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Elucidation of generating mechanism of P-waves during REM sleep

Research Project

Project/Area Number 17H06520
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionTohoku University

Principal Investigator

Tsunematsu Tomomi  東北大学, 学際科学フロンティア研究所, 助教 (80726539)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords睡眠 / レム睡眠 / P波 / ノンレム睡眠 / 脳幹 / PGO波 / 大規模細胞外記録 / 神経科学 / 電気生理学
Outline of Final Research Achievements

Why we have to sleep? Surprisingly, nobody knows the answer exactly so far although sleep is an absolutely essential instinctive behavior to maintain normal health in animals. In particular, the function of REM (rapid eye movement) sleep, which is considered to be dreaming, has not been clarified yet. In this study, the generation mechanism of P-wave, which are local field potentials that are characteristically observed during REM sleep, was analyzed in detail electrophysiologically to ultimately intend to elucidate the physiological function of REM sleep.

Academic Significance and Societal Importance of the Research Achievements

我々は人生のおよそ3分の1の時間を眠って過ごす。睡眠を知り、より良い睡眠をとることは、人生の3分の1の質を上げるだけではない。睡眠不足が日常生活のパフォーマンスを落とすことから、より良い睡眠のおかげで、起きている生活もより豊かになる。しかしながら、睡眠の意義のみならず、睡眠を惹起するメカニズムも依然分かっていない点が多い。本研究では、睡眠のうち、夢を見ているレム睡眠時の脳幹の神経活動を明らかにした。さらに、ノンレム睡眠とレム睡眠では、脳内の情報伝達の方向が逆向きになることを示唆する結果を得た。本研究は、睡眠の機能にも迫る結果を得ており、睡眠の意義を明らかにしていく可能性を秘めている。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (14 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Book (1 results)

  • [Int'l Joint Research] University of Strathclyde/University of Edinburgh(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Strathclyde(英国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Distinct Temporal Coordination of Spontaneous Population Activity between Basal Forebrain and Auditory Cortex2017

    • Author(s)
      Yague Josue G.、Tsunematsu Tomomi、Sakata Shuzo
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 11 Pages: 1-14

    • DOI

      10.3389/fncir.2017.00064

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Neural ensemble dynamics during P-waves in mice2019

    • Author(s)
      Tomomi Tsunematsu, Arno Onken, Shuzo Sakata
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural ensemble dynamics during REM sleep and P-waves in mice2018

    • Author(s)
      Tomomi Tsunematsu
    • Organizer
      The 7th Annual IIIS Symposium, ~ Solving the mystery of sleep ~
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pontine neural ensemble dynamics during P-waves in mice2018

    • Author(s)
      Tomomi Tsunematsu, Shuzo Sakata
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Dynamics of Brainstem Neuronal Activity during P-waves in Mice2018

    • Author(s)
      Tomomi Tsunematsu, Shuzo Sakata
    • Organizer
      11th FENS Forum of European Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスにおけるレム睡眠P波発生機序の電気生理学的解析2018

    • Author(s)
      常松友美、坂田秀三
    • Organizer
      日本睡眠学会第43回定期学術集会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Brainstem neural ensemble dynamics during P-waves in mice2018

    • Author(s)
      Tomomi Tsunematsu and Shuzo Sakata
    • Organizer
      11th FENS Forum of Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization and optogenetics manipulation of P waves during REM sleep in mice2017

    • Author(s)
      Tomomi Tsunematsu
    • Organizer
      9th Optogenetics Research Society Japan International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスを用いたレム睡眠P波発生時の多神経活動記録と光操作2017

    • Author(s)
      常松友美、坂田秀三
    • Organizer
      日本睡眠学会第42回定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization and optogenetic manipulation of sub-second brain waves during REM sleep in mice2017

    • Author(s)
      常松友美、坂田秀三
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウスを用いたレム睡眠P波発生時の多神経活動記録2017

    • Author(s)
      常松友美、坂田秀三
    • Organizer
      生理学研究所研究会
    • Related Report
      2017 Annual Research Report
  • [Book] Clinical Neuroscience Vol. 36 08月号 光が拓く神経科学の未来―オプトジェネティクスと光イメージング2018

    • Author(s)
      常松友美、森澤陽介、松井広
    • Total Pages
      125
    • Publisher
      (株)中外医学社
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-08-25   Modified: 2020-03-30  

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