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大脳メタ記憶神経回路の解明:光遺伝学による内省の因果的制御

Research Project

Project/Area Number 17H06161
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research (2018-2021)
Juntendo University (2017)

Principal Investigator

宮下 保司  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (40114673)

Co-Investigator(Kenkyū-buntansha) 内山 安男  順天堂大学, 医学部, 特任教授 (10049091)
松崎 政紀  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50353438)
小西 清貴  順天堂大学, 医学(系)研究科(研究院), 教授 (90323609)
大木 研一  東京大学, 大学院医学系研究科(医学部), 教授 (50332622)
Project Period (FY) 2017-05-31 – 2022-03-31
Project Status Declined (Fiscal Year 2021)
Budget Amount *help
¥209,300,000 (Direct Cost: ¥161,000,000、Indirect Cost: ¥48,300,000)
Fiscal Year 2021: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2020: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2019: ¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2018: ¥52,000,000 (Direct Cost: ¥40,000,000、Indirect Cost: ¥12,000,000)
Fiscal Year 2017: ¥67,730,000 (Direct Cost: ¥52,100,000、Indirect Cost: ¥15,630,000)
Keywords認知神経科学 / 磁気共鳴機能画像法 / 霊長類 / メタ記憶 / 光遺伝学 / 磁気刺激法 / 記憶
Outline of Annual Research Achievements

前年度から開始した松崎研究室との共同研究は順調に進捗し、マーモセットにおける高次認知課題を用いた初期の成果が得られ、1年以内には論文発表の見込みである。ヒトを被験者とした渡部博士のfMRI解析も順調に進捗し初期の成果が得られつつある。また、ArchTを用いる抑制的光遺伝学的介入の新規方法を論文発表した(Setsuie et al., iScience 2020):in vivoにおいては、in vitro における最適波長である532nmではなく、594nmのレーザー光照射が最も広範囲の大脳皮質を活性化できることを見出した。この結果は、サルの光遺伝学実験において、オプシン分子活性化波長とヘモグロビン等の脳内吸光分子の吸収波長の両方を最適化することが重要であることを示している。
本研究において既に同定した大脳前頭葉の複数領域は、記憶の種類毎に特異的に機能するメタ記憶読み出し領域であるが、これらから統一的な確信度判断を導くプロセスの解明のためにマカクサルを用いたfMRI解析を進めてきた。その結果、大脳後下頭頂葉(pIPL)が、読みだされたメタ記憶情報を統合してメタ判断を下す中心部位であることを見出した。更にpIPLから背側前帯状皮質(dACC)へと送られる信号が最終的な行動へと導くことも明らかになった(Miyamoto, Setsuie, Miyashita, in revision 2021)。
以上のように2019年度までの実験・研究は順調に進捗した。しかし、2020年2月以降のCOVID-19の影響は大きく、集中的なまとめ実験を行うべき2020年度の研究遂行が困難に直面し、2021年度においても研究遂行の為の十分な実験研究環境を整備することが困難であると考えられた為、2021年度における本基盤(S)研究費投入は妥当性を欠くと判断し、2021年度研究費申請を辞退することとした。

Research Progress Status

翌年度、交付申請を辞退するため、記入しない。

Strategy for Future Research Activity

翌年度、交付申請を辞退するため、記入しない。

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(8 results)
  • 2020 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (37 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 13 results) Presentation (20 results) (of which Int'l Joint Research: 9 results,  Invited: 4 results) Book (1 results) Remarks (2 results) Funded Workshop (1 results)

  • [Journal Article] Neuronal representations of reward-predicting cues and outcome history with movement in the frontal cortex2021

    • Author(s)
      Kondo Masashi、Matsuzaki Masanori
    • Journal Title

      Cell Reports

      Volume: 34 Issue: 5 Pages: 108704-108704

    • DOI

      10.1016/j.celrep.2021.108704

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Off-Peak 594-nm Light Surpasses On-Peak 532-nm Light in Silencing Distant ArchT-Expressing Neurons In Vivo2020

    • Author(s)
      Setsuie Rieko、Tamura Keita、Miyamoto Kentaro、Watanabe Takamitsu、Takeda Masaki、Miyashita Yasushi
    • Journal Title

      iScience

      Volume: 23 Issue: 7 Pages: 101276-101276

    • DOI

      10.1016/j.isci.2020.101276

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A numerical study on efficient jury size2020

    • Author(s)
      Watanabe Takamitsu
    • Journal Title

      Humanities and Social Sciences Communications

      Volume: 7 Issue: 1

    • DOI

      10.1057/s41599-020-00556-1

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Perirhinal circuits for memory processing2019

    • Author(s)
      Miyashita Yasushi
    • Journal Title

      Nature Reviews Neuroscience

      Volume: 20 Issue: 10 Pages: 577-592

    • DOI

      10.1038/s41583-019-0213-6

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Essential Role of the Intraparietal Sulcus in Response Inhibition Predicted by Parcellation-Based Network.2019

    • Author(s)
      Osada T, Ohta S, Ogawa A, Tanaka M, Suda A, Kamagata K, Hori M, Aoki S, Shimo Y, Hattori N, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S.
    • Journal Title

      J Neurosci.

      Volume: 39 Issue: 13 Pages: 2509-2521

    • DOI

      10.1523/jneurosci.2244-18.2019

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] More subjects are required for ventrolateral than dorsolateral prefrontal TMS because of intolerability and potential drop-out2019

    • Author(s)
      3.Han S, Ogawa A, Osada T, Suda A, Tanaka M, Nanjo H, Shimo Y, Hattori N, Konishi S
    • Journal Title

      PLOS One

      Volume: 14 Issue: 6 Pages: 0217826-0217826

    • DOI

      10.1371/journal.pone.0217826

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex2019

    • Author(s)
      Tamura K†, Osada T†, Ogawa A, Tanaka M, Suda A, Shimo Y, Hattori N, Kamagata K, Hori M, Aoki S, Shimizu T, Enomoto H, Hanajima R, Ugawa Y, Konishi S († equal contribution)
    • Journal Title

      PLOS One

      Volume: 14 Issue: 10 Pages: 0224175-0224175

    • DOI

      10.1371/journal.pone.0224175

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study2019

    • Author(s)
      Someya Yuki、Tamura Yoshifumi、Kaga Hideyoshi、Nojiri Shuko、Shimada Kazunori、Daida Hiroyuki、Ishijima Muneaki、Kaneko Kazuo、Aoki Shigeki、Miida Takashi、Hirayama Satoshi、Konishi Seiki、Hattori Nobutaka、Motoi Yumiko、Naito Hisashi、Kawamori Ryuzo、Watada Hirotaka
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 9 Pages: e031584-e031584

    • DOI

      10.1136/bmjopen-2019-031584

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex2018

    • Author(s)
      Takeda, M., Hirabayashi, T., Adachi, Y., and Miyashita, Y.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4629-4629

    • DOI

      10.1038/s41467-018-07007-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible silencing of the frontopolar cortex selectively impairs metacognitive judgment on non-experience in primates2018

    • Author(s)
      Miyamoto K, Setsuie R, Osada T, Miyashita Y
    • Journal Title

      Neuron

      Volume: 97 Issue: 4 Pages: 980-987

    • DOI

      10.1016/j.neuron.2017.12.040

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Striatal subdivisions that coherently interact with multiple cerebrocortical networks2018

    • Author(s)
      Ogawa A†, Osada T†, Tanaka M, Hori M, Aoki S, Nikolaidis A, Milham MP, Konishi S († equal contribution)
    • Journal Title

      Human Brain Mapping

      Volume: 39 Issue: 11 Pages: 4349-4359

    • DOI

      10.1002/hbm.24275

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition2018

    • Author(s)
      Yamasaki Tomoko、Ogawa Akitoshi、Osada Takahiro、Jimura Koji、Konishi Seiki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 1-9

    • DOI

      10.3389/fnhum.2018.00208

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conversion of object identity to object-general semantic value in the primate temporal cortex.2017

    • Author(s)
      Tamura, K., Takeda, M., Setsuie, R., Tsubota, T., Hirabayashi, T., Miyamoto, K., and Miyashita, Y.
    • Journal Title

      Science

      Volume: 357 Issue: 6352 Pages: 687-692

    • DOI

      10.1126/science.aan4800

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳科学の未来と社会貢献2020

    • Author(s)
      Miyashita Yasushi
    • Organizer
      理化学研究所と産業界との交流会 第33回
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Beyond memory circuit: Origins of metamemory and retrospection in the primate.2019

    • Author(s)
      Miyashita Yasushi
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Necessity of the posterior parietal cortex in response inhibition revealed by fMRI and TMS.2019

    • Author(s)
      Osada Takahiro、Ohta Shinri、Ogawa Akitoshi、Tanaka Masizu Takahiro、Enomoto Hiroyuki、Hanaki、Suda Akimitsu、Kamagata Koji、Hori Masaaki、Aoki Shigeki、Shimo Yasushi、Hattori Nobutaka、Shimajima Ritsuko、Ugawa Yoshikazu、Konishi Seiki
    • Organizer
      Human Brain Mapping Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatial extent of rTMS-induced cortical plasticity in the primary motor cortex detected by resting-state fMRI.2019

    • Author(s)
      Tamura Kaori、Osada Tatahiro、Ogawa Akitoshi、Tanaka Masaki、Suda Akimitsu、Shimo Yasushi、Hattori Nobutaka、Kamagata Koji、Hori Masaaki、Aoki Shigeki、Shimizu Takahiro、Enomoto Hiroyuki、Hanajima Ritsuko、Ugawa Yoshikazi、Konishi Seiki
    • Organizer
      Society for Neuroscience Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Beyond memory circuit: Origins of metamemory and retrospection in the primate.2019

    • Author(s)
      Miyashita Yasushi
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A neuroanatomical basis linking perceptual inflexibility to cognitive rigidity in autism.2019

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      49th Annual meeting of the society for Neuroscience 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatial extent of rTMS-induced cortical plasticity in the primary motor cortex detected by resting-state fMRI.2019

    • Author(s)
      Tamura Kaori, Osada Takahiro, Ogawa Akitoshi,Tanaka Masaki, Suda Aitsu, kimShimo Yasushi, Hattori Nobutaka, Kamagata Koji, Hori Masaaki, Aoki Shigeki, Shimizu Takahiro, Enomoto Hiroyuki, Hanajima Ritsuko, Ugawa Yoshikazu, Konishi Seiki
    • Organizer
      49th Annual meeting of the society for Neuroscience 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Timescales in autistic brains.2019

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Data-driven approach to illustrate brain dynamics and its application.2019

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      生理学研究所研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Atypicality in local and global brain dynamics in autism.2019

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      日本精神神経学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Necessity of the posterior parietal cortex in response inhibition revealed by fMRI and TMS.2019

    • Author(s)
      Osada Takahiro, Ohta Shinri, Ogawa Akitoshi, Tanaka Masaki, Suda Akimitsu, Kamagata Koji, Hori Masaki, Aoki Shigeki, Shimo Yasushi, Hattori Nobutaka, Shimizu Takahiro, Enomoto Hiroyuki, Hanajima Ritsuko,Ugawa Yoshikazu, Konishi Seiki
    • Organizer
      Organization for Human Brain Mapping Annual Meeting 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional connectivity changes after rTMS used to detect plasticity decline associated with obesity.2019

    • Author(s)
      Han Shuyan, Osada Takahiro, Ogawa Akitoshi, Tanaka Masaki, Kamagata Koji, Hori Masaaki, Aoki Shigeaki, Shimizu Takahiro, Enomoto Hiroyuki, Hanajima Ritsuko, Ugawa Yoshikazu, Konishi Seiki
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Beyond memory circuits: Origin of our metamemory and self-reflection.2018

    • Author(s)
      Miyashita Yasushi
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Causally essential neural network for performing metacognitive judgement on experience and ignorance in primates.2018

    • Author(s)
      Miyamoto Kentaro, Setsuie Rieko, Osada Takahiro, Miyashita Yasushi
    • Organizer
      48th Annual meeting of the society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neural retainability in autism.2018

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      48th Annual meeting of the society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Associations between atypicality in local neural retainability and core symptoms of autism2018

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      第2回ヒト脳イメージング学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Causal role of the frontopolar cortex for metacognitive judgement on non-experienced.2018

    • Author(s)
      Miyamoto Kentaro, Setsuie Rieko, Osada Takahiro, Miyashita Yasushi
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Brain dynamics underlying typical and atypical intelligence.2018

    • Author(s)
      Watanabe Takamitsu
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Causally essential neural network for performing metacognitive judgement on experience and ignorance in primates.2018

    • Author(s)
      Miyamoto Kentaro、Setsuie Rieko、Osada Takahiro、Miyashita Yasushi
    • Organizer
      The Society for Neuroscience’s 48th Annual Meeting.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ArchT-mediated optogenetic inhibition in vivo by red-shifted off-peak 594 nm light compared with that by on-peak 532 nm light.2017

    • Author(s)
      Setsuie Rieko、Tamura Keita、Takeda Masaki、Miyamoto Kentaro、Miyashita Yasushi
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Book] The History of Neuroscience in Autobiography2020

    • Author(s)
      Yasushi. Miyashita
    • Total Pages
      40
    • Publisher
      Society for Neuroscience
    • ISBN
      9780916110031
    • Related Report
      2020 Annual Research Report
  • [Remarks] 理化学研究所脳神経科学研究センター高次認知機能動態研究チーム

    • URL

      https://www.riken.jp/research/labs/cbs/cogn_circ_dyn/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 順天堂大学大学院医学研究科神経生理学

    • URL

      http://square.umin.ac.jp/physio-1/

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] From Neuron to Cognition: the Past, Present and Future of the Neuronal Circuit Doctrine2019

    • Related Report
      2019 Annual Research Report

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Published: 2017-06-01   Modified: 2023-10-16  

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