|Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|Outline of Final Research Achievements
[Background] REBOA increases proximal pressure, and simultaneously induces distal ischemia. The association between the degree of P-REBOA and organ ischemia has not been evaluated. [Methods] Total REBOA was defined as the cessation of distal pulse pressure, and the maximum volume was recorded. The animals were scanned at each 20% inflation of the maximum volume, and CT perfusion data were analyzed at PV, liver parenchyma, and SMV (indicating mesenteric perfusion). AUC of the TDC were calculated. [Results] The TDC of the PV, liver, and SMV showed a decreased peak and delayed TTP, and the AUC of the TDC decreased linearly consistently with balloon inflation (PV, Y=-1.071*X+106.8, r2=0.972, P=0.0003; liver, Y=-1.050*X+101.8, r2=0.933, P=0.0017; SMV, Y=-0.985*X+100.3, r2=0.952, P=0.0009). [Conclusion] CT perfusion analysis may indicate blood flow and organ ischemia during P-REBOA. The AUC of the TDCs at PV, liver, and SMV changed linearly according to balloon inflation.