Colonization resistance against enteric pathogen by gut microbiota
Project/Area Number |
17H05068
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Bacteriology (including mycology)
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Research Institution | Keio University |
Principal Investigator |
Kim Yun-Gi 慶應義塾大学, 薬学部(芝共立), 准教授 (00620220)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2017: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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Keywords | 腸内細菌 / 腸管病原細菌 / 食餌 / 代謝物 / 食餌因子 |
Outline of Final Research Achievements |
In this study, two projects were conducted to clarify the effect of gut microbiota on enteropathogenic bacterial infection. 1) We assessed the growth mechanism in the intestine of Clostridia which strongly inhibit colonization of enteropathogenic bacteria. As a result, a metabolite (succinic acid) produced by the gut microbiota from infants promoteed the growth of Clostridia in the intestine. 2) Focusing on the diet that influences the composition and metabolism of gut microbiota, we assessed the effect of the diet on the colonization and growth of enteropathogenic bacteria via gut microbiota. As a result, the gut microbiota composition was changed by switching the diet, and that influenced the resistance against the enteric pathogen infection.
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、乳幼児型から大人型への腸内細菌叢の成熟ステップが、腸管病原細菌に対する感染抵抗性を獲得するのに重要なプロセスであることが明らかとなった。また、食事因子が腸内細菌を介して腸管病原細菌感染に対する感受性に影響をすることも観察された。これらの成果は、腸内細菌を介した腸管病原細菌に対する感染予防薬開発のための基盤となる知見を提供するものであり、臨床応用への波及効果も大きいと考えている。
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Protection of gut microbiome from antibiotics: development of a vancomycin-specific adsorbent with high adsorption capacity2020
Author(s)
1.Yuzuriha K, Yakabe K, Nagai H, Li S, Zendo T, Zai K, Kishimura A, Hase K, Kim YG, Mori T, Katayama Y.
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Journal Title
Biosci Microbiota Food Health
Volume: accepted
Related Report
Peer Reviewed
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[Journal Article] Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon.2020
Author(s)
Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi, Koji Hase
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Journal Title
International Immunology
Volume: 32
Issue: 4
Pages: 243-258
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens2017
Author(s)
Kim, YG., Sakamoto, K., Seo, SU., Pickard, JM., Gillilland, M.G. 3rd, Pudlo, NA., Hoostal, M., Li, X., Feehley, T., Stefka, AT., Schmidt, TM., Martens, EC., Fukuda, S., Inohara, N., Nagler, CR., Nunez, G.
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Journal Title
Science
Volume: 356
Issue: 6335
Pages: 315-319
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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