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Analysis of interaction between streptococci and host during bacterial dissemination

Research Project

Project/Area Number 17H04369
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

Masanobu Nakata  大阪大学, 歯学研究科, 准教授 (90444497)

Co-Investigator(Kenkyū-buntansha) 川端 重忠  大阪大学, 歯学研究科, 教授 (50273694)
岡橋 暢夫  大阪大学, 歯学研究科, 准教授 (40150180)
住友 倫子  大阪大学, 歯学研究科, 講師 (50423421)
山口 雅也  大阪大学, 歯学研究科, 助教 (00714536)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsレンサ球菌
Outline of Final Research Achievements

Streptococcus sanguinis, a member of commensal oral streptococci, and Streptococcus pneumoniae, responsible for pneumonia and meningitis, belong to the mitis group of streptococci. Members of this streptococcal group are frequently isolated from lesions associated with systemic disease. In this study, results of pilus component analysis led to detection of a new pilus subunit involved in biofilm formation. Furthermore, data obtained by analysis of S. pneumoniae suggested that a change in culture temperature has impact on the profile of proteins secreted from the bacterium, as well as the ability of the organism to adhere to lung epithelial cells. Examinations of a mouse infection model also revealed that culture temperature alteration had effects on bacterial survival rate in mouse blood.

Academic Significance and Societal Importance of the Research Achievements

これまで申請者らが世界で初めて発見した口腔内レンサ球菌Streptococcus sanguinisの線毛について,新たな構成タンパク質を発見し,特定の条件においてバイオフィルム形成を促進することを明らかにした.これらの結果は類似する線毛の解析と生物学的特性の更なる理解に貢献すると考えられる.一方,肺炎球菌は主に高齢者に肺炎や髄膜炎などの侵襲性疾患を起こすため,超高齢社会を迎えた我が国において社会的問題となっている.本研究で明らかにした環境温度の変化により発現量が調節される細菌因子群は肺炎球菌感染症に対する治療標的となる可能性がある.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (84 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (20 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 20 results,  Open Access: 19 results,  Acknowledgement Compliant: 1 results) Presentation (57 results) (of which Int'l Joint Research: 6 results,  Invited: 6 results) Book (2 results) Remarks (3 results)

  • [Int'l Joint Research] ロストック大学医学部病院(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Rostock(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency.2020

    • Author(s)
      Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S.
    • Journal Title

      Mol Microbiol

      Volume: 113 Issue: 1 Pages: 173-189

    • DOI

      10.1111/mmi.14408

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcal H2O2 Inhibits IgE-triggered Degranulation of RBL-2H3 Mast Cell/Basophil Cell Line by Inducing Cell Death2020

    • Author(s)
      Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, KawabataS.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 4 Pages: e0231101-e0231101

    • DOI

      10.1371/journal.pone.0231101

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pneumoniae surface adhesin PfbA exhibits host specificity by binding to human serum albumin but not bovine,rabbit and porcine serum albumins.2020

    • Author(s)
      Sankar S,Yamaguchi M,Kawabata S,Ponnuraj K.
    • Journal Title

      Protein J.

      Volume: 39 Issue: 1 Pages: 1-9

    • DOI

      10.1007/s10930-019-09875-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antibacterial activity of hinokitiol against both antibiotic‐resistant and ‐susceptible pathogenic bacteria that predominate in the oral cavity and upper airways2019

    • Author(s)
      Domon Hisanori、Hiyoshi Takumi、Maekawa Tomoki、Yonezawa Daisuke、Tamura Hikaru、Kawabata Shigetada、Yanagihara Katsunori、Kimura Osamu、Kunitomo Eiji、Terao Yutaka
    • Journal Title

      Microbiology and Immunology

      Volume: 63 Issue: 6 Pages: 213-222

    • DOI

      10.1111/1348-0421.12688

    • NAID

      40021941640

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA.2019

    • Author(s)
      Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S.
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 9 Pages: 301-301

    • DOI

      10.3389/fcimb.2019.00301

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surface pre-reacted Glass filler contributes to tertiary dentin Formation through a Mechanism different than that of hydraulic calcium-silicate cement.2019

    • Author(s)
      Okamoto M, Ali M, Komichi S, Watanabe M, Huang H, Ito Yuki, Miura J, Hirose Y, Mizuhira M, Takahashi Y, Okuzaki D, Kawabata S, Imazato S, Hayashi M.
    • Journal Title

      Journal of Clinical Medicine.

      Volume: 8 Issue: 9 Pages: 11-11

    • DOI

      10.3390/jcm8091440

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis.2019

    • Author(s)
      Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S.
    • Journal Title

      Appl Environ Microbiol

      Volume: 85 Issue: 21

    • DOI

      10.1128/aem.01428-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis.2019

    • Author(s)
      Takeda K, Sakakibara S, Yamashita K, Motooka D, Nakamura S, El Hussien MA, Katayama J, Maeda Y, Nakata M, Hamada S, Standley DM, Hayama M, Shikina T, Inohara H, Kikutani H.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 143 Issue: 3 Pages: 1163-1175

    • DOI

      10.1016/j.jaci.2018.07.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis.2018

    • Author(s)
      Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S.
    • Journal Title

      Virulence

      Volume: 9 Issue: 1 Pages: 1576-1587

    • DOI

      10.1080/21505594.2018.1526530

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells.2018

    • Author(s)
      Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y.
    • Journal Title

      Microbiol Immuno

      Volume: 62 Issue: 10 Pages: 617-623

    • DOI

      10.1111/1348-0421.12647

    • NAID

      40021702611

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pneumoniae surface adhesin PfbA and its interaction with erythrocytes and hemoglobin2018

    • Author(s)
      Radhakrishnan D, Yamaguchi M, Kawabata S, Ponnuraj K.
    • Journal Title

      Int Biol Macromol

      Volume: 120 Pages: 135-143

    • DOI

      10.1016/j.ijbiomac.2018.08.080

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia2018

    • Author(s)
      Domon Hisanori、Nagai Kosuke、Maekawa Tomoki、Oda Masataka、Yonezawa Daisuke、Takeda Wataru、Hiyoshi Takumi、Tamura Hikaru、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Front Immunol

      Volume: 印刷中 Pages: 732-732

    • DOI

      10.3389/fimmu.2018.00732

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 42018

    • Author(s)
      Nagai Kosuke、Domon Hisanori、Maekawa Tomoki、Oda Masataka、Hiyoshi Takumi、Tamura Hikaru、Yonezawa Daisuke、Arai Yoshiaki、Yokoji Mai、Tabeta Koichi、Habuka Rie、Saitoh Akihiko、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Cell Immunol

      Volume: 325 Pages: 14-22

    • DOI

      10.1016/j.cellimm.2018.01.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus sanguinis non-coding csRNAs negatively regulate expression of type IV pilus retraction ATPase PilT and biofilm formation2018

    • Author(s)
      Ota C, Morisaki H, Nakata M, Arimoto T, Fukamachi H, Kataoka H, Masuda Y, Suzuki N, Miyazaki T, Okahashi N, Kuwata H
    • Journal Title

      Infect Immun

      Volume: 86 Issue: 3 Pages: 1-13

    • DOI

      10.1128/iai.00894-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection2018

    • Author(s)
      Sumitomo Tomoko、Mori Yasushi、Nakamura Yuumi、Honda-Ogawa Mariko、Nakagawa Seitaro、Yamaguchi Masaya、Matsue Hiroyuki、Terao Yutaka、Nakata Masanobu、Kawabata Shigetada
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 8 Pages: 10-10

    • DOI

      10.3389/fcimb.2018.00010

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease ?Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase2018

    • Author(s)
      Kriebel Katja、Hieke Cathleen、Muller-Hilke Brigitte、Nakata Masanobu、Kreikemeyer Bernd
    • Journal Title

      Front.Microbiol

      Volume: 9 Pages: 53-53

    • DOI

      10.3389/fmicb.2018.00053

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway2018

    • Author(s)
      Kurosawa Mie、Oda Masataka、Domon Hisanori、Isono Toshihito、Nakamura Yuki、Saitoh Issei、Hayasaki Haruaki、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Microbes Infect

      Volume: 20 Issue: 1 Pages: 9-18

    • DOI

      10.1016/j.micinf.2017.09.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus gallolyticus subsp. gallolyticus endocarditis isolate interferes with coagulation and activates the contact system2017

    • Author(s)
      Isenring Julia、Kohler Juliane、Nakata Masanobu、Frank Marcus、Jans Christoph、Renault Pierre、Danne Camille、Dramsi Shaynoor、Kreikemeyer Bernd、Oehmcke-Hecht Sonja
    • Journal Title

      Virulence

      Volume: 9 Issue: 1 Pages: 248-261

    • DOI

      10.1080/21505594.2017.1393600

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] treptococcus pyogenes Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1q2017

    • Author(s)
      Honda-Ogawa M., Sumitomo T., Mori Y., Hamd DT, Ogawa T., Yamaguchi M., Nakata M., Kawabata S.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 10 Pages: 4244-4254

    • DOI

      10.1074/jbc.m116.749275

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems2017

    • Author(s)
      Yamaguchi Masaya、Nakata Masanobu、Sumioka Ryuichi、Hirose Yujiro、Wada Satoshi、Akeda Yukihiro、Sumitomo Tomoko、Kawabata Shigetada
    • Journal Title

      Virulence

      Volume: 8 Issue: 8 Pages: 1516-1524

    • DOI

      10.1080/21505594.2017.1328333

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 肺炎球菌の菌体表層タンパク質群に着目した病態形成機構の解明.2020

    • Author(s)
      山口雅也.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 肺炎球菌の菌体表層タンパク質BgaAが病態形成に果たす役割.2020

    • Author(s)
      竹村萌,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pyogenes emm 89型の侵襲性に寄与する因子の検索.2020

    • Author(s)
      広瀬雄二郎,山口雅也,秋山徹,竹本訓彦,奥野ルミ,山口貴弘,大塚仁,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザに続発する細菌性肺炎の発症におけるGP96の機能解析.2020

    • Author(s)
      住友倫子,中田匡宣,長瀬賢史,高原悠樹,山口雅也,岡本成史,川端重忠.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] mRNAサーモセンサーにより制御される化膿レンサ球菌の温度感受性線毛産生.2020

    • Author(s)
      中田匡宣.
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 化膿レンサ球菌のアルギニン代謝系は皮膚上で病原性発揮機構に寄与する.2019

    • Author(s)
      広瀬雄二郎,山口雅也,住友倫子,川端重忠.
    • Organizer
      第93回日本感染症学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 化膿レンサ球菌による温度依存性の線毛産生(Temperature-dependent pilus production of Streptococcus pyogenes).2019

    • Author(s)
      中田匡宣,住友倫子,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Influenza virus-induced dysfunction of pulmonary epithelial barrier promotes secondary bacterial infection.2019

    • Author(s)
      住友倫子.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Streptococcus pyogenes のアルギニン代謝系が病変形成に果たす役割の解析.2019

    • Author(s)
      広瀬雄二郎,山口雅也,毛利泰士,後藤花奈,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Component analysis of cell-wall anchored pili in Streptococcus sanguinis.2019

    • Author(s)
      李怡萱,中田匡宣,岡橋暢夫,山口雅也,住友倫子,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Involvement of two-component regulatory system TCS08 in pneumococcal pneumonia pathogenesis.2019

    • Author(s)
      本多-小川真理子,住友倫子,Dalia Hamd,毛利泰士,山口雅也,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺炎球菌の β-ガラクトシダーゼ BgaA の進化的な保存性と病態に 果たす役割の解析.2019

    • Author(s)
      竹村萌,山口雅也,後藤花奈,広瀬雄二郎,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 進化的な保存性の評価に基づく肺炎球菌の病原因子の探索.2019

    • Author(s)
      山口雅也,後藤 花奈,竹村 萌,広瀬 雄二郎,住友 倫子,中田 匡宣,川端重忠.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 日本における劇症型感染症由来Streptococcus pyogenes emm 89型の解析.2019

    • Author(s)
      広瀬雄二郎,山口雅也,奥野ルミ,秋山徹,菅原庸,浜田茂幸,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第51回レンサ球菌研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Two-component regulatory system TCS08 contributes to pathogenesis in pneumococcal pneumonia.2019

    • Author(s)
      Sumitomo T,Hamd DT,Honda-Ogawa M,Mori Y,Yamaguchi M,Nakata M,Kawabata S.
    • Organizer
      ASM Microbe 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肺炎球菌のβ-ガラクトシダーゼBgaAは敗血症の病原因子として働く.2019

    • Author(s)
      竹村萌,山口雅也,住友倫子,中田匡宣,鵜澤成一,川端重忠.
    • Organizer
      大阪大学歯学会第128回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pneumoniae のコリン結合タンパク質CbpJおよびCbpLの機能解析.2019

    • Author(s)
      後藤花奈,山口雅也,川端重忠.
    • Organizer
      大阪大学歯学会第128回例会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 宿主―細菌相互作用による肺炎重症化メカニズム解析.2019

    • Author(s)
      土門久哲,永井康介,山口雅也,川端重忠,寺尾豊.
    • Organizer
      第13回細菌学若手コロッセウムin みやぎ蔵王
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肺炎球菌の菌体表層タンパク質PfbAが自然免疫系に対して果たす役割の解明.2019

    • Author(s)
      山口雅也,広瀬雄二郎,竹村萌,大野誠之,住友倫子,中田匡宣,寺尾豊,川端重忠.
    • Organizer
      第13回細菌学若手コロッセウムin みやぎ蔵王
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザに続発する細菌性肺炎の重症化機構.2019

    • Author(s)
      川端重忠.
    • Organizer
      第73回日本細菌学会東北支部総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] マウス壊死性筋膜炎モデルの感染局所におけるStreptococcus pyogenesの遺伝子発現解析.2019

    • Author(s)
      花田知己,広瀬雄二郎,山口雅也,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インフルエンザ感染によるGP96シャペロンの活性化は肺炎球菌の肺胞上皮細胞への付着を亢進させる.2019

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Restoration of intact nra into serotype M18 Streptococcus pyogenes restored thermosensitive pilus production.2019

    • Author(s)
      Li Y,Nakata M,Sumitomo T,Hirose Y,Takemura M,Yamaguchi M,Okahashi N,Kawabata S.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pyogenesは低グルコース環境においてアルギニン代謝依存的に遺伝子発現を変動させる.2019

    • Author(s)
      広瀬雄二郎,山口雅也,花田知己,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Streptococcus pneumoniaeは種特異的なタンパク質PfbAにより過剰な免疫応答を伴う宿主の死亡を抑制する.2019

    • Author(s)
      山口雅也,広瀬雄二郎,竹村萌,大野誠之,住友倫子,中田匡宣,寺尾豊,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 温度感受性転写因子の翻訳効率に依存する化膿レンサ球菌の線毛発現.2019

    • Author(s)
      中田匡宣,住友倫子,川端重忠.
    • Organizer
      第61回歯科基礎医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Restoration of transcriptional regulator nra in serotype M18 Streptococcus pyogenes leads to phenotypic change.2019

    • Author(s)
      Li Y,Nakata M,Sumitomo T,Hirose Y,Takemura M,Yamaguchi M,Kawabata S.
    • Organizer
      第7回口腔微生物研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of pneumococcal virulence factors based on selective pressure analysis.2019

    • Author(s)
      山口雅也.
    • Organizer
      2019年「先進ゲノム支援」拡大班会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] PilX is a pilus subunit of Streptococcus sanguinis that contributes to biofilm formation.2018

    • Author(s)
      李怡萱, 中田匡宣, 山口雅也, 住友倫子, 川端重忠.
    • Organizer
      第6回 口腔微生物研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミティス群レンサ球菌が産生する過酸化水素はマスト細胞の細胞死を誘導し,脱顆粒を抑制する.2018

    • Author(s)
      岡橋暢夫, 中田匡宣, 広瀬雄二郎, 桑田啓貴, 川端重忠.
    • Organizer
      第60回 歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pneumococcal Ccs4 facilitates its invasion into brain tissue and develops meningitis.2018

    • Author(s)
      Hirose Y, Yamaguchi M, Goto K, Sumitomo T, Nakata M, Kawabata S.
    • Organizer
      ASM Microbe 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of novel pneumococcal virulence factor CbpJ by molecular evolutional analysis.2018

    • Author(s)
      Yamaguchi M, Goto K, Hirose Y, Yamaguchi Y, Sumitomo T, Nakata M, Kawabata S.
    • Organizer
      Gordon Research Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniaeのコリン結合タンパク質群の系統関係と種内における選択圧の解析.2018

    • Author(s)
      山口雅也,後藤花奈,広瀬雄二郎,竹村萌,住友倫子,中田匡宣,川端重忠.
    • Organizer
      第6回 口腔微生物研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺炎球菌性の重症化メカニズム解析 -新規肺炎制御法への展開-2018

    • Author(s)
      土門久哲, 永井康介, 前川知樹, 山口雅也, 川端重忠, 寺尾豊.
    • Organizer
      第6回 口腔微生物研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Component analysis of cell-wall anchored pili of Streptococcus sanguinis.2018

    • Author(s)
      李怡萱, 中田匡宣, 岡橋暢夫, 山口雅也, 住友倫子, 川端重忠.
    • Organizer
      第60回 歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化膿レンサ球菌におけるヒアルロン酸分解酵素の分子系統解析およびタンパク質構造解析.2018

    • Author(s)
      東孝太郎, 武部克己, 山口雅也, 住友倫子, 中田匡宣, 鈴木守, 川端重忠.
    • Organizer
      第60回 歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化膿レンサ球菌のアルギニンデイミナーゼArcAは低グルコース環境下で病原因子の発現に寄与する.2018

    • Author(s)
      広瀬雄二郎, 山口雅也, 毛利泰士, 後藤花奈, 住友倫子, 中田匡宣, 川端重忠.
    • Organizer
      第60回 歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Streptococcus pneumoniaeのCbpJは肺炎において好中球からの殺菌回避に寄与する.2018

    • Author(s)
      後藤花奈, 山口雅也, 広瀬雄二郎, 住友倫子, 中田匡宣, 川端重忠.
    • Organizer
      第50回 レンサ球菌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] インフルエンザウイルスとStreptococcus sanguinis の共感染による肺炎発症メカニズムの解析.2018

    • Author(s)
      長瀬賢史, 住友倫子, 中田匡宣, 川端重忠, 岡本成史.
    • Organizer
      第50回 レンサ球菌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺炎球菌のジンクメタロプロテアーゼZmpCが髄膜炎発症に果たす役割の解明.2018

    • Author(s)
      山口雅也, 中田匡宣, 住友倫子, 川端重忠.
    • Organizer
      第38回 近畿腸管微生物研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺炎球菌はPfbAを介して好中球による殺菌を回避する.2018

    • Author(s)
      山口雅也, 広瀬雄二郎, 後藤花奈, 住友倫子, 川端重忠.
    • Organizer
      第92回 日本感染症学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺炎球菌のコリン結合タンパク質CbpJは好中球による殺菌の回避に働く.2018

    • Author(s)
      後藤花奈, 山口雅也, 川端重忠, 仲野和彦.
    • Organizer
      第56回 小児歯科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Streptococcus pyogenesが産生するArcAは皮膚病変形成に寄与する2018

    • Author(s)
      広瀬雄二郎,山口雅也,後藤花奈,住友倫子,中田匡宣,川端重忠
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺炎球菌のbeta-ヘリックス構造タンパク質PfbAを介した貪食回避機構の解析2018

    • Author(s)
      山口雅也,広瀬雄二郎,後藤花奈,竹村 萌,住友倫子,中田匡宣,川端重忠
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺炎球菌のコリン結合タンパク質CbpJおよびCbpLの肺炎発症における役割の解析2018

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第91回 日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化膿レンサ球菌における温度感受性の線毛発現機構2017

    • Author(s)
      中田匡宣,住友倫子,川端重忠
    • Organizer
      第59回 歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔レンサ球菌が産生する過酸化水素は上皮細胞に対する細胞傷害性を有する2017

    • Author(s)
      岡橋暢夫,中田匡宣,住友倫子,桜井敦朗,桑田啓喜,川端重忠
    • Organizer
      第59回 歯科基礎医学会学術大会59回 歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcal cysteine protease-mediated cleavage of desmogleins contributes to development of cutaneous infection2017

    • Author(s)
      Sumitomo T., Mori Y., Nakamura Y., Ogawa-Honda M., Yamaguchi M., Terao Y., Nakata M., Kawabata S.
    • Organizer
      IUMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniae Ccs4 that is involved in invasion into brain across blood-brain barrier impacts its virulence in meningitis2017

    • Author(s)
      Hirose Y., Yamaguchi M., Goto K., Sumitomo T., Nakata M., Kawabata S
    • Organizer
      LISSSD 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniae evades host innate immunity through parallel beta-helix protein PfbA2017

    • Author(s)
      Yamaguchi M., Hirose Y., Goto K., Sumitomo T., Nakata M., Kawabata S
    • Organizer
      LISSSD 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A型インフルエンザウイルス感染に伴い表在化するGP96は化膿レンサ球菌の上皮細胞への付着を亢進させる2017

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第65回 日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インフルエンザウイルス感染によるSnail1 の発現誘導は化膿レンサ球菌の上皮バリア突破を亢進させる2017

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第59回 歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcus pneumoniae のコリン結合タンパク質CbpJ は肺炎発症における病原因子として働く2017

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宜,川端重忠
    • Organizer
      第59回 歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺炎球菌の CbpJ が肺炎発症に果たす役割の解析2017

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第70回 日本細菌学会関西支部総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcus pneumoniae Ccs4は脳血管内皮細胞への付着・侵入を促進する病原因子である2017

    • Author(s)
      広瀬雄二郎,山口雅也,後藤花奈,住友倫子,中田匡宣,川端重忠
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化膿レンサ球菌の線毛発現機構2017

    • Author(s)
      中田匡宣,住友倫子,山口雅也,川端重忠
    • Organizer
      第49回 近畿腸管微生物研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 化膿レンサ球菌のヒアルロン酸分解酵素HylAの分子系統解析と病原性に果たす役割の解析2017

    • Author(s)
      山口雅也,中田匡宣,広瀬雄二郎,後藤花奈,住友倫子,川端重忠
    • Organizer
      第49回 レンサ球菌研究会
    • Related Report
      2017 Annual Research Report
  • [Book] Group A Streptococcus Methods and Protocols (Editors: Proft T, Loh J)2020

    • Author(s)
      Nakata M, Kawabata S.
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2019 Annual Research Report
  • [Book] 化学療法の領域.レンサ球菌の病原因子, 特集「改めて考えるレンサ球菌感染症」2017

    • Author(s)
      中田匡宣, 川端重忠
    • Total Pages
      8
    • Publisher
      医薬ジャーナル社
    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学 大学院歯学研究科 口腔細菌学教室

    • URL

      http://web.dent.osaka-u.ac.jp/~mcrbio/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科 口腔細菌学教室

    • URL

      https://web.dent.osaka-u.ac.jp/mcrbio/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科 口腔細菌学教室

    • URL

      http://web.dent.osaka-u.ac.jp/~mcrbio/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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