|Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
|Outline of Final Research Achievements
We have been working on the study of innate signaling via pattern recognition mediated receptor for antiviral responses. In this study, we identified a novel innate signaling pathway via cytosolic RNA sensor RIG-I that activates cell death in cancer cells but not normal cells. This novel pathway is different from conventional pathway via MAVS/IPS-1 mediated IFN inducing pathway. Importantly, localization of a kinase protein is not only nucleus but also cytosol in cancer cells while the localization of this is only nucleus in normal cells. RIG-I in cancer cells activate this kinase and activates apoptosis in cancer cells. Based on our finding that a kinase is localized in cytosol of cancer cells, we propose a novel strategy to modulate ectopic protein for cancer therapy for cancer cells' death.