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Production of functional materials from biocompatibility nanofibers and water

Research Project

Project/Area Number 17H04893
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Polymer/Textile materials
Research InstitutionShinshu University

Principal Investigator

Osada Mitsumasa  信州大学, 学術研究院繊維学系, 准教授 (70435402)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Keywordsナノファイバー / 糖鎖 / タンパク質 / 蛋白質
Outline of Final Research Achievements

Biocompatibility nanofibers such as cellulose, chitin, and proteins were converted to a self-sustaining hydrogel through wet pulverization and hydrothermal gelation. The effects of temperature and treatment time on the physicochemical properties of hydrogel were revealed. The cellulose nanofiber hydrogels formed via hydrothermal treatment were physical gels, and that the network structure may have formed through simple attractive forces.

Academic Significance and Societal Importance of the Research Achievements

安心安全かつ生体適合性の高い材料が,再生医療分野で求められている.各種細胞を培養する基材としてハイドロゲルが注目されているが,その作製過程では有害な化学物質が用いられており,その残存が懸念される.これに対して本研究では,生体親和性の高い自然由来の素材と水だけを用いたハイドロゲルの作製を達成した.生体に優しい素材と水だけで,なぜゲル化が起こるのかを解明したことの学術的意義も大きい.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (42 results)

All 2020 2019 2018 2017

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (31 results) (of which Int'l Joint Research: 14 results,  Invited: 8 results) Book (2 results)

  • [Journal Article] Effect of the degree of acetylation on the physicochemical properties of α-chitin nanofibers2020

    • Author(s)
      Machida Junnosuke、Suenaga Shin、Osada Mitsumasa
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 155 Pages: 350-357

    • DOI

      10.1016/j.ijbiomac.2020.03.213

    • NAID

      120007099525

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrothermal Gelation of Pure Cellulose Nanofiber Dispersions2019

    • Author(s)
      Suenaga Shin、Osada Mitsumasa
    • Journal Title

      ACS Applied Polymer Materials

      Volume: 1 Issue: 5 Pages: 1045-1053

    • DOI

      10.1021/acsapm.9b00076

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-catalytic conversion of chitin into Chromogen I in high-temperature water2019

    • Author(s)
      Osada Mitsumasa、Kobayashi Hisaya、Miyazawa Tatsuya、Suenaga Shin、Ogata Makoto
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 136 Pages: 994-999

    • DOI

      10.1016/j.ijbiomac.2019.06.123

    • NAID

      120007099830

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conversion of N-acetyl-d-glucosamine to nitrogen-containing chemicals in high-temperature water2019

    • Author(s)
      Osada Mitsumasa、Shoji Shinya、Suenaga Shin、Ogata Makoto
    • Journal Title

      Fuel Processing Technology

      Volume: 195 Pages: 106154-106154

    • DOI

      10.1016/j.fuproc.2019.106154

    • NAID

      120007099708

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Self-Sustaining Hydrogels by Hydrothermal Gelation of Biomass-Derived Nanofibers2019

    • Author(s)
      Osada Mitsumasa
    • Journal Title

      The Review of High Pressure Science and Technology

      Volume: 29 Issue: 3 Pages: 194-198

    • DOI

      10.4131/jshpreview.29.194

    • NAID

      130007723997

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Preparation of β-chitin nanofiber aerogels by lyophilization2019

    • Author(s)
      Suenaga Shin、Osada Mitsumasa
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 126 Pages: 1145-1149

    • DOI

      10.1016/j.ijbiomac.2019.01.006

    • NAID

      120007100082

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parameters of hydrothermal gelation of chitin nanofibers determined using a severity factor2018

    • Author(s)
      Suenaga Shin、Osada Mitsumasa
    • Journal Title

      Cellulose

      Volume: 25 Issue: 12 Pages: 6873-6885

    • DOI

      10.1007/s10570-018-2053-3

    • NAID

      120007100097

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-sustaining Cellulose Nanofiber Hydrogel Produced by Hydrothermal Gelation without Additives2018

    • Author(s)
      Suenaga Shin、Osada Mitsumasa
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 4 Pages: 1536-1545

    • DOI

      10.1021/acsbiomaterials.8b00026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic Dynamic Viscoelasticity Measurements for Chitin Nanofibers Prepared with Various Concentrations, Disintegration Times, Acidities, and Crystalline Structures2018

    • Author(s)
      Suenaga Shin、Osada Mitsumasa
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 115 Pages: 431-437

    • DOI

      10.1016/j.ijbiomac.2018.04.082

    • NAID

      120007100336

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Preparation of Self-standing Hydrogels based on Biomass Nanofibers by Hydrothermal Gelation2019

    • Author(s)
      Mitsumasa Osada
    • Organizer
      13th Pacific Rim Conference of Ceramic Societies (PACRIM13)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Production of Self-sustaining Hydrogel of Cellulose Nanofiber by Using Only Heat and Pressure2019

    • Author(s)
      Mitsumasa Osada, Shin Suenaga
    • Organizer
      1st International Conferences on Noncovalent Interactions (ICNI-2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Functional Groups on Monosaccharide Reactions in High-temperature and High-pressure Water2019

    • Author(s)
      Mitsumasa Osada, Takashi Onoda, Makoto Ogata
    • Organizer
      The 18th Congress of Asian-Pacific Confederation of Chemical Engineering (APCChE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Chitin Nanofiber Dispersion with High Viscosity and Self-sustaining Hydrogel from α-Chitin2019

    • Author(s)
      Junnosuke Machida, Shin Suenaga, Iori Shimada, Hiroshi Fukunaga, Nobuhide Takahashi, Mitsumasa Osada
    • Organizer
      The 18th Congress of Asian-Pacific Confederation of Chemical Engineering (APCChE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 水だけを用いたセルロースおよびキチンのナノファイバー化と高強度ハイドロゲル作製2019

    • Author(s)
      長田光正
    • Organizer
      第50回 中部化学関係学協会支部連合秋季大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 水だけを利用したβキチン調製とナノファイバー化2019

    • Author(s)
      長田光正, 西脇瑞貴, 末永信
    • Organizer
      第33回日本キチン・キトサン学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高温高圧水中での単糖変換の反応速度におよぼす置換基の影響2019

    • Author(s)
      長田光正, 小野田崇司, 尾形慎
    • Organizer
      日本応用糖質科学会令和元年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 部分脱アセチル化αキチンのナノファイバー化とハイドロゲルの作製2019

    • Author(s)
      町田純之介, 末永信, 嶋田五百里, 福長博, 高橋伸英, 長田光正
    • Organizer
      第50回 中部化学関係学協会支部連合秋季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] β-Chitin Nanofiber Preparation from Squid Pen by a Water Jet Machine2019

    • Author(s)
      Mitsumasa Osada, Shin Suenaga, Iori Shimada, Hiroshi Fukunaga, Nobuhide Takahashi
    • Organizer
      6th International Conference on Multifunctional, Hybrid and Nanomaterials
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Self-standing Hydrogel of Cellulose Nanofiber by Using Only Heat and Pressure2019

    • Author(s)
      Shin Suenaga, Mitsumasa Osada
    • Organizer
      6th International Conference on Multifunctional, Hybrid and Nanomaterials
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Green Technology for Chitin Utilization Using Only Water2018

    • Author(s)
      Mitsumasa Osada
    • Organizer
      14th International Chitin and Chitosan Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preparation of Self-standing Hydrogel Using α- and β-Chitin Nanofiber by Hydrothermal Treatment2018

    • Author(s)
      Shin Suenaga, Mitsumasa Osada
    • Organizer
      14th International Chitin and Chitosan Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preparation of Chitin Nanofiber Dispersion with High Viscosity and High Transmittance from α-Chitin2018

    • Author(s)
      Junnosuke Machida, Shin Suenaga, Mitsumasa Osada
    • Organizer
      14th International Chitin and Chitosan Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purification of β-Chitin from Squid Pens Using Only Water and Production of β-Chitin Hydrogel2018

    • Author(s)
      Mizuki Nishiwaki, Shin Suenaga, Mitsumasa Osada
    • Organizer
      14th International Chitin and Chitosan Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Production of Porous Material by using Chitin Nanofiber2018

    • Author(s)
      Mitsumasa Osada, Shin Suenaga
    • Organizer
      The 11th Textile Bioengineering and Informatics Symposium (TBIS 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Gelation Method of Cellulose Nanofiber: Using Only Heat and Pressure2018

    • Author(s)
      Shin Suenaga, Mitsumasa Osada
    • Organizer
      NANOFIBERS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バイオマスナノファイバーの水熱ゲル化による自立可能な強度のハイドロゲル生成2018

    • Author(s)
      長田光正
    • Organizer
      化学工学会 超臨界流体部会 第17 回サマースクール 「エネルギー・環境問題に挑戦する超臨界流体」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 高温高圧水処理によるセルロースおよびキチンのナノファイバー分散液からの高強度ハイドロゲル調製2018

    • Author(s)
      長田光正
    • Organizer
      第7回 応用糖質フレッシュシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 酸化セルロースナノファイバーの水熱処理による自立可能な強度のハイドロゲル調製2018

    • Author(s)
      末永信, 長田光正
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] セルロースナノファイバー分散液の水熱処理による高強度ハイドロゲル化2018

    • Author(s)
      末永信, 長田光正
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高温高圧水中でのシアル酸からのN-acetyl-mannosamine(ManNAc)配糖体と2,7-anhydro-Neu5Acの合成2018

    • Author(s)
      小野田崇司, 尾形慎, 長田光正
    • Organizer
      日本応用糖質科学会 平成30年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Production of Functional Materials and Chemicals from Chitin Biomass by using various Water Media2018

    • Author(s)
      Mitsumasa Osada
    • Organizer
      Indo-Japan International Conference (IJC-2018) on “New Insights into Multifunctional Catalysis for Biomass Transformation”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel Preparation Method of Self-sustaining Hydrogel using only Cellulose Nanofiber Dispersion2018

    • Author(s)
      Shin Suenaga, Mitsumasa Osada
    • Organizer
      The 255th American Chemical Society National Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高温高圧水処理がキチンの酵素糖化と物性におよぼす影響の解明2017

    • Author(s)
      長田光正
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高温高圧水処理によるキチン調製と物性評価2017

    • Author(s)
      長田光正
    • Organizer
      第120回触媒討論会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 動的粘弾性試験によるキチンナノファイバーのレオロジー特性2017

    • Author(s)
      末永信, 戸谷一英, 野村義宏, 山下和彦, 嶋田五百里, 福長博, 高橋伸英,長田光正
    • Organizer
      第66回高分子学会年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] βキチンナノファイバーの高温高圧水処理による自立可能な強度のハイドロゲル生成2017

    • Author(s)
      末永信, 戸谷一英, 野村義宏, 山下和彦, 長田光正
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高温高圧水中でのN-アセチルグルコサミンの脱水反応における酸塩基触媒の影響2017

    • Author(s)
      東海林真也, 末永信, 尾形慎, 戸谷一英, 長田光正
    • Organizer
      第31回日本キチン・キトサン学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 黒酵母由来β-グルカンの水熱処理によるオリゴ糖生成2017

    • Author(s)
      長田光正, 河角奨太, 甲野裕之, 尾形慎, 戸谷一英, 池松真也, 近藤修啓, 平林克樹
    • Organizer
      日本応用糖質科学会平成29年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高温高圧水処理によるβ-グルカンからのオリゴ糖生成2017

    • Author(s)
      河角奨太, 甲野裕之, 尾形慎, 戸谷一英, 池松真也, 近藤修啓, 平林克樹, 長田光正
    • Organizer
      化学工学会第49回秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高温高圧水処理によるシルクフィブロインからのポリペプチド生成2017

    • Author(s)
      片岡康慈, 嶋田五百里, 福長博, 高橋伸英, 玉田靖, 長田光正
    • Organizer
      化学工学会第49回秋季大会
    • Related Report
      2017 Annual Research Report
  • [Book] ナノファイバーの製造・加工技術と応用事例 (第4節キチン系バイオマスの湿式解繊によるナノファイバー化)2019

    • Author(s)
      長田光正(共著)
    • Total Pages
      483
    • Publisher
      技術情報協会
    • Related Report
      2019 Annual Research Report
  • [Book] 超臨界流体を用いる合成と加工 (5.3節 キチン・アミノ糖の高温高圧水処理)2017

    • Author(s)
      長田光正 (共著)
    • Total Pages
      252
    • Publisher
      シーエムシー出版
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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