|Budget Amount *help
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|Outline of Final Research Achievements
One of the causes of male infertility is impaired sperm motility and several causative genes have been reported. These genes are involved in not only sperm flagellar motility but also ciliary motility in the trachea and ventricles (PCD: primary ciliary dyskinesia), which results in postnatal lethality in knockout mice. In this study, (1) we established the ES cells which exhibit red fluorescence in the mitochondria and (2) chimeric mice were generated using the ES cells to avoid postnatal lethality, and the function of Hydin, which is the causative gene of PCD, was analyzed.