| Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|
|---|
| Outline of Final Research Achievements |
Chronic pain consists of sensory and emotional aspects, and both two aspects interact each other. However, the neural mechanisms and circuits on sensory-emotional interactions are still unknown. We focused on the anterior cingulate cortex (ACC), which is involved in chronic pain and anxiety, and studied the selective projections to form presynaptic long-term potentiation in the ACC. We found that the ACC receives inputs from thalamus mono-synaptically as well as poly-synaptically. Furthermore, an animal model of chronic pain attenuated GABAergic inhibitory synaptic transmission in the ACC. An electrophysilogical study showed that a chronic pain model reduced the release of GABA. When we activate muscarinic M1 receptors within the ACC, mechanical hypersensitivity was alleviated through facilitating muscarinic M1 receptors on GABAergic transmissions in the ACC.
|
