|Budget Amount *help
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|Outline of Final Research Achievements
The number of people with dementia is rapidly growing along with the aging of society and is becoming a social issue worldwide. There are various underlying causes of dementia, with the most frequent being Alzheimer’s disease. Tau is known as a major component of neurofibrillary tangles, one of the cardinal pathological features in Alzheimer's disease. In this project, we investigated the role of pathological tau in the pathogenesis of Alzheimer’s disease aiming at developing a novel therapeutic intervention.