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Establishment of a new image analysis system of animal behavior

Research Project

Project/Area Number 17H06252
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeSingle-year Grants
Research Field Veterinary medical science, Animal science, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Murata Takahisa  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40422365)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2019: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords実験動物 / 画像解析 / 人工知能 / 行動評価 / 行動解析
Outline of Final Research Achievements

In vivo evaluation of laboratory animals has major problems in terms of reproducibility and objectivity, and it is necessary to use many animals to overcome them. In this project, we applied image analysis technology and artificial intelligence (AI) to make it easier to evaluate more information from experimental animals with objectivity and reproducibility. We attempted to establish a new laboratory animal evaluation system that can evaluate the biological information and emotions of mice in an unrestrained and non-invasive state, without anesthesia. Specifically, we developed a technology that enables general behavior such as spontaneous movement and scratching of mice and rats, and individual identification. And then we applied it to the evaluation of the disease models of mouse and rat.

Academic Significance and Societal Importance of the Research Achievements

病気の診断や治療法の開発には、実験動物の評価が欠かせない。現在は動物の行動を目視で観察して評価することが多い。しかし、これでは再現性や客観性に欠け、実験する人間の違いによる差も多いため、繰り返し動物を使って実験する必要がある。本研究では、実験動物からより多くの情報を、より簡単に、客観性と再現性をもって評価できるようにすることを目的に、画像解析技術や人工知能(AI)を応用することで、無麻酔、無拘束、非侵襲の状態で、マウスの生体情報や情動を評価できる、新しい実験動物評価系の確立を試みた。また、それを 実際の病態モデルの評価に応用した。

Report

(3 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (83 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 3 results) Presentation (61 results) (of which Int'l Joint Research: 9 results,  Invited: 14 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Automated detection of mouse scratching behaviour using convolutional recurrent neural network2021

    • Author(s)
      Koji Kobayashi, Seiji Matsushita, Naoyuki Shimizu, Sakura Masuko, Masahito Yamamoto, and Takahisa Murata
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 658-658

    • DOI

      10.1038/s41598-020-79965-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The assessment of mouse spontaneous locomotor activity using motion picture2020

    • Author(s)
      Kobayashi Koji、Shimizu Naoyuki、Matsushita Seiji、Murata Takahisa
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 143 Issue: 2 Pages: 83-88

    • DOI

      10.1016/j.jphs.2020.02.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-PGDS-derived PGD2 attenuates acute lung injury by enhancing endothelial barrier formation2019

    • Author(s)
      Horikami Daiki、Toya Naoki、Kobayashi Koji、Omori Keisuke、Nagata Nanae、Murata Takahisa
    • Journal Title

      The Journal of Pathology

      Volume: 印刷中 Issue: 3 Pages: 280-290

    • DOI

      10.1002/path.5253

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic prostaglandin D synthase-derived prostaglandin D2 ameliorates adjuvant-induced joint inflammation in mice.2019

    • Author(s)
      Yoshiki Tsubosaka, Toko Maehara, Daiki Imai, Tatsuro Nakamura, Koji Kobayashi, Nanae Nagata, Wataru Fujii, Takahisa Murata
    • Journal Title

      FASEB Journal

      Volume: 印刷中 Issue: 6 Pages: 6829-6837

    • DOI

      10.1096/fj.201802153r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of D prostanoid receptor 1 signal enhancement in a murine model of food allergy.2019

    • Author(s)
      Nakamura T, Hirai R, Tachibana Y, Masuko S, Nagata N, Murata T.
    • Journal Title

      The journal of allergy and clinical and immunology

      Volume: 印刷中 Issue: 6 Pages: 2290-2293

    • DOI

      10.1016/j.jaci.2019.01.039

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial cell?derived prostaglandin D2 inhibits chronic allergic lung inflammation in mice2019

    • Author(s)
      Maehara Toko、Nakamura Tatsuro、Maeda Shingo、Aritake Kosuke、Nakamura Masataka、Murata Takahisa
    • Journal Title

      The FASEB Journal

      Volume: 印刷中 Issue: 7 Pages: 8202-8210

    • DOI

      10.1096/fj.201802817r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of lipid mediators in mastitic milk of cow.2019

    • Author(s)
      Hayashi A, Fujii S, Nakamura T, Kobayashi K, Sakatani M, Endo M, Takahashi T, Murata T.
    • Journal Title

      Anim Sci J

      Volume: 90(8): Issue: 8 Pages: 999-1007

    • DOI

      10.1111/asj.13222

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of lipid mediators across different disease stages of dextran sodium sulfate-induced colitis in mice.2018

    • Author(s)
      Hamabata T, Nakamura T, Masuko S, Maeda S, Murata T.
    • Journal Title

      J Lipid Res.

      Volume: 59(4) Issue: 4 Pages: 586-595

    • DOI

      10.1194/jlr.m079095

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of IgE in allergic diseases2018

    • Author(s)
      Hayashi A, Nakamura T, Murata T.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 151 Issue: 3 Pages: 130-130

    • DOI

      10.1254/fpj.151.130

    • NAID

      130006470912

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular permeability in anaphylaxis2018

    • Author(s)
      Nakamura T, *Murata T.
    • Journal Title

      British Journal of Pharmacology

      Volume: 175(13) Issue: 13 Pages: 2538-2542

    • DOI

      10.1111/bph.14332

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary PGDM, a prostaglandin D2 metabolite, is a novel biomarker for objectively detecting allergic reactions of food allergy2018

    • Author(s)
      Inagaki S, Maeda S, Narita M, Nakamura T, Shimosawa T, *Murata T and *Ohya Y.
    • Journal Title

      J Allergy Clin Immunol

      Volume: S0091-6749(18) Issue: 5 Pages: 30995-3

    • DOI

      10.1016/j.jaci.2018.06.032

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of prostaglandins in tumor microenvironment2018

    • Author(s)
      Kobayashi K, Omori K, *Murata T.
    • Journal Title

      Cancer Metastasis Rev

      Volume: 37(2-3) Issue: 2-3 Pages: 347-354

    • DOI

      10.1007/s10555-018-9740-2

    • NAID

      40022508034

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of mast cells in tumor microenvironment2018

    • Author(s)
      Yamazaki A, Kobayashi K, *Murata T.
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 152 Issue: 3 Pages: 160-162

    • DOI

      10.1254/fpj.152.160

    • NAID

      130007472337

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas.2018

    • Author(s)
      Omori K, Nagata N, Kurata K, Fukushima Y, Sekihachi E, Fujii N, Namba-Hamano T, Takabatake Y, Fruttiger M, Nagasawa T, Uemura A, Murata T
    • Journal Title

      JCI Insight

      Volume: 3 Issue: 23 Pages: 120706-120706

    • DOI

      10.1172/jci.insight.120706

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells2017

    • Author(s)
      Omori Keisuke、Morikawa Teppei、Kunita Akiko、Nakamura Tatsuro、Aritake Kosuke、Urade Yoshihiro、Fukayama Masashi、Murata Takahisa
    • Journal Title

      The Journal of Pathology

      Volume: 244 Issue: 1 Pages: 84-96

    • DOI

      10.1002/path.4993

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] PGDM as a Specific Maker of Food Allergy2020

    • Author(s)
      Takahisa Murata
    • Organizer
      Food Allergy Gordon Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アトピー性皮膚炎モデルマウス及び患者における尿中脂質プロファイルの解析2020

    • Author(s)
      永田 奈々恵、濵﨑 雄大、稲垣 真一郎、中村 達朗、堀上 大貴、山本 貴和子、犬塚 祐介、下澤 達雄、橘 侑里、成田 雅美、大矢 幸弘、村田 幸久
    • Organizer
      第2回比較薬理学・毒性学会春季研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 5,6-DiHETEはTRPV4チャネルを阻害して腸炎の治癒を促進する2020

    • Author(s)
      小林幸司、芦名功平、Derouiche Sandra、濱端大貴、中村達朗、永田奈々恵、富永真琴、村田幸久
    • Organizer
      第2回比較薬理学・毒性学会春季研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 疾患における生理活性脂質の役割の解明と応用2020

    • Author(s)
      大森啓介、前原都有子、藤原祐樹、宮崎悠介、藤井省太、堀上大貴, 山崎愛理沙、今井大貴、橘侑里、益子櫻、林亜佳音、濱崎雄太、木田美聖、小林唯、宮田佳奈、山本晃子、竹ノ内晋也、原口大雅、芦名功平、小林幸司、中村達朗、永田奈々恵、村田幸久
    • Organizer
      第2回比較薬理学・毒性学会春季研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロスタグランジンD2を毒仮説から考える2020

    • Author(s)
      中村達朗、藤原祐樹、木田美聖、村田幸久
    • Organizer
      第2回比較薬理学・毒性学会春季研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The role of Prostaglandin D2 synthase in retinal angiogenesis2020

    • Author(s)
      堰八英里香、大森啓介、小林幸司、永田奈々恵、中村達朗、倉田薫里、植村明嘉、村田幸久
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 動物の心を読む:薬理学における動物行動研究の新展開 画像解析による動物行動評価方法の開発2020

    • Author(s)
      小林幸司、松下誠司、清水直行、村田幸久
    • Organizer
      第93回日本薬理学会年会 公募シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PGD2シグナルの欠損と強化で変わる食物アレルギー病態フェノタイプ2019

    • Author(s)
      中村達朗、平井里奈、橘侑里、村田 幸久
    • Organizer
      第1回日本比較薬理毒性学会春季研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pharmacological stimulation of DP receptor is beneficial for food allergy in mice2019

    • Author(s)
      Takahisa Murata, Tatsuro Nakamura, Rina Hirai, Sakura Masuko
    • Organizer
      2019 AAAAI Annual Meeting
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体における脂質の役割解明とその応用2019

    • Author(s)
      村田幸久
    • Organizer
      日本医学会連合risign starリトリート
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動画を用いたマウス自発運動の自動測定方法の確立2019

    • Author(s)
      小林幸司、清水直行、松下誠司、村田幸久
    • Organizer
      第66回日本実験動物学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マーモセット消耗症候群における尿中脂質代謝産物の産生プロファイル2019

    • Author(s)
      山崎愛理沙1, 中村達朗1, 宮部貴子2, 平田暁大3, 井上理香子1, 小林幸司1, 宮崎悠介1, 石上暁代2, 兼子明久2, 小泉誠4, 太田裕貴5, 岡野ジェイムス洋尚5, 村田幸久1
    • Organizer
      第66回日本実験動物学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The role of PGD2/CRTH2 signaling in host defense against bee venom2019

    • Author(s)
      Misato Kida, Tatsuro Nakamura, Yuki Fujiwara, Takahisa Murata.
    • Organizer
      The 68th Annual Meeting of Japanese Society of Allergology
    • Related Report
      2019 Annual Research Report
  • [Presentation] 8-iso PGE2 causes nasal congestion in allergic rhinitis of mice2019

    • Author(s)
      Yuri Tachibana, Tatsuro Nakamura, Takahisa Murata
    • Organizer
      The 68th Annual Meeting of Japanese Society of Allergology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lipid profiling in nasal lavage fluid of a murine model of allergic rhinitis2019

    • Author(s)
      Tatsuro Nakamura, Yuri Tachibana, Takahisa Murata
    • Organizer
      The 68th Annual Meeting of Japanese Society of Allergology
    • Related Report
      2019 Annual Research Report
  • [Presentation] リピドーム解析の病態解明や診断への応用2019

    • Author(s)
      村田幸久
    • Organizer
      脂質生化学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 5,6-DiHETEは血管の透過性を抑制する2019

    • Author(s)
      濱端大貴、中村達朗、芦名功平、橘侑里、堀上大貴、小林幸司、○村田幸久
    • Organizer
      脂質生化学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] L-PGDS由来のPGD2がエストロゲン 枯渇による骨破壊に与える影響2019

    • Author(s)
      今井 大貴、大森 啓介、壺坂 義記、永田 奈々恵、小林 幸司、中村 達郎、村田 幸久
    • Organizer
      第140回日本薬理学会関東部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] がん内血管内皮細胞の抗がん剤感受性においてL-PGDSが果たす役割の解明2019

    • Author(s)
      小林唯、宮崎悠介、大森啓介、小林幸司、村田幸久
    • Organizer
      第140回日本薬理学会関東部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハチ毒に対する生体防御反応においてプロスタグランジンD2受容体CRTH2シグナルが果たす役割2019

    • Author(s)
      木田美聖、中村達朗、藤原祐樹、村田幸久.
    • Organizer
      第140回日本薬理学会関東部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂質が循環に与える影響2019

    • Author(s)
      村田幸久
    • Organizer
      日本血管生物医学会 血管研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mediator Lipidomics: Towards Comprehensive Metabolic Profiling of Eicosanoids and Related Fatty Acids2019

    • Author(s)
      Atsuhiko Toyama, Tatsuro Nakamura, Takahisa Murata.
    • Organizer
      The Omics Rebolution: Beyond Genomics
    • Related Report
      2019 Annual Research Report
  • [Presentation] L-PGDSがエストロゲン枯渇による骨破壊に与える影響2019

    • Author(s)
      今井大貴、大森啓介、壷阪義記、永田奈々恵、小林 幸司、藤井渉、 中村達郎、村田幸久
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] L-PGDSはがん血管内皮細胞の薬剤感受性を低下させる2019

    • Author(s)
      小林唯、宮崎悠介、大森啓介、小林幸司、村田幸久
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハチ毒に対する生体防御反応においてプロスタグランジンD2受容体CRTH2シグナルが果たす役割2019

    • Author(s)
      木田美聖、中村達朗、藤原祐樹、村田幸久.
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アレルギー性鼻炎モデルマウスの鼻汁における 脂質メディエーターの産生量の変化2019

    • Author(s)
      橘 侑里、中村 達朗、荒井 美乃、曽根 正好、村田 幸久
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マーモセットウェイスティングシンドロームにおける尿中脂質代謝産物の 産生プロファイル2019

    • Author(s)
      山崎愛理沙、中村達朗 、宮部貴子、平田暁大 、井上理香子、 小林幸司 、宮﨑悠介、石上暁代、兼子明久、小泉誠、 太田裕貴、岡野ジェイムス洋尚、村田幸久
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 急性肺障害におけるリポカリン型プロスタグランジンD合成酵素の役割解明2019

    • Author(s)
      堀上大貴、遠矢直樹、小林幸司、大森啓介、永田奈々恵、村田幸久
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DBPCFC with N of 1 RCT and PGDM improve diagnostic accuracy of food allergies in a 9-year-old boy2019

    • Author(s)
      Yusuke Inuzuka, Kiwako Yamamoto-Hanada, Motoko iwama, Kenji Toyokuni, Koji Nishimura, Makoto Irahara, Fumi Ishikawa, Makiko Miyata, Miori Sato, Yumiko Miyaji, Mayako Saito, Tatsuki Fukuie, Masami Narita, Ichiro Nomura, Tatsuro Nakamura, Tatsuo Shimosawa, Takahisa Murata, Yukihiro Ohya
    • Organizer
      Pediatric Allergy and Asthma Meeting (PAAM) 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] お腹の調子を整える新規ω3脂肪酸の発見2019

    • Author(s)
      村田 幸久
    • Organizer
      DHAEPA協議会 第21回公開講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Application of lipid mediator for Animal Health2019

    • Author(s)
      Takahisa Murata
    • Organizer
      Animal Health Innovation Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of prostaglandin D2 in food allergy2019

    • Author(s)
      Takahisa Murata
    • Organizer
      The 1st ToBEST symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 無拘束・非侵襲環境下での 動物評価技術の開発2019

    • Author(s)
      村田幸久
    • Organizer
      新日本科学発表
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 5,6-DiHETEは血管透過性を抑制する新規生理活性脂質である2019

    • Author(s)
      村田幸久、濱端大貴、中村達朗、芦名功平、橘侑里、堀上大貴、小林幸司
    • Organizer
      第29回日本循環薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The profiling of lipid metabolites in the nasal lavage fluid of a murine model of allergic rhinitis2019

    • Author(s)
      Yuri Tachibana, Tatsuro Nakamura. Takahisa Murata
    • Organizer
      World Allergy Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mast cell-derived PGD2 limits absorption of bee venom locally in skin2019

    • Author(s)
      Murata T, Fujiwara Y, Kida M, Maehara T, Nakamura T
    • Organizer
      第27回日本血管生物医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 質量分析装置を用いた食物アレルギーマーカーの探索2018

    • Author(s)
      村田 幸久
    • Organizer
      島津質量分析セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Urinary Prostaglandin D2 metabolite predicts the change of oral food antigen-induced allergic symptom in mice2018

    • Author(s)
      Tatsuro Nakamura, Rina Hirai, Yuri Tachibana, and Takahisa Murata
    • Organizer
      AAAAI annual meeting/World Allergy Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can urinary tetranor-PGDM, a metabolite from prostaglandin D2, be used as a reliable marker for evaluating the effectiveness of oral immunotherapies for children with food allergies?2018

    • Author(s)
      S. Inagaki, M. Narita, T. Nakamura, T.Shimosawa, T. Murata, Y. Ohya.
    • Organizer
      AAAAI annual meeting/World Allergy Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery a novel bioactive lipid in murine model of colitis2018

    • Author(s)
      Taiki Hamabata, Tatsuro Nakamura, Sakura Masuko, Shingo Maeda, Takahisa Murata.
    • Organizer
      6th Shimadzu International Collaborative Laboratory Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 肥満細胞由来のPGD2は蜂毒の皮膚からの血中移行を抑制する2018

    • Author(s)
      藤原祐樹、中村達朗、前原都有子、村田幸久
    • Organizer
      第138回日本薬理学会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PGD2が血管内皮細胞への単球の接着に与える影響2018

    • Author(s)
      藤井省太、前原都有子、中村達朗、村田幸久
    • Organizer
      第138回日本薬理学会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アレルギー性鼻炎モデルマウスの鼻汁における 脂質メディエーターの産生量の変化2018

    • Author(s)
      橘侑里、中村達郎、堀上大貴、村田幸久
    • Organizer
      第138回日本薬理学会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 尿中PGD2代謝産物は食物アレルギーの新規バイオマーカーである2018

    • Author(s)
      村田幸久、稲垣真一郎、前田真吾、中村達朗、成田雅美、原田広顕、下澤達雄、矢冨裕、大矢幸弘、
    • Organizer
      第121回日本小児科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食物アレルギー減感作マウスモデルにおける尿中tetranor-PGDMの動態2018

    • Author(s)
      中村達朗 平井里奈 橘侑里 村田幸久
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PGD2受容体DPシグナル強化は食物アレルギーの進行を抑制する2018

    • Author(s)
      益子櫻 中村達朗 平井里奈 村田幸久
    • Organizer
      第60回日本脂質生化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Characteristics of infiltrating mast cells in murine lung carcinoma2018

    • Author(s)
      山崎愛理沙、中村達朗、林亜佳音、堀口和秀、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Production of lipid mediators in bovine milk with mastitis2018

    • Author(s)
      林亜佳音, 藤井省太, 中村達朗, 小林幸司, 阪谷美樹, 高橋友継, 遠藤麻衣子, 村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] The role of PGD2/CRTH2 signal in defense reaction to bee venom2018

    • Author(s)
      Misato Kida, Tatsuro Nakamura, Yuki Fujiwara, Takahisa Murata
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] アレルギー性鼻炎モデルマウスの鼻汁中における脂質メディエーターの産生量の変化2018

    • Author(s)
      橘侑里、中村達郎、村田幸久
    • Organizer
      東京大学生命科学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児食物アレルギー患者の免疫療法効果予測としてのプロスタグランジンD2尿中代謝産物の有用性2018

    • Author(s)
      稲垣真一郎、成田雅美、中村達郎、石川史、苛原誠、佐藤未織、三井元子、齋藤麻耶子、宮田真貴子、宮地裕美子、山本貴和子、福家辰樹、野村伊知郎、村田幸久、大矢幸弘
    • Organizer
      第67回日本アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Urinary tetranor-PGDM predicts the change of oral food antigen-induced allergic symptom in mice2018

    • Author(s)
      Tatsuro Nakamura, Rina Hirai, Takahisa Murata
    • Organizer
      第67回日本アレルギー学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Signal enhancement of D prostanoid receptor prevents the development of food allergy2018

    • Author(s)
      Tatsuro Nakamura, Rina Hirai, Takahisa Murata
    • Organizer
      第18回 国際薬理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] L-PGDS-derived PGD2 attenuated acute lung injury by protecting endothelial cells2018

    • Author(s)
      Horikami D, Naoki T, Kobayashi K, Omori K, Nakamura T, Aritake K, Murata T.
    • Organizer
      第18回 国際薬理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス食物アレルギーモデルにおけるDP1作動薬の抑制効果2018

    • Author(s)
      中村達朗、平井里奈、村田幸久
    • Organizer
      第161回日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The anti-inflammatory role of L-PGDS on acute lung injury2018

    • Author(s)
      Horikami D, Naoki T, Kobayashi K, Omori K, Nagata N, Murata T.
    • Organizer
      第26回 日本血管生物医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス移植癌における肥満細胞の性状変化2018

    • Author(s)
      山崎愛理沙、中村達朗、堀口和秀、林亜佳音、小林幸司、村田幸久
    • Organizer
      第26回 日本血管生物医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 感染性およびアレルギー性結膜炎における涙液中の脂質産生量の比較2018

    • Author(s)
      林亜佳音, 中村達朗, 永田奈々恵, 村田幸久
    • Organizer
      日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳房炎牛の乳汁中における 脂質メディエーターの産生2018

    • Author(s)
      林亜佳音, 藤井省太, 中村達朗, 小林幸司, 阪谷美樹, 高橋友継, 遠藤麻衣子, 村田幸久
    • Organizer
      日本獣医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アレルギー性結膜炎における涙液中脂質産生動態の解明およびPGD2シグナル阻害の治療効果の検討2018

    • Author(s)
      林亜佳音, 中村達朗, 永田奈々恵, 村田幸久
    • Organizer
      薬理学会関東部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 炎症性疾患においてPGD2が血管機能に与える影響2018

    • Author(s)
      村田幸久
    • Organizer
      第14回血管病態リサーチセミナー
    • Related Report
      2018 Annual Research Report
  • [Book] 画像解析技術を利用した実験動物の行動評価2020

    • Author(s)
      小林幸司 村田幸久
    • Total Pages
      3
    • Publisher
      画像ラボ
    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学 大学院農学生命科学研究科 放射線動物科学研究室

    • URL

      http://www.vm.a.u-tokyo.ac.jp/houshasen/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学 大学院農学生命科学研究科

    • URL

      https://www.a.u-tokyo.ac.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学 大学院農学生命科学研究科 応用動物科学専攻

    • URL

      https://www.facebook.com/utokyo.ars.5

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学 大学院農学生命科学研究科 放射線動物科学研究室

    • URL

      http://www.vm.a.u-tokyo.ac.jp/houshasen/

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 情報処理装置、情報処理方法及びプログラム2020

    • Inventor(s)
      村田幸久 小林幸司 松下誠司 清水直行 湯浅智之 港高志
    • Industrial Property Rights Holder
      村田幸久 小林幸司 松下誠司 清水直行 湯浅智之 港高志
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 情報処理装置、情報処理方法及びプログラム2020

    • Inventor(s)
      村田幸久 小林幸司 松下誠司 清水直行 湯浅智之 港高志
    • Industrial Property Rights Holder
      村田幸久 小林幸司 松下誠司 清水直行 湯浅智之 港高志
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report

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Published: 2017-07-21   Modified: 2023-12-25  

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