Advance in amino acid isotope approaches for human paleo-nutritional studies
Project/Area Number |
17H05018
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Physical anthropology
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Research Institution | Nagoya University |
Principal Investigator |
Naito Yuichi 名古屋大学, 博物館, 研究員 (10754848)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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Keywords | 栄養学 / 古病理 / アミノ酸 / 同位体 / ケラチン / 同位体比 / 健康 / ガスクロマトグラフィー / 人類学 / 安定同位体 / 古病理学 / 質量分析 / 古人骨 |
Outline of Final Research Achievements |
Several new protocols were developed for analyzing specific amino acids in keratin in human hair and fingernail with mass spectrometry and stable isotope analysis. It was suggested that cystine in these body tissues could be analyzed as cysteic acid and used as a new biomarker of human nutritional conditions. Besides, through the careful examination of GC columns, solvents, derivatization techniques, etc., stable isotope measurements of minor essential amino acids were succeeded. Applying these techniques may open a new window in nutritional studies.
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Academic Significance and Societal Importance of the Research Achievements |
本研究の手法を用いれば、過去の資料の分析によって当時の人々の健康状態や飢餓に関する知見が得られるため、考古学・人類学等の分野に貢献しうる。たとえば飢饉の際の人々の栄養状態を直接分析できるため、文献情報以外のデータを提供できる。過去の気象災害の人類社会に対する影響を新たな視点から分析できる。 一方、本手法は栄養状態の新たなバイオマーカーとして用いられれば、健康科学にも貢献する可能性がある。国外では類似のアプローチがすでに応用されはじめているが、本邦ではまだほとんどない。今後ヒトを対象とした分析例を増やすことで、新たな健康科学のツールとなることが期待される。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Heavy reliance on plants for Romanian cave bears evidenced by amino acid nitrogen isotope analysis2020
Author(s)
Naito, Y.I., Meleg, I.N., Robu, M., Vlaicu, M., Drucker, D.G., Wissing, C., Hofreiter, M., Barlow, A., Bocherens, H.
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 6612-6612
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Stable isotopes reveal patterns of diet and mobility in last Neanderthals and first modern humans in Europe2019
Author(s)
Wiβing, C., H. Rougier, I. Crevecoeur, D.G. Drucker, S. Gaudzinski-Windheuser, M. Germonpre, A. Gomez-Olivencia, J. Krause, T. Matthies, Y.I. Naito(連携研究者), C. Posth, P. Semal, M. Street, and H. Bocherens
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Journal Title
Scientific Reports
Volume: 9
Issue: 1
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A high burden of asymptomatic gastrointestinal infections in traditional communities in Papua New Guinea2017
Author(s)
Horwood, P.F., K.W. Soli, T. Maure, Y.I. Naito(連携研究者), A. Morita, K. Natsuhara, K. Tadokoro, J. Baba, S. Odani, E. Tomitsuka, K. Igai, J. Larkins, P.M. Siba, W. Pomat, E. McBryde, M. Umezaki, and A.R. Greenhill
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Journal Title
The American Journal of Tropical Medicine and Hygiene
Volume: 97-6
Issue: 6
Pages: 1872-1875
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Isotopic analyses suggest mammoth and plant in the diet of the oldest anatomically modern humans from far southeast Europe2017
Author(s)
Drucker, D.G., Y.I. Naito(連携研究者), S.Pean, S. Prat, L. Crepin, Y. Chikaraishi, N. Ohkouchi, S. Puaud, M. Laznickova-Galetova, M. Patou-Mathis, A. Yanevich, and H. Bocherens
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Journal Title
Scientific Report
Volume: 7
Issue: 1
Pages: 6833-6833
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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