| Budget Amount *help |
¥196,170,000 (Direct Cost: ¥150,900,000、Indirect Cost: ¥45,270,000)
Fiscal Year 2021: ¥33,150,000 (Direct Cost: ¥25,500,000、Indirect Cost: ¥7,650,000)
Fiscal Year 2020: ¥31,850,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥7,350,000)
Fiscal Year 2019: ¥33,800,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥7,800,000)
Fiscal Year 2018: ¥57,850,000 (Direct Cost: ¥44,500,000、Indirect Cost: ¥13,350,000)
Fiscal Year 2017: ¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000)
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| Outline of Final Research Achievements |
We examined the response of host chromatin structures upon viral infection with influenza virus and SARS-CoV2. We found that the host chromatin structure dynamically changes upon influenza virus infection. Suv4-20h2, a trimethyltransferase of H4K20 that binds to cohesin was involved in the maintenance of heterochromatin structure in the uninfected condition. Upon infection, cohesin was dissociated from Suv4-20h2 and loaded to the boundary of a specific genomic region, forming a chromatin loop, activating the gene expression in the region responsible for virus infection. Furthermore, using specimens from patients with COVID-19, we performed genome-wide host chromatin structure analysis and obtained the findings suggesting a link to the severity of the disease.
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