バングラデシュにおけるポスト・カラ・アザール皮膚リーシュマニア症新規診断法の検証

• Project/Area Number: 17H04649
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Oita University
• Principal Investigator: 小林 隆志 大分大学, 医学部, 教授 (30380520)
• Co-Investigator(Kenkyū-buntansha): 濱野 真二郎 長崎大学, 熱帯医学研究所, 教授 (70294915)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: PKDL / バングラディッシュ / 診断技術 / 節足動物媒介感染症 / バングラデシュ / チクングニア熱 / ジカ熱 / 動物モデル / 内臓型リーシュマニア症 / ポスト・カラアザール皮膚リーシュマニア症 / Dry LAMP法 / Leishmania donovani

Outline of Annual Research Achievements

バングラデシュでは多くの節足動物媒介感染症が問題となっている。致命的な疾患である内臓型リーシュマニア症(VL)は、治療による全身症状寛解後に一部の患者がポスト・カラ・アザール皮膚リーシュマニア症（PKDL）を発症する。VLの制圧には、PKDLの発症機序を理解し、的確に診断・治療することが不可欠である。一方、ウイルスによる節足動物媒介感染症としては、チクングニア熱やジカ熱が問題となっている。これらは、蚊によって媒介され、日本でも輸入症例があり、迅速診断キットの開発が望まれる。
本研究では、バングラデシュにおいて、①VL患者のPKDL発症の原因となるリスクファクターの集積と解析を行い、②新規迅速診断キット（Dry LAMP）の現地での有用性を検証する。また、③チクングニア熱の新規迅速診断キットも開発しその有用性を検証する。④ジカ熱の増悪化因子の探求を行う。これらによりバングラデシュにおける節足動物媒介感染症の予防法・治療法・診断法の開発に応用する。
PKDLのリスクファクターを念頭に置きつつ、不顕性リーシュマニア症の感染率とリスク因子に関するメタ解析を行い、系統的レヴューの執筆を進めた。また、現地での実証試験において安定性が問題となったL. donovaniのDry LAMPの開発では、複数の新たなプライマーを検討した結果、感度と特異性の高いものが見つかり、次年度以降の実証試験に臨む体制が整った。一方、共同研究者の依頼によりチクングニア熱に対するCHIKV-Dry LAMPを開発し、実験室レベルでの試験を重ねた上、感度と特異性の高いものが得られた。さらに、現地での実証試験に臨み良好な結果が得られた。ジカ熱の増悪化因子の解析では、人工ウイルス粒子（SRIPs）を用いてジカウイルスの細胞侵入に必要なエンベロープ内のアミノ酸解析を行い、候補アミノ酸の絞り込みに成功した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①バングラデシュにおけるPKDL患者の検体を用いて、VL患者のPKDL発症の原因となるリスクファクターの集積と解析を行い、昨年度までにPKDL発症患者群において上昇したmicroRNAを8種類、減少したものを10種類同定した。本年度は、これら18種類のmicroRNAと免疫反応、代謝および細胞内シグナル伝達等の関連の解析を進めた。
②L. donovaniの新規迅速診断キットの開発では、前年にDry LAMPを現地に持ち込んで行った実証試験において長期間保存したキットの安定性が問題となったため、新たにプライマーセットを検討し感度と特異性の高いものが得られた。
③昨年度、共同研究者の依頼を受けチクングニア熱に対する新規診断法としてCHIKV-Dry LAMPの開発に取り組んだ。実験室レベルでの試験を重ねた上、高感度で特異性の高い診断法が開発され、現地での実証試験においても良好な結果が得られたので学術論文の執筆に着手した。
④ジカ熱の増悪化因子の解析では、人工ウイルス粒子（SRIPs）を用いてジカウイルスの細胞侵入に必要なエンベロープ内のアミノ酸解析を行い、候補アミノ酸の絞り込みに成功した。

Strategy for Future Research Activity

①PKDLのリスクファクターについては、昨年度までの研究に引き続き、PKDL患者検体において免疫抑制性因子（IL-10，IL-27，TGF-β、STAT3，Foxp3）、免疫チェックポイント調節分子（CTLA-4，PD-1，SOCS3）、リーシュマニア原虫の定量的検出、末梢血白血球および皮膚パンチ生検中の宿主免疫関連分子の発現解析、血中サイトカイン、血漿および尿検体中の抗原、抗体等の定量、SNP解析を実施し、PKDL発症率との相関を解析し、PKDL発症の成否を規定する分子を特定する。
②L. donovaniの新規迅速診断キットの開発については、前年度に検討した新規プライマーのさらなる条件検討を実験室で行った後、再びバングラデシュでの実証試験を行う。
③CHIKV-Dry LAMPについては、研究論文を作成するとともにバングラデシュの共同研究者と社会実装の検討を進める。
④前年度にジカ熱のprM＋Eを有するSRIPsを構築し、細胞侵入に重要なエンベロープ内のアミノ酸を複数個絞り込んだので、そこから必要不可欠なアミノ酸を同定する。また、ジカ熱が宿主免疫応答に与える影響を解析し増悪化のリスクファクターを明らかにする。

Research Products

• [Int'l Joint Research] icddr,b/IEDCR(バングラデシュ)
• [Int'l Joint Research] icddr,b(バングラデシュ)
• [Journal Article] CLP1 acts as the main RNA kinase in mice (2020)
  • Author(s): Fujinami H, Shiraishi H, Hada K, Inoue M, Morisaki I, Higa R, Shin T, Kobayashi T, Hanada R, Penninger JM, Mimata H, Hanada T.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 525 Pages: 129-134
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  • Peer Reviewed / Int'l Joint Research
• [Journal Article] What does soil-transmitted helminth elimination look like? Results from a targeted molecular detection survey in Japan (2020)
  • Author(s): Hasegawa Mitsuko、the DeWorm3 Project Team、Pilotte Nils、Kikuchi Mihoko、Means Arianna R.、Papaiakovou Marina、Gonzalez Andrew M.、Maasch Jacqueline R. M. A.、Ikuno Hiroshi、Sunahara Toshihiko、 Asbjornsdottir Kristjana H.、Walson Judd L.、Williams Steven A.、Hamano Shinjiro
  • Journal Title: Parasites & Vectors Volume: 13 Pages: 6-16
  • DOI: 10.1186/s13071-019-3875-z
  • NAID: 120006988333
  • Peer Reviewed / Open Access
• [Journal Article] Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner (2019)
  • Author(s): Musa Md. Abu、Nakamura Risa、Hena Asma、Varikuti Sanjay、Nakhasi Hira L.、Goto Yasuyuki、Satoskar Abhay R.、Hamano Shinjiro
  • Journal Title: PLOS Neglected Tropical Diseases Volume: 13
  • DOI: 10.1371/journal.pntd.0007865
  • NAID: 120006988346
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of Entamoeba histolytica adenosine 5′-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis (2019)
  • Author(s): Mi-ichi Fumika, Ishikawa Takeshi, Tam Vo Kha, Deloer Sharmina, Hamano Shinjiro, Hamada Tsuyoshi, Yoshida Hiroki
  • Journal Title: PLoS Negl Trop Dis. Volume: 13
  • DOI: 10.1371/journal.pntd.0007633
  • NAID: 120006988415
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A high-intensity cluster of Schistosoma mansoni infection around Mbita causeway, western Kenya: a confirmatory cross-sectional survey. (2019)
  • Author(s): Chadeka EA, Nagi S, Cheruiyot NB, Bahati F, Sunahara T, Njenga SM, Hamano S.
  • Journal Title: Trop Med Health. Volume: 47 Pages: 26-26
  • DOI: 10.1186/s41182-019-0152-y
  • NAID: 120006987734
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Galectin-2 suppresses nematode development by binding to the invertebrate-specific galactoseβ1-4fucose glyco-epitope. (2019)
  • Author(s): Takeuchi, T. Tamura, M., Ishiwata, K., Hamasaki, M., Hamano, S., Arata, Y., Hatanaka, T.
  • Journal Title: Glycobiology Volume: 29 Pages: 504-512
  • DOI: 10.1093/glycob/cwz022
  • NAID: 120006871140
  • Peer Reviewed
• [Journal Article] Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice (2019)
  • Author(s): Gendo Y、Matsumoto T、Kamiyama N、Saechue B、Fukuda C、Dewayani A、Hidano S、Noguchi K、Sonoda A、Ozaki T、Sachi N、Hirose H、Ozaka S、Eshita Y、Mizukami K、Okimoto T、Kodama M、Yoshimatsu T、Nishida H、Daa T、Yamaoka Y、Murakami K、Kobayashi T
  • Journal Title: Inflammatory Intestinal Diseases. Volume: 3 Pages: 145-154
  • DOI: 10.1159/000495462
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. (2018)
  • Author(s): Kanaya T, Sakakibara S, Jinnohara T, Hachisuka M, Tachibana N, Hidano S, Kobayashi T, Kimura S, Iwanaga T, Nakagawa T, Katsuno T, Kato N, Akiyama T, Sato T, Williams IR, Ohno H.
  • Journal Title: J. Exp. Med Volume: 5;215(2) Pages: 501-519
  • DOI: 10.1084/jem.20160659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains (2018)
  • Author(s): Ichiro Takada, Megumi Tsuchiya, Kaori Yanaka, Shinya, Hidano, Sayuri Takahashi, Takashi Kobayashi, Hidesato Ogawa, Sinichi Nakagawa, Makoto Makishima
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 497 Pages: 597-604
  • DOI: 10.1016/j.bbrc.2018.02.110
  • Peer Reviewed / Open Access
• [Journal Article] Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation (2018)
  • Author(s): Saga Kunihiro、Iwashita Yukio、Hidano Shinya、Aso Yuiko、Isaka Kenji、Kido Yasutoshi、Tada Kazuhiro、Takayama Hiroomi、Masuda Takashi、Hirashita Teijiro、Endo Yuichi、Ohta Masayuki、Kobayashi Takashi、Inomata Masafumi
  • Journal Title: Int J Mol Sci. Volume: 19 Pages: 3043-3043
  • DOI: 10.3390/ijms19103043
  • Peer Reviewed / Open Access
• [Journal Article] Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice (2018)
  • Author(s): Noguchi Kaori、Kamiyama Naganori、Hidano Shinya、Gendo Yoshiko、Sonoda Akira、Ozaki Takashi、Hirose Haruna、Sachi Nozomi、Saechue Benjawan、Ozaka Sotaro、Eshita Yuki、Mizukami Kazuhiro、Kawano Kenji、Kobayashi Takashi
  • Journal Title: Biochem Biophys Res Commun Volume: 504 Pages: 245-250
  • DOI: 10.1016/j.bbrc.2018.08.162
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis (2018)
  • Author(s): Ji RC, Eshita Y, Kobayashi T, Hidano S, Kamiyama N, Onishi Y
  • Journal Title: Clinical & Experimental Metastasis Volume: 35(8) Pages: 785-796
  • DOI: 10.1007/s10585-018-9940-8
  • Peer Reviewed
• [Journal Article] Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice (2018)
  • Author(s): Sonoda Akira、Kamiyama Naganori、Ozaka Sotaro、Gendo Yoshiko、Ozaki Takashi、Hirose Haruna、Noguchi Kaori、Saechue Benjawan、Sachi Nozomi、Sakai Kumiko、Mizukami Kazuhiro、Hidano Shinya、Murakami Kazunari、Kobayashi Takashi
  • Journal Title: Genes Cells Volume: 23 Pages: 1043-1055
  • DOI: 10.1111/gtc.12649
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Modulation of immune responses by Plasmodium falciparum infection in asymptomatic children living in the endemic region of Mbita, western Kenya (2018)
  • Author(s): Kijogi Caroline、Kimura Daisuke、Bao Lam Quoc、Nakamura Risa、Chadeka Evans Asena、Cheruiyot Ngetich Benard、Bahati Felix、Yahata Kazuhide、Kaneko Osamu、Njenga Sammy M.、Ichinose Yoshio、Hamano Shinjiro、Yui Katsuyuki
  • Journal Title: Parasit International Volume: 67 Pages: 284-293
  • DOI: 10.1016/j.parint.2018.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages. (2018)
  • Author(s): Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka EA, Yamaguchi T, Osada-Oka M, Ono K, Oda T, Mwende F, Kaneko Y, Matsumoto M, Kaneko S, Ichinose Y, Njenga SM, Hamano S, Matsumoto S.
  • Journal Title: Sci Re Volume: 8 Pages: 1-11
  • DOI: 10.1038/s41598-018-24233-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of Real-time PCR for Diagnosis of Post-Kala-azar Dermal Leishmaniasis in Endemic Foci of Bangladesh (2018)
  • Author(s): Ghosh Prakash、Hasnain Md Golam、Hossain Faria、Khan Md Anik Ashfaq、Chowdhury Rajashree、Faisal Khaledul、Mural Moshtaq Ahmed、Baker James、Nath Rupen、Ghosh Debashis、Maruf Shomik、Shomik Mohammad Sohel、Haque Rashidul、Matlashewski Greg、Hamano Shinjiro、Duthie Malcolm S、Mondal Dinesh
  • Journal Title: Open Forum Infectious Diseases Volume: 5 Pages: 1-6
  • DOI: 10.1093/ofid/ofy234
• [Journal Article] Novel Potential Biomarkers for Opisthorchis viverrini Infection and Associated Cholangiocarcinoma (2018)
  • Author(s): AKSORN NITHIKOON、ROYTRAKUL SITTIRUK、KITTISENACHAI SUTHATHIP、LEELAWAT KAWIN、CHANVORACHOTE PITHI、TOPANURAK SUPACHAI、HAMANO SHINJIRO、LEK-UTHAI USA
  • Journal Title: In Vivo Volume: 32 Pages: 871-878
  • DOI: 10.21873/invivo.11321
• [Journal Article] Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ (2018)
  • Author(s): Shimokawa C, Senba M, Kobayashi S, Kikuchi M, Obi S, Olia A, Hamano S, Hisaeda H
  • Journal Title: The Journal of Immunology Volume: 200 Pages: 1101-1109
  • DOI: 10.4049/jimmunol.1700806
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes. (2018)
  • Author(s): Moriyasu, T., Nakamura, R., Deloer, S., Senba, M., Kubo, M., Inoue, M., Culleton, R., Hamano, S.
  • Journal Title: PLOS Neglected Tropical Diseases Volume: 12
  • DOI: 10.1371/journal.pntd.0006197
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 「生涯教育シリーズ」熱帯感染症の克服を目指して (2018)
  • Author(s): 濱野真二郎
  • Journal Title: 長崎市医師会報 Volume: 613(3) Pages: 16-19
• [Journal Article] アニサキス症の最近の知見と動向 (2017)
  • Author(s): 飛彈野真也、水上一弘、、佐知望美、神山長慶、小林隆志
  • Journal Title: 医学と薬学 Volume: 74巻 11号 Pages: 1387-1392
• [Journal Article] Ribavirin inhibits Zika virus (ZIKV) replication inハvitro and suppresses viremia in ZIKV- infected STAT1-deficient mice. (2017)
  • Author(s): Kamiyama N, Soma R, Hidano S, Watanabe K, Umekita H, Fukuda C, Noguchi K, Gendo Y, Ozaki T, Sonoda A, Sachi N, Runtuwene LR, Miura Y, Matsubara E, Tajima S, Takasaki T, Eshita Y, Kobayashi T.
  • Journal Title: Antiviral Research Volume: 146 Pages: 1-11
  • DOI: 10.1016/j.antiviral.2017.08.007
  • Peer Reviewed
• [Journal Article] 蚊媒介性ウイルス疾患 (2017)
  • Author(s): 神山長慶、佐知望美、飛彈野真也、小林隆志
  • Journal Title: 臨床免疫・アレルギー科 Volume: 68 (1) Pages: 79-85
  • NAID: 40021263510
• [Journal Article] IL-17A contributes to reducing IFN-gamma/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis (2017)
  • Author(s): Deloer, S. Nakamura, R. Kikuchi, M. Moriyasu, T. Kalenda, Y. D. J. Mohammed, E. S. Senba, M. Iwakura, Y. Yoshida, H. Hamano, S.
  • Journal Title: Parasitology International Volume: 66 Pages: 817-823
  • DOI: 10.1016/j.parint.2017.09.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya. (2017)
  • Author(s): Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S.
  • Journal Title: PLoS Negl Trop Dis. Volume: 11
  • DOI: 10.1371/journal.pntd.0005872
  • NAID: 120006987400
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tacrolimus prevents murine cerebral malaria. Immunology (2017)
  • Author(s): Bao LQ, Nhi DM, Huy NT, Hamano S, Hirayama K
  • Journal Title: Immunology Volume: 150 Pages: 155-161
  • DOI: 10.1111/imm.12661
  • Peer Reviewed
• [Journal Article] 貝媒介性感染症: 住血吸虫症、「増刊号 グローバル化・温暖化と感染症対策」 (2017)
  • Author(s): 田中美緒・中村梨沙・濱野真二郎
  • Journal Title: 小児科臨床 Volume: 70 Pages: 2289-2295
• [Journal Article] 「特集 寄生虫症（Ⅱ）」 (2017)
  • Author(s): 田中美緒・濱野真二郎：アメーバ赤痢
  • Journal Title: 医学と薬学 Volume: 74(11) Pages: 1399-1405
• [Journal Article] One Healthの視点からみた寄生虫感染症、「特集 One Healthの視点からみた感染症の現状と対策」 (2017)
  • Author(s): 安達圭司・濱野真二郎
  • Journal Title: 最新醫學 Volume: 70(11) Pages: 2407-2414
  • NAID: 40021181252
• [Presentation] TRAF6 in T cells exacerbates the severity of experimental autoimmune encephalomyelitis by up-regulating CCR6 expression (2020)
  • Author(s): 神山長慶、Benjawan Saechue、Astri Dewayani、Thanyakorn Chalalai、飛彈野真也、佐知望美、小坂聡太郎、有木晋平、、曽我泰裕、後藤美月、小林隆志
  • Organizer: 第97回日本生理学会大会
• [Presentation] Analysis of pathogenic mechanism in Anisakis infection (2020)
  • Author(s): Shinya Hidano, Kazuhiro Mizukami, Naganori Kamiyama, Nozomi Sachi, Sotaro Ozaka, Kazunari Murakami and Takashi Kobayashi.
  • Organizer: 第13回寄生虫感染免疫研究会
• [Presentation] ジカウイルスの細胞侵入能を規定するアミノ酸の同定および神経変性疾患の増悪メカニズムの解明 (2019)
  • Author(s): 神山長慶、Benjawan Saechue、Astri Dewayani、Thanyakorn Chalalai、Thanyakorn Chalalai、佐知望美、小坂聡太郎、有木晋平、曽我泰裕、後藤美月、飛彈野真也、小林隆志
  • Organizer: 第10回癌・炎症と抗酸化研究会
• [Presentation] 抗生物質や抗菌ペプチドによる腸内環境の変化が腸内細菌叢に及ぼす影響 (2019)
  • Author(s): 小坂聡太郎、有木晋平、園田光、Benjawan Saechue、Astri Dewayani、神山長慶、飛彈野真也、水上一弘、村上和成、小林隆志
  • Organizer: 第10回癌・炎症と抗酸化研究会
• [Presentation] SOCS１欠損によるマウス腸内細菌叢への影響 (2019)
  • Author(s): 有木晋平、玄同淑子、松本昂、小林隆志
  • Organizer: 第10回癌・炎症と抗酸化研究会
• [Presentation] 抗生物質起因性大腸炎モデルマウスに対する柴苓湯の保護効果の解明 (2019)
  • Author(s): 小坂聡太郎、有木晋平、園田光、佐知望美、後藤美月、曽我泰裕、広瀬晴奈、尾崎貴士、Benjawan Saechue、Astri Dewayani、神山長慶、飛彈野真也、水上一弘、村上和成、小林隆志
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] TRAF6 Regulation in TH9 Cell Responses to Tumor Growth (2019)
  • Author(s): Astri Dewayani, Naganori Kamiyama, Shinya Hidano, Takashi Ozaki, Akira Sonoda, Nozomi Sachi, Sotaro Ozaka, Shimpei Ariki, Benjawan Saechue, Takashi Kobayashi
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] Development of a portable reverse transcription loop-mediated isothermal amplification (RT-LAMP) system to detect the Chikungunya virus in a cost-effective manner (2019)
  • Author(s): Benjawan Saechue, Dinesh Mondal, and Takashi Kobayashi et al
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] "Zika virus African strain has higher entry ability to host cell than Asian strain, and exacerbates EAE" (2019)
  • Author(s): Naganori Kamiyama, Benjawan Saechue, Astri Dewayani, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Shinpei Ariki, Yasuhiro Soga, Mizuki Goto, Ryosuke Suzuki ,Takashi Kobayashi
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] ゲノム編集マウスを用いたケモカインCCL20の腸管組織における生理的機能の解析 (2019)
  • Author(s): Nozomi Sachi, Chiaki Fukuda, Shinya Hidano, Naganori Kamiyama, Benjawan Saechue, Sotaro Ozaka, Astri Dewayani, Shimpei Ariki, Yasuhiro Soga, Mizuki Goto, Takashi Kobayashi
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] TRAF6を介した炎症シグナルを定量化するレポーターアッセイ系の樹立と炎症を抑制する新規分子の探索 (2019)
  • Author(s): "Yasuhiro Soga, Naganori Kamiyama, Benjawan Saechue, Astri Dewayani, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Shinpei Ariki, Mizuki Goto, Takashi Kobayashi"
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 白癬菌増殖抑制効果を有するわさびの機能分子の探索 (2019)
  • Author(s): Mizuki Goto, Haruna Hirose, Naganori Kamiyama, Benjawan Saechue, Astri Dewayani, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Shinpei Ariki, Yasuhiro Soga, Takashi Kobayashi
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] Zika virus African strain has higher cell entry ability than Asian strain, and exacerbates EAE (2019)
  • Author(s): Naganori Kamiyama, Nozomi Sachi, Shinya Hidano, Takashi Kobayashi
  • Organizer: 第48回 日本免疫学会総会
• [Presentation] TRAF6 deficiency in dendritic cells exacerbates the disease severity of Toxoplasma gondii infection in mice. (2019)
  • Author(s): Shinya Hidano, Naganori Kamiyama, Nozomi Sachi, Sotaro Ozaka and Takashi Kobayashi.
  • Organizer: 第48回 日本免疫学会総会
• [Presentation] Role of Secretory leukocyte proteinase inhibitor (SLPI) in the pathogenesis of Inflammatory bowel disease (2019)
  • Author(s): Takashi Kobayashi, Sotaro Ozaka, Nozomi Sachi, Naganori Kamiyama, Shinya Hidano, Kiyoshi Takeda
  • Organizer: 第48回 日本免疫学会総会
• [Presentation] TRAF6 in dendritic cells is required for resistance to Toxoplasma gondii infection. (2019)
  • Author(s): Shinya Hidano, Naganori Kamiyama, Nozomi Sachi, Sotaro Ozaka and Takashi Kobayashi
  • Organizer: 第12回寄生虫感染免疫研究会
• [Presentation] Regulation of innate and adaptive immunity by TRAF6 (2019)
  • Author(s): Takashi Kobayashi
  • Organizer: Bangkok, Department of Microbiology, Faculty of Science, Chulalongkorn University
  • Invited
• [Presentation] シグナル伝達分子TRAF6による自然免疫と獲得免疫の制御 (2019)
  • Author(s): Takashi Kobayashi
  • Organizer: 第38回岡山免疫懇話会
  • Invited
• [Presentation] アニサキス感染におけるIgE誘導機序の解析 (2019)
  • Author(s): 小林隆志, 飛彈野真也, 水上 一弘, 財津 純可, 草野 耀永, 伊藤 秀幸, Astri Dewayani, 小坂 聡太郎, Benjawan Saechue, 佐知望美, 神山長慶, 村上 和成
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] 樹状細胞のTRAF6シグナルは、トキソプラズマ感染早期コントロールに重要である (2019)
  • Author(s): 飛彈野真也, 神山長慶, 佐知望美, Astri Dewayani, 小坂 聡太郎, Benjawan Saechue, 小林隆志,
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] An effective and safe live attenuated vaccine developed by CRISPR gene editing for leishmaniasis. (2019)
  • Author(s): Shinjiro H
  • Organizer: 第12回寄生虫感染免疫研究会
• [Presentation] Functional expression and biochemical studies of Schistosoma mansoni sulfide : quinone oxidoreductase. (2019)
  • Author(s): Keith K. T, Daniel K. I, Yuichi M, Tetsuro K, Endah D. H, Tomoyoshi N, Shinjiro H, Kiyoshi K
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] Live attenuated Leishmania major as a prophylactic vaccine. (2019)
  • Author(s): Md. A. M, Nakamura R, Asma H, Greg M, Hira L. N, Abhay R. S, Shinjiro H
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] Spatio-temporal Transmission and Environmental Determinants of Schistosoma mansoni in Mbita, western Kenya. (2019)
  • Author(s): Evans C, Cheruiyot N. B, Sachiyo N, Toshihiko S, Njenga S. M, Shinjiro H
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] Novel inhibitors of Plasmodium falciparum mitochondrial malate:quinone oxidoreductase. (2019)
  • Author(s): Endah D. H, Daniel K. I, Takaya S, Xinying W, Kota M, Rajib A, Yuichi M, Mihoko M, Kazuro S, Tomoyoshi N, Shinjiro H, Kiyoshi K
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] ２型自然リンパ球は好中球及び好酸球の集積を調節することでアメーバ性肝膿瘍の病態形成を増悪させる。ILC2 exacerbates the pathogenesis of amebic liver abscess through promoting the accumulation of eosinophil and neutrophil. (2019)
  • Author(s): Risa N, Deloer S, Mihoko K, Shigeo K, Kazuyo M, Shinjiro H
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] 劇症型アニサキス症における発症要因・メカニズムの解明 (2018)
  • Author(s): 飛彈野真也、水上一弘、財津純可、草野耀永、伊藤秀幸、佐知望美、神山長慶、村上和成、小林隆志
  • Organizer: 第26回分子寄生虫ワークショップ
• [Presentation] SUPPRESSION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY SELECTIVE DELETION OF TRAF6 IN T-CELLS IN MICE (2018)
  • Author(s): Takashi Kobayashi, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi
  • Organizer: FMSA 2018
  • Int'l Joint Research
• [Presentation] 胃アニサキス症の劇症化メカニズムの解明 (2018)
  • Author(s): 飛彈野真也、水上一弘、財津純可、草野耀永、伊藤秀幸、佐知望美、神山長慶、村上和成、小林隆志
  • Organizer: 第9回癌・炎症と抗酸化研究会
• [Presentation] Development of a rapid and simple reverse transcription loop-mediated isothermal amplification for Chikungunya virus (2018)
  • Author(s): Benjawan Saechue, Naganori Kamiyama, Shinya Hidano, Kaori Noguchi, Yoshiko Gendo, Takashi Ozaki, Akira Sonoda, Haruna Hirise, Nozomi Sachi, Sotaro Ozaka, Takashi Kobayashi,
  • Organizer: 41回日本分子生物学会年会
• [Presentation] アフリカ株とアジア株SRIPsを用いた、ジカウイルスの宿主細胞侵入効率の解析 (2018)
  • Author(s): 神山長慶, 渡辺 景, Benjawan Saechue, 飛彈野真也, 野口香緒里, 玄同淑子, 尾崎貴士, 園田光, 広瀬 晴奈, 小坂 聡太郎, 佐知望美, 鈴木 亮介, 小林隆志
  • Organizer: 41回日本分子生物学会年会
• [Presentation] TRAF6 in dendritic cells regulates innate immune control of Toxoplasma gondii. (2018)
  • Author(s): Shinya Hidano, Naganori Kamiyama, Nozomi Sachi, Sotaro Ozaka and Takashi Kobayashi
  • Organizer: 第47回 日本免疫学会総会
• [Presentation] TRAF6 in Th17 cells exacerbates the severity of experimental autoimmue encephalomyelitis by regulating CCR6 expression (2018)
  • Author(s): Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Sotaro Ozaka, Takashi Kobayashi
  • Organizer: 第47回 日本免疫学会総会
• [Presentation] Combinatorial treatment of ampicillin and vancomycin induces colitis due to metabolic disorders and impaired epithelial barrier function in the gut (2018)
  • Author(s): Sotaro Ozaka, Akira Sonoda, Shinya Hidano, Naganori Kamiyama, Nozomi Sachi, Takashi Kobayashi
  • Organizer: 第47回 日本免疫学会総会
• [Presentation] Analysis of the localization of immunu cells in mice deficient in CC chemokine ligand CCL20 (2018)
  • Author(s): Nozomi Sachi, Shinya Hidano, Naganori Kamiyama, Sotaro Ozaka, Takashi Kobayashi
  • Organizer: 第47回 日本免疫学会総会
• [Presentation] Real-time PCRを用いた日本の土壌伝播蠕虫感染状況調査 (2018)
  • Author(s): 長谷川光子，Nils P，菊池三穂子，Arianna R. M，Judd L. W，Steven A. W，濱野真二郎
  • Organizer: 第29回日本臨床寄生虫学会
• [Presentation] Group 2 innate lymphoid cells exacerbate severe amebic liver abscess by IFN-γ independent manner in mice. (2018)
  • Author(s): Risa N, Sharmina D, Masachika S, Mihoko K, Shigeo K, Kazuyo M, Shinjiro H
  • Organizer: ICOPA2018 14th INTERNATIONAL CONGRESS OF PARASITOLOGY
  • Int'l Joint Research
• [Presentation] A persistent high intensity cluster of Schistosoma mansoni infection around Mbita causeway, western Kenya. (2018)
  • Author(s): Evans A, Benard N. C, Sammy M. N, Shinjiro H
  • Organizer: ICOPA2018 14th INTERNATIONAL CONGRESS OF PARASITOLOGY
  • Int'l Joint Research
• [Presentation] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes. (2018)
  • Author(s): Taeko M, Risa N, Sharmina D, Masachika S, Masato K, Megumi I, Richard C, Shinjiro H
  • Organizer: ICOPA2018 14th INTERNATIONAL CONGRESS OF PARASITOLOGY
  • Int'l Joint Research
• [Presentation] Live attenuated Leishmania major as a prophylactic vaccine. (2018)
  • Author(s): Md. A. M, Asma H, Risa N, Greg M, Hira L. N, Abhay R. S, Shinjiro H
  • Organizer: ICOPA2018 14th INTERNATIONAL CONGRESS OF PARASITOLOGY
  • Int'l Joint Research
• [Presentation] Host factors associated with the settlement of ameba in the gut and defense mechanisms to ameba. (2018)
  • Author(s): Shinjiro H
  • Organizer: ICOPA2018 14th INTERNATIONAL CONGRESS OF PARASITOLOGY
  • Int'l Joint Research
• [Presentation] Live attenuated Leishmania major as a prophylactic vaccine. (2018)
  • Author(s): Md. A. M, Asma H, Risa N, Greg M, Hira L. N, Abhay R. S, Shinjiro H
  • Organizer: 第17回あわじしま感染症・免疫フォーラム
  • Int'l Joint Research
• [Presentation] A Novel diagnostic method for schistosomiasis: detecting antibody against single proteins in human serum and urine. (2018)
  • Author(s): Mio T, Taeko M, Evans C. A, Benard N. C, Yoshito F, Satoshi K, Risa N, Shinjiro H
  • Organizer: 第71回日本寄生虫学会南日本支部大会・第68回日本衛生動物学会南日本支部大会合同大会
• [Presentation] Spatiotemporal epidemiology of Schistosoma mansoni infection at a small-scale level in Mbita, western Kenya. (2018)
  • Author(s): Chadeka E, Benard. N C, Sammy M. N, Shinjiro H
  • Organizer: 第71回日本寄生虫学会南日本支部大会・第68回日本衛生動物学会南日本支部大会合同大会
• [Presentation] Group 2 innate lymphoid cells exacerbate the pathogenesis of amebic liver abscess through promoting the accumulation of eosinophil and neutrophil. (2018)
  • Author(s): Risa N, Sharmina D, Masachika S, Mihoko K, Shigeo K, Kazuyo M, Shinjiro H
  • Organizer: 第71回日本寄生虫学会南日本支部大会・第68回日本衛生動物学会南日本支部大会合同大会
• [Presentation] Live attenuated Leishmania major as a prophylactic vaccine. (2018)
  • Author(s): Md. A. M, Risa N, Asma H, Greg M, Hira L. N, Abhay R. S, Shinjiro H
  • Organizer: 第71回日本寄生虫学会南日本支部大会・第68回日本衛生動物学会南日本支部大会合同大会
• [Presentation] Have soil-transmitted helminths been eliminated in Japan?-Targeted prevalence survey using highly sensitive and specific multi-parallel real-time PCR. (2018)
  • Author(s): Mitsuko H, Shinjiro H
  • Organizer: ASTMH 67th Annual Meeting
  • Int'l Joint Research
• [Presentation] Have soil-transmitted helminths been eliminated in Japan?-Targeted prevalence survey using highly sensitive and specific multi-parallel real-time PCR. (2018)
  • Author(s): Hasegawa M, Pilotte N, Kikuchi M, Means A, Walson J, Williams S, Hamano S
  • Organizer: ASTMH 67th Annual Meeting
  • Int'l Joint Research
• [Presentation] Evaluation of safety and efficacy of Leishmania major centrin deleted (LmCen-/-) live attenuated parasites as a prophylactic vaccine against Visceral Leishmaniasis (2018)
  • Author(s): Karmakar S, Dey R, Oliveira F, Ismail N, Zhang W, Hamano S, Matlashewski G, Satoskar A, Kamhawi S, Valenzuela JG., Nakhasi HL
  • Organizer: ASTMH 67th Annual Meeting
  • Int'l Joint Research
• [Presentation] Evaluation of real time PCR for diagnosis of Post-kala-azar dermal leishmaniasis (PKDL) in an endemic foci of Bangladesh (2018)
  • Author(s): Ghosh P, Hasnain Md G, Hossain Faria, Khan Md AA, Chowdhury R, Faisal K, Mural MH, Baker J, Nath R, Ghosh D, Maruf S, Haque R, Matlashewsk G, Hamano S, Duthie M, Mondal D
  • Organizer: ASTMH 67th Annual Meeting
  • Int'l Joint Research
• [Presentation] Group 2 innate lymphoid cells exacerbate amebic liver abscess through promoting the accumulation of eosinophil and neutrophil. (2018)
  • Author(s): 中村 梨沙, Deloer S, 千馬 正敬, 菊池 三穂子, 小安 重夫, 茂呂 和世, 濱野 真二郎
  • Organizer: 第59回日本熱帯医学会大会
• [Presentation] Serological surveillance system for multiple tropical infectious diseases using simultaneous microsphere-based multiplex assays and satellite images. (2018)
  • Author(s): 金子 聰, サムソン ムウオ, マチル ムワウ, 柴崎 亮介, 大平 亘, 宮崎 浩之, 多賀 優, 森保 妙子, 濱野 真二郎, 平山 謙二
  • Organizer: 第59回日本熱帯医学会大会
• [Presentation] ビクトリア湖浮遊ホテイアオイと未知の住血吸虫宿主貝の可能性 (2018)
  • Author(s): 二見 恭子, 菊池 三穂子, 原 史絵, 胡 錦萍, 皆川 昇, 濱野 真二郎
  • Organizer: 第59回日本熱帯医学会大会
• [Presentation] 土壌伝播蠕虫感染状況調査において任意の糞便検査参加に影響を及ぼす要因の調査 (2018)
  • Author(s): 長谷川光子, Chen-Yu Ma, Arianna R. M, 菊池三穂子, Judd L. W, 濱野真二郎
  • Organizer: 第12回蠕虫研究会
• [Presentation] A Novel diagnostic method for schistosomiasis: detecting antibody against single proteins in human serum and urine. (2018)
  • Author(s): Mio T, Taeko M, Evans C. A, Benard N. C, Yoshito F, Satoshi K, Risa N, Shinjiro H
  • Organizer: 第12回蠕虫研究会
• [Presentation] Group 2 innate lymphoid cells exacerbate severe amebic liver abscess by IFN-γ independent manner in mice. (2018)
  • Author(s): Risa N, Sharmina D, Masachika S, Mihoko K, Shigeo K, Kazuyo M, Shinjiro H
  • Organizer: ILC2018; The 3rd International Conference on Innate Lymphoid Cells
  • Int'l Joint Research
• [Presentation] Group 2 innate lymphoid cells exacerbate severe amebic liver abscess by IFN-γ independent manner in mice. (2018)
  • Author(s): Risa N, Sharmina D, Masachika S, Mihoko K, Shigeo K, Kazuyo M, Shinjiro H
  • Organizer: 第47回日本免疫学会学術集会
• [Presentation] 子ども感染症教室in対馬～正しい知識で感染症から身を守ろう！～ (2018)
  • Author(s): 森保 妙子, 嶋田 聡, 今西 望
  • Organizer: 対馬学フォーラム2017
• [Presentation] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes (2018)
  • Author(s): Taeko Moriyasu, Risa Nakamura, Richard Culleton, Shinjiro Hamano
  • Organizer: 日米医学寄生虫疾患部会合同会議
  • Int'l Joint Research
• [Presentation] Group 2 innate lymphoid cells exacerbate severe amebic liver abscess by IFN-g independent manner in mice (2018)
  • Author(s): Risa Nakamura, Sharmina Deloer, Masachika Senba, Mihoko Kikuchi, Shigeo Koyasu, Kazuyo Moro, Shinjiro Hamano
  • Organizer: 第11回寄生虫感染免疫研究会
• [Presentation] Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya. (2018)
  • Author(s): Evans Asena Chadeka, Sachiyo Nagi, Toshihiko Sunahara, 他19名, Shinjiro Hamano
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes. (2018)
  • Author(s): Taeko Moriyasu, Risa Nakamura, Richard Culleton, Shinjiro Hamano
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] Group 2 innate lymphoid cells exacerbate severe amebic liver abscess by IFN-g independent manner in mice. (2018)
  • Author(s): Risa Nakamura, Sharmina Deloer, Masachika Senba, Mihoko Kikuchi, Shigeo Koyasu, Kazuyo Moro, Shinjiro Hamano
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] Analysis of a fluorescent material in Anisakis larvae. (2018)
  • Author(s): Shinya Hidano, Tadashi Kondo, Kazuhiro Mizukami, Makoto Nakatani, Naganori Kamiyama, Nozomi Sachi, Kazunari Murakami, Osamu Hirose and Takashi Kobayashi
  • Organizer: 第11回寄生虫感染免疫研究会
• [Presentation] Analysis of a fluorescent material in Anisakis larvae. (2018)
  • Author(s): Naganori Kamiyama, Benjawan Sae-chue, Yinan Wang, Akinaga Kusano, Nozomi Sachi, Shinya Hidano and Takashi Kobayashi
  • Organizer: 第11回寄生虫感染免疫研究会
• [Presentation] T細胞特異的TRAF6欠損マウスは実験的自己免疫性脳脊髄炎の発症が抑制される (2018)
  • Author(s): Naganori Kamiyama, Benjawan Saechu, Shinya Hidano, Kei Watanabe, Hidekazu Matsuoka, Kaori Noguchi, Yoshiko Gendo, Takashi Ozaki, Akira Sonoda, Nozomi Sachi, Yuki Eshita, Takashi Kobayashi
  • Organizer: 第4回病因研究会別府シンポジウム
• [Presentation] アストロサイトのSTAT1シグナルは、トキソプラズマ脳炎のコントロールに重要である。 (2017)
  • Author(s): Shinya Hidano, Christoph Konradt, Daniel P. Beiting, Lothar Hennighausen, Serge Fuchs, Anita A. Koshy, Naganori Kamiyama, Takashi Kobayashi and Christopher A Hunter.
  • Organizer: 第86回 日本寄生虫学会大会
• [Presentation] 蛍光特性を示すアニサキス種の同定ならびに食品検査への応用 (2017)
  • Author(s): 近藤 雅，中谷 誠 , 飛彈野 真也 ，小林 隆志
  • Organizer: 第86回 日本寄生虫学会大会
• [Presentation] ヒト感染アニサキス症における種の同定と臨床症状との関連の検討 (2017)
  • Author(s): 水上一弘、飛騨野真也、伊藤秀幸、神山長慶、相馬 渉、阿部寿徳、勝田真琴、安部高志、永井敬之、後藤康彦、井上邦光、大場一生、卜部繁俊、吉田 亮、大仁田賢、安部高志、永井敬之、後藤康彦、井上邦光、大場一生、卜部繁俊、吉田 亮、大仁田賢、村上和成、小林隆志
  • Organizer: 第86回 日本寄生虫学会大会
• [Presentation] トキソプラズマ脳炎におけるアストロサイトの感染防御機構の解明 (2017)
  • Author(s): 飛彈野真也, Christoph Konradt, Daniel P. Beiting, 神山長慶, 小林隆志、Christopher A Hunter.
  • Organizer: 第２５回分子寄生虫学ワークショップ
• [Presentation] アストロサイトのSTAT1シグナルは、トキソプラズマ脳炎のコントロールに重要である。 (2017)
  • Author(s): Shinya Hidano, Christoph Konradt, Daniel P. Beiting, Lothar Hennighausen, Serge Fuchs, Anita A. Koshy, Naganori Kamiyama, Takashi Kobayashi and Christopher A Hunter.
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice (2017)
  • Author(s): Naganori Kamiyama, Ryusuke Soma, Shinya Hidano, Benjawan Saechue, Nozomi Sachi, Kaori Noguchi, Takashi Ozaki, Akira Sonoda, Yoshiko Gendo, Yuki Eshita, and Takashi Kobayashi,
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Inhibition of TLR9-induced dendritic cell activation and pro-inflammatory cytokine production by Oleoylethanolamide, whose level is reduced in MRL/lpr mice (2017)
  • Author(s): 尾崎貴士, 園田光, 玄同淑子 , 野口香緒里, 佐知望美, 神山長慶 , 飛彈野真也 , 石井宏治 , 柴田洋孝 , 小林隆志
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] 新規脂質メディエーターのOEA及びPEAは、Toll様受容体9（TLR9）刺激による樹状細胞とB細胞の活性化を抑制する (2017)
  • Author(s): 尾崎 貴士 , 後藤 亮, 園田 光, 広瀬 晴奈, 玄同 淑子 , 野口 香緒里 , 神山 長慶 , 飛彈野 真也 , 石井 宏治 , 柴田 洋孝 , 小林 隆志
  • Organizer: 第8回 癌・炎症と抗酸化研究会（CIA研究会）
• [Presentation] "Analysis for the induction and pathophysiological role of CCL20 in the intestinal tissue " (2017)
  • Author(s): Nozomi Sachi, Shinya Hidano, Naganori Kamiyama, Kaori Noguchi, Takashi Ozaki, Akira Sonoda, Yoshiko Gendo, Takashi Kobayashi
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Sharing the experiences of soil-transmitted helminth elimination in Japan to contribute to developing elimination strategies. (2017)
  • Author(s): Mitsuko Hasegawa, Shinjiro Hamano, Mihoko Kikuchi
  • Organizer: The 13th Nagasaki-Singapore Medical Symposium / Leading Program International Symposium 2017
  • Int'l Joint Research
• [Presentation] Spatial Distribution and Risk Factors of Schistosoma haematobium and Hookworm Infections among Schoolchildren in Kwale, Kenya (2017)
  • Author(s): Evans Chadeka, Sachiyo Nagi, Toshihiko Sunahara, Ngetich Cheruiyot, Felix Bahati, Shinjiro Hamano
  • Organizer: The 13th Nagasaki-Singapore Medical Symposium / Leading Program International Symposium 2017
  • Int'l Joint Research
• [Presentation] IL-17A may help to persist of Entamoeba histolytica by keeping antagonistic relationship with Th1 response in animal model of intestinal amebiasis. (2017)
  • Author(s): Sharmina Deloer, Risa Nakamura, Mihoko Kikuchi, Masachika Senba, Taeko Moriyasu, Eman Sayed Mohammed, Shinjiro Hamano
  • Organizer: The 13th Nagasaki-Singapore Medical Symposium / Leading Program International Symposium 2017
  • Int'l Joint Research
• [Presentation] Pre-existing Schistosoma mansoni infection dampened sporozoite-induced malaria liver burden (2017)
  • Author(s): Taeko Moriyasu, Risa Nakamura, Richard Culleton, Shinjiro Hamano
  • Organizer: The 13th Nagasaki-Singapore Medical Symposium / Leading Program International Symposium 2017
  • Int'l Joint Research
• [Presentation] Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice. (2017)
  • Author(s): Risa Nakamura, Sharmina Deloer, Kazuyo Moro, Shinjiro Hamano
  • Organizer: The 13th Nagasaki-Singapore Medical Symposium / Leading Program International Symposium 2017
  • Int'l Joint Research
• [Presentation] Risk factor for VL and predictors of relapse after treatment in VL. (2017)
  • Author(s): Dinesh Mondal, Shinjiro Hamano, Debashis Ghosh, Abdul Alim, Md. Golam Hasnain, M. Mamun Huda, Moshtaq Ahmed Mural, Md. Shakhawat Hossain, Jorge Alvar, Byron Arana, Jose Postigo, Daniel Argaw, Greg Matlashewski, Be-Nazir Ahmed, Malcolm Duthie, Steve G Reed
  • Organizer: 6ｔｈ World Congress on Leishmaniasis
  • Int'l Joint Research
• [Presentation] Dinesh Mondal: Post Kala-azar Dermal Leishmaniasis without previous history of visceral leishmaniasis: A case series on identification, confirmation, and treatment. (2017)
  • Author(s): Md Hasnain Golam, Mohammad Shomik Sohel; Prakash Ghosh; Mamun Rashid Or; Md Hossain Shakhawat; Shinjiro Hamano
  • Organizer: 6ｔｈ World Congress on Leishmaniasis
  • Int'l Joint Research
• [Presentation] マンソン住血吸虫の先行感染がマラリア肝臓ステージに及ぼす影響 (2017)
  • Author(s): 森保妙子、中村梨沙、Richard Culleton、濱野真二郎
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice. (2017)
  • Author(s): 中村梨沙, Sharmina Deloer, 茂呂和世, 濱野真二郎
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] ケニア共和国、ビクトリア湖畔のマンソン住血吸虫症浸淫地における中間宿主Biomphalaria spp.のマンソン住血吸虫感染率について (2017)
  • Author(s): 菊池三穂子、二見恭子、凪幸世、Evans A. Chadeka、原史絵、皆川昇、平山謙二、濱野真二郎
  • Organizer: 第11回蠕虫研究会
• [Presentation] 日本の土壌伝播蠕虫感染率調査 ―検便回収率と回収率向上要因― (2017)
  • Author(s): 長谷川 光子、濱野 真二郎、菊池 三穂子
  • Organizer: 第11回蠕虫研究会
• [Presentation] Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice (2017)
  • Author(s): Risa Nakamura, Sharmina Deloer, Kazuyo Moro, Shinjiro Hamano
  • Organizer: 第16回あわじしま感染症・免疫フォーラム
• [Presentation] Modulation of the immune responses by Plasmodium falciparum infection in asymptomatic children living in the endemic region of Mbita, western Kenya (2017)
  • Author(s): Kijogi C, Kimura D, Bao L.Q, Nakamura R, Chadeka E.A, Cheruiyot N.B, Bahati F, Yahata K, Kaneko O, Njenga S.M, Ichinose Y, Hamano S, Yui K
  • Organizer: 第16回あわじしま感染症・免疫フォーラム
• [Presentation] Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice. (2017)
  • Author(s): Risa Nakamura, Sharmina Deloer, Kazuyo Moro, Shinjiro Hamano
  • Organizer: The 5th Annual Meeting of the International Cytokine and Interferon Society
• [Presentation] IL-17A contributes to the decrease of IFN-γ/IL-4 ratio and the persistence of Entamoeba histolytica during intestinal amebiasis. (2017)
  • Author(s): Sharmina Deloer, Risa Nakamura, Mihoko Kikuchi, Taeko Moriyasu, Yombo Dan Justin Kalenda, Eman Sayed Mohammed, Masachika Senba, Yoichiro Iwakura, Hiroki Yoshida, Shinjiro Hamano
  • Organizer: The 5th Annual Meeting of the International Cytokine and Interferon Society
• [Presentation] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes (2017)
  • Author(s): Taeko Moriyasu, Risa Nakamura, Sharmina Deloer, Richard Culleton, Shinjiro Hamano
  • Organizer: 第70回日本寄生虫学会南日本支部大会第67回日本衛生動物学会南日本支部大会合同大会（2017）
• [Presentation] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes (2017)
  • Author(s): Taeko Moriyasu, Risa Nakamura, Sharmina Deloer, Richard Culleton, Shinjiro Hamano
  • Organizer: グローバルヘルス合同大会2017
• [Presentation] 未来への礎をいかに築くべきか How should we lay the foundation for the future of tropical medicine. (2017)
  • Author(s): 濱野 真二郎
  • Organizer: グローバルヘルス合同大会2017
• [Presentation] Type 2 innate lymphoid cells exacerbate severe amebic liver abscess in mice. (2017)
  • Author(s): Risa Nakamura, Sharmina Deloer, Kazuyo Moro, Shinjiro Hamano
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] combined administration of ampicillin and vancomycin induces mild colitis with decreased diversity of gut microbiota and perturbation of glutamine and short chain fatty acid metabolisms. (2017)
  • Author(s): A.Sonoda，N.Sachi，Y.Gendo，T.0zaki，N.Kamiyama，S.Hidano，K.Mizukami，T.0kimoto，K.Murakami，T.Kobayashi
  • Organizer: 25th United European Gastroenterology Week
• [Presentation] アンピシリンとバンコマイシンの投与によってグルタミン酸代謝と短鎖脂肪酸の発酵が障害され、マウス腸炎が誘発される。 (2017)
  • Author(s): 園田光、玄同淑子、尾崎貴士、佐知望美、飛弾野真也、神山長慶、村上和成、小林隆志
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Book] 寄生虫症薬物治療の手引き (2019)
  • Author(s): 濱野真二郎
  • Total Pages: 111
  • Publisher: 熱帯病治療薬研究班
• [Book] 標準微生物学 第13版 (2018)
  • Author(s): 中込 治, 濱野 真二郎
  • Total Pages: 663
  • Publisher: 医学書院
  • ISBN: 4260034561
• [Book] 今日の治療指針 2018年版［デスク判］ (2018)
  • Author(s): 福井 次矢, 濱野 真二郎
  • Total Pages: 2066
  • Publisher: 医学書院
  • ISBN: 426003233X
• [Book] “Feigin, Cherry, Demmler, Kaplan: Textbook of Pediatric Infectious Disease, 8th edition” (2018)
  • Author(s): James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, Peter J Hotez, Shinjiro H
  • Total Pages: 3152
  • Publisher: Elsevier
• [Book] 第40章 寄生虫と宿主、第41章 原虫学、第42章 蠕虫学、標準微生物学 第13版 (2018)
  • Author(s): 濱野真二郎
  • Publisher: 医学書院
  • ISBN: 9784260034562
• [Book] Chapter 209: Amoebiasis in “Feigin, Cherry, Demmler, Kaplan: Textbook of Pediatric Infectious Disease, 8th edition” Elsevier (2018)
  • Author(s): Hamano, S. and William A. Petri Jr.
  • Publisher: London
  • ISBN: 9780323376921
• [Book] 鞭虫症、今日の治療指針 2018 (2018)
  • Author(s): 濱野真二郎
  • Publisher: 医学書院
  • ISBN: 9784260032339
• [Book] Protozoan Diseases: Amebiasis. In: Quah, S.R. and Cockerham, W.C. (eds.) The International Encyclopedia of Public Health, 2nd edition. (2017)
  • Author(s): Hamano, S. Protozoan Diseases: Amebiasis. In
  • Total Pages: 6
  • Publisher: Oxford: Academic
  • ISBN: 9780128036785
• [Book] リーシュマニア症、今日の治療指針 2017 (2017)
  • Author(s): 濱野真二郎
  • Total Pages: 3
  • Publisher: 医学書院
  • ISBN: 9784260028097
• [Patent(Industrial Property Rights)] 迅速・簡便なチクングニア熱診断に資するRT-LAMPの為の新規プライマーの発明 (2019)
  • Inventor(s): 小林 隆志、神山 長慶、セーシュ ベンジャワン
  • Industrial Property Rights Holder: 小林 隆志、神山 長慶、セーシュ ベンジャワン
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] ジカウイルス感染症治療用医薬組成物 (2017)
  • Inventor(s): 小林隆志、神山長慶、相馬颯介、飛彈野真也
  • Industrial Property Rights Holder: 国立大学法人大分大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017