • Author(s)
      Ohshima H, Saito K, Nakatomi M, Ida-Yonemochi H
    • Organizer
      6th Tripartite Conference on Tooth and Bone in Development & Regeneration
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pulpal healing mechanism after exogenous tooth injuries and prospects for regenerative medicine in dentistry2018

    • Author(s)
      Ohshima H
    • Organizer
      5th TERMIS World
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウス切歯・臼歯の静的幹細胞維持に関わるShh シグナルの役割2018

    • Author(s)
      石川裕子,依田浩子,斎藤浩太郎,中富満城,大島勇人
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 外的侵襲後の歯髄修復メカニズムと再生医学への展開2017

    • Author(s)
      大島勇人
    • Organizer
      第17回日本外傷歯学会総会・学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 歯の外的侵襲後の歯髄修復機構と歯髄幹細胞の特性2017

    • Author(s)
      大島勇人
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 組織連続切片三次元構築法とBrdUラベリングによるモルモット臼歯apical budの観察2017

    • Author(s)
      清野雄多,中富満城,依田浩子,大島勇人
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯の発生・創傷治癒過程における歯髄恒常性維持に関わるIGF binding protein 5の役割2017

    • Author(s)
      斎藤浩太郎,大島勇人
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 他家歯胚移植におけるドナー・ホスト相互作用:歯周組織に着目して2017

    • Author(s)
      中木哲朗,大島邦子,石川裕子,斎藤浩太郎,依田浩子,大島勇人
    • Organizer
      平成29年度新潟歯学会第2回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸素濃度依存的Sox2-RhoAシグナルによるエナメル上皮幹細胞制御機構2017

    • Author(s)
      大津圭史,依田浩子,藤原尚樹,大島勇人,原田英光
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sox2免疫組織化学と組織連続切片三次元構築法によるモルモット臼歯apical budの観察2017

    • Author(s)
      清野雄多,依田浩子,中富満城,大島勇人
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 組織内酸素濃度応答性RhoA-Sox2シグナルによるエナメル上皮幹細胞制御2017

    • Author(s)
      大津圭史,依田浩子,藤原尚樹,大島勇人,原田英光
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス歯髄発生・再生過程におけるグリコーゲン代謝機構2017

    • Author(s)
      依田浩子,滝澤 舞,大島勇人
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科顎顔面再建学講座硬組織形態学分野

    • URL

      https://www5.dent.niigata-u.ac.jp/~hard-tissue/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 2017年 硬組織形態学分野 業績集

    • URL

      http://www.dent.niigata-u.ac.jp/anatomy1/bibliography/2017.htm

    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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