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International Study for Development and Clinical Aplication of Lupus Biomarkers Reflecting Renal Inflammation

Research Project

Project/Area Number 17H04667
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Kidney internal medicine
Research InstitutionFujita Health University (2018-2019)
Nagoya University (2017)

Principal Investigator

Tsuboi Naotake  藤田医科大学, 医学部, 教授 (50566958)

Co-Investigator(Kenkyū-buntansha) 湯澤 由紀夫  藤田医科大学, 医学部, 教授 (00191479)
丸山 彰一  名古屋大学, 医学系研究科, 教授 (10362253)
林 宏樹  藤田医科大学, 医学部, 准教授 (10378086)
勝野 敬之  愛知医科大学, 医学部, 准教授 (60642337)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsループス腎炎 / 白血球 / バイオマーカー / 疾患活動性予測 / 腎生検 / 尿中バイオマーカー / 活動性予測 / 生体分子 / 臨床診断 / CD11b / Fcg受容体 / CD163 / 疾患活動性 / 組織分類
Outline of Final Research Achievements

Because kidney biopsy essential for diagnosis is associated with risk of bleeding and requires hospitalization of patients, repeated examinations for the evaluation of therapeutic efficacy and disease recurrence are not encouraged.
We hypothesized that surface molecules on inflammatory glomerular leukocytes leak into urine. Accordingly, we analyzed bio-samples from domestic and international patients with kidney diseases. The study revealed significant elevation of urinary CD11b with increased numbers of glomerular leukocytes expressing CD11b in patients with lupus nephritis, a major kidney complication of systemic lupus erhythematosus, and in patients with vasculitis. Further analysis of the diagnostic performance for predicting active lupus nephritis demonstrated marked superiority of urinary CD11b compared with two other leukocyte-derived molecules (CD163 and CD16b).

Academic Significance and Societal Importance of the Research Achievements

本研究成果から、尿中CD11bはループス腎炎、血管炎関連腎炎の診断法としてのみならず、経過中の治療効果判定や再発予測のための検査法として有用だと示唆されました。また、本国での腎疾患の治療現場のみならず、不充分な医療環境から患者が正確に組織診断されることなく末期の腎不全に陥るような発展途上国においても、本法は外来の尿検査で行える負担の低い検査法として期待できます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (13 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] Zhongshan Hospital, Fudan University(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Inst. Nac. Cien. Med. Nutr. Sal. Zubiran(メキシコ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Investigadora en Ciencias Medicas(Mexico)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Zhongshan Hospital, Fudan University(China)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Clinical Impact of Urinary CD11b and CD163 on the Renal Outcomes of Anti-neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis2020

    • Author(s)
      Yuki Yokoe, Naotake Tsuboi, Takahiro Imaizumi, Akimitsu Kitagawa, Munetoshi Karasawa, Takaya Ozeki, Nobuhide Endo, Yuriko Sawa, Sawako Kato, Takayuki Katsuno, Shoichi Maruyama, and Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis and for Intractable Renal Disease
    • Journal Title

      Nephrol Dial Transplant.

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis.2019

    • Author(s)
      Kitagawa A, Tsuboi N, Yokoe Y, Katsuno T, Ikeuchi H, Kajiyama H, Endo N, Sawa Y, Suwa J, Sugiyama Y, Hachiya A, Mimura T, Hiromura K, Maruyama S.
    • Journal Title

      Kidney Int.

      Volume: 95(3) Issue: 3 Pages: 680-692

    • DOI

      10.1016/j.kint.2018.10.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis.2018

    • Author(s)
      Katsuno T, Ozaki T, Ozeki T, Hachiya A, Kim H, Kato N, Ishimoto T, Kato S, Kosugi T, Mizuno M, Ito Y, Marutama S.
    • Journal Title

      Clin Exp nephrol.

      Volume: 22 Issue: 6 Pages: 1341-1350

    • DOI

      10.1007/s10157-018-1590-2

    • NAID

      120006627981

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] CLINICAL IMPACTS OF URINARY CD11B AND CD163 ON PATIENT OUTCOMES IN ANCA-ASSOCIATED GLOMERULONEPHRITIS2019

    • Author(s)
      N. Tsuboi, Y. Yokoe, M. Karasawa, Y. Yuzawa, S. Maruyama
    • Organizer
      ASN Kidney Week 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Urinary CD11b and CD163 Reflect Clinical and Histological Diseas Activity in Renal Involvement of Anti-Neutrophil Cytoplasmic Anti-body-Associated Vasculitides.2018

    • Author(s)
      Yuki Yokoe, Naotake Tsuboi, Shoichi Maruyama
    • Organizer
      Kidney Week 2018 - San Diego, CA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic Efficacy and Safety of Human Adipose-Derived Stem Cells for Anti-GBM Nephritis.2018

    • Author(s)
      Yuko Shimamura, Naotake Tsuboi, Yutaka Kamimura, Shoichi Maruyama
    • Organizer
      Kidney Week 2018 - San Diego, CA
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ANCA関連血管炎における尿中可溶性CD11bとCD163の意義2018

    • Author(s)
      横江優貴、島村涌子、北川晃充、坪井直毅、丸山 彰一
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] glomerular inflammation in antibody-mediated glomerulonephritis2018

    • Author(s)
      Akimitsu Kitagawa, Naotake Tsuboi, Yuko Shimamura, Yutaka Kamimura, Shoichi Maruyama
    • Organizer
      ISN Frontiers Meetings 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Urinary AlphaM Subunit of Integrin Mac-1 Associates With Glomerular Inflammation in Lupus Nephritis2017

    • Author(s)
      Akimitsu Kitagawa, Naotake Tsuboi, Yutaka Kamimura, Takayuki Katsuno, Shoichi Maruyama
    • Organizer
      50th Annual Meeting of the American Society of Nephrology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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