Elucidation of genetic factors of muscle injury risk

• Project/Area Number: 17H04752
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Juntendo University (2018-2020); National Institute of Fitness and Sports in Kanoya (2017)
• Principal Investigator: Miyamoto Eri 順天堂大学, スポーツ健康科学研究科, 助教 (00793390)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2019: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2017: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
• Keywords: 遺伝子多型 / 肉離れ / 骨格筋 / 材料特性 / スポーツ障害 / GWAS / 筋スティフネス / スポーツ傷害

Outline of Final Research Achievements

The present study examined the associations of candidate gene polymorphisms with muscle injury risk in Japanese athletes. Four gene polymorphisms (ACE I/D [rs1799752], COL1A1 A/C [rs1107946], COL22A1 A/C [rs11784270]・T/C [rs6577958]）were associated with muscle injury risk in Japanese athletes. Our results suggest that the COL1A1 A/C polymorphism affects risk of muscle injury by altering the properties of muscle tissue, potentially owing to different composition of type I collagen.

Academic Significance and Societal Importance of the Research Achievements

本研究は、人が生まれながらに持つ遺伝子多型が、骨格筋の特性に影響し、肉離れの受傷リスクに影響することを明らかにした。この結果は、骨格筋の特性をターゲットとした新たな予防法の開発、さらには個人の遺伝的体質を考慮したスポーツ外傷・障害予防法の構築につながる知見である。

Research Products

• [Int'l Joint Research] University of Cagliari(イタリア)
• [Int'l Joint Research] University of Cagliari(イタリア)
• [Int'l Joint Research] University of Cagliari(イタリア)
• [Journal Article] Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury (2021)
  • Author(s): Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N
  • Journal Title: Medicine & Science in Sports & Exercise Volume: Publish Ahead of Print Pages: 0-0
  • DOI: 10.1249/mss.0000000000002658
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players (2020)
  • Author(s): Massidda Myosotis、Miyamoto-Mikami Eri、Kumagai Hiroshi、Ikeda Hayato、Shimasaki Yu、Yoshimura Masafumi、Cugia Paolo、Piras Francesco、Scorcu Marco、Kikuchi Naoki、Cal? Carla Maria、Fuku Noriyuki
  • Journal Title: Journal of Sports Sciences Volume: 38 Pages: 2423-2429
  • DOI: 10.1080/02640414.2020.1787683
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness (2019)
  • Author(s): Hiroshi Kumagai、Eri Miyamoto-Mikami、Kosuke Hirata、Naoki Kikuchi、Nobuhiro Kamiya、Seigo Hoshikawa、Hirofumi Zempo、Hisashi Naito、Naokazu Miyamoto、Noriyuki Fuku
  • Journal Title: Medicine and Science in Sports and Exercise. Volume: 1 Pages: 19-26
  • DOI: 10.1249/mss.0000000000001750
  • Peer Reviewed / Open Access
• [Journal Article] COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes. (2019)
  • Author(s): Miyamoto-Mikami E, Miyamoto N, Kumagai H, Hirata K, Kikuchi N, Zempo H, Kimura N, Kamiya N, Kanehisa H, Naito H, Fuku N.
  • Journal Title: BMC Medical Genetics Volume: 20 Pages: 192-192
  • DOI: 10.1186/s12881-019-0928-2
  • Peer Reviewed / Open Access
• [Journal Article] Associations of passive muscle stiffness, muscle stretch tolerance, and muscle slack angle with range of motion: individual and sex differences (2018)
  • Author(s): Miyamoto Naokazu、Hirata Kosuke、Miyamoto-Mikami Eri、Yasuda Osamu、Kanehisa Hiroaki
  • Journal Title: Scientific Reports Volume: 8 Pages: 8274-8274
  • DOI: 10.1038/s41598-018-26574-3
  • Peer Reviewed / Open Access
• [Journal Article] Association analysis of the ACTN3 R577X polymorphism with passive muscle stiffness and muscle strain injury (2018)
  • Author(s): Miyamoto N、Miyamoto-Mikami E、Hirata K、Kimura N、Fuku N
  • Journal Title: Scandinavian Journal of Medicine & Science in Sports Volume: 28 Pages: 1209-1214
  • DOI: 10.1111/sms.12994
  • Peer Reviewed
• [Journal Article] Heritability estimates of endurance-related phenotypes: A systematic review and meta-analysis. (2018)
  • Author(s): Miyamoto-Mikami E, Zempo H, Fuku N, Kikuchi N, Miyachi M, Murakami H.
  • Journal Title: Scand J Med Sci Sports. Volume: 28 Pages: 834-845
  • DOI: 10.1111/sms.12958
  • Peer Reviewed
• [Journal Article] AGTR2 and sprint/power performance: a case-control replicationstudy for rs11091046 polymorphism in two ethnicities (2018)
  • Author(s): Yvert TP、Zempo H、Gabdrakhmanova LJ、Kikuchi N、Miyamoto-Mikami E、Murakami H、Naito H、Miyachi M、Fuku N et al.
  • Journal Title: Biology of Sport. Volume: - Pages: 105-109
  • DOI: 10.5114/biolsport.2018.71599
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness (2017)
  • Author(s): Willems Sara M.、Wright Daniel J.、Day Felix R.、Fuku N, et al.
  • Journal Title: Nature Communications Volume: 8 Pages: 16015-16015
  • DOI: 10.1038/ncomms16015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contributions of Hamstring Stiffness to Straight-Leg-Raise and Sit-and-Reach Test Scores (2017)
  • Author(s): Miyamoto Naokazu、Hirata Kosuke、Kimura Noriko、Miyamoto-Mikami Eri
  • Journal Title: International Journal of Sports Medicine Volume: 39 Pages: 110-114
  • DOI: 10.1055/s-0043-117411
  • Peer Reviewed
• [Presentation] Implication of genetic polymorphisms on sports performance (2019)
  • Author(s): Eri Miyamoto-Mikami
  • Organizer: 9th FAOPS Congress
  • Int'l Joint Research
• [Presentation] Association analysis of COL1A1 and COL5A1 polymorphisms with muscle stiffness and muscle injury (2018)
  • Author(s): Eri Miyamoto-Mikami, Kosuke Hirata, Hiroshi Kumagai, Naoki Kikuchi, Noriko Kimura, Nobuhiro Kamiya, Noriyuki Fuku, Naokazu Miyamoto
  • Organizer: 23th Annual Congress of the ECSS
  • Int'l Joint Research
• [Presentation] I型コラーゲン遺伝子多型は女性の関節柔軟性および筋傷害受傷に関連する (2018)
  • Author(s): 宮本(三上) 恵里, 熊谷 仁, 平田 浩祐, 菊池 直樹, 神谷 宣広, 膳法 浩史, 星川 精豪, 内藤 久士, 宮本 直和, 福 典之
  • Organizer: 第73回日本体力医学会大会
• [Presentation] rs2234693 polymorphism in the ESR1 is associated with muscle injury and muscle stiffness in Japanese population (2018)
  • Author(s): Hiroshi Kumagai, Eri Miyamoto-Mikami, Kosuke Hirata, Naoki Kikuchi, Nobuhiro Kamiya, Seigo Hoshikawa, Hirofumi Zempo, Hisashi Naito, Naokazu Miyamoto, Noriyuki Fuku
  • Organizer: 23th Annual Congress of the ECSS
  • Int'l Joint Research
• [Presentation] ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players (2018)
  • Author(s): Myosotis Massidda, Eri Miyamoto-Mikami, Hiroshi Kumagai, Carla Maria Calò, Paolo Cugia, Naoki Kikuchi, Marco Scorcu, Noriyuki Fuku
  • Organizer: 35the FIMS World Congress of Sports Medicine
  • Int'l Joint Research
• [Presentation] Association analysis of ACTN3 R577X polymorphism with muscle stiffness and muscle strain injury (2017)
  • Author(s): Miyamoto-Mikami E、Hirata K、Fuku N、Kimura N、Miyamoto N
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] エストロゲン受容体遺伝子多型は筋硬度および筋損傷の発症歴に関連する (2017)
  • Author(s): 熊谷仁、平田浩祐、膳法浩史、宮本（三上）恵里、宮本直和、福典之
  • Organizer: 日本体力医学会大会
• [Presentation] 椎間板変性疾患感受性遺伝子多型がボート選手の腰椎椎間板変性に与える影響 (2017)
  • Author(s): 関根千恵、宮本（三上）恵里、大久保雄、半谷美夏、金岡恒治
  • Organizer: 日本腰痛学会
• [Remarks] 順天堂ニュース プレスリリース
  • URL: https://www.juntendo.ac.jp/news/20210407-01.html