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Establishment of photodynamic therapy with a novel photosensitizer for gemcitabine resistant pancreatic cancer

Research Project

Project/Area Number 17H07008
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNagoya City University

Principal Investigator

Kato Akihisa  名古屋市立大学, 大学院医学研究科, 臨床研究医 (10803489)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords膵癌 / 光線力学療法 / PDT / Gemcitabine耐性 / gemcitabine / 腹膜播種
Outline of Final Research Achievements

Photodynamic therapy (PDT) has gained considerable attention as an alternative to management of cancer. We synthesized oligosaccharide-conjugated chlorin (O-chlorin) to improve cancer selectivity as well as antitumor effect, and investigated its effect for Gemcitabine(GEM) resistant pancreatic cancer. After establishment of GEM resistant pancreatic cancer cell lines, we showed the cytotoxic effects were about 11 - 16 times higher than those of Talaporfin, which is clinically used. We additionally established experimental peritoneal disseminated xenograft mouse models of GEM resistant pancreatic cancer cells and demonstrated the high cancer selectivity of O-chlorin in in vivo model. However, O-chlorin PDT did not suppress tumor growth of peritoneal disseminated tumor in mice compared with the Talaporfin group. Therefore, further studies are needed to establish the usefulness of this novel PDT for GEM resistant pancreatic cancer.

Academic Significance and Societal Importance of the Research Achievements

我々は高い腫瘍細胞選択性を可能にしたオリゴ糖連結クロリンを開発し,次世代のPDTとして期待される.この技術はWarburg効果としてFDG-PET検査にも応用されているように,癌細胞に普遍的な糖の取り込みを応用しているので,新規糖鎖連結光感受性物質はほぼすべての癌に応用が可能であり,実臨床において問題となるGEM耐性の膵癌などに対しても非常に有用な抗癌治療法である.そこで本研究では,GEMが無効となり腹膜播種病変が出現した際,現在の医療では治療選択肢が何もない中で,積極的かつ低侵襲な腹膜播種巣に対する治療としての一つの治療選択を提案することを目的としている.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (2 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Funded Workshop (1 results)

  • [Journal Article] Excellent antitumor effects for gastrointestinal cancers using photodynamic therapy with a novel glucose conjugated chlorin e62018

    • Author(s)
      Nishie Hirotada、Kataoka Hiromi、Yano Shigenobu、Yamaguchi Hiroaki、Nomoto Akihiro、Tanaka Mamoru、Kato Akihisa、Shimura Takaya、Mizoshita Tsutomu、Kubota Eiji、Tanida Satoshi、Joh Takashi
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 496 Issue: 4 Pages: 1204-1209

    • DOI

      10.1016/j.bbrc.2018.01.171

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Funded Workshop] Digestive Disease Week2018

    • Related Report
      2018 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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