| Budget Amount *help |
¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
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| Outline of Final Research Achievements |
In recent years, the study of optogenetics and light-responsive molecules has become so popular that we are now able to manipulate diverse biological phenomena with light. Though this technology has led to the discovery of new molecular networks in neuroscience and many other fields, the signaling mechanisms has not been clarified at the molecular level in many cases. The main reason is the lack of sensitive and time-resolved methods for detecting intra- and inter-molecular reactions. In this study, we have established a new reaction detection method by combining a unique spectroscopic method (transient grating method) with various opto-control techniques. Using this method, we investigated the molecular mechanisms of apoptosis. We have also applied this method to light-responsive artificial molecules, promoting the elucidation of intermolecular reactions that have been difficult to detect using conventional techniques.
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