Estimation of preclinical AD used DNA methylation analyses
Project/Area Number |
17H06286
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Research Category |
Grant-in-Aid for Challenging Research (Pioneering)
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Allocation Type | Single-year Grants |
Research Field |
Health science and related fields
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Research Institution | National Center for Geriatrics and Gerontology |
Principal Investigator |
Shimada Hiroyuki 国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター, センター長 (00370974)
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Co-Investigator(Kenkyū-buntansha) |
原田 健次 中京大学, 体育学研究科, 実験実習助手 (70736058)
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Project Period (FY) |
2017-06-30 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
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Keywords | プレクリニカルAD / DNAメチル化 / メチル化 |
Outline of Final Research Achievements |
In the present study, we aimed to identify the preclinical AD by amyloid PET imaging and investigate DNA methylation pattern related to amyloid accumulation using genome-wide DNA methylation analysis. A total of 103 community-dwelling older adults without dementia or neuropsychological diseases were enrolled in this study. According to amyloid PET imaging, 18 (17.5%) individuals were classified as amyloid positive. In the genome-wide DNA methylation analysis of peripheral blood, 2,194 probes were selected as amyloid-related methylation sites. Trough the gene enrichment analysis, several neighboring genes involved in AD or amyloid β were found. These results suggested that DNA methylation could be a useful indicator for screening the preclinical AD.
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Academic Significance and Societal Importance of the Research Achievements |
現在、ADの治療は、先制医療を実施する必要性があると考えられており、予防薬の開発とともにプレクリニカルADをどのように発見するかが重要な課題となっている。血液サンプルのDNAメチル化からアミロイドの蓄積を予測することが可能となれば、ADの疾病修飾薬開発のレジストリ構築に大きく寄与できる。さらに、本研究の知見を基にプレクリニカルADを高感度に抽出可能なDNAメチル化の解明が進むことで、比較的安価で簡便なスクリーニングが可能となり、広く一般化可能な知見を提示することができる。
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Report
(4 results)
Research Products
(179 results)
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[Journal Article] Automatic Detection of Cognitive Impairments through Acoustic Analysis of Speech2020
Author(s)
Nagumo R, Zhang Y, Ogawa Y, Hosokawa M, Abe K, Ukeda T, Sumi S, Kurita S, Nakakubo S, Lee S, Doi T, Shimada H
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Journal Title
Curr Alzheimer Res
Volume: 17
Issue: 1
Pages: 60-68
DOI
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Peer Reviewed
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[Journal Article] Effects of a Fall-Prevention Program for Older Adults with Dementia Based on Person-Centered Care2019
Author(s)
Suzuki M, Kanamori M, Furuta Y, Abe K, Kato M, Taniguchi Y, Hiramatsu T, Maruoka N, Kobayashi S, Naito T, Shimada H, Izumi K
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Journal Title
Int J Gerontol,
Volume: Special Issue
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Peer Reviewed
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[Journal Article] The Relationships Between Components of Metabolic Syndrome and Mild Cognitive Impairment Subtypes: A Cross-Sectional Study of Japanese Older Adults.2017
Author(s)
Bae S, Shimada H, Lee S, Makizako H, Lee S, Harada K, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Park H, Suzuki T.
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Journal Title
J Alzheimers Dis
Volume: 60
Issue: 3
Pages: 913-921
DOI
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Peer Reviewed / Int'l Joint Research
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[Presentation] Cortical Thinning in the Motoric Cognitive Risk (MCR) Neuroimaging Consortium2019
Author(s)
Blumen H, Schwartz E, Allali G, Beauchet O, Brickman A, Callisaya M, Doi T, Lipton R, Shimada H, Srikanth V, Verghese J
Organizer
Alzheimer’s Association International Conference 2019
Related Report
Int'l Joint Research
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[Presentation] 介護予防を目的としたセルフモニタリングの効果検証:ランダム化比較試験2019
Author(s)
島田裕之, 李相侖, 牧野圭太郎, 裵成琉, 新海陽平, 千葉一平, 片山脩, 原田健次, 山城由華吏, 高柳直人, 須藤元喜, 仁木佳文
Organizer
第9回日本認知症予防学会学術集会
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[Book] 転倒予防白書20192019
Author(s)
武藤芳照, 鈴木みずえ, 原田敦, 島田裕之(分担), 他
Total Pages
408
Publisher
日本医事新報社
ISBN
9784784961696
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