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Mechanism and Reconstitution In Vitro of Human Germ Cell Development

Research Project

Project/Area Number 17H06098
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

Saitou Mitinori  京都大学, 高等研究院, 教授 (80373306)

Co-Investigator(Kenkyū-buntansha) 築山 智之  滋賀医科大学, 動物生命科学研究センター, 特任准教授 (60612132)
中村 紳一朗  滋賀医科大学, 動物生命科学研究センター, 准教授 (50307980)
Project Period (FY) 2017-04-25 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥565,890,000 (Direct Cost: ¥435,300,000、Indirect Cost: ¥130,590,000)
Fiscal Year 2021: ¥111,800,000 (Direct Cost: ¥86,000,000、Indirect Cost: ¥25,800,000)
Fiscal Year 2020: ¥121,680,000 (Direct Cost: ¥93,600,000、Indirect Cost: ¥28,080,000)
Fiscal Year 2019: ¥111,410,000 (Direct Cost: ¥85,700,000、Indirect Cost: ¥25,710,000)
Fiscal Year 2018: ¥143,000,000 (Direct Cost: ¥110,000,000、Indirect Cost: ¥33,000,000)
Fiscal Year 2017: ¥78,000,000 (Direct Cost: ¥60,000,000、Indirect Cost: ¥18,000,000)
Keywords生殖細胞 / iPS細胞 / エピゲノムリプログラミング / 卵母細胞 / 試験管内誘導 / ヒト発生生物学 / 発生・分化 / 再生医学 / ゲノム / 発現制御 / 進化 / ヒト / 発生 / 試験管内再構成 / 減数分裂 / 霊長類 / マウス
Outline of Final Research Achievements

This study aims at understanding the mechanism of human germ-cell development and promoting the in vitro reconstitution of human germ-cell development, using knowledges obtained from mice and cynomolgus monkeys as models and from human induced pluripotent stem cells (hiPSCs)-based in vitro systems. The key achievements include the elucidation of the mechanism for the female germ-cell sex determination in mice, in vitro reconstitution of entire male germ-cell development from PSCs in mice, elucidation of the X-chromosome dosage compensation program during the development of cynomolgus monkeys, elucidation of the ontogeny of the gonadal somatic cells in mice and monkeys, establishment of a method for long-term in vitro expansion of human primordial germ cell-like cells (hPGCLCs), and induction of human early oocyte-like cells from hiPSCs.

Academic Significance and Societal Importance of the Research Achievements

生殖細胞は、ヒトを含む多細胞生物の遺伝情報を次世代に継承し、その多様性を形成する、生命の根幹をなす細胞である。生殖細胞の発生機構の解明は、遺伝情報継承機構の解明や、その異常に起因する不妊や発生異常、遺伝病の発症機序解明、治療法の開発につながる。本研究により、ヒト生殖細胞試験管内再構成研究の基盤が形成され、ヒト生殖細胞発生機構の解明が進展した。本研究の成果は、生命科学の重要な礎となると同時に、生殖医学に新しい可能性を提示するものである。

Assessment Rating
Verification Result (Rating)

A+

Assessment Rating
Result (Rating)

A+: Progress in the research exceeds the initial goal. More than expected research results are expected.

Report

(12 results)
  • 2022 Research Progress Assessment (Verification Result) ( PDF )
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report   Research Progress Assessment (Comments on the Site Visits) ( PDF )
  • 2017 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Products Report
  • Research Products

    (109 results)

All 2024 2023 2022 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (12 results) Journal Article (34 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 33 results,  Open Access: 19 results) Presentation (53 results) (of which Int'l Joint Research: 25 results,  Invited: 51 results) Remarks (4 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] University of Hawaii/MIT(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Institute of Molecular Biotechnology/IMP(オーストリア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Univ Montpellier(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Cambridge(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Center for Genomic Regulation(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Hawaii(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of California/University of Hawaii(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Montpellier(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Crick Institute/University of Cambridge/University of Oxford(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Curie Institute(フランス)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] In vitro reconstitution of epigenetic reprogramming in the human germ line2024

    • Author(s)
      Yusuke Murase, Ryuta Yokogawa, Yukihiro Yabuta, Masahiro Nagano, Yoshitaka Katou, Manami Mizuyama, Ayaka Kitamura, Pimpitcha Puangsricharoen, Chika Yamashiro, Bo Hu, Ken Mizuta, Taro Tsujimura, Takuya Yamamoto, Kosuke Ogata, Yasushi Ishihama, Mitinori Saitou
    • Journal Title

      Nature

      Volume: 631 Issue: 8019 Pages: 170-178

    • DOI

      10.1038/s41586-024-07526-6

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys2023

    • Author(s)
      Gyobu‐Motani Sayuri、Yabuta Yukihiro、Mizuta Ken、Katou Yoshitaka、Okamoto Ikuhiro、Kawasaki Masanori、Kitamura Ayaka、Tsukiyama Tomoyuki、Iwatani Chizuru、Tsuchiya Hideaki、Tsujimura Taro、Yamamoto Takuya、Nakamura Tomonori、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: - Issue: 9

    • DOI

      10.15252/embj.2022112962

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells2022

    • Author(s)
      Ishikura Yukiko、Ohta Hiroshi、Nagano Masahiro、Saitou Mitinori
    • Journal Title

      STAR Protocols

      Volume: 3 Issue: 3 Pages: 101544-101544

    • DOI

      10.1016/j.xpro.2022.101544

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nucleome programming is required for the foundation of totipotency in mammalian germline development2022

    • Author(s)
      Nagano Masahiro, Hu Bo, Yokobayashi Shihori et al.
    • Journal Title

      The EMBO Journal

      Volume: 41 Issue: 13

    • DOI

      10.15252/embj.2022110600

    • Related Report
      Products Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mammalian Germ Cell Development: From Mechanism to In?Vitro Reconstitution2021

    • Author(s)
      Saitou Mitinori
    • Journal Title

      Stem Cell Reports

      Volume: 16 Issue: 4 Pages: 669-680

    • DOI

      10.1016/j.stemcr.2021.01.008

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program2021

    • Author(s)
      Kojima Yoji、Yamashiro Chika、Murase Yusuke、Yabuta Yukihiro、Okamoto Ikuhiro、Iwatani Chizuru、Tsuchiya Hideaki、Nakaya Masataka、Tsukiyama Tomoyuki、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Life Science Alliance

      Volume: 4 Issue: 5 Pages: 202000974-202000974

    • DOI

      10.26508/lsa.202000974

    • NAID

      120006979739

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.2020

    • Author(s)
      Matsumoto S, Porter CJ, Ogasawara N, Iwatani C, Tsuchiya H, Seita Y, Chang YW, Okamoto I, Saitou M, Ema M, Perkins TJ, Stanford WL, Tanaka S.
    • Journal Title

      Sci Rep

      Volume: 10(1) Issue: 1 Pages: 6827-6827

    • DOI

      10.1038/s41598-020-63602-7

    • NAID

      120006888480

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long‐term expansion with germline potential of human primordial germ cell‐like cells in?vitro2020

    • Author(s)
      Murase Yusuke、Yabuta Yukihiro、Ohta Hiroshi、Yamashiro Chika、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: 39 Issue: 21 Pages: 104929-104929

    • DOI

      10.15252/embj.2020104929

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†2020

    • Author(s)
      Ohta Hiroshi、Yabuta Yukihiro、Kurimoto Kazuki、Nakamura Tomonori、Murase Yusuke、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Biology of Reproduction

      Volume: 104 Issue: 2 Pages: 344-360

    • DOI

      10.1093/biolre/ioaa195

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys.2020

    • Author(s)
      Sakai Y, Nakamura T, Okamoto I, Gyobu-Motani S, Ohta H, Yabuta Y, Tsukiyama T, Iwatani C, Tsuchiya H, Ema M, Morizane A, Takahashi J, Yamamoto T, Saitou M.
    • Journal Title

      Biol Reprod

      Volume: 102(3) Issue: 3 Pages: 620-638

    • DOI

      10.1093/biolre/ioz205

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ZGLP1 is a determinant for the oogenic fate in mice2020

    • Author(s)
      Nagaoka So I.、Nakaki Fumio、Miyauchi Hidetaka、Nosaka Yoshiaki、Ohta Hiroshi、Yabuta Yukihiro、Kurimoto Kazuki、Hayashi Katsuhiko、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Science

      Volume: 367 Issue: 6482 Pages: 4115-4115

    • DOI

      10.1126/science.aaw4115

    • NAID

      120006850276

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generation of human oogonia from induced pluripotent stem cells in culture2020

    • Author(s)
      Yamashiro Chika、Sasaki Kotaro、Yokobayashi Shihori、Kojima Yoji、Saitou Mitinori
    • Journal Title

      Nature Protocols

      Volume: 15 Issue: 4 Pages: 1560-1583

    • DOI

      10.1038/s41596-020-0297-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A symmetric toggle switch explains the onset of random X inactivation in different mammals.2019

    • Author(s)
      Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG.
    • Journal Title

      Nat Struct Mol Biol.

      Volume: 26(5) Issue: 5 Pages: 350-360

    • DOI

      10.1038/s41594-019-0214-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Germ cell reprogramming2019

    • Author(s)
      Kurimoto Kazuki、Saitou Mitinori
    • Journal Title

      Curr Top Dev Biol

      Volume: 125 Pages: 91-125

    • DOI

      10.1016/bs.ctdb.2019.04.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenome regulation during germ cell specification and development from pluripotent stem cells2018

    • Author(s)
      Kurimoto K, Saitou M
    • Journal Title

      Curr Opin Genet Dev

      Volume: 52 Pages: 57-64

    • DOI

      10.1016/j.gde.2018.06.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of human oogonia from induced pluripotent stem cells in vitro.2018

    • Author(s)
      30.Yamashiro C, Sasaki K, Yabuta Y, Kojima Y, Nakamura T, Okamoto I, Yokobayashi S, Murase Y, Ishikura Y, Shirane K, Sasaki H, Yamamoto T, Saitou M.
    • Journal Title

      Science

      Volume: 362(6412) Issue: 6412 Pages: 356-360

    • DOI

      10.1126/science.aat1674

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.2018

    • Author(s)
      S. Sakamoto, D. Thumkeo, H. Ohta, Z. Zhang, S.R. Huang, P. Kanchenawong, T. Fuu, S. Watanabe, K. Shimada, Y. Fujihara, S. Yoshida, M. Ikawa, N. Watanabe, M. Saitou and S. Narumiya
    • Journal Title

      Plos Biology

      Volume: 16 Issue: 9 Pages: e2004874-e2004874

    • DOI

      10.1371/journal.pbio.2004874

    • NAID

      120006531249

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Segregation of mitochondrial DNA heteroplasmy through a development genetic bottleneck in human embryos2018

    • Author(s)
      Floros, V. I., Pyle, A., Dietmann, S., Wei, W., Tang, W. W. C., Irie, N., Payne, B. A. I., Capalbo, A., Noli, L., Coxhead, J., Hudson, G., Crosier, M., Strahl, H., Khalaf, Y., Saitou, M., Ilic, D., Surani, M. A., Chinnery, P. F.
    • Journal Title

      Nature Cell Biology

      Volume: 20(2) Issue: 2 Pages: 144-151

    • DOI

      10.1038/s41556-017-0017-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of fetal primary oocytes and the meiotic prophase from mouse pluripotent stem cells.2018

    • Author(s)
      Miyauchi H, Ohta H, Saitou M.
    • Journal Title

      Methods Cell Biol.

      Volume: 144 Pages: 409-429

    • DOI

      10.1016/bs.mcb.2018.03.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reconstitution of germ cell development in vitro2018

    • Author(s)
      Yokobayashi, Y. and Saitou, M.
    • Journal Title

      Cell Biology of the Ovary - Stem Cells, Development, and Clinical Aspects

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Spermatogenesis2018

    • Author(s)
      Ishikura, Y. and Saitou, M.
    • Journal Title

      Encyclopedia of Reproduction, Second Edition

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flexible adaptation of male germ cells from female iPSCs of endangered Tokudaia osimensis2017

    • Author(s)
      Arata Honda, Narantsog Choijookhuu, Haruna Izu, Yoshihiro Kawano, Mizuho Inokuchi, Kimiko Honsho, Ah-Reum Lee, Hiroki Nabekura, Hiroshi Ohta, Tomoyuki Tsukiyama, Yasuhide Ohinata, Asato Kuroiwa, Yoshitaka Hishikawa, Mitinori Saitou, Takamichi Jogahara, Chihiro Koshimoto
    • Journal Title

      Science Advances

      Volume: - Issue: 5

    • DOI

      10.1126/sciadv.1602179

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clonal variation of human induced pluripotent stem cells for induction into the germ cell fate†2017

    • Author(s)
      Yokobayashi Shihori、Okita Keisuke、Nakagawa Masato、Nakamura Tomonori、Yabuta Yukihiro、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Biology of Reproduction

      Volume: 96 Issue: 6 Pages: 1154-1166

    • DOI

      10.1093/biolre/iox038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys.2017

    • Author(s)
      Nakamura, T., Yabuta, Y., Okamoto, I., Sasaki, K., Iwatani, C., Tsuchiya, H., and Saitou, M.
    • Journal Title

      Scientific Data

      Volume: 4 Issue: 1 Pages: 170067-170067

    • DOI

      10.1038/sdata.2017.67

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.2017

    • Author(s)
      Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M
    • Journal Title

      EMBO J

      Volume: 36 Issue: 13 Pages: 1888-1907

    • DOI

      10.15252/embj.201695862

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM22017

    • Author(s)
      Ogushi Sugako、Yamagata Kazuo、Obuse Chikashi、Furuta Keiko、Wakayama Teruhiko、Matzuk Martin M.、Saitou Mitinori
    • Journal Title

      J Cell Sci.

      Volume: 130 Issue: 14 Pages: 2416-2429

    • DOI

      10.1242/jcs.195875

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential epigenetic memory states and reactivation kinetics of the inactive X chromosome in the inner cell mass2017

    • Author(s)
      Borensztein, M., Okamoto, I., Syx, L., Guilbaud, G., Christel, P., Ancelin, K., Diabangouaya, P., Servant, N., Barillot, E., Surani, A., Saitou, M., Chen, C-J., Anastassiadis, K., and Heard, E.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1297-1297

    • DOI

      10.1038/s41467-017-01415-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fertile offspring from sterile sex chromosome trisomic mice2017

    • Author(s)
      Hirota Takayuki、Ohta Hiroshi、Powell Benjamin E.、Mahadevaiah Shantha K.、Ojarikre Obah A.、Saitou Mitinori、Turner James M. A.
    • Journal Title

      Science

      Volume: 357 Issue: 6354 Pages: 932-935

    • DOI

      10.1126/science.aam9046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1.2017

    • Author(s)
      Mitani T, Yabuta Y, Ohta H, Nakamura T, Yamashiro C, Yamamoto T, Saitou M, Kurimoto K
    • Journal Title

      Nucleic Acids Research

      Volume: 45 Issue: 21 Pages: 12152-12169

    • DOI

      10.1093/nar/gkx798

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone morphogenetic protein and retinoic acid synergistically specify female germ‐cell fate in mice2017

    • Author(s)
      Miyauchi Hidetaka、Ohta Hiroshi、Nagaoka So、Nakaki Fumio、Sasaki Kotaro、Hayashi Katsuhiko、Yabuta Yukihiro、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      The EMBO Journal

      Volume: 36 Issue: 21 Pages: 3100-3119

    • DOI

      10.15252/embj.201796875

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf42017

    • Author(s)
      Azami Takuya、Waku Tsuyoshi、Matsumoto Ken、Jeon Hyojung、Muratani Masafumi、Kawashima Akihiro、Yanagisawa Jun、Manabe Ichiro、Nagai Ryozo、Kunath Tilo、Nakamura Tomonori、Kurimoto Kazuki、Saitou Mitinori、Takahashi Satoru、Ema Masatsugu
    • Journal Title

      Development

      Volume: 144 Issue: 20 Pages: 3706-3718

    • DOI

      10.1242/dev.150755

    • NAID

      120007134671

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells2017

    • Author(s)
      Kojima Yoji、Sasaki Kotaro、Yokobayashi Shihori、Sakai Yoshitake、Nakamura Tomonori、Yabuta Yukihiro、Nakaki Fumio、Nagaoka So、Woltjen Knut、Hotta Akitsu、Yamamoto Takuya、Saitou Mitinori
    • Journal Title

      Cell Stem Cell

      Volume: 21 Issue: 4 Pages: 517-532

    • DOI

      10.1016/j.stem.2017.09.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoting In Vitro Gametogenesis Research with a Social Understanding.2017

    • Author(s)
      Ishii T, Saitou M.
    • Journal Title

      Trends Mol Med.

      Volume: 23 Issue: 11 Pages: 985-988

    • DOI

      10.1016/j.molmed.2017.09.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of Female Germ Cell Fate Determination and Meiotic Initiation in Mammals.2017

    • Author(s)
      Nagaoka, S. and Saitou, M.
    • Journal Title

      Cold Spring Harbor Symposia on Quantitative Biology

      Volume: 80 Pages: 033803-033803

    • DOI

      10.1101/sqb.2017.82.033803

    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2021

    • Author(s)
      斎藤 通紀
    • Organizer
      せとうちART研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      The 85th CSHL Symposium: Genome Stability & Integrity ※延期
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ISSCR Momentum Award Lecture2020

    • Author(s)
      斎藤 通紀
    • Organizer
      ISSCR ※WEB
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      RIKEN-BDR-CuSTOM Symposium ※WEB
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2020

    • Author(s)
      斎藤 通紀
    • Organizer
      分子生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ-Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      第19回国際小児脳腫瘍シンポジウム
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      ITMAT国際シンポジウム ※延期
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      Seminar at Jackson Laboratory in Bar Harbor ※延期
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      BIRS Workshop on Synthetic Embryology in Mexico ※中止
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      Evolution of Reproduction in Portugal ※延期
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      EMBO Workshop in Kyoto ※延期
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Mammalian Germ Cell Development2020

    • Author(s)
      斎藤 通紀
    • Organizer
      Meeting at Weizmann Institute ※延期
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and reconstitution in vitro of human germ cell development2019

    • Author(s)
      斎藤 通紀
    • Organizer
      Organ regeneration and stem cells in animals
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and Reconstitution?In Vitro?of Human Germ Cell Development2019

    • Author(s)
      斎藤 通紀
    • Organizer
      Gordon Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生殖細胞の発生機構の解明とその試験管内再構成2019

    • Author(s)
      斎藤 通紀
    • Organizer
      遺伝研研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生殖細胞発生機構の解明とその試験管内再構成2019

    • Author(s)
      斎藤 通紀
    • Organizer
      日本アンドロロジー学会第38回学術大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 精子と卵子を創る科学:生命継承機構の探求2019

    • Author(s)
      斎藤 通紀
    • Organizer
      「生命と時間の未来」フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2019

    • Author(s)
      斎藤 通紀
    • Organizer
      第11回シグナルネットワーク研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2019

    • Author(s)
      斎藤 通紀
    • Organizer
      第22回日本IVF学会学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mechanism and?In Vitro Reconstitutio?of Mammalian Germ Cell Development2019

    • Author(s)
      斎藤 通紀
    • Organizer
      理化学研究所 生命機能科学研究センター
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mechanism and reconstitution in vitro of mammalian germ cell development2019

    • Author(s)
      斎藤 通紀
    • Organizer
      CiRA 2019 国際シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞発生機構の解明とその試験管内再構成2019

    • Author(s)
      斎藤 通紀
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2019

    • Author(s)
      斎藤 通紀
    • Organizer
      第10回日本がん・生殖医療学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2019

    • Author(s)
      斎藤通紀
    • Organizer
      第15回日本A-PART学術講演会2019
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Epigenetic Reprogramming, Female Sex Determination and Meiotic Entry of Mouse Germ Cells In Vitro2018

    • Author(s)
      斎藤通紀
    • Organizer
      117th From oocyte to embryo ? illuminating the origins of life, Titisee conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic Reprogramming, Female Sex Determination and Meiotic Entry of Mouse Germ Cells In Vitro2018

    • Author(s)
      斎藤通紀
    • Organizer
      BSDB Annual Spring Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and Reconstitution In Vitro of Germ Cell Development in Mice, Monkeys, and Humans2018

    • Author(s)
      斎藤通紀
    • Organizer
      Weinstein Cardiovascular Development & Regeneration Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2018

    • Author(s)
      斎藤通紀
    • Organizer
      第59 回日本卵子学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 精子と卵子を創る科学:生命継承機構の探求2018

    • Author(s)
      斎藤通紀
    • Organizer
      第5回バイオ・フロンティア・プラットフォームシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanism and Reconstitution In Vitro of Germ Cell Development in Mice, Monkeys, and Humans2018

    • Author(s)
      斎藤通紀
    • Organizer
      The ISSCR annual meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞の発生機構の解明とその試験管内再構成2018

    • Author(s)
      斎藤通紀
    • Organizer
      第36回日本受精着床学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Germ Cell Development in Mice, Monkeys and Humans2018

    • Author(s)
      斎藤通紀
    • Organizer
      AMGEN Program 床学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2018

    • Author(s)
      斎藤通紀
    • Organizer
      高遠シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2018

    • Author(s)
      斎藤通紀
    • Organizer
      第63回日本生殖医学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanism and In Vitro Reconstitution of Human germ cell development2018

    • Author(s)
      斎藤通紀
    • Organizer
      From Stem Cells to Human Development
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2018

    • Author(s)
      斎藤通紀
    • Organizer
      日本生殖工学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanism and Reconstitution In Vitro of Germ Cell Development in Mice, Monkeys, and Humans2018

    • Author(s)
      斎藤通紀
    • Organizer
      EPFL
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2018

    • Author(s)
      斎藤通紀
    • Organizer
      日本生殖発生医学会第14回学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2018

    • Author(s)
      斎藤通紀
    • Organizer
      第9回日本がん・生殖医療学会 学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ヒト生殖細胞の試験管内誘導に向けて:霊長類を用いた発生生物学の基盤形成2018

    • Author(s)
      斎藤 通紀
    • Organizer
      日本マーモセット研究会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 精子と卵子を創る科学:生命継承機構の探求2018

    • Author(s)
      斎藤 通紀
    • Organizer
      第27回泌尿器科分子・細胞研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 精子と卵子を創る科学:生命継承機構の探求2018

    • Author(s)
      斎藤 通紀
    • Organizer
      第50回神戸ラボ全体研究会議(神戸大学大学院医学研究科 病態シグナル学部門)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 精子と卵子を創る科学:生命継承機構の探求2018

    • Author(s)
      斎藤 通紀
    • Organizer
      第5回 Medical Frontier Consortium Beyond the Organcentric Dogma
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS細胞からの生殖細胞の誘導2018

    • Author(s)
      斎藤 通紀
    • Organizer
      日本生殖発生医学会 第13回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Female sex determination and meiotic entry of mouse germ cells in vitro2017

    • Author(s)
      斎藤 通紀
    • Organizer
      82nd Cold Spring Harbor Symposium on Quantiative Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism and Reconstitution In Vitro of Germ Cell Developmentin in Mice, Monkeys, and Humans2017

    • Author(s)
      斎藤 通紀
    • Organizer
      ISSCR 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In Vitro Reconstitution of Germ Cell Development2017

    • Author(s)
      斎藤 通紀
    • Organizer
      Germinal Stem Cell Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Specification of the Germ Cell Fate in Mice, Monkeys and Humans2017

    • Author(s)
      斎藤 通紀
    • Organizer
      The International Symposium of Germ Cell Development in vivo and in vitro
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic Reprogramming, Female Sex Determination and Meiotic Entry of Mouse Germ Cells In Vitro2017

    • Author(s)
      斎藤 通紀
    • Organizer
      EMBL, Mammalian Genetics and Genomics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epigenetic Reprogramming, Female Sex Determination and Meiotic Entry of Mouse Germ Cells In Vitro2017

    • Author(s)
      斎藤 通紀
    • Organizer
      CiRA 2017 International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト生殖細胞試験管内誘導研究の現状と展望2017

    • Author(s)
      斎藤 通紀
    • Organizer
      第35回日本受精着床学会総会・学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 精子と卵子を創る科学:生命継承機構の探求2017

    • Author(s)
      斎藤 通紀
    • Organizer
      京都大学 東京フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精子・卵子を創る研究とは2017

    • Author(s)
      斎藤 通紀
    • Organizer
      市民ワークショップ「考えよう再生医療」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Remarks] 京都大学 医学研究科 生体構造医学講座 機能微細形態学

    • URL

      http://anat.cell.med.kyoto-u.ac.jp/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 京都大学 高等研究院 ヒト生物学高等研究拠点

    • URL

      https://ashbi.kyoto-u.ac.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 京都大学 iPS細胞研究所

    • URL

      https://www.cira.kyoto-u.ac.jp/j/research/msaitou_summary.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 京都大学 高等研究院 ヒト生物学高等研究拠点

    • URL

      http://ashbi.kyoto-u.ac.jp/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 卵原細胞又は前精原細胞の製造方法2023

    • Inventor(s)
      斎藤通紀、村瀬佑介、横川隆太
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-133928
    • Filing Date
      2023
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 観測ノイズ削減法の開発2020

    • Inventor(s)
      井元祐介、中村友紀、平岡裕章、斎藤通紀
    • Industrial Property Rights Holder
      井元祐介、中村友紀、平岡裕章、斎藤通紀
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] MAINTENANCE-AND-AMPLIFICATION METHOD FOR HUMAN PRIMORDIAL GERM CELLS/HUMAN PRIMORDIAL GERM CELL-LIKE CELLS2020

    • Inventor(s)
      Mitinori Saitou, Yusuke Murase
    • Industrial Property Rights Holder
      Mitinori Saitou, Yusuke Murase
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] MAINTENANCE-AND-AMPLIFICATION METHOD FOR HUMAN PRIMORDIAL GERM CELLS/HUMAN PRIMORDIAL GERM CELL-LIKE CELLS2020

    • Inventor(s)
      Mitinori Saitou, Yusuke Murase
    • Industrial Property Rights Holder
      Mitinori Saitou, Yusuke Murase
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 始原生殖細胞/始原生殖細胞様細胞の維持増幅及び分化誘導方法2017

    • Inventor(s)
      斎藤通紀、大田浩、宮内英孝
    • Industrial Property Rights Holder
      斎藤通紀、大田浩、宮内英孝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞から生殖系列幹細胞様細胞への分化誘導方法2017

    • Inventor(s)
      斎藤通紀、石藏友紀子
    • Industrial Property Rights Holder
      斎藤通紀、石藏友紀子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2017-05-02   Modified: 2025-03-27  

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