| Budget Amount *help |
¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2019: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
Hematopoietic stem cells are one of the tissue stem cells that exist in the bone marrow and can supply all blood cells throughout the life of the body while remaining undifferentiated. By clarifying the dormancy mechanism of hematopoietic stem cells, the applicant demonstrated that TGF-beta is important for maintaining hibernation of hematopoietic stem cells. We also reported that activation of TGF-beta by Schwann cells in bone marrow induces dormancy of hematopoietic stem cells. In this project, based on the knowledge and experience that the applicant has reported so far, by analyzing the temporal dynamics of hematopoietic stem cells in the bone marrow microenvironment, we revealed a complex and complicated hematopoietic stem cell niche cell and its structure. We aimed to establish a foundation to establish a culture method for maintaining the undifferentiated state of hematopoietic stem cells in vitro.
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