Fabrication of beta-tricalcium phosphate granular cement with self-setting property on bleeding site
| Project/Area Number |
17H06910
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FUKUDA Naoyuki 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (10804156)
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨補填材 / リン酸三カルシウム / 顆粒セメント / 自己硬化性 / リン酸水素カルシウム / 増粘剤 / β-TCP顆粒 / 歯学 / 外科 / 生体材料 / 再生医学 / セラミックス |
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| Outline of Final Research Achievements |
This study aimed for fabrication and evaluation of beta-tricalcium phosphate (β-TCP) granular cement (β-TCP GC) with self-setting property on bleeding site. β-TCP GC, using the 20 mmol/L acidic Ca-P solution as liquid phase, was recommended as this concentration allowed surgical techniques to be performed easily and provided good mechanical strength. The maximum amount of carboxymethyl‐cellulose as thickening agent was 10wt% to the liquid phase. In fact, this new material was set even in the bleeding site of rat calvarial bone defects, and it was suggested that it would be an attractive material.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果において，既に開発しているβ-TCP顆粒セメントに、出血がある状況でも硬化が阻害されない性質を付与できることを確認した。これにより、現在臨床応用されているβ-TCP顆粒の問題点である充填後の骨欠損部からの移動や流出が克服できることが期待される。さらに、出血部位でも硬化することで、骨からの出血に対する止血剤としても応用できる可能性が示唆された。
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Report
(3 results)
Research Products
(5 results)
