| Project/Area Number |
17H06879
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Okayama University |
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Principal Investigator |
Saitoh Yasunori 岡山大学, 異分野基礎科学研究所, 特任助教 (10808786)
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 穀物 / 膜タンパク質 / 膜輸送体 / チャネル / アクアポリン / Ｘ線結晶構造解析 / ケイ酸 / X線結晶構造解析 / 構造解析 |
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| Outline of Final Research Achievements |
Silicon is an element abundantly contained in the soil, and influences the growth and productivity of important grains such as rice, corn and barley. Grains acquire resistance to biotic and abiotic stress by uptake of silicon from the soil, so it is expected that understanding of silicon uptake mechanism will greatly contribute to improving the robustness and productivity of grains. In this research project, I aimed to elucidate the structure of silicic acid channel responsible for silicon uptake at atomic level and clarify the atomic basis of silicon uptake. Through this research project, I was able to elucidate the structure of silicic acid channel at the atomic level, and identified amino acid residues that are important for silicic acid transport. These amino acids were never predicted from previous knowledge so far.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題を通して、世界で初めて穀物のケイ酸チャネルの詳細な構造を明らかにすることが出来た。これにより、穀物の生育および生産性を左右するケイ素の取り込み機構を詳細に理解することが出来るようになったので、穀物の生育および生産性を以前よりも効率よく向上させることが可能となった。また、ケイ酸を輸送する膜タンパク質の構造はこれまでに報告例がないため、輸送基質の選択性がどのようにして発揮されているのかという点について新しい知見を提供できる極めて重要な成果である。
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