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Basic examination of anti-tumor effect and mechanism of anti-hypertensive drug telmisartan for hepatocellular carcinoma

Research Project

Project/Area Number 17H06915
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionKagawa University

Principal Investigator

Toyota Yuka  香川大学, 医学部, 協力研究員 (00801565)

Research Collaborator Masaki Tutomu  
Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肝細胞癌 / 降圧薬テルミサルタン / テルミサルタン / 非ウイルス性肝細胞癌 / ARB / microRNA
Outline of Final Research Achievements

In 3 types (HLE, HLF, HepG2) of HCC cultured cell lines,telmisartan showed cell growth inhibitory effect, and 2 types (HuH-7, PLC / PRF / 5)were not delected anti-tumor effect.G1 arrest was observed due to the reduction in the expression of cyclinD1, Cdk4 and cyclinE induced from G1 to S phase of the cell cycle by the addition of telmisartan. Increased expression of phospho-p53 (Ser392) and decreased expression of survivin, increased degradation product of CCK-18 were detected, and induction of apoptosis were also observed.

Academic Significance and Societal Importance of the Research Achievements

降圧薬telmisartanはいくつかのHCC細胞株でmiRNAを介したG1アレストおよびアポトーシスの誘導を起こし、抗腫瘍効果を併せ持つ薬剤と考えられる。本研究は、今後高血圧や糖尿病性腎症を有するHCC患者にどの降圧薬を選択するかの1つの指針となる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] シスプラチンによる肝癌細胞増殖抑制の分子機構2017

    • Author(s)
      龍田美和、森下朝洋、坂本鉄平、田所智子、豊田由花、藤田浩二、野村貴子、谷丈二、米山弘人、正木勉
    • Organizer
      第53回日本肝臓学会総会
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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