|Budget Amount *help
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
|Outline of Final Research Achievements
Synaptic dysfunction is thought to be an early intracerebral change that occurs before brain atrophy during the pathological progression of dementia. Recent large-scale epidemiological studies have shown risk factors that influence the progression of dementia. Disruption of biological homeostasis by aging and abnormal glucose metabolism is the greatest risk factor for dementia, and its relationship with synaptic function has been considered to be important. In this study, we investigated that disregulation of synaptic insulin signaling affects neuronal plasticity in hippocampus and medial prefrontal cortex involved in dementia like behaviors.