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Investigation of marine organisms in Indonesia intended for sustainable use as medicinal resources

Research Project

Project/Area Number 17H04645
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Natural medicines
Research InstitutionOsaka University

Principal Investigator

Arai Masayoshi  大阪大学, 薬学研究科, 特任教授(常勤) (80311231)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords海洋薬用資源 / インドネシア / 医薬シーズ / 底生海洋生物 / 海洋微生物
Outline of Final Research Achievements

For the purpose of sustainable use and development of Indonesian marine medicinal resources, totally 158 samples of benthic marine organisms were collected in the coral reefs of Panaitan Island in western Java, Banyuwedang in western Bali and Gorontalo area in northern Sulawesi. In order to use the resources sustainably, we preserved the whole genome of the collected marine organisms and separated totally 175 species of endophytic microorganisms. Then, the biological samples were saved as specimens, and information of habitat, environments, morphological characteristics was listed based on the pictures of marine organisms under the water. In addition, the extracts library was constructed from marine organisms and cultured microorganisms, and then information of biological activities and bioactive constituents were also listed.

Academic Significance and Societal Importance of the Research Achievements

海洋薬用資源の調査研究が遅れ、環境破壊も進んでいるインドネシアにおいて、海洋薬用資源の現状把握とともに、資源の保全と持続的な利用を勘案した開拓を実施した例はこれまでにない。また各種試料の保存を行うだけではなく、一連の情報の体系化も行っていることから、これらの学術的価値は高く、今後、特に創薬研究領域に大きく貢献できると思われる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (26 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] ランプン大学(インドネシア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ランプン大学(インドネシア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ランプン大学(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation2020

    • Author(s)
      Tang Rui、Kimishima Atsushi、Setiawan Andi、Arai Masayoshi
    • Journal Title

      Journal of Natural Medicines

      Volume: 74 Issue: 2 Pages: 495-500

    • DOI

      10.1007/s11418-020-01390-0

    • NAID

      40022183716

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis2020

    • Author(s)
      Sumii Yuji、Kotoku Naoyuki、Han Chisu、Kamiya Kentaro、Setiawan Andi、Vilch?ze Catherine、Jacobs William R.、Arai Masayoshi
    • Journal Title

      Tetrahedron Letters

      Volume: 61 Issue: 22 Pages: 151924-151924

    • DOI

      10.1016/j.tetlet.2020.151924

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure–Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge2019

    • Author(s)
      Ryosuke Ishida, Hirokazu Matsumoto, Sayaka Ichii, Motomasa Kobayashi, Masayoshi Arai, Naoyuki Kotoku
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 67 Issue: 3 Pages: 210-223

    • DOI

      10.1248/cpb.c18-00587

    • NAID

      130007606467

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2019-03-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytotoxicity of New Diterpene Alkaloids, Ceylonamides G-I, Isolated From Indonesian Marine Sponge of Spongia sp.2019

    • Author(s)
      Jomori Takahiro、Setiawan Andi、Sasaoka Miho、Arai Masayoshi
    • Journal Title

      Natural Product Communications

      Volume: 14 Issue: 6 Pages: 1-7

    • DOI

      10.1177/1934578x19857294

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger2019

    • Author(s)
      Jomori Takahiro、Hara Yasumasa、Sasaoka Miho、Harada Kazuo、Setiawan Andi、Hirata Kazumasa、Kimishima Atsushi、Arai Masayoshi
    • Journal Title

      Journal of Natural Medicines

      Volume: 74 Issue: 1 Pages: 76-82

    • DOI

      10.1007/s11418-019-01345-0

    • NAID

      40022130030

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation2019

    • Author(s)
      Tang Rui、Kimishima Atsushi、Ishida Ryosuke、Setiawan Andi、Arai Masayoshi
    • Journal Title

      Journal of Natural Medicines

      Volume: 74 Issue: 1 Pages: 153-158

    • DOI

      10.1007/s11418-019-01357-w

    • NAID

      40022130204

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis.2018

    • Author(s)
      Ueda S, Kitani S, Namba T, Arai M, Ikeda H, Nihira T.
    • Journal Title

      J Antibiot (Tokyo).

      Volume: 71 Issue: 10 Pages: 854-861

    • DOI

      10.1038/s41429-018-0074-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-dormant mycobacterial activity of viomellein and xanthomegnin, naphthoquinone dimers produced by marine-derived Aspergillus sp.2017

    • Author(s)
      K. Kamiya, M. Arai, A. Setiawan, M. Kobayashi
    • Journal Title

      Nat. Prod. Commun.

      Volume: 12 Pages: 579-581

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biakamides A-D, Unique Polyketides from a Marine Sponge, Act as Selective Growth Inhibitors of Tumor Cells Adapted to Nutrient Starvation2017

    • Author(s)
      Naoyuki Kotoku, Ryosuke Ishida, Hirokazu Matsumoto, Masayoshi Arai, Kazunari Toda, Andi Setiawan, Osamu Muraoka, and Motomasa Kobayashi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 82 Issue: 3 Pages: 1705-1718

    • DOI

      10.1021/acs.joc.6b02948

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II2017

    • Author(s)
      Arai Masayoshi、Shin Dayoung、Kamiya Kentaro、Ishida Ryosuke、Setiawan Andi、Kotoku Naoyuki、Kobayashi Motomasa
    • Journal Title

      Journal of Natural Medicines

      Volume: 71 Issue: 1 Pages: 44-49

    • DOI

      10.1007/s11418-016-1025-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 潜在性結核菌に有効な海綿由来抗菌物質の探索2019

    • Author(s)
      木下遼祐,君嶋敦, 荒井雅吉
    • Organizer
      日本生薬学会第66回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Bioactive Compounds from Marine Resources and their Mode of Action2019

    • Author(s)
      Masayoshi Arai
    • Organizer
      The 3rd Joint Symposium of Osaka University with Higher Educational Institutions of Brunei Darussalam
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 表現型スクリーニングによる天然物探索と標的分子解析2018

    • Author(s)
      荒井雅吉
    • Organizer
      第42回白金シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 表現型スクリーニングによるMONOTORI(ものとり)と標的分子解析2018

    • Author(s)
      荒井雅吉
    • Organizer
      第22回天然薬物の開発と応用シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Search for new medicinal seeds and drug targets from natural resources2018

    • Author(s)
      Masayoshi Arai
    • Organizer
      The 2nd Joint Symposium of Osaka University with Higher Educational Institutions of Brunei Darussalam
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 微生物共培養法を利用した活性天然物の探索2018

    • Author(s)
      城森啓宏、原康雅、笹岡美歩、Andi Setiawan、荒井雅吉
    • Organizer
      第68回 日本薬学会近畿支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 海洋天然物の魅力と創薬研究への応用2017

    • Author(s)
      荒井雅吉
    • Organizer
      第40回新適塾
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 海洋天然物を活用するケミカルバイオロジー研究2017

    • Author(s)
      荒井雅吉
    • Organizer
      第216回Kitasato Microbial Chemistryセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Exploring new medicinal seeds and drug targets from marine resources2017

    • Author(s)
      Masayoshi Arai
    • Organizer
      Joint Symposium of Osaka University with Higher Educational Institutions of Brunei Darussalam
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 海洋由来微生物が産生する栄養飢餓環境適応がん細胞増殖阻害物質の探索2017

    • Author(s)
      ○石田良典、唐 睿、木村出海、小林資正、荒井雅吉
    • Organizer
      第67回日本近畿支部総会・大会
    • Related Report
      2017 Annual Research Report
  • [Book] Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules2019

    • Author(s)
      Yuichi Kobayashi (Ed), Masayoshi Arai
    • Total Pages
      355
    • Publisher
      Springer-Nature
    • Related Report
      2018 Annual Research Report
  • [Book] アルカロイドの科学2017

    • Author(s)
      高山廣光編, 荒井雅吉, 小林資正
    • Total Pages
      546
    • Publisher
      化学同人
    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学大学院 薬学研究科 天然物創薬学分野 ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b012/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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