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Towards thorough understanding of molecular and neural circuit basis of behavioral switch

Research Project

Project/Area Number 17H06113
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Basic / Social brain science
Research InstitutionThe University of Tokyo

Principal Investigator

Iino Yuichi  東京大学, 大学院理学系研究科(理学部), 教授 (40192471)

Co-Investigator(Kenkyū-buntansha) 石原 健  九州大学, 理学研究院, 教授 (10249948)
Project Period (FY) 2017-05-31 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥203,840,000 (Direct Cost: ¥156,800,000、Indirect Cost: ¥47,040,000)
Fiscal Year 2021: ¥37,180,000 (Direct Cost: ¥28,600,000、Indirect Cost: ¥8,580,000)
Fiscal Year 2020: ¥36,270,000 (Direct Cost: ¥27,900,000、Indirect Cost: ¥8,370,000)
Fiscal Year 2019: ¥38,870,000 (Direct Cost: ¥29,900,000、Indirect Cost: ¥8,970,000)
Fiscal Year 2018: ¥46,540,000 (Direct Cost: ¥35,800,000、Indirect Cost: ¥10,740,000)
Fiscal Year 2017: ¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Keywords線虫 / 行動 / 学習 / 神経回路 / 神経伝達 / 神経可塑性 / 化学走性 / 走化性 / 線虫C.elegans / 学習記憶 / シナプス伝達 / 全脳イメージング / 線虫C. elegans
Outline of Final Research Achievements

C. elegans changes the behavior through learning of salt concentrations. In addition, depending on whether they were fed or starved when they experienced salt, they switch the behavior from attraction to avoidance. In this study, the mechanisms for learning-dependent changes of behavior were investigated at the levels of molecules, neural circuit and behavioral regulation. As a result, previous questions were solved in the mechanisms of changes of neurotransmission caused by salt and food experiences, information flow in the neural circuits, and behavioral mechanisms of chemotaxis, leading to a comprehensive understanding of the behavioral switch.

Academic Significance and Societal Importance of the Research Achievements

興奮性、抑制性の神経伝達物質受容体の感受性が異なることが原因で、行動反転の原因となる神経間伝達の反転が起こるという新規の機構を発見した。この成果は外部環境の変化により即時に神経伝達の極性を変える新たな神経可塑性の機構を提唱した点で大きな学術的な意義がある。さらには特定の神経および全頭部神経の活動測定により、神経回路上の情報の流れを解明し、今後の脳機能解明への新たな手法を提供した点で大きな意義がある。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2023 Research Progress Assessment (Verification Result) ( PDF )
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (177 results)

All 2023 2022 2021 2020 2019 2018 2017 Other

All Journal Article (31 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 30 results,  Open Access: 30 results) Presentation (141 results) (of which Int'l Joint Research: 56 results,  Invited: 13 results) Remarks (5 results)

  • [Journal Article] Different modes of stimuli delivery elicit changes in glutamate driven, experience-dependent interneuron response in C. elegans2023

    • Author(s)
      Mabardi Llian、Sato Hirofumi、Toyoshima Yu、Iino Yuichi、Kunitomo Hirofumi
    • Journal Title

      Neuroscience Research

      Volume: 186 Pages: 33-42

    • DOI

      10.1016/j.neures.2022.10.004

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin/IGF signaling regulates presynaptic glutamate release in aversive olfactory learning.2022

    • Author(s)
      Du Cheng, James S Lee, Maximillian Brown, Margaret S Ebert, Patrick T McGrath, Masahiro Tomioka, Yuichi Iino, Cornelia I Bargmann
    • Journal Title

      Cell reports

      Volume: 41(8) Issue: 8 Pages: 111685-111685

    • DOI

      10.1016/j.celrep.2022.111685

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans2022

    • Author(s)
      Hiroki Shingo、Yoshitane Hikari、Mitsui Hinako、Sato Hirofumi、Umatani Chie、Kanda Shinji、Fukada Yoshitaka、Iino Yuichi
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 2928-2928

    • DOI

      10.1038/s41467-022-30279-7

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior2022

    • Author(s)
      Mori Keita、Koebis Michinori、Nakao Kazuki、Kobayashi Shizuka、Kiyama Yuji、Watanabe Masahiko、Manabe Toshiya、Iino Yuichi、Aiba Atsu
    • Journal Title

      Molecular Brain

      Volume: 15 Issue: 1 Pages: 23-23

    • DOI

      10.1186/s13041-022-00909-8

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans2022

    • Author(s)
      Yasuaki Ike, Masahiro Tomioka, Yuichi Iino
    • Journal Title

      Genetics

      Volume: 220(4) Issue: 4

    • DOI

      10.1093/genetics/iyac025

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The redundancy and diversity between two novel PKC isotypes that regulate learning in Caenorhabditis elegans.2022

    • Author(s)
      Hiroki S, Iino, Y.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 119(3) Issue: 3

    • DOI

      10.1073/pnas.2106974119

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DAF-2c signaling promotes taste avoidance after starvation in Caenorhabditis elegans by controlling distinct phospholipase C isozymes2022

    • Author(s)
      Masahiro Tomioka, Moon Sun Jang, Yuichi Iino
    • Journal Title

      Communications Biology

      Volume: 5 Issue: 1 Pages: 30-30

    • DOI

      10.1038/s42003-021-02956-8

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-172022

    • Author(s)
      Ide Soichiro、Kunitomo Hirofumi、Iino Yuichi、Ikeda Kazutaka
    • Journal Title

      Frontiers in Pharmacology

      Volume: 12 Pages: 802701-802701

    • DOI

      10.3389/fphar.2021.802701

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Probabilistic generative modeling and reinforcement learning extract the intrinsic features of animal behavior2022

    • Author(s)
      Keita Mori, Naohiro Yamauchi, Haoyu Wang, Ken Sato, Yu Toyoshima, Yuichi Iino
    • Journal Title

      Neural Networks

      Volume: 145 Pages: 107-120

    • DOI

      10.1016/j.neunet.2021.10.002

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of Diacylglycerol Content in Olfactory Neurons Determines Forgetting or Retrieval of Olfactory Memory in<i>Caenorhabditis elegans</i>2022

    • Author(s)
      Arai Mary、Kurokawa Itsuki、Arakane Hoshinosuke、Kitazono Tomohiro、Ishihara Takeshi
    • Journal Title

      The Journal of Neuroscience

      Volume: 42 Issue: 43 Pages: 8039-8053

    • DOI

      10.1523/jneurosci.0090-22.2022

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in <i>Caenorhabditis elegans</i>2022

    • Author(s)
      Teo Jamine Hooi-Min、Kurokawa Itsuki、Onishi Yuuki、Sato Noriko、Kitazono Tomohiro、Tokunaga Terumasa、Fujiwara Manabi、Ishihara Takeshi
    • Journal Title

      eneuro

      Volume: 9 Issue: 4 Pages: 0084-0084

    • DOI

      10.1523/eneuro.0084-22.2022

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forward and backward locomotion patterns in C. elegans generated by a connectome-based model simulation2021

    • Author(s)
      Sakamoto, K., Soh, Z., Suzuki, M., Iino, Y., and Tsuji, T.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-92690-2

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamate signaling from a single sensory neuron mediates experience-dependent bidirectional behavior in Caenorhabditis elegans2021

    • Author(s)
      Sato Hirofumi、Kunitomo Hirofumi、Fei Xianfeng、Hashimoto Koichi、Iino Yuichi
    • Journal Title

      Cell Reports

      Volume: 35 Issue: 8 Pages: 109177-109177

    • DOI

      10.1016/j.celrep.2021.109177

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans2021

    • Author(s)
      Park Chanhyun、Sakurai Yuki、Sato Hirofumi、Kanda Shinji、Iino Yuichi、Kunitomo Hirofumi
    • Journal Title

      eLife

      Volume: 10 Pages: 1-27

    • DOI

      10.7554/elife.55701

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] EGL‐4/PKG regulates the role of an interneuron in a chemotaxis circuit of C. elegans through mediating integration of sensory signals2021

    • Author(s)
      Hino Takahiro、Hirai Shota、Ishihara Takeshi、Fujiwara Manabi
    • Journal Title

      Genes to Cells

      Volume: 26 Issue: 6 Pages: 411-425

    • DOI

      10.1111/gtc.12849

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images2021

    • Author(s)
      Wen Chentao、Miura Takuya、Voleti Venkatakaushik、Yamaguchi Kazushi、Tsutsumi Motosuke、Yamamoto Kei、Otomo Kohei、Fujie Yukako、Teramoto Takayuki、Ishihara Takeshi、Aoki Kazuhiro、Nemoto Tomomi、Hillman Elizabeth MC、Kimura Koutarou D
    • Journal Title

      eLife

      Volume: 10

    • DOI

      10.7554/elife.59187

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging.2020

    • Author(s)
      Harada K*, Chihara T*, Hayasaka Y*, Mita M, Takizawa M, Ishida K, Arai M, Tsuno S, Matsumoto M, Ishihara T, Ueda H, Kitaguchi T, Tsuboi T. *Equal contribution
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-020-76440-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuron ID dataset facilitates neuronal annotation for whole-brain activity imaging of C. elegans2020

    • Author(s)
      Yu Toyoshima, Stephen Wu, Manami Kanamori, Hirofumi Sato, Moon Sun Jang, Suzu Oe, Yuko Murakami, Takayuki Teramoto, Chanhyun Park, Yuishi Iwasaki, Takeshi Ishihara, Ryo Yoshida & Yuichi Iino
    • Journal Title

      BMC Biology

      Volume: 18 Issue: 1 Pages: 30-30

    • DOI

      10.1186/s12915-020-0745-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Caenorhabditis elegans: a model to understand host?microbe interactions2019

    • Author(s)
      Kumar Arun、Baruah Aiswarya、Tomioka Masahiro、Iino Yuichi、Kalita Mohan C.、Khan Mojibur
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 77 Issue: 7 Pages: 1229-1249

    • DOI

      10.1007/s00018-019-03319-7

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DAF-16/FOXO Promotes Taste Avoidance Learning Independently of Axonal Insulin-Like Signaling2019

    • Author(s)
      Takashi Nagashima, Yuichi Iino, Masahiro Tomioka
    • Journal Title

      PLoS Genet.

      Volume: 15 Issue: 7 Pages: e1008297-e1008297

    • DOI

      10.1371/journal.pgen.1008297

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple Sensory Neurons Mediate Starvation-Dependent Aversive Navigation in Caenorhabditis elegans2019

    • Author(s)
      Jang MS, Toyoshima Y, Tomioka M, Kunitomo H, Iino Y.
    • Journal Title

      Proc Natl Acad Sci U S A .

      Volume: 116 Issue: 37 Pages: 18673-18683

    • DOI

      10.1073/pnas.1821716116

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The ClC-type chloride channel CLH-1 regulates gustatory learning in the nematode C. elegans.2019

    • Author(s)
      Park, C., Sakurai, Y., Kanda, S., Iino, Y., and Park, H.
    • Journal Title

      IBRO Reports

      Volume: 6 Pages: S442-S442

    • DOI

      10.1016/j.ibror.2019.07.1398

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A computational model of internal representations of chemical gradients in environments for chemotaxis of Caenorhabditis elegans2018

    • Author(s)
      Soh Zu、Sakamoto Kazuma、Suzuki Michiyo、Iino Yuichi、Tsuji Toshio
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17190-17190

    • DOI

      10.1038/s41598-018-35157-1

    • NAID

      120006800826

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] OFF-responses of interneurons optimize avoidance behaviors depending on stimulus strength via electrical synapses.2018

    • Author(s)
      Hori S, Oda S, Suehiro Y, Iino Y, Mitani S
    • Journal Title

      PLoS Genet.

      Volume: 14 Issue: 6 Pages: e1007477-e1007477

    • DOI

      10.1371/journal.pgen.1007477

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An improved inverse-type Ca2+ indicator can detect putative neuronal inhibition in Caenorhabditis elegans by increasing signal intensity upon Ca2+ decrease2018

    • Author(s)
      Hara-Kuge Sayuri、Nishihara Tomonobu、Matsuda Tomoki、Kitazono Tomohiro、Teramoto Takayuki、Nagai Takeharu、Ishihara Takeshi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 4 Pages: e0194707-e0194707

    • DOI

      10.1371/journal.pone.0194707

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SPF-CellTracker: Tracking multiple cells with strongly-correlated moves using a spatial particle filter2017

    • Author(s)
      Hirose Osamu、Kawaguchi Shotaro、Tokunaga Terumasa、Toyoshima Yu、Teramoto Takayuki、Kuge Sayuri、Ishihara Takeshi、Iino Yuichi、Yoshida Ryo
    • Journal Title

      IEEE/ACM Transactions on Computational Biology and Bioinformatics

      Volume: - Issue: 6 Pages: 1-1

    • DOI

      10.1109/tcbb.2017.2782255

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calcium dynamics regulating the timing of decision-making in C. elegans2017

    • Author(s)
      Tanimoto Yuki、Yamazoe-Umemoto Akiko、Fujita Kosuke、Kawazoe Yuya、Miyanishi Yosuke、Yamazaki Shuhei J、Fei Xianfeng、Busch Karl Emanuel、Gengyo-Ando Keiko、Nakai Junichi、Iino Yuichi、Iwasaki Yuishi、Hashimoto Koichi、Kimura Koutarou D
    • Journal Title

      eLife

      Volume: 6

    • DOI

      10.7554/elife.21629

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans2017

    • Author(s)
      Sakai Naoko、Ohno Hayao、Tomioka Masahiro、Iino Yuichi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: e0177900-e0177900

    • DOI

      10.1371/journal.pone.0177900

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Luqin-like RYamide peptides regulate food-evoked responses in C. elegans2017

    • Author(s)
      Ohno H, Yoshida M, Sato T, Kato J, Miyazato M, Kojima M, Ida T, Iino Y
    • Journal Title

      Elife

      Volume: 6. pii Pages: 1-23

    • DOI

      10.7554/elife.28877

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics of Presynaptic Diacylglycerol in a Sensory Neuron Encode Differences Between Past and Current Stimulus Intensity2017

    • Author(s)
      Ohno H, Sakai N, Adachi T, Iino Y.
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 10 Pages: 2294-2303

    • DOI

      10.1016/j.celrep.2017.08.038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans2017

    • Author(s)
      Kitazono T, Hara-Kuge S, Matsuda O, Inoue A, Fujiwara M, Ishihara T
    • Journal Title

      J Neurosci

      Volume: 37(42) Issue: 42 Pages: 10240-10251

    • DOI

      10.1523/jneurosci.0031-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 線虫C. elegansにおける糖濃度学習の機能解析2023

    • Author(s)
      富永 慶子、富岡 征大、飯野 雄一
    • Organizer
      日本動物学会関東支部第75回大会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] p38 MAPK シグナル経路は複数の感覚神経においてC. elegansの塩走性学習を制御する2022

    • Author(s)
      黄 涛若、富岡 征大、飯野 雄一
    • Organizer
      第45回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] Investigating how worms integrate sensory and motor information in salt klinotaxis2022

    • Author(s)
      Ayaka Matsumoto, Chenqi Zhang, Akihiro Isozaki, Keisuke Goda, Yu Toyoshima, Yuichi Iino
    • Organizer
      CeNeuro2022
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecules and neural network underlying salt preference2022

    • Author(s)
      Shingo Hiroki, Hirofumi Sato, Yu Toyoshima, Llian Mabardi, Hikari Yoshitane, Hinako Mitsui, Manami Kanamori, Chie Umatani, Shinji Kanda, Mashiro Tomoioka, Koichi Hashimoto, Hirofumi Kunitomo, Yoshitaka Fukada, Takeshi Ishihara & Yuichi Iino
    • Organizer
      CeNeuro2022(C. elegans Topic Meeting: Neuronal Development, Synaptic Function and Behavior)
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FMRFamide-like neuropeptide FLP-2 and pigment dispersing factor-like neuropeptide PDF-1 may modulate salt chemotaxis of C. elegans by mediating food signals2022

    • Author(s)
      Yucheng Xie, Koji Yamada, Takeshi Adachi, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      Ceneuro2022
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FMRFamide様神経ペプチドFLP-2は餌のシグナルを仲介してC.エレガンスの塩走性を調節する(FMRFamide-like neuropeptide FLP-2 may modulate salt chemotaxis of C. elegans by mediating food signals)2022

    • Author(s)
      Yucheng Xie, Koji Yamada, Takeshi Adachi, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      NEURO2022
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of neural activity underlying turning movement by tracking-imaging of freely moving C. elegans.2022

    • Author(s)
      Ukyo T. Tazawa, Koyo Kuze, Ayaka Matsumoto, Yu Toyoshima, Suzu Oe, Takayuki Teramoto, Takeshi Ishihara, Yuichi Iino
    • Organizer
      NEURO2022
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫が侵害受容から忌避応答を引き起こす神経回路の解析2022

    • Author(s)
      久世晃暢、田澤右京、豊島有、大江紗、寺本孝行、石原健、飯野雄一
    • Organizer
      NEURO2022
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫C.elegansにおいて糖依存的に塩嗜好性を変化させる分子機構2022

    • Author(s)
      梅村 悠介、上岡 雄太郎、内山 千紘、陳 立峻、片江 圭太、飯野 雄一、富岡 征大
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線_ C. elegans の介在神経における複数の嗅覚情報の統合機構2022

    • Author(s)
      東亮太郎 石原健 藤原学
    • Organizer
      分子生物学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 線虫の匂い識別行動を指標にした、嗅覚回路における匂い情報伝達経路の解析2022

    • Author(s)
      徳升太一 石原健 藤原学
    • Organizer
      分子生物学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] Regulation of diacylglycerol content in olfactory neurons determines forgetting or retrieval of olfactory memory in Caenorhabditis elegans2022

    • Author(s)
      Mary Arai, Itsuki Kurokawa, Hoshinosuke Arakane, Tomohiro Kitazono, Takeshi Ishihara
    • Organizer
      記憶研究会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Invited
  • [Presentation] Analyses of neuropeptides and receptors required for forgetting2022

    • Author(s)
      Yuuki Onishi Takeshi Ishihara
    • Organizer
      記憶研究会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] Neuropeptide NLP-47 and its receptor GNRR-1 promote forgetting of olfactory memory in C. elegans2022

    • Author(s)
      Yuuki Onishi;Jamine Teo,Tomohiro Kitazono,Takeshi Ishihara
    • Organizer
      CeNeuro2022
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経ペプチドNLP-47とその受容体GNRR-1は、線虫C. elegansの嗅覚学習の忘却を促進する2022

    • Author(s)
      大西 湧己、Teo Jamine、北園 智弘、石原 健
    • Organizer
      神経科学学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫の塩走性における感覚運動統合と行動制御の神経機構の解明2021

    • Author(s)
      松本朱加、豊島有、Zhang Chenqi、磯崎瑛宏、合田圭介、飯野雄一
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫C. elegansの頭部全神経イメージングデータを用いた神経活動解析2021

    • Author(s)
      永田大貴、豊島有、佐藤博文、久世晃暢、寺本孝行、石原健、飯野雄一
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫C. elgansの塩走性におけるp38 MAPKの働き2021

    • Author(s)
      黄 涛若、富岡 征大、飯野 雄一
    • Organizer
      第44回 日本分子生物学会年会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] Functions of insulin-like peptide signaling in the C. elegans nervous system2021

    • Author(s)
      Masahiro Tomioka
    • Organizer
      Kick-off Symposium of “International Research on Regulation of Insulin-Like Activities for Extension of Health Life Span”
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫の味覚における記憶学習を制御する分子機構2021

    • Author(s)
      富岡 征大
    • Organizer
      生理研研究会2021 「記憶・学習の多角的理解に向けたアプローチ」
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 塩走性に働く神経ペプチドの同定と機能の解明2021

    • Author(s)
      Yucheng Xie, Koji Yamada, Takeshi Adachi, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      線虫研究の未来を創る会2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] ASEL神経における塩応答機構の解明2021

    • Author(s)
      Sayako Satomi, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      線虫研究の未来を創る会2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] Roles of the nlp-3 neuropeptide gene in salt chemotaxis in C. elegans2021

    • Author(s)
      児玉未来、安達健、山田康嗣、飯野雄一、國友博文
    • Organizer
      線虫研究の未来を創る会2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫の行動制御神経回路機構の強化学習による探索2021

    • Author(s)
      山内直寛、森啓太、飯野雄一、銅谷賢治
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] ’Molecular Encoding and Synaptic Decoding of Memory of Chemical Concentration in C. elegans’2021

    • Author(s)
      Shingo Hiroki, Hikari Yoshitane, Yoshitaka Fukada, Masahiro Tomioka, Muneki Ikeda, Ikue Mori, Yuichi Iino
    • Organizer
      International C. elegans Conference
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The regulation of olfactory circuit by EGL-4/PKG2021

    • Author(s)
      Takahiro Hino, Shota Hirai, Takeshi Ishihara,Manabi Fujiwara
    • Organizer
      International Worm Meeting 2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diacylglycerol content controls proper memory utilization through switching between forgetting and retrieving.2021

    • Author(s)
      Mary Arai, Itsuki Kurokawa, Akitoshi Inoue, Takeshi Ishihara
    • Organizer
      International Worm Meeting 2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of neuropeptides accelerating forgetting in C. elegans with a reverse genetic apporach2021

    • Author(s)
      Yuuki Onishi, Jamine Teo, Tomohiro Kitazono Takeshi Ishihara
    • Organizer
      International Worm Meeting 2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous measurements of membrane voltage and intracellular Ca2+ of AWA neurons by a gene encoded voltage indicator and GCaMP2021

    • Author(s)
      Noriko Sato, Takeshi Ishihara, Terumasa Tokunaga
    • Organizer
      International Worm Meeting 2021
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫の嗅覚記憶の忘却におけるAIA介在神経の関与2021

    • Author(s)
      Jamine Teo, Tomohiro Kitazono,Takeshi Ishihara
    • Organizer
      日本分子生物学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 神経ペプチドNLP-47は線虫のC. elegansの嗅覚学習の忘却を促進する2021

    • Author(s)
      大西 湧己、Teo Jamine、石原 健
    • Organizer
      日本分子生物学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫の脳における複数の情報処理の実行機構2021

    • Author(s)
      藤原学 平井祥太 石原 健
    • Organizer
      日本分子生物学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 線虫 C. elegans を用いて高精度な神経回路解析を行うことを目指し た実験系の改良2021

    • Author(s)
      白井洸充 村上 悠子、豊島 有、大江 紗、Stephen Wu、金森 真奈実、寺本 孝行、Moon-Sun Jang、佐藤 博文、吉田 亮、飯野 雄一、石原 健
    • Organizer
      日本分子生物学会
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Presentation] 全脳イメージングを用いた線虫の機能的神経回路の同定に向けて2020

    • Author(s)
      遠藤 雄人,Chentao Wen、三浦 拓也、熊谷 里加子、石原 健、木村 幸太郎
    • Organizer
      日本神経科学学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3DeeCellTracker: 三次元時系列画像データから細胞活動を追跡・抽出する深層学習を用いたソフトウェア2020

    • Author(s)
      木村 幸太郎、三浦 拓也、Venkatakaushik Voleti、藤江 由香子、寺本 孝行、石原 健、Elizabeth M.C. Hillman、Chentao Wen
    • Organizer
      日本神経科学学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 線虫の塩走性におけるnlp-3の役割の解明2020

    • Author(s)
      児玉未来、安達健、山田康嗣、飯野雄一、國友博文
    • Organizer
      第43回 日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Molecular and neural network mechanisms for the alteration in taste evaluation of C. elegans2019

    • Author(s)
      飯野雄一
    • Organizer
      第48回内藤コンファレンス
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 線虫全脳の機能的イメージングと動態解析2019

    • Author(s)
      豊島 有
    • Organizer
      第44回レーザー顕微鏡研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 線虫全脳の機能的イメージングと動態解析2019

    • Author(s)
      豊島 有
    • Organizer
      第9回光科学異分野横断萌芽研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The function of synaptic insulin-like signaling in behavioral switch in C. elegans2019

    • Author(s)
      富岡征大
    • Organizer
      Gordon Research Conferences IGF & Insulin System in Physiology & Disease
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular and neural mechanisms of salt concentration memory-dependent chemotaxis of Caenorhabditis elegans2019

    • Author(s)
      國友博文
    • Organizer
      第48回内藤コンファレンス
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bio-image informatics for whole-brain activity imaging of C. elegans2018

    • Author(s)
      豊島 有
    • Organizer
      CeNeuro2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An analysis of the regulatory mechanisms of learning through the DAG/PKC pathway in the nematode C. elegans2018

    • Author(s)
      廣木 信吾
    • Organizer
      C. elegans Neuronal Development, Synaptic Function & Behavior Topic Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of DAF-16/FOXO in the ASER sensory neuron in taste avoidance learning2018

    • Author(s)
      永嶋 宇
    • Organizer
      C. elegans Neuronal Development, Synaptic Function & Behavior Topic Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural Dynamics of Experience-Dependent Gustatory Behavior2018

    • Author(s)
      佐藤博文
    • Organizer
      CeNeuro2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of Synaptic Plasticity in a Neural Circuit that Regulates Memory Dependent Behavior in C. elegans2018

    • Author(s)
      Llian Mabardi
    • Organizer
      Ceneuro 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular and circuit-level analyses reveal the neural mechanisms for the experience-dependent salt chemotaxis in C. elegans.2018

    • Author(s)
      飯野 雄一
    • Organizer
      Asia-Pacific C. elegans meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A neural mechanism for the conditioned salt-avoidance behavior in C. elegans.2018

    • Author(s)
      Jang MoonSun
    • Organizer
      Asia-Pacific C. elegans meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A regulatory mechanism for starvation-induced behavioral plasticity by the axonal DAF-2 signaling2018

    • Author(s)
      富岡征大
    • Organizer
      2018 Asia-Pacific C. elegans Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple ubiquitin ligases contribute to taste avoidance learning in C. elegans2018

    • Author(s)
      池 泰明
    • Organizer
      2018 Asia-Pacific C. elegans Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of the ClC chloride channel CLH-1: Searching for new molecular mechanisms of food-associated salt chemotaxis learning2018

    • Author(s)
      Chanhyun Park
    • Organizer
      2018 Asia-Pacific C. elegans Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of the CLC chloride channel CLH-1 in food-associated salt chemotaxis learning of C. elegans2018

    • Author(s)
      Chanhyun Park
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 感覚神経におけるDAF-16/FOXO転写因子が線虫の学習・記憶を制御する(The DAF-16/FOXO transcription factor regulates learning and memory in a sensory neuron in C. elegans)2018

    • Author(s)
      永嶋 宇
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C. elegansにおける化学物質に対する誘引行動と忌避行動との切り替えの神経回路機構2018

    • Author(s)
      飯野 雄一
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫全脳イメージングのための高速三次元蛍光顕微鏡の開発2018

    • Author(s)
      佐藤 研
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の塩走性学習の分子・神経機構2018

    • Author(s)
      國友博文
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Simultaneous measurement of whole-brain activity and behavior toward comprehensive understanding of salt chemotaxis of C. elegans2018

    • Author(s)
      豊島 有
    • Organizer
      International Symposium on Systems Science of Bio-Navigation 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 塩走性学習を調節するClC型クロライドチャネルCLH-1 の機能解析2018

    • Author(s)
      Chanhyun Park
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bio-image informatics for whole-brain activity imaging of C. elegans2018

    • Author(s)
      豊島 有
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 味覚学習の分子・神経機構2018

    • Author(s)
      國友博文
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の学習行動から見たスプライシング制御因子の機能2018

    • Author(s)
      昆野史弥
    • Organizer
      線虫の未来を創る会/Future of the nematodes studies
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の頭部全神経のイメージングによる神経回路の動態解析2018

    • Author(s)
      飯野雄一
    • Organizer
      日本動物学会 第89回大会 2018札幌
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 軸索で働くインスリンシグナル伝達により制御されるC. elegansの学習記憶2018

    • Author(s)
      富岡 征大
    • Organizer
      日本動物学会 第89回大会 2018札幌
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の味覚忌避学習に関わる神経の同定及び神経機能の解析2018

    • Author(s)
      ジャン ムンソン
    • Organizer
      日本動物学会 第89回大会 2018札幌
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の動きと神経応答の同時測定2018

    • Author(s)
      佐藤博文
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Observation and Anayses of the Dynamics of the Whole Head Nervous System in C. elegans2018

    • Author(s)
      Yuichi Iino
    • Organizer
      JNN2018(日本神経回路学会第28回全国大会)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Behavioral and histological phenotypes of calsyntenin triple knock out mice2018

    • Author(s)
      Keita Mori
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Understanding how the interneuron AIY mediates salt concentration memory dependent behavior in C. elegans2018

    • Author(s)
      Llian Mabardi
    • Organizer
      SFN 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploring the role of the chloride channel CLH-1 in salt chemotaxis learning in the nematode C. elegans2018

    • Author(s)
      Chanhyun Park
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫の学習行動から見たスプライシング制御因子の機能2018

    • Author(s)
      昆野史弥
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C.elegansの成虫と子孫との相互作用におけるネマトシンの制御機構の解析 Analysis of a nematocin-dependent soial interaction between adult and larvae C. elegans2018

    • Author(s)
      桜井 瞭
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanisms of taste avoidance learning in the nematode C. elegans2018

    • Author(s)
      Yuichi Iino
    • Organizer
      The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception((ISMNTOP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit through the function of a guanylyl cyclase, GCY-28.2018

    • Author(s)
      Manabi Fujiwara, Hiroshi wada, Takeshi Ishihara
    • Organizer
      The 8th Asia Pacific C.elegans Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular genetic analysis of gene mutations that inhibit the forgetting of olfactory adaptation regardless of food condition2018

    • Author(s)
      Soyoka Tanaka
    • Organizer
      The 8th Asia Pacific C.elegans Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyzing whole neural activities to elucidate the mechanisms underlying sensory integration2018

    • Author(s)
      Yuko Murakami, Suzu Oe, Kawahara Yuki, Takumi Katsume, Takayuki Teramoto, Yu Toyoshima, Terumasa Tokunaga, Osamu Hirose, Wu Stephan, Jang Moon-Song, Hirofumi Sato, Sayuri Kuge, Yuishi Iwasaki, Ryo Yoshida, Yuichi Iino, Takeshi Ishihara
    • Organizer
      The 8th Asia Pacific C.elegans Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] C. elegansの嗅覚学習をモデルとした餌シグナルを介した忘却の制御機構の解析2018

    • Author(s)
      新井 美存、井上 明俊、石原 健
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C. elegansの嗅覚回路におけるPKGを介した情報処理機構の解析2018

    • Author(s)
      日野 喬央、藤原 学、石原 健
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cellular analysis in forgetting of an olfactory memory in Caenorhabditis elegans2018

    • Author(s)
      Jamine H Teo、Tomohiro Kitazono、Takeshi Ishihara
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫を用いた分子遺伝学的解析による忘却機構の解明2018

    • Author(s)
      田中 想世花、新井 美存、石原 健
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 感覚統合のメカニズム2018

    • Author(s)
      村上 悠子、大江 紗、勝目 拓海、寺本 孝行、豊島 有、徳永 旭将、広瀬 修、Stephan Wu、Song Jang Moon、佐藤 博文、久下 小百合、岩崎 唯史、吉田 亮、飯野 雄一、石原 健
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analyzing whole neural activities to elusidate the mechanisms underlying sensory integration2018

    • Author(s)
      Yuko Murakami, Suzu Oe, Takumi Katsume, Takayuki Teramoto, Yu Toyoshima, Terumasa Tokunaga, Osamu Hirose, Wu Stephan, Jang Moon-Song, Hirofumi Sato, Sayuri Kuge, Yuishi Iwasaki, Ryo Yoshida, Yuichi Iino, Takeshi Ishihara
    • Organizer
      Symposium on Systems Science of Bio-Navigation 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の全脳イメージングとその解析2018

    • Author(s)
      石原 健
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] How the gonadal maturation changes the neural processing in the olfactory circuitry of C.elegans.2018

    • Author(s)
      藤原 学
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cellular analysis if forgetting of an olfactory memory in Caenorhabditis elegans.2018

    • Author(s)
      Jamine Teo Hooi Min
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C.elegansを用いたストレスによる感覚応答変化の原因解析2018

    • Author(s)
      串田 啄哉
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C.elegansの嗅覚順応の忘却シグナルを担う神経ペプチドの解析2018

    • Author(s)
      大西 湧己
    • Organizer
      線虫研究の未来を創る会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C. elegans の性成熟にともなう匂いの好みの変化とその神経回路基盤2018

    • Author(s)
      藤原 学、和田 寛史、石原 健
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の、成長に伴う行動変化における神経活動のカルシウムイメージング2018

    • Author(s)
      和田 寛史、藤原 学、石原 健
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C.elegansのベンズアルデヒドに対する嗅覚順応の忘却変異体の解析2018

    • Author(s)
      木代成 優大、竹本 怜央、藤原 学、石原 健
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫C. elegansの嗅覚順応の忘却シグナルを担う神経ペプチドの解析2018

    • Author(s)
      大西 湧己、Jamine Hooi Min Teo、北園 智弘、石原 健
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫の嗅覚神経においてポリモーダルな情報伝達を可能にする機構の解析2018

    • Author(s)
      日野 喬央、藤原 学、石原 健
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Generation and characterization of calsyntenin triple knockout mice2018

    • Author(s)
      Keita Mori, Michinori Koebisu, Shizuka Kobayashi, Yuji Kiyama, Toshiya Manabe, Atsu Aiba, Yuichi Iino
    • Organizer
      "Principles of memory dynamism elucidated from a diversity of learning systems"2018 Workshop & Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of the CLC chloride channel CLH-1 in salt chemotaxis learning of Caenorhabditis elegans2018

    • Author(s)
      Park ChanHyun(パク チャンヒョン)、櫻井裕樹、飯野雄一、國友博文
    • Organizer
      Roles of the CLC chloride channel CLH-1 in salt chemotaxis learning of Caenorhabditis elegans
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular and neural circuit mechanisms for experience-dependent behavioral switching in C. elegans2017

    • Author(s)
      YUICHI IINO
    • Organizer
      37th Blankenese Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学走性行動の先天的な機構と後天的な変化2017

    • Author(s)
      飯野 雄一
    • Organizer
      平成29年度生理学研究所研究会 「先天的と後天的なメカニズムの融合による情動・行動の理解と制御」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] How taste preference is modulated in the nematode2017

    • Author(s)
      Yuichi Iino, Takashi Nagasima, Hirofumi Sato, Jang Moon-Sun, Suzu Oe, Yu Toyoshima, Masahiro Tomioka, Hirofumi Kunitomo, Stephen Wu, Ryo Yoshida, Yuishi Iwasaki, Takeshi Ishihara
    • Organizer
      The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YRUF2017/AISCRIB2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding the mechanisms underlying learning in C. elegans2017

    • Author(s)
      Yuichi Iino
    • Organizer
      The 2nd Indian C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A versatile role of insulin-like signaling in learning behavior in C. elegans2017

    • Author(s)
      Masahiro Tomioka, Takashi Nagashima, Mai Goyashiki, Yuichi Iino
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多彩なインスリン様シグナル伝達により制御されるC. elegansの学習記憶2017

    • Author(s)
      富岡 征大、永嶋 宇、後屋敷 舞、飯野 雄一
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of the ClC chloride channel clh-1 in salt chemotaxis learning of Caenorhabditis elegans.2017

    • Author(s)
      ChanHyun Park, Yuki Sakurai, Yuichi Iino, Hirofumi Kunitomo
    • Organizer
      第17回東京大学生命科学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Long-lasting memory of salt chemotaxis learning in C. elegans2017

    • Author(s)
      Shuichi Yanagi, Mai Uemura, Yuichi Iino, Hirofumi Kunitomo
    • Organizer
      37th Blankenese Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Labeling of active neural circuits by the calcium probe CaMPARI2017

    • Author(s)
      Keita Mori, Yu Toyoshima, Yuichi Iino
    • Organizer
      The 21st International C. elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple isoforms of the DAF-16/FOXO transcription factor regulate taste avoidance learning2017

    • Author(s)
      Takashi NAGASHIMA, Masahiro TOMIOKA, Yuichi IINO
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of the CLC chloride channel clh-1 in food-associated salt chemotaxis learning of Caenorhabditis elegans.2017

    • Author(s)
      ChanHyun Park, Yuki Sakurai, Yuichi Iino, Hirofumi Kunitomo
    • Organizer
      21st International C. elegans conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of neurons and analysis of the neural circuit involved in the learned salt-avoidance behavior in C. elegans.2017

    • Author(s)
      M.S. Jang1,2, Y. Toyoshima1,2, H. Kunitomo1,2, Y. Iino1,2
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A gustatory neural circuit for experience-dependent behavioral plasticity.2017

    • Author(s)
      Hirofumi Sato, Hirofumi Kunitomo, Xianfeng Fei, Koichi Hashimoto, Yuichi Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural mechanisms for sugar chemotaxis learning in Caenorhabditis elegans.2017

    • Author(s)
      Risshun Chin, Yutaro Ueoka, Chihiro Uchiyama, Keita Katae, Masahiro Tomioka, Yuichi Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A versatile insulin-like signaling regulates taste avoidance learning2017

    • Author(s)
      Masahiro Tomioka and Yuichi Iino
    • Organizer
      21st International C. elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diacylglycerol encodes differences between past and current stimulus intensity2017

    • Author(s)
      Hayao Ohno, Naoko Sakai, Takeshi Adachi, and Yuichi Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Analysis of function of TORC2 Signaling Pathway in Associative Learning in Caenorhabditis elegans2017

    • Author(s)
      N. Sakai, H. Ohno, M. Tomioka, Y. Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple isoforms of a DAF-16/FOXO transcription factor are involved in learning and memory in C. elegans2017

    • Author(s)
      Takashi NAGASHIMA, Masahiro TOMIOKA, Yuichi IINO
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Generation and characterization of calsyntenin triple knockout mice2017

    • Author(s)
      〇森 啓太、古戎 道典、大野 速雄 、小林静香、真鍋俊也、饗場 篤、飯野 雄一
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of primary interneurons that regulate memory-dependent salt concentration chemotaxis in C. elegans.2017

    • Author(s)
      Hirofumi Kunitomo, Hirofumi Sato and Yuichi Iino.
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Identification of neurons and analysis of the neural circuit involved in the learned salt-avoidance behavior in C. elegans2017

    • Author(s)
      Jang Moon-Sun, Yu Toyoshima, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Roles of the CLC chloride channel CLH-1 in salt chemotaxis learning of Caenorhabditis elegans2017

    • Author(s)
      Park ChanHyun(パク チャンヒョン)、櫻井裕樹、飯野雄一、國友博文
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫C. elegansの連合学習におけるE3ユビキチンリガーゼの制御機構の解析2017

    • Author(s)
      池 泰明、姜 涛、富岡 征大、飯野 雄一
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫 Caenorhabditis elegansの糖走性学習を生み出す神経機 構2017

    • Author(s)
      陳 立峻、上岡 雄太郎、内山 千紘、片江 圭太、富岡 征大、飯野 雄一
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 哺乳類におけるカルシンテニンの機能:トリプルノックアウト マウスを用いた解析2017

    • Author(s)
      森 啓太、古戎 道典、小林 静香、城山 優冶、真鍋 俊也、饗場 篤、飯野 雄一
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫 C. elegansの DAG/PKC経路による学習制御機構の解析2017

    • Author(s)
      廣木 進吾、田村 成宏、富岡 征大、國友 博文、飯野 雄一
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit through the function of a guanylyl cyclase, GCY-282017

    • Author(s)
      Manabi Fujiwara, Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An inverse-type of fluorescent Ca2+ indicator for detecting neuronal inhibition2017

    • Author(s)
      Sayuri Kuge, Tomonobu Nishihara, Tomoki Matsuda, Takayuki Teramoto, Takeharu Nagai and Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the regulation of forgetting by the food signals in the olfactory learning of C. elegans.2017

    • Author(s)
      Mary Arai, Akitoshi Inoue, Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyses of the molecular mechanism regulating developmental change in odor preference of C. elegans2017

    • Author(s)
      Takahiro Hino, Manabi Fujiwara, Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyses of the mechanisms of information processing controlling behavior by whole-brain imaging in?C.?elegans.2017

    • Author(s)
      Suzu Oe, Yuko Murakami, Takumi Katsume, Takayuki Teramoto, Terumasa Tokunaga, Yu Toyoshima, Wu Stephan, Osamu hirose, Jang Moon-Sung, Hirofumi Sato, Hiroki Takizawa, Sayuri Kuge, Yuishi Iwasaki, Ryo Yoshida, Yuichi Iino, Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyses in forgetting of an olfactory memory in C. elegans2017

    • Author(s)
      Jamine H. Teo, Tomohiro Kitazono, Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of monoamine neurotransmitters on forgetting of olfactory adaptation in C. elegans2017

    • Author(s)
      Ryo Takahashi, Mary Arai, Tomohiro Kitazono, Manabi Fujiwara, Takeshi Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of pheromones in behavioral changes during development of Caenorhabditis elegans.2017

    • Author(s)
      H. Wada, R.A. Butcher, M Fujiwara, T Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisms of holding memory of butanone enhancement of C. elegans2017

    • Author(s)
      N. Iwase, E. Sawatari, M. Fujiwara, T. Ishihara
    • Organizer
      21st International C.elegans Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫C. elegansの成長に伴う行動変化とその神経回路基盤2017

    • Author(s)
      藤原 学、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抑制性神経活動を検出する消光型蛍光カルシウムプローブタンパク質2017

    • Author(s)
      久下 小百合、西原 知伸、松田 知己、寺本 孝行、永井 健治、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫C. elegansの嗅覚学習をモデルとした餌シグナルを介した忘却の制御機構の解析2017

    • Author(s)
      新井 美存、井上 明俊、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫C. elegansにおいて、嗅覚順応の忘却は複数のシグナル伝達経路による感覚応答の調節により、協調的・時間的に制御される2017

    • Author(s)
      北園 智弘、久下 小百合、井上 明俊、藤原 学、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫C. elegansの成長にともなう化学走性変化を制御する神経機構の解析2017

    • Author(s)
      日野 喬央、藤原 学、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫の全脳イメージングによる行動を制御する情報処理機構の解析2017

    • Author(s)
      大江 紗、勝目 拓海、寺本 孝行、豊島 有、徳永 旭将、Wu Stephan、広瀬 修、Moon-Sun Jang、佐藤 博文、滝沢 拓己、久下 小百合、岩崎 唯史、吉田 亮、飯野 雄一、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cellular and molecular analyses in forgetting of an olfactory memory in C. elegans2017

    • Author(s)
      Jamine H Teo、Tomohiro Kitazono、Takeshi Ishihara
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫のブタノンエンハンスメントの忘却のメカニズム2017

    • Author(s)
      岩瀬 なみ、猿渡 悦子、藤原 学、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] モノアミン神経伝達物質が線虫の嗅覚順応の忘却に与える影響2017

    • Author(s)
      高橋 龍、新井 美存、北園 智弘、藤原 学、石原 健
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成長に伴う行動変化の役割におけるフェロモンの役割2017

    • Author(s)
      和田 寛史
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単一ニューロンにおけるCa2+ ダイナミクス2017

    • Author(s)
      久下 小百合、寺本 孝行、徳永 旭将、石原 健
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] C. elegansの嗅覚学習をモデルとした餌シグナルを介した忘却の制御機構の解析2017

    • Author(s)
      新井 美存、井上 明俊、石原 健
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫C. elegansにおいて、記憶の忘却は、感覚応答をコントロールを介して、複数のシグナル伝達経路により、協調的・時期特異的に行われる2017

    • Author(s)
      北園 智弘、久下 小百合、井上 明俊、藤原 学、石原 健
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 飯野研究室

    • URL

      http://molecular-ethology.bs.s.u-tokyo.ac.jp/labHP/J/JTop.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 飯野研究室

    • URL

      http://molecular-ethology.bs.s.u-tokyo.ac.jp/labHP/J/JPublications/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 九州大学大学院理学研究院生物科学専攻情報生物学講座遺伝学研究室

    • URL

      http://www.biology.kyushu-u.ac.jp/~bunsiide/publication2nd.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 飯野研究室ホームページ

    • URL

      http://molecular-ethology.bs.s.u-tokyo.ac.jp/labHP/J/JTop.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 分子遺伝学研究室

    • URL

      http://www.biology.kyushu-u.ac.jp/~bunsiide/

    • Related Report
      2017 Annual Research Report

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Published: 2017-06-01   Modified: 2024-03-28  

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