|Budget Amount *help
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|Outline of Final Research Achievements
Rewiring of neural circuits is one of the key processes to promote functional recovery after brain injuries. However, the mechanisms underlying the rewiring are not fully understood. The aim of this study is to reveal the structures and functions of rewired circuits, and the mechanism of rewiring after the injury. In particular, we examined the structures and functions of corticospinal circuit, the main neural pathway for voluntary movement, in control and injured brain. We first found that the corticospinal circuit consists of multiple pathways and connections, and each has distinct sensorimotor function. After the injury, we examined the degree and patterns of rewiring, and found several molecules and methods to promote axonal growth. Our data will contribute to understand the mechanism of neural reorganization and develop novel strategies to restore neural network and functions after the injuries.