Establishment of a novel periodontal tissue regeneration therapy through acquisition of periodontal ligament stem cell induction factor
| Project/Area Number |
17H06953
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯根膜幹細胞 / MEST / 培養上清 / 歯周組織再生 / 幹細胞 / 歯根膜 / 再生 / 歯学 / 再生医学 |
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| Outline of Final Research Achievements |
In this study, we found that the human periodontal ligament cell line transfected with MEST gene acquired stem cell characteristics. In addition, the MEST-overexpressed cell supernatant was found to promote the migration ability of human periodontal ligament cells. Furthermore, we identified a factor X, which related to acquisition of stem cell characteristic by MEST. These results suggested that MEST was involved in the acquisition of human periodontal ligament stem cells and was a key factor for periodontal tissue regeneration therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、本研究で得られた知見により、MESTによって獲得した歯根膜幹細胞を用いた新たな歯周組織再生治療法の開発に繋がるのではないかと考えている。
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Report
(3 results)
Research Products
(2 results)
